ISMARA results: SMAD2

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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for SMAD2

Z-value: 0.84

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Transcription factors associated with SMAD2

Gene Symbol	Gene ID	Gene Info
SMAD2 Ensembl NCBI GeneCards UniProt	ENSG00000175387.11	SMAD family member 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SMAD2	hg19_v2_chr18_-_45456930_45456970	-0.98	1.7e-02	Click!

Activity profile of SMAD2 motif

Sorted Z-values of SMAD2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_-_7297833 Show fit	0.73	ENST00000571802.1 ENST00000576201.1 ENST00000573213.1 ENST00000324822.11	TMEM256-PLSCR3 Ensembl NCBI GeneCards UniProt Show fit	TMEM256-PLSCR3 readthrough (NMD candidate)
chr19_+_11466062 Show fit	0.57	ENST00000251473.5 ENST00000591329.1 ENST00000586380.1	DKFZP761J1410 Ensembl NCBI GeneCards UniProt Show fit	Lipid phosphate phosphatase-related protein type 2
chr18_+_20715416 Show fit	0.57	ENST00000580153.1	CABLES1 Ensembl NCBI GeneCards UniProt Show fit	Cdk5 and Abl enzyme substrate 1
chr19_+_50148087 Show fit	0.50	ENST00000601038.1 ENST00000595242.1	SCAF1 Ensembl NCBI GeneCards UniProt Show fit	SR-related CTD-associated factor 1
chr19_-_3551043 Show fit	0.45	ENST00000589995.1	MFSD12 Ensembl NCBI GeneCards UniProt Show fit	major facilitator superfamily domain containing 12
chr2_-_228028829 Show fit	0.41	ENST00000396625.3 ENST00000329662.7	COL4A4 Ensembl NCBI GeneCards UniProt Show fit	collagen, type IV, alpha 4
chr1_-_44482979 Show fit	0.35	ENST00000360584.2 ENST00000357730.2 ENST00000528803.1	SLC6A9 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr1_-_44497118 Show fit	0.34	ENST00000537678.1 ENST00000466926.1	SLC6A9 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr6_-_27841289 Show fit	0.34	ENST00000355981.2	HIST1H4L Ensembl NCBI GeneCards UniProt Show fit	histone cluster 1, H4l
chr19_-_46272462 Show fit	0.34	ENST00000317578.6	SIX5 Ensembl NCBI GeneCards UniProt Show fit	SIX homeobox 5

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0061536	glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1	0.5	GO:0070843	misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.0	0.4	GO:0038203	TORC2 signaling(GO:0038203)
0.0	0.4	GO:0032836	glomerular basement membrane development(GO:0032836)
0.0	0.4	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.1	0.3	GO:1902723	negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.1	0.3	GO:0060738	intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908) positive regulation of immature T cell proliferation in thymus(GO:0033092) right lung development(GO:0060458) primary prostatic bud elongation(GO:0060516) epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738) sclerotome development(GO:0061056)
0.1	0.3	GO:0006669	sphinganine-1-phosphate biosynthetic process(GO:0006669)
0.0	0.3	GO:0046618	drug export(GO:0046618)
0.0	0.3	GO:1904327	protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)

Showing 1 to 10 of 33 entries

Gene overrepresentation in cellular_component category:

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Total log-likelihood	Term	Description
0.4	GO:0005587	collagen type IV trimer(GO:0005587)
0.4	GO:0031932	TORC2 complex(GO:0031932)
0.3	GO:0070436	Grb2-EGFR complex(GO:0070436)
0.3	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.3	GO:0071818	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.2	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	GO:0070931	Golgi-associated vesicle lumen(GO:0070931)

Showing 1 to 7 of 7 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0015375	glycine:sodium symporter activity(GO:0015375)
0.0	0.7	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.1	0.5	GO:0042903	tubulin deacetylase activity(GO:0042903)
0.0	0.5	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	0.4	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0	0.3	GO:0015307	drug:proton antiporter activity(GO:0015307)
0.0	0.3	GO:0008481	sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0	0.3	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.3	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.3	GO:0015643	toxic substance binding(GO:0015643)

Showing 1 to 10 of 21 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.8	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.7	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.3	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport

Showing 1 to 3 of 3 entries

Results for SMAD2

Z-value: 0.84

Motif logo

Transcription factors associated with SMAD2

Activity-expression correlation:

Activity profile of SMAD2 motif

Sorted Z-values of SMAD2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP:REACTOME category: