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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for SIX5_SMARCC2_HCFC1
Z-value: 2.44
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Transcription factors associated with SIX5_SMARCC2_HCFC1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000177045.6 | SIX homeobox 5 | |
| ENSG00000139613.7 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 | |
| ENSG00000172534.9 | host cell factor C1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HCFC1 | hg19_v2_chrX_-_153236819_153236978 | 1.00 | 3.3e-03 | Click! |
| SIX5 | hg19_v2_chr19_-_46272462_46272562 | 0.95 | 5.3e-02 | Click! |
| SMARCC2 | hg19_v2_chr12_-_56583243_56583293 | 0.23 | 7.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_30934376 Show fit | 4.36 |
ENST00000562798.1
ENST00000471231.2 |
F-box and leucine-rich repeat protein 19 |
|
| chr19_-_51014345 Show fit | 3.26 |
ENST00000391815.3
ENST00000594350.1 ENST00000601423.1 |
Josephin domain containing 2 |
|
| chr19_-_47551836 Show fit | 3.19 |
ENST00000253047.6
|
transmembrane protein 160 |
|
| chr19_-_51014588 Show fit | 2.84 |
ENST00000598418.1
|
Josephin domain containing 2 |
|
| chr19_+_3185910 Show fit | 2.84 |
ENST00000588428.1
|
nicalin |
|
| chr17_-_43138463 Show fit | 2.70 |
ENST00000310604.4
|
dephospho-CoA kinase domain containing |
|
| chr19_-_51611623 Show fit | 2.65 |
ENST00000421832.2
|
cytosolic thiouridylase subunit 1 |
|
| chr19_-_51014460 Show fit | 2.62 |
ENST00000595669.1
|
Josephin domain containing 2 |
|
| chr4_-_1723040 Show fit | 2.31 |
ENST00000382936.3
ENST00000536901.1 ENST00000303277.2 |
transmembrane protein 129 |
|
| chr19_+_51152702 Show fit | 2.31 |
ENST00000425202.1
|
chromosome 19 open reading frame 81 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIX5_SMARCC2_HCFC1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.1 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.0 | 4.5 | GO:0000209 | protein polyubiquitination(GO:0000209) |
| 0.2 | 4.2 | GO:1990001 | inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001) |
| 0.1 | 3.9 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.4 | 2.7 | GO:0034227 | tRNA thio-modification(GO:0034227) |
| 0.1 | 2.7 | GO:0007220 | Notch receptor processing(GO:0007220) |
| 0.1 | 2.6 | GO:0045008 | depyrimidination(GO:0045008) |
| 0.0 | 2.6 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 2.4 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.3 | 2.3 | GO:0019075 | virus maturation(GO:0019075) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 2.9 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.2 | 2.7 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.0 | 2.7 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.6 | 2.3 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
| 0.1 | 2.3 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 2.2 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
| 0.0 | 2.0 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.1 | 1.9 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.0 | 1.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.5 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 4.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.9 | 3.6 | GO:0004140 | dephospho-CoA kinase activity(GO:0004140) |
| 0.0 | 2.7 | GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) |
| 0.0 | 2.7 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 2.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 2.6 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 2.5 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.6 | 2.3 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
| 0.1 | 2.3 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 1.7 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 1.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.4 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 1.1 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 0.7 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 0.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.3 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 0.2 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 0.1 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.7 | REACTOME REGULATED PROTEOLYSIS OF P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 0.1 | 2.3 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 2.1 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.0 | 2.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 1.8 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 1.5 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.0 | 1.5 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 1.5 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 1.4 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 1.4 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |