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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for SIX4

Z-value: 0.60

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Transcription factors associated with SIX4

Gene Symbol Gene ID Gene Info
SIX4
ENSG00000100625.8 SIX homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX4hg19_v2_chr14_-_61190754_61190852-0.712.9e-01Click!

Activity profile of SIX4 motif

Sorted Z-values of SIX4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_191188 0.36 ENST00000575634.1
RPH3AL
rabphilin 3A-like (without C2 domains)
chr1_+_156611900 0.35 ENST00000457777.2
ENST00000424639.1
BCAN
brevican
chrX_+_54466829 0.30 ENST00000375151.4
TSR2
TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
chr22_-_39268192 0.28 ENST00000216083.6
CBX6
chromobox homolog 6
chr6_-_27840099 0.26 ENST00000328488.2
HIST1H3I
histone cluster 1, H3i
chr19_-_58892389 0.24 ENST00000427624.2
ENST00000597582.1
ZNF837
zinc finger protein 837
chr19_+_50270219 0.24 ENST00000354293.5
ENST00000359032.5
AP2A1
adaptor-related protein complex 2, alpha 1 subunit
chr1_+_156611704 0.22 ENST00000329117.5
BCAN
brevican
chr15_+_41245160 0.22 ENST00000444189.2
ENST00000446533.3
CHAC1
ChaC, cation transport regulator homolog 1 (E. coli)
chr22_-_30960876 0.22 ENST00000401975.1
ENST00000428682.1
ENST00000423299.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr3_-_183966717 0.22 ENST00000446569.1
ENST00000418734.2
ENST00000397676.3
ALG3
ALG3, alpha-1,3- mannosyltransferase
chr22_-_39268308 0.22 ENST00000407418.3
CBX6
chromobox homolog 6
chr3_+_183967409 0.21 ENST00000324557.4
ENST00000402825.3
ECE2
endothelin converting enzyme 2
chr1_+_156611960 0.20 ENST00000361588.5
BCAN
brevican
chr19_+_11466062 0.19 ENST00000251473.5
ENST00000591329.1
ENST00000586380.1
DKFZP761J1410
Lipid phosphate phosphatase-related protein type 2
chr17_+_7465216 0.19 ENST00000321337.7
SENP3
SUMO1/sentrin/SMT3 specific peptidase 3
chr2_-_219134343 0.18 ENST00000447885.1
ENST00000420660.1
AAMP
angio-associated, migratory cell protein
chr12_-_58135903 0.18 ENST00000257897.3
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr19_+_50887585 0.18 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
POLD1
polymerase (DNA directed), delta 1, catalytic subunit
chr12_+_43086018 0.17 ENST00000550177.1
RP11-25I15.3
RP11-25I15.3
chr4_-_176828307 0.16 ENST00000513365.1
ENST00000513667.1
ENST00000503563.1
GPM6A
glycoprotein M6A
chr6_+_160693591 0.15 ENST00000419196.1
RP1-276N6.2
RP1-276N6.2
chr19_+_11466167 0.15 ENST00000591608.1
DKFZP761J1410
Lipid phosphate phosphatase-related protein type 2
chr2_-_42160486 0.14 ENST00000427054.1
AC104654.2
AC104654.2
chr14_+_38065052 0.14 ENST00000556845.1
TTC6
tetratricopeptide repeat domain 6
chr12_+_30948600 0.14 ENST00000550292.1
LINC00941
long intergenic non-protein coding RNA 941
chr17_-_61523622 0.13 ENST00000448884.2
ENST00000582297.1
ENST00000582034.1
ENST00000578072.1
ENST00000360793.3
CYB561
cytochrome b561
chr7_+_2687173 0.12 ENST00000403167.1
TTYH3
tweety family member 3
chr1_+_17559776 0.11 ENST00000537499.1
ENST00000413717.2
ENST00000536552.1
PADI1
peptidyl arginine deiminase, type I
chr3_-_183967296 0.11 ENST00000455059.1
ENST00000445626.2
ALG3
ALG3, alpha-1,3- mannosyltransferase
chr1_-_154934200 0.11 ENST00000368457.2
PYGO2
pygopus family PHD finger 2
chr19_+_13135386 0.11 ENST00000360105.4
ENST00000588228.1
ENST00000591028.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr2_+_120687335 0.11 ENST00000544261.1
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr19_+_13134772 0.11 ENST00000587760.1
ENST00000585575.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr11_+_46958248 0.11 ENST00000536126.1
ENST00000278460.7
ENST00000378618.2
ENST00000395460.2
ENST00000378615.3
ENST00000543718.1
C11orf49
chromosome 11 open reading frame 49
chr20_+_816695 0.11 ENST00000246100.3
FAM110A
family with sequence similarity 110, member A
chr4_-_13546632 0.10 ENST00000382438.5
NKX3-2
NK3 homeobox 2
chr11_-_46615498 0.10 ENST00000533727.1
ENST00000534300.1
ENST00000528950.1
ENST00000526606.1
AMBRA1
autophagy/beclin-1 regulator 1
chr2_-_74710078 0.10 ENST00000290418.4
CCDC142
coiled-coil domain containing 142
chr9_+_132427883 0.10 ENST00000372469.4
PRRX2
paired related homeobox 2
chr2_+_128458514 0.09 ENST00000310981.4
SFT2D3
SFT2 domain containing 3
chr8_+_95907993 0.09 ENST00000523378.1
NDUFAF6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr1_+_149239529 0.09 ENST00000457216.2
RP11-403I13.4
RP11-403I13.4
chr1_+_15736359 0.09 ENST00000375980.4
EFHD2
EF-hand domain family, member D2
chr10_+_102759045 0.08 ENST00000370220.1
LZTS2
leucine zipper, putative tumor suppressor 2
chr5_-_1295104 0.08 ENST00000334602.6
ENST00000508104.2
ENST00000310581.5
ENST00000296820.5
TERT
telomerase reverse transcriptase
chr1_+_8378140 0.08 ENST00000377479.2
SLC45A1
solute carrier family 45, member 1
chr2_+_219135115 0.08 ENST00000248451.3
ENST00000273077.4
PNKD
paroxysmal nonkinesigenic dyskinesia
chr5_+_85913721 0.08 ENST00000247655.3
ENST00000509578.1
ENST00000515763.1
COX7C
cytochrome c oxidase subunit VIIc
chr7_-_14880892 0.08 ENST00000406247.3
ENST00000399322.3
ENST00000258767.5
DGKB
diacylglycerol kinase, beta 90kDa
chr1_-_207119738 0.07 ENST00000356495.4
PIGR
polymeric immunoglobulin receptor
chr3_-_49158218 0.06 ENST00000417901.1
ENST00000306026.5
ENST00000434032.2
USP19
ubiquitin specific peptidase 19
chr1_-_32264356 0.06 ENST00000452755.2
SPOCD1
SPOC domain containing 1
chr11_+_2415061 0.06 ENST00000481687.1
CD81
CD81 molecule
chr3_-_69249863 0.06 ENST00000478263.1
ENST00000462512.1
FRMD4B
FERM domain containing 4B
chr3_-_93692681 0.06 ENST00000348974.4
PROS1
protein S (alpha)
chr11_-_96076334 0.05 ENST00000524717.1
MAML2
mastermind-like 2 (Drosophila)
chr12_-_10282742 0.05 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chrX_-_110655391 0.05 ENST00000356915.2
ENST00000356220.3
DCX
doublecortin
chr7_+_69064300 0.05 ENST00000342771.4
AUTS2
autism susceptibility candidate 2
chr20_-_43150601 0.05 ENST00000541235.1
ENST00000255175.1
ENST00000342374.4
SERINC3
serine incorporator 3
chrY_+_22737678 0.04 ENST00000382772.3
EIF1AY
eukaryotic translation initiation factor 1A, Y-linked
chr9_-_95298314 0.04 ENST00000344604.5
ENST00000375540.1
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr11_+_123325106 0.04 ENST00000525757.1
LINC01059
long intergenic non-protein coding RNA 1059
chr7_-_26578407 0.04 ENST00000242109.3
KIAA0087
KIAA0087
chr5_+_78365536 0.04 ENST00000255192.3
BHMT2
betaine--homocysteine S-methyltransferase 2
chr4_-_2420357 0.03 ENST00000511071.1
ENST00000509171.1
ENST00000290974.2
ZFYVE28
zinc finger, FYVE domain containing 28
chr2_+_74710194 0.03 ENST00000410003.1
ENST00000442235.2
ENST00000233623.5
TTC31
tetratricopeptide repeat domain 31
chr1_+_38022572 0.03 ENST00000541606.1
DNALI1
dynein, axonemal, light intermediate chain 1
chr12_+_133757995 0.03 ENST00000536435.2
ENST00000228289.5
ENST00000541211.2
ENST00000500625.3
ENST00000539248.2
ENST00000542711.2
ENST00000536899.2
ENST00000542986.2
ENST00000537565.1
ENST00000541975.2
ZNF268
zinc finger protein 268
chr6_+_41040678 0.03 ENST00000341376.6
ENST00000353205.5
NFYA
nuclear transcription factor Y, alpha
chr1_-_173176452 0.03 ENST00000281834.3
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr2_-_113999260 0.03 ENST00000468980.2
PAX8
paired box 8
chr19_+_19174795 0.03 ENST00000318596.7
SLC25A42
solute carrier family 25, member 42
chr7_-_111428957 0.03 ENST00000417165.1
DOCK4
dedicator of cytokinesis 4
chr11_+_117049445 0.02 ENST00000324225.4
ENST00000532960.1
SIDT2
SID1 transmembrane family, member 2
chrX_-_19504642 0.02 ENST00000469203.2
MAP3K15
mitogen-activated protein kinase kinase kinase 15
chr19_+_13135439 0.02 ENST00000586873.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr1_+_116184566 0.02 ENST00000355485.2
ENST00000369510.4
VANGL1
VANGL planar cell polarity protein 1
chr5_-_78365437 0.02 ENST00000380311.4
ENST00000540686.1
ENST00000255189.3
DMGDH
dimethylglycine dehydrogenase
chr17_-_72527605 0.02 ENST00000392621.1
ENST00000314401.3
CD300LB
CD300 molecule-like family member b
chr10_+_89622870 0.01 ENST00000371953.3
PTEN
phosphatase and tensin homolog
chrX_+_135388147 0.01 ENST00000394141.1
GPR112
G protein-coupled receptor 112
chr9_-_95298254 0.01 ENST00000444490.2
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr12_+_133758115 0.01 ENST00000541009.2
ENST00000592241.1
ZNF268
zinc finger protein 268
chr7_-_38969150 0.01 ENST00000418457.2
VPS41
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr1_-_114414316 0.01 ENST00000528414.1
ENST00000538253.1
ENST00000460620.1
ENST00000420377.2
ENST00000525799.1
ENST00000359785.5
PTPN22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chr4_-_2420335 0.01 ENST00000503000.1
ZFYVE28
zinc finger, FYVE domain containing 28
chr8_+_56014949 0.01 ENST00000327381.6
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr1_+_231473743 0.00 ENST00000295050.7
SPRTN
SprT-like N-terminal domain
chr2_-_219134822 0.00 ENST00000444053.1
ENST00000248450.4
AAMP
angio-associated, migratory cell protein
chrX_+_70503037 0.00 ENST00000535149.1
NONO
non-POU domain containing, octamer-binding
chr11_+_117049910 0.00 ENST00000431081.2
ENST00000524842.1
SIDT2
SID1 transmembrane family, member 2
chr12_-_10282836 0.00 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr11_+_117049854 0.00 ENST00000278951.7
SIDT2
SID1 transmembrane family, member 2
chr3_-_87325612 0.00 ENST00000561167.1
ENST00000560656.1
ENST00000344265.3
POU1F1
POU class 1 homeobox 1
chrX_+_41583408 0.00 ENST00000302548.4
GPR82
G protein-coupled receptor 82
chr1_-_152196669 0.00 ENST00000368801.2
HRNR
hornerin

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0 0.8 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.2 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.0 0.1 GO:1900369 transcription, RNA-templated(GO:0001172) negative regulation of RNA interference(GO:1900369)
0.0 0.1 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.1 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 0.2 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.1 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386) immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.0 0.0 GO:0046022 positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.2 GO:0006751 glutathione catabolic process(GO:0006751)
0.0 0.1 GO:0043128 regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043126) positive regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043128)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.1 GO:0031379 RNA-directed RNA polymerase complex(GO:0031379)
0.0 0.2 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 0.2 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.4 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.1 GO:0035034 histone acetyltransferase regulator activity(GO:0035034)
0.0 0.1 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.0 0.1 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.0 0.1 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.2 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.2 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.2 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.3 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein