ISMARA results: SP3

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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for SP3

Z-value: 2.16

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Transcription factors associated with SP3

Gene Symbol	Gene ID	Gene Info
SP3 Ensembl NCBI GeneCards UniProt	ENSG00000172845.9	Sp3 transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SP3	hg19_v2_chr2_-_174830430_174830563	-0.98	1.8e-02	Click!

Activity profile of SP3 motif

Sorted Z-values of SP3 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_+_47778119 Show fit	3.68	ENST00000552360.2	PRR24 Ensembl NCBI GeneCards UniProt Show fit	proline rich 24
chr8_-_145691031 Show fit	3.08	ENST00000424149.2 ENST00000530637.1 ENST00000306145.5	CYHR1 Ensembl NCBI GeneCards UniProt Show fit	cysteine/histidine-rich 1
chr19_-_1863567 Show fit	2.91	ENST00000250916.4	KLF16 Ensembl NCBI GeneCards UniProt Show fit	Kruppel-like factor 16
chr2_-_178129551 Show fit	2.82	ENST00000430047.1	NFE2L2 Ensembl NCBI GeneCards UniProt Show fit	nuclear factor, erythroid 2-like 2
chr14_-_21566731 Show fit	2.73	ENST00000360947.3	ZNF219 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 219
chr9_+_130922537 Show fit	2.72	ENST00000372994.1	C9orf16 Ensembl NCBI GeneCards UniProt Show fit	chromosome 9 open reading frame 16
chr11_+_64073022 Show fit	2.63	ENST00000406310.1 ENST00000000442.6 ENST00000539594.1	ESRRA Ensembl NCBI GeneCards UniProt Show fit	estrogen-related receptor alpha
chr19_+_54694119 Show fit	2.57	ENST00000456872.1 ENST00000302937.4 ENST00000429671.2	TSEN34 Ensembl NCBI GeneCards UniProt Show fit	TSEN34 tRNA splicing endonuclease subunit
chr19_+_6373482 Show fit	2.55	ENST00000596657.1	ALKBH7 Ensembl NCBI GeneCards UniProt Show fit	alkB, alkylation repair homolog 7 (E. coli)
chr14_+_105559784 Show fit	2.51	ENST00000548104.1	RP11-44N21.1 Ensembl NCBI GeneCards UniProt Show fit	RP11-44N21.1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SP3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	7.0	GO:0030202	heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.2	6.7	GO:0050655	dermatan sulfate proteoglycan metabolic process(GO:0050655)
0.7	6.5	GO:0006049	UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.5	6.2	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.6	6.1	GO:0030259	lipid glycosylation(GO:0030259)
1.1	5.5	GO:0009440	cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440)
0.3	5.5	GO:1901642	nucleoside transmembrane transport(GO:1901642)
0.1	5.4	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
0.9	5.2	GO:1902445	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.1	5.1	GO:0035428	hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)

Showing 1 to 10 of 1,146 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	184.3	GO:0016021	integral component of membrane(GO:0016021)
0.1	22.7	GO:0043202	lysosomal lumen(GO:0043202)
0.0	19.6	GO:0005759	mitochondrial matrix(GO:0005759)
0.0	18.4	GO:0005765	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.2	14.1	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.1	7.2	GO:0031526	brush border membrane(GO:0031526)
0.1	7.0	GO:0005581	collagen trimer(GO:0005581)
0.1	6.6	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.3	5.1	GO:0000813	ESCRT I complex(GO:0000813)
0.1	5.1	GO:0045171	intercellular bridge(GO:0045171)

Showing 1 to 10 of 309 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.8	GO:0030695	GTPase regulator activity(GO:0030695)
0.1	7.4	GO:0051213	dioxygenase activity(GO:0051213)
0.1	6.7	GO:0017091	AU-rich element binding(GO:0017091)
0.3	6.6	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.7	6.5	GO:0003827	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.6	6.4	GO:0019826	oxygen sensor activity(GO:0019826)
0.1	5.6	GO:0017166	vinculin binding(GO:0017166)
0.9	5.5	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.5	5.2	GO:0019534	toxin transporter activity(GO:0019534)
0.2	5.2	GO:0017154	semaphorin receptor activity(GO:0017154)

Showing 1 to 10 of 663 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	13.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	9.9	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.1	9.4	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.1	7.5	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	5.6	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.1	5.2	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	4.5	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	4.2	ST GAQ PATHWAY	G alpha q Pathway
0.1	3.7	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	3.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks

Showing 1 to 10 of 63 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	12.9	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.2	11.7	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.2	11.3	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.1	10.6	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.3	7.4	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.1	6.9	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.4	6.2	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.1	6.2	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.1	6.0	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.2	5.5	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis

Showing 1 to 10 of 132 entries

Results for SP3

Z-value: 2.16

Motif logo

Transcription factors associated with SP3

Activity-expression correlation:

Activity profile of SP3 motif

Sorted Z-values of SP3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SP3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: