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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for SMAD1
Z-value: 1.79
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Transcription factors associated with SMAD1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMAD1 | hg19_v2_chr4_+_146402925_146402957 | -0.72 | 2.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_51152702 Show fit | 1.30 |
ENST00000425202.1
|
chromosome 19 open reading frame 81 |
|
| chr19_-_56056888 Show fit | 1.29 |
ENST00000592464.1
ENST00000420723.3 |
SH3 domain binding kinase family, member 3 |
|
| chr2_-_24307635 Show fit | 0.97 |
ENST00000313482.4
|
tumor protein p53 inducible protein 3 |
|
| chr19_-_10227503 Show fit | 0.94 |
ENST00000593054.1
|
eukaryotic translation initiation factor 3, subunit G |
|
| chrX_-_153707545 Show fit | 0.92 |
ENST00000357360.4
|
L antigen family, member 3 |
|
| chr20_-_36794902 Show fit | 0.92 |
ENST00000373403.3
|
transglutaminase 2 |
|
| chr2_+_220306238 Show fit | 0.91 |
ENST00000435853.1
|
SPEG complex locus |
|
| chr20_-_36794938 Show fit | 0.89 |
ENST00000453095.1
|
transglutaminase 2 |
|
| chr19_+_41092680 Show fit | 0.89 |
ENST00000594298.1
ENST00000597396.1 |
SH3KBP1 binding protein 1 |
|
| chr11_+_127140956 Show fit | 0.87 |
ENST00000608214.1
|
RP11-480C22.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SMAD1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.8 | GO:0018153 | isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262) |
| 0.0 | 1.7 | GO:0006739 | NADP metabolic process(GO:0006739) |
| 0.0 | 1.7 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 1.6 | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) |
| 0.2 | 1.4 | GO:0061143 | alveolar primary septum development(GO:0061143) |
| 0.2 | 1.3 | GO:0010940 | positive regulation of necrotic cell death(GO:0010940) |
| 0.0 | 1.3 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
| 0.2 | 1.2 | GO:0006438 | valyl-tRNA aminoacylation(GO:0006438) |
| 0.0 | 1.2 | GO:0097502 | mannosylation(GO:0097502) |
| 0.1 | 1.1 | GO:0010248 | establishment or maintenance of transmembrane electrochemical gradient(GO:0010248) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.8 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.3 | 2.1 | GO:0000408 | EKC/KEOPS complex(GO:0000408) |
| 0.0 | 1.6 | GO:0031228 | intrinsic component of Golgi membrane(GO:0031228) |
| 0.0 | 1.6 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 1.4 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 1.3 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 1.3 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 1.1 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 1.0 | GO:0097361 | CIA complex(GO:0097361) |
| 0.1 | 1.0 | GO:0070552 | BRISC complex(GO:0070552) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.2 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.0 | 1.7 | GO:0003954 | NADH dehydrogenase activity(GO:0003954) |
| 0.1 | 1.5 | GO:0051183 | vitamin transporter activity(GO:0051183) |
| 0.2 | 1.4 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
| 0.1 | 1.4 | GO:0005280 | hydrogen:amino acid symporter activity(GO:0005280) |
| 0.0 | 1.4 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.2 | 1.3 | GO:0003960 | NADPH:quinone reductase activity(GO:0003960) |
| 0.0 | 1.3 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.2 | 1.2 | GO:0008665 | 2'-phosphotransferase activity(GO:0008665) |
| 0.2 | 1.2 | GO:0004832 | valine-tRNA ligase activity(GO:0004832) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 2.3 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.9 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 1.6 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 1.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.3 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.1 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 1.0 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.0 | 1.0 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 0.8 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 2.4 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.0 | 1.9 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 1.6 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 1.5 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 1.4 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 1.3 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 1.3 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 1.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 1.2 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |