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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for SMAD3

Z-value: 2.20

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Transcription factors associated with SMAD3

Gene Symbol Gene ID Gene Info
SMAD3
ENSG00000166949.11 SMAD family member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMAD3hg19_v2_chr15_+_67358163_673581920.514.9e-01Click!

Activity profile of SMAD3 motif

Sorted Z-values of SMAD3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_26027480 3.66 ENST00000377364.3
HIST1H4B
histone cluster 1, H4b
chr6_+_27782788 2.76 ENST00000359465.4
HIST1H2BM
histone cluster 1, H2bm
chr6_+_27114861 2.74 ENST00000377459.1
HIST1H2AH
histone cluster 1, H2ah
chr6_-_26189304 2.73 ENST00000340756.2
HIST1H4D
histone cluster 1, H4d
chr6_+_26273144 2.30 ENST00000377733.2
HIST1H2BI
histone cluster 1, H2bi
chr6_-_27782548 1.97 ENST00000333151.3
HIST1H2AJ
histone cluster 1, H2aj
chr6_-_27775694 1.86 ENST00000377401.2
HIST1H2BL
histone cluster 1, H2bl
chr6_+_27791862 1.86 ENST00000355057.1
HIST1H4J
histone cluster 1, H4j
chr6_-_27860956 1.63 ENST00000359611.2
HIST1H2AM
histone cluster 1, H2am
chr6_+_27775899 1.58 ENST00000358739.3
HIST1H2AI
histone cluster 1, H2ai
chr6_-_26033796 1.16 ENST00000259791.2
HIST1H2AB
histone cluster 1, H2ab
chr6_-_26285737 1.14 ENST00000377727.1
ENST00000289352.1
HIST1H4H
histone cluster 1, H4h
chr1_+_149804218 1.12 ENST00000610125.1
HIST2H4A
histone cluster 2, H4a
chr16_-_31076273 0.91 ENST00000426488.2
ZNF668
zinc finger protein 668
chr16_-_31076332 0.91 ENST00000539836.3
ENST00000535577.1
ENST00000442862.2
ZNF668
zinc finger protein 668
chr11_+_35222629 0.85 ENST00000526553.1
CD44
CD44 molecule (Indian blood group)
chr6_-_27100529 0.83 ENST00000607124.1
ENST00000339812.2
ENST00000541790.1
HIST1H2BJ
histone cluster 1, H2bj
chr20_+_55926625 0.81 ENST00000452119.1
RAE1
ribonucleic acid export 1
chr5_-_180242534 0.77 ENST00000333055.3
ENST00000513431.1
MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr6_-_26216872 0.77 ENST00000244601.3
HIST1H2BG
histone cluster 1, H2bg
chr19_+_18283959 0.73 ENST00000597802.2
IFI30
interferon, gamma-inducible protein 30
chr6_+_26204825 0.71 ENST00000360441.4
HIST1H4E
histone cluster 1, H4e
chr11_+_57531292 0.69 ENST00000524579.1
CTNND1
catenin (cadherin-associated protein), delta 1
chr6_+_27861190 0.68 ENST00000303806.4
HIST1H2BO
histone cluster 1, H2bo
chr1_-_156399184 0.67 ENST00000368243.1
ENST00000357975.4
ENST00000310027.5
ENST00000400991.2
C1orf61
chromosome 1 open reading frame 61
chr6_-_27806117 0.60 ENST00000330180.2
HIST1H2AK
histone cluster 1, H2ak
chr19_+_36132631 0.57 ENST00000379026.2
ENST00000379023.4
ENST00000402764.2
ENST00000479824.1
ETV2
ets variant 2
chr5_-_180242576 0.57 ENST00000514438.1
MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr6_+_27100811 0.57 ENST00000359193.2
HIST1H2AG
histone cluster 1, H2ag
chr15_+_63889577 0.56 ENST00000534939.1
ENST00000539570.3
FBXL22
F-box and leucine-rich repeat protein 22
chr16_+_699319 0.55 ENST00000549091.1
ENST00000293879.4
WDR90
WD repeat domain 90
chrX_+_47444613 0.54 ENST00000445623.1
TIMP1
TIMP metallopeptidase inhibitor 1
chr8_+_22250334 0.53 ENST00000520832.1
SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr10_-_106098162 0.45 ENST00000337478.1
ITPRIP
inositol 1,4,5-trisphosphate receptor interacting protein
chr1_+_200863949 0.44 ENST00000413687.2
C1orf106
chromosome 1 open reading frame 106
chr17_-_73874654 0.43 ENST00000254816.2
TRIM47
tripartite motif containing 47
chr14_-_65409502 0.42 ENST00000389614.5
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr16_-_57798253 0.42 ENST00000565270.1
KIFC3
kinesin family member C3
chr20_+_55926566 0.42 ENST00000411894.1
ENST00000429339.1
RAE1
ribonucleic acid export 1
chr16_-_84220604 0.41 ENST00000567759.1
TAF1C
TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
chr2_-_220110187 0.40 ENST00000295759.7
ENST00000392089.2
GLB1L
galactosidase, beta 1-like
chr16_-_84220633 0.40 ENST00000566732.1
ENST00000561955.1
ENST00000564454.1
ENST00000341690.6
ENST00000541676.1
ENST00000570117.1
ENST00000564345.1
TAF1C
TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
chr20_+_44036900 0.40 ENST00000443296.1
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr16_-_425205 0.39 ENST00000448854.1
TMEM8A
transmembrane protein 8A
chr20_-_43280325 0.39 ENST00000537820.1
ADA
adenosine deaminase
chr7_-_55620433 0.38 ENST00000418904.1
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr14_+_96858454 0.38 ENST00000555570.1
AK7
adenylate kinase 7
chr6_-_26124138 0.38 ENST00000314332.5
ENST00000396984.1
HIST1H2BC
histone cluster 1, H2bc
chr16_+_57847684 0.37 ENST00000335616.2
CTD-2600O9.1
uncharacterized protein LOC388282
chr8_+_128747661 0.37 ENST00000259523.6
MYC
v-myc avian myelocytomatosis viral oncogene homolog
chr7_+_139528952 0.36 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr11_-_65150103 0.36 ENST00000294187.6
ENST00000398802.1
ENST00000360662.3
ENST00000377152.2
ENST00000530936.1
SLC25A45
solute carrier family 25, member 45
chr5_+_140566 0.35 ENST00000502646.1
PLEKHG4B
pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
chr5_+_140625147 0.35 ENST00000231173.3
PCDHB15
protocadherin beta 15
chr20_+_44036620 0.33 ENST00000372710.3
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr22_+_20877924 0.33 ENST00000445189.1
MED15
mediator complex subunit 15
chr2_-_208031943 0.33 ENST00000421199.1
ENST00000457962.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr2_+_28615669 0.33 ENST00000379619.1
ENST00000264716.4
FOSL2
FOS-like antigen 2
chr6_+_41888926 0.32 ENST00000230340.4
BYSL
bystin-like
chr16_-_30773372 0.32 ENST00000545825.1
ENST00000541260.1
C16orf93
chromosome 16 open reading frame 93
chr15_+_63889552 0.32 ENST00000360587.2
FBXL22
F-box and leucine-rich repeat protein 22
chr5_+_140529630 0.32 ENST00000543635.1
PCDHB6
protocadherin beta 6
chr7_+_139529040 0.31 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr6_-_27841289 0.31 ENST00000355981.2
HIST1H4L
histone cluster 1, H4l
chr20_-_43280361 0.31 ENST00000372874.4
ADA
adenosine deaminase
chr7_-_22862448 0.31 ENST00000358435.4
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr1_-_44482979 0.31 ENST00000360584.2
ENST00000357730.2
ENST00000528803.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr19_+_42724423 0.30 ENST00000301215.3
ENST00000597945.1
ZNF526
zinc finger protein 526
chr19_-_42724261 0.29 ENST00000595337.1
DEDD2
death effector domain containing 2
chr16_-_11036300 0.29 ENST00000331808.4
DEXI
Dexi homolog (mouse)
chr1_+_202385953 0.29 ENST00000466968.1
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr11_+_62538775 0.29 ENST00000294168.3
ENST00000526261.1
TAF6L
TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
chr1_-_9189229 0.28 ENST00000377411.4
GPR157
G protein-coupled receptor 157
chr9_+_44867571 0.28 ENST00000377548.2
RP11-160N1.10
RP11-160N1.10
chr1_-_9189144 0.28 ENST00000414642.2
GPR157
G protein-coupled receptor 157
chr6_-_41888843 0.28 ENST00000434077.1
ENST00000409312.1
MED20
mediator complex subunit 20
chr11_-_107729504 0.28 ENST00000265836.7
SLC35F2
solute carrier family 35, member F2
chr17_-_43487780 0.28 ENST00000532038.1
ENST00000528677.1
ARHGAP27
Rho GTPase activating protein 27
chr11_-_107729287 0.27 ENST00000375682.4
SLC35F2
solute carrier family 35, member F2
chr17_-_39093672 0.27 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
KRT23
keratin 23 (histone deacetylase inducible)
chr20_+_55926583 0.26 ENST00000395840.2
RAE1
ribonucleic acid export 1
chr8_+_145065705 0.25 ENST00000533044.1
GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr19_-_55691614 0.24 ENST00000592470.1
ENST00000354308.3
SYT5
synaptotagmin V
chr14_+_91580708 0.24 ENST00000518868.1
C14orf159
chromosome 14 open reading frame 159
chr17_-_26733604 0.24 ENST00000584426.1
ENST00000584995.1
SLC46A1
solute carrier family 46 (folate transporter), member 1
chr4_+_2813946 0.24 ENST00000442312.2
SH3BP2
SH3-domain binding protein 2
chr17_-_39942322 0.23 ENST00000449889.1
ENST00000465293.1
JUP
junction plakoglobin
chr19_+_34850385 0.23 ENST00000587521.2
ENST00000587384.1
ENST00000592277.1
GPI
glucose-6-phosphate isomerase
chr4_-_103940791 0.22 ENST00000510559.1
ENST00000394789.3
ENST00000296422.7
SLC9B1
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
chr16_-_3306587 0.22 ENST00000541159.1
ENST00000536379.1
ENST00000219596.1
ENST00000339854.4
MEFV
Mediterranean fever
chr17_+_30813576 0.20 ENST00000313401.3
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr9_+_114287433 0.20 ENST00000358151.4
ENST00000355824.3
ENST00000374374.3
ENST00000309235.5
ZNF483
zinc finger protein 483
chr20_-_30311703 0.19 ENST00000450273.1
ENST00000456404.1
ENST00000420488.1
ENST00000439267.1
BCL2L1
BCL2-like 1
chr12_+_14927270 0.19 ENST00000544848.1
H2AFJ
H2A histone family, member J
chr14_-_65409438 0.19 ENST00000557049.1
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr1_+_59762642 0.18 ENST00000371218.4
ENST00000303721.7
FGGY
FGGY carbohydrate kinase domain containing
chr11_-_71781096 0.18 ENST00000535087.1
ENST00000535838.1
NUMA1
nuclear mitotic apparatus protein 1
chr14_+_91581011 0.18 ENST00000523894.1
ENST00000522322.1
ENST00000523771.1
C14orf159
chromosome 14 open reading frame 159
chr16_+_30773636 0.18 ENST00000402121.3
ENST00000565995.1
ENST00000563683.1
ENST00000357890.5
ENST00000565931.1
RNF40
ring finger protein 40, E3 ubiquitin protein ligase
chr4_-_38666430 0.17 ENST00000436901.1
AC021860.1
Uncharacterized protein
chr19_-_13947099 0.17 ENST00000587762.1
MIR24-2
microRNA 24-2
chr19_-_55691377 0.17 ENST00000589172.1
SYT5
synaptotagmin V
chr2_-_136594740 0.17 ENST00000264162.2
LCT
lactase
chr10_+_94451574 0.17 ENST00000492654.2
HHEX
hematopoietically expressed homeobox
chr22_+_41956767 0.17 ENST00000306149.7
CSDC2
cold shock domain containing C2, RNA binding
chr11_-_3147835 0.16 ENST00000525498.1
OSBPL5
oxysterol binding protein-like 5
chr17_+_12859080 0.16 ENST00000583608.1
ARHGAP44
Rho GTPase activating protein 44
chr7_+_39125365 0.15 ENST00000559001.1
ENST00000464276.2
POU6F2
POU class 6 homeobox 2
chr12_+_119616447 0.15 ENST00000281938.2
HSPB8
heat shock 22kDa protein 8
chr5_+_52776228 0.15 ENST00000256759.3
FST
follistatin
chr16_+_618837 0.15 ENST00000409439.2
PIGQ
phosphatidylinositol glycan anchor biosynthesis, class Q
chr2_-_75788424 0.15 ENST00000410071.1
EVA1A
eva-1 homolog A (C. elegans)
chr19_-_55691472 0.14 ENST00000537500.1
SYT5
synaptotagmin V
chr4_-_90759440 0.14 ENST00000336904.3
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chrX_-_2847366 0.14 ENST00000381154.1
ARSD
arylsulfatase D
chr11_-_72145426 0.14 ENST00000535990.1
ENST00000437826.2
ENST00000340729.5
CLPB
ClpB caseinolytic peptidase B homolog (E. coli)
chr14_+_91580357 0.14 ENST00000298858.4
ENST00000521081.1
ENST00000520328.1
ENST00000256324.10
ENST00000524232.1
ENST00000522170.1
ENST00000519950.1
ENST00000523879.1
ENST00000521077.2
ENST00000518665.2
C14orf159
chromosome 14 open reading frame 159
chr12_+_50135351 0.13 ENST00000549445.1
ENST00000550951.1
ENST00000549385.1
ENST00000548713.1
ENST00000548201.1
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr20_+_55926274 0.13 ENST00000371242.2
ENST00000527947.1
RAE1
ribonucleic acid export 1
chr11_+_46383121 0.13 ENST00000454345.1
DGKZ
diacylglycerol kinase, zeta
chr12_+_50135327 0.13 ENST00000549966.1
ENST00000547832.1
ENST00000547187.1
ENST00000548894.1
ENST00000546914.1
ENST00000552699.1
ENST00000267115.5
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr15_+_22736484 0.13 ENST00000560659.2
GOLGA6L1
golgin A6 family-like 1
chr11_+_72983246 0.13 ENST00000393590.2
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr6_-_99842041 0.13 ENST00000254759.3
ENST00000369242.1
COQ3
coenzyme Q3 methyltransferase
chr1_-_9129735 0.12 ENST00000377424.4
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr14_+_91580777 0.12 ENST00000525393.2
ENST00000428926.2
ENST00000517362.1
C14orf159
chromosome 14 open reading frame 159
chr16_+_30484054 0.12 ENST00000564118.1
ENST00000454514.2
ENST00000433423.2
ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr19_-_46148820 0.12 ENST00000587152.1
EML2
echinoderm microtubule associated protein like 2
chr12_-_110906027 0.11 ENST00000537466.2
ENST00000550974.1
ENST00000228827.3
GPN3
GPN-loop GTPase 3
chr3_+_126243126 0.11 ENST00000319340.2
CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr1_+_209602771 0.11 ENST00000440276.1
MIR205HG
MIR205 host gene (non-protein coding)
chr19_-_11688500 0.11 ENST00000433365.2
ACP5
acid phosphatase 5, tartrate resistant
chr19_-_41196458 0.11 ENST00000598779.1
NUMBL
numb homolog (Drosophila)-like
chr11_+_60869867 0.11 ENST00000347785.3
CD5
CD5 molecule
chrX_-_48931648 0.11 ENST00000376386.3
ENST00000376390.4
PRAF2
PRA1 domain family, member 2
chr17_-_43487741 0.10 ENST00000455881.1
ARHGAP27
Rho GTPase activating protein 27
chr12_+_49212514 0.10 ENST00000301050.2
ENST00000548279.1
ENST00000547230.1
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr15_+_22736246 0.10 ENST00000316397.3
GOLGA6L1
golgin A6 family-like 1
chr11_+_117070037 0.10 ENST00000392951.4
ENST00000525531.1
ENST00000278968.6
TAGLN
transgelin
chr15_-_82338460 0.09 ENST00000558133.1
ENST00000329713.4
MEX3B
mex-3 RNA binding family member B
chr6_+_123038689 0.09 ENST00000354275.2
ENST00000368446.1
PKIB
protein kinase (cAMP-dependent, catalytic) inhibitor beta
chr8_+_10530133 0.09 ENST00000304519.5
C8orf74
chromosome 8 open reading frame 74
chr2_-_220110111 0.08 ENST00000428427.1
ENST00000356283.3
ENST00000432839.1
ENST00000424620.1
GLB1L
galactosidase, beta 1-like
chr6_+_30850697 0.08 ENST00000509639.1
ENST00000412274.2
ENST00000507901.1
ENST00000507046.1
ENST00000437124.2
ENST00000454612.2
ENST00000396342.2
DDR1
discoidin domain receptor tyrosine kinase 1
chr1_-_160832642 0.08 ENST00000368034.4
CD244
CD244 molecule, natural killer cell receptor 2B4
chr22_-_36635563 0.08 ENST00000451256.2
APOL2
apolipoprotein L, 2
chr12_+_50135588 0.08 ENST00000423828.1
ENST00000550445.1
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr4_+_2814011 0.08 ENST00000502260.1
ENST00000435136.2
SH3BP2
SH3-domain binding protein 2
chr20_-_23030296 0.07 ENST00000377103.2
THBD
thrombomodulin
chr18_+_43753974 0.07 ENST00000282059.6
ENST00000321319.6
C18orf25
chromosome 18 open reading frame 25
chr17_+_78193443 0.06 ENST00000577155.1
SLC26A11
solute carrier family 26 (anion exchanger), member 11
chr3_+_12838161 0.06 ENST00000456430.2
CAND2
cullin-associated and neddylation-dissociated 2 (putative)
chr10_+_129796390 0.06 ENST00000455661.1
PTPRE
protein tyrosine phosphatase, receptor type, E
chr6_+_116937636 0.06 ENST00000368581.4
ENST00000229554.5
ENST00000368580.4
RSPH4A
radial spoke head 4 homolog A (Chlamydomonas)
chr16_+_30483962 0.06 ENST00000356798.6
ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr14_+_91580732 0.06 ENST00000519019.1
ENST00000523816.1
ENST00000517518.1
C14orf159
chromosome 14 open reading frame 159
chr17_-_34195889 0.05 ENST00000311880.2
C17orf66
chromosome 17 open reading frame 66
chr18_+_55862622 0.05 ENST00000456173.2
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr15_-_83315874 0.05 ENST00000569257.1
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr6_+_27806319 0.05 ENST00000606613.1
ENST00000396980.3
HIST1H2BN
histone cluster 1, H2bn
chr6_+_30850862 0.04 ENST00000504651.1
ENST00000512694.1
ENST00000515233.1
DDR1
discoidin domain receptor tyrosine kinase 1
chr14_+_93389425 0.04 ENST00000216492.5
ENST00000334654.4
CHGA
chromogranin A (parathyroid secretory protein 1)
chr3_+_69811858 0.04 ENST00000433517.1
MITF
microphthalmia-associated transcription factor
chr16_-_58328923 0.04 ENST00000567164.1
ENST00000219301.4
ENST00000569727.1
PRSS54
protease, serine, 54
chr6_-_133119668 0.03 ENST00000275227.4
ENST00000538764.1
SLC18B1
solute carrier family 18, subfamily B, member 1
chr3_+_125687987 0.03 ENST00000514116.1
ENST00000251776.4
ENST00000504401.1
ENST00000513830.1
ENST00000508088.1
ROPN1B
rhophilin associated tail protein 1B
chr18_+_77623668 0.03 ENST00000316249.3
KCNG2
potassium voltage-gated channel, subfamily G, member 2
chr17_-_34195862 0.03 ENST00000592980.1
ENST00000587626.1
C17orf66
chromosome 17 open reading frame 66
chr22_-_46644182 0.03 ENST00000404583.1
ENST00000404744.1
CDPF1
cysteine-rich, DPF motif domain containing 1
chr4_-_186696425 0.02 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
SORBS2
sorbin and SH3 domain containing 2
chr8_+_38586068 0.02 ENST00000443286.2
ENST00000520340.1
ENST00000518415.1
TACC1
transforming, acidic coiled-coil containing protein 1
chr15_-_83316087 0.02 ENST00000568757.1
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr1_+_52682052 0.02 ENST00000371591.1
ZFYVE9
zinc finger, FYVE domain containing 9
chr5_+_55147205 0.02 ENST00000396836.2
ENST00000396834.1
ENST00000447346.2
ENST00000359040.5
IL31RA
interleukin 31 receptor A
chr6_-_41888814 0.01 ENST00000409060.1
ENST00000265350.4
MED20
mediator complex subunit 20
chr20_-_6103666 0.01 ENST00000536936.1
FERMT1
fermitin family member 1
chr12_+_65563329 0.01 ENST00000308330.2
LEMD3
LEM domain containing 3
chr8_+_10530155 0.01 ENST00000521818.1
C8orf74
chromosome 8 open reading frame 74
chr15_-_23414193 0.01 ENST00000558241.1
RP11-467N20.5
Protein LOC440233
chr18_+_13611763 0.01 ENST00000585931.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr11_+_35211511 0.01 ENST00000524922.1
CD44
CD44 molecule (Indian blood group)
chr2_+_220110177 0.01 ENST00000409638.3
ENST00000396738.2
ENST00000409516.3
STK16
serine/threonine kinase 16
chr6_-_66417107 0.00 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
EYS
eyes shut homolog (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0006154 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
0.2 0.6 GO:0060796 regulation of transcription involved in primary germ layer cell fate commitment(GO:0060796)
0.1 1.3 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.1 1.1 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 1.6 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.1 0.2 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.1 0.3 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.9 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.4 GO:0090096 regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
0.1 0.2 GO:0061010 gall bladder development(GO:0061010)
0.1 0.2 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.1 0.1 GO:0010265 SCF complex assembly(GO:0010265)
0.1 0.4 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.1 6.6 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.5 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.3 GO:1904721 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.6 GO:0060019 radial glial cell differentiation(GO:0060019)
0.0 0.2 GO:0019242 methylglyoxal biosynthetic process(GO:0019242)
0.0 0.4 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.2 GO:0051958 methotrexate transport(GO:0051958)
0.0 0.4 GO:0032494 response to peptidoglycan(GO:0032494)
0.0 0.7 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 4.9 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.2 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.2 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.0 0.2 GO:0007402 ganglion mother cell fate determination(GO:0007402)
0.0 0.5 GO:1903874 ferrous iron transport(GO:0015684) ferrous iron transmembrane transport(GO:1903874)
0.0 0.1 GO:0051585 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.0 0.1 GO:0044376 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.0 0.1 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 0.1 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.0 0.2 GO:0098886 modification of dendritic spine(GO:0098886)
0.0 0.1 GO:0035740 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.0 0.2 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.0 0.3 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.2 GO:1902846 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.0 0.1 GO:2001168 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.0 0.3 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.7 GO:0035635 entry of bacterium into host cell(GO:0035635)
0.0 0.8 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.0 0.0 GO:1900738 dense core granule biogenesis(GO:0061110) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
0.0 0.3 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.3 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.2 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 12.7 GO:0000786 nucleosome(GO:0000786)
0.1 0.6 GO:1990769 proximal neuron projection(GO:1990769)
0.1 0.9 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.8 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.1 0.2 GO:0071665 gamma-catenin-TCF7L2 complex(GO:0071665)
0.1 1.1 GO:0005915 zonula adherens(GO:0005915)
0.0 0.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 1.8 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0001534 radial spoke(GO:0001534)
0.0 0.3 GO:0030914 STAGA complex(GO:0030914)
0.0 0.1 GO:0033503 HULC complex(GO:0033503)
0.0 0.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0004796 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.1 1.3 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.1 0.7 GO:0047820 D-glutamate cyclase activity(GO:0047820)
0.1 0.3 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 0.2 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.1 0.4 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.1 0.2 GO:0005199 structural constituent of cell wall(GO:0005199)
0.1 0.7 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.2 GO:0004347 glucose-6-phosphate isomerase activity(GO:0004347)
0.0 0.5 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.0 0.3 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.2 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.2 GO:0015350 methotrexate transporter activity(GO:0015350)
0.0 0.5 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 0.1 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.0 0.6 GO:0001163 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0 0.8 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0008169 C-methyltransferase activity(GO:0008169)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.0 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.6 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.3 GO:0015266 protein channel activity(GO:0015266)
0.0 0.2 GO:0051434 BH3 domain binding(GO:0051434)
0.0 13.2 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.4 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.2 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.4 GO:0070888 E-box binding(GO:0070888)
0.0 0.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.9 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 1.2 PID IL6 7 PATHWAY IL6-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 24.2 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.9 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.6 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.7 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.8 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.3 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.9 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.4 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.6 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type