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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for SMAD3
Z-value: 2.20
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Transcription factors associated with SMAD3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMAD3 | hg19_v2_chr15_+_67358163_67358192 | 0.51 | 4.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_26027480 Show fit | 3.66 |
ENST00000377364.3
|
histone cluster 1, H4b |
|
| chr6_+_27782788 Show fit | 2.76 |
ENST00000359465.4
|
histone cluster 1, H2bm |
|
| chr6_+_27114861 Show fit | 2.74 |
ENST00000377459.1
|
histone cluster 1, H2ah |
|
| chr6_-_26189304 Show fit | 2.73 |
ENST00000340756.2
|
histone cluster 1, H4d |
|
| chr6_+_26273144 Show fit | 2.30 |
ENST00000377733.2
|
histone cluster 1, H2bi |
|
| chr6_-_27782548 Show fit | 1.97 |
ENST00000333151.3
|
histone cluster 1, H2aj |
|
| chr6_-_27775694 Show fit | 1.86 |
ENST00000377401.2
|
histone cluster 1, H2bl |
|
| chr6_+_27791862 Show fit | 1.86 |
ENST00000355057.1
|
histone cluster 1, H4j |
|
| chr6_-_27860956 Show fit | 1.63 |
ENST00000359611.2
|
histone cluster 1, H2am |
|
| chr6_+_27775899 Show fit | 1.58 |
ENST00000358739.3
|
histone cluster 1, H2ai |
Network of associatons between targets according to the STRING database.
First level regulatory network of SMAD3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.6 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.0 | 4.9 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.1 | 1.6 | GO:0000972 | transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972) |
| 0.1 | 1.3 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
| 0.1 | 1.1 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.1 | 0.9 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.0 | 0.8 | GO:0006363 | termination of RNA polymerase I transcription(GO:0006363) |
| 0.2 | 0.7 | GO:0006154 | adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103) |
| 0.0 | 0.7 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.0 | 0.7 | GO:0035635 | entry of bacterium into host cell(GO:0035635) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.7 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 1.8 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.1 | 1.1 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.1 | 0.9 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.1 | 0.8 | GO:0000120 | RNA polymerase I transcription factor complex(GO:0000120) |
| 0.1 | 0.6 | GO:1990769 | proximal neuron projection(GO:1990769) |
| 0.0 | 0.6 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.3 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.0 | 0.3 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.1 | 0.2 | GO:0071665 | gamma-catenin-TCF7L2 complex(GO:0071665) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.2 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.1 | 1.3 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.0 | 0.9 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.8 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
| 0.2 | 0.7 | GO:0004796 | thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134) |
| 0.1 | 0.7 | GO:0047820 | D-glutamate cyclase activity(GO:0047820) |
| 0.1 | 0.7 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.0 | 0.6 | GO:0001163 | RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164) |
| 0.0 | 0.6 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 0.5 | GO:0015093 | ferrous iron transmembrane transporter activity(GO:0015093) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.2 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.9 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.9 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 24.2 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 1.6 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 1.3 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 0.9 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 0.9 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.8 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 0.7 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.0 | 0.6 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 0.5 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.4 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |