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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for SMAD4
Z-value: 2.64
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Transcription factors associated with SMAD4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMAD4 | hg19_v2_chr18_+_48556470_48556640 | -0.95 | 5.3e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SMAD4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.8 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
| 0.2 | 2.2 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.7 | 2.1 | GO:0061537 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
| 0.4 | 1.7 | GO:1903803 | glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803) |
| 0.3 | 1.7 | GO:0070221 | sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221) |
| 0.3 | 1.6 | GO:0030037 | actin filament reorganization involved in cell cycle(GO:0030037) |
| 0.0 | 1.6 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.0 | 1.6 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.4 | 1.5 | GO:0006669 | sphinganine-1-phosphate biosynthetic process(GO:0006669) |
| 0.2 | 1.5 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | GO:0031514 | motile cilium(GO:0031514) |
| 0.0 | 2.2 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 1.7 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.2 | 1.3 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
| 0.1 | 1.3 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.0 | 1.3 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.2 | 1.2 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
| 0.0 | 1.2 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.0 | 1.2 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 1.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.3 | 2.8 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 0.1 | 2.5 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.8 | 2.4 | GO:0033867 | Fas-activated serine/threonine kinase activity(GO:0033867) |
| 0.5 | 2.1 | GO:0015375 | glycine:sodium symporter activity(GO:0015375) |
| 0.3 | 1.8 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.2 | 1.7 | GO:0015186 | L-glutamine transmembrane transporter activity(GO:0015186) |
| 0.1 | 1.6 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 1.5 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.1 | 1.4 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 2.0 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 2.0 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.5 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.4 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.9 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 0.7 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 3.0 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 2.3 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 2.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.9 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 1.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 1.8 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 1.7 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 1.6 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.1 | 1.3 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |