ISMARA results: RUNX1

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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for RUNX1_RUNX2

Z-value: 0.74

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Transcription factors associated with RUNX1_RUNX2

Gene Symbol	Gene ID	Gene Info
RUNX1 Ensembl NCBI GeneCards UniProt	ENSG00000159216.14	RUNX family transcription factor 1
RUNX2 Ensembl NCBI GeneCards UniProt	ENSG00000124813.16	RUNX family transcription factor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
RUNX2	hg19_v2_chr6_+_45296048_45296106	-0.99	5.7e-03	Click!
RUNX1	hg19_v2_chr21_-_36421401_36421462	-0.98	2.4e-02	Click!

Activity profile of RUNX1_RUNX2 motif

Sorted Z-values of RUNX1_RUNX2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_+_73780852 Show fit	0.61	ENST00000589666.1	UNK Ensembl NCBI GeneCards UniProt Show fit	unkempt family zinc finger
chr17_+_75316336 Show fit	0.54	ENST00000591934.1	SEPT9 Ensembl NCBI GeneCards UniProt Show fit	septin 9
chr14_-_81425828 Show fit	0.47	ENST00000555529.1 ENST00000556042.1 ENST00000556981.1	CEP128 Ensembl NCBI GeneCards UniProt Show fit	centrosomal protein 128kDa
chr19_+_54495542 Show fit	0.46	ENST00000252729.2 ENST00000352529.1	CACNG6 Ensembl NCBI GeneCards UniProt Show fit	calcium channel, voltage-dependent, gamma subunit 6
chr6_+_24126350 Show fit	0.42	ENST00000378491.4 ENST00000378478.1 ENST00000378477.2	NRSN1 Ensembl NCBI GeneCards UniProt Show fit	neurensin 1
chr19_-_55895966 Show fit	0.41	ENST00000444469.3	TMEM238 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 238
chr11_+_2923423 Show fit	0.38	ENST00000312221.5	SLC22A18 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 22, member 18
chr1_+_179051160 Show fit	0.37	ENST00000367625.4 ENST00000352445.6	TOR3A Ensembl NCBI GeneCards UniProt Show fit	torsin family 3, member A
chr5_-_108063949 Show fit	0.37	ENST00000606054.1	LINC01023 Ensembl NCBI GeneCards UniProt Show fit	long intergenic non-protein coding RNA 1023
chr11_+_2923499 Show fit	0.36	ENST00000449793.2	SLC22A18 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 22, member 18

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of RUNX1_RUNX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	GO:0046618	drug export(GO:0046618)
0.1	0.8	GO:0030259	lipid glycosylation(GO:0030259)
0.0	0.8	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.7	GO:1901748	leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.1	0.6	GO:0031914	negative regulation of synaptic plasticity(GO:0031914)
0.0	0.6	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
0.0	0.6	GO:1990573	potassium ion import across plasma membrane(GO:1990573)
0.1	0.5	GO:0060480	lung goblet cell differentiation(GO:0060480) lobar bronchus epithelium development(GO:0060481)
0.1	0.5	GO:0048295	positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.0	0.5	GO:0006957	complement activation, alternative pathway(GO:0006957)

Showing 1 to 10 of 163 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	0.6	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0	0.5	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0	0.5	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	0.5	GO:0031105	septin complex(GO:0031105)
0.0	0.5	GO:0005640	nuclear outer membrane(GO:0005640)
0.1	0.4	GO:0097058	CRLF-CLCF1 complex(GO:0097058)
0.0	0.4	GO:0000408	EKC/KEOPS complex(GO:0000408)
0.0	0.4	GO:0042599	lamellar body(GO:0042599)
0.0	0.4	GO:0048188	Set1C/COMPASS complex(GO:0048188)

Showing 1 to 10 of 40 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	GO:0015307	drug:proton antiporter activity(GO:0015307)
0.0	0.8	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	0.7	GO:0036374	glutathione hydrolase activity(GO:0036374)
0.0	0.7	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.1	0.6	GO:0003947	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity(GO:0003947)
0.0	0.6	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0	0.6	GO:0050699	WW domain binding(GO:0050699)
0.0	0.5	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.4	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.0	0.4	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)

Showing 1 to 10 of 100 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
0.9	ST GA13 PATHWAY	G alpha 13 Pathway
0.4	ST GA12 PATHWAY	G alpha 12 Pathway
0.3	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.3	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.2	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions

Showing 1 to 6 of 6 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	0.7	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.6	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.0	0.4	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.4	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	0.3	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	0.3	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0	0.3	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.2	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	0.2	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation

Showing 1 to 10 of 11 entries

Results for RUNX1_RUNX2

Z-value: 0.74

Motif logo

Transcription factors associated with RUNX1_RUNX2

Activity-expression correlation:

Activity profile of RUNX1_RUNX2 motif

Sorted Z-values of RUNX1_RUNX2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of RUNX1_RUNX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: