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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for RORC

Z-value: 0.76

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Transcription factors associated with RORC

Gene Symbol Gene ID Gene Info
RORC
ENSG00000143365.12 RAR related orphan receptor C

Activity profile of RORC motif

Sorted Z-values of RORC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_64527425 0.84 ENST00000377432.3
PYGM
phosphorylase, glycogen, muscle
chr19_-_39735646 0.82 ENST00000413851.2
IFNL3
interferon, lambda 3
chr19_+_39759154 0.80 ENST00000331982.5
IFNL2
interferon, lambda 2
chr8_+_71485681 0.55 ENST00000391684.1
AC120194.1
AC120194.1
chr11_-_69867159 0.44 ENST00000528507.1
RP11-626H12.2
RP11-626H12.2
chr12_+_93963590 0.30 ENST00000340600.2
SOCS2
suppressor of cytokine signaling 2
chr1_-_150207017 0.28 ENST00000369119.3
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr12_+_93964158 0.27 ENST00000549206.1
SOCS2
suppressor of cytokine signaling 2
chr11_+_13299186 0.24 ENST00000527998.1
ENST00000396441.3
ENST00000533520.1
ENST00000529825.1
ENST00000389707.4
ENST00000401424.1
ENST00000529388.1
ENST00000530357.1
ENST00000403290.1
ENST00000361003.4
ENST00000389708.3
ENST00000403510.3
ENST00000482049.1
ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr12_+_13061894 0.23 ENST00000540125.1
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chrX_+_69501943 0.21 ENST00000509895.1
ENST00000374473.2
ENST00000276066.4
RAB41
RAB41, member RAS oncogene family
chr14_+_21785693 0.21 ENST00000382933.4
ENST00000557351.1
RPGRIP1
retinitis pigmentosa GTPase regulator interacting protein 1
chr1_-_211752073 0.20 ENST00000367001.4
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr4_+_85504075 0.19 ENST00000295887.5
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr17_-_48785216 0.18 ENST00000285243.6
ANKRD40
ankyrin repeat domain 40
chr19_-_7698599 0.17 ENST00000311069.5
PCP2
Purkinje cell protein 2
chr19_-_8567505 0.15 ENST00000600262.1
PRAM1
PML-RARA regulated adaptor molecule 1
chr3_-_117716418 0.15 ENST00000484092.1
RP11-384F7.2
RP11-384F7.2
chr19_-_10450287 0.14 ENST00000589261.1
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
ICAM3
intercellular adhesion molecule 3
chrX_-_43832711 0.14 ENST00000378062.5
NDP
Norrie disease (pseudoglioma)
chr4_-_170948361 0.13 ENST00000393702.3
MFAP3L
microfibrillar-associated protein 3-like
chr17_-_42992856 0.13 ENST00000588316.1
ENST00000435360.2
ENST00000586793.1
ENST00000588735.1
ENST00000588037.1
ENST00000592320.1
ENST00000253408.5
GFAP
glial fibrillary acidic protein
chr12_+_56414795 0.13 ENST00000431367.2
IKZF4
IKAROS family zinc finger 4 (Eos)
chr14_-_68157084 0.13 ENST00000557564.1
RP11-1012A1.4
RP11-1012A1.4
chr1_+_114447763 0.13 ENST00000369563.3
DCLRE1B
DNA cross-link repair 1B
chr6_+_89855765 0.12 ENST00000275072.4
PM20D2
peptidase M20 domain containing 2
chr2_+_162016916 0.11 ENST00000405852.1
TANK
TRAF family member-associated NFKB activator
chr17_-_37764128 0.11 ENST00000302584.4
NEUROD2
neuronal differentiation 2
chr6_+_43738444 0.11 ENST00000324450.6
ENST00000417285.2
ENST00000413642.3
ENST00000372055.4
ENST00000482630.2
ENST00000425836.2
ENST00000372064.4
ENST00000372077.4
ENST00000519767.1
VEGFA
vascular endothelial growth factor A
chr10_-_121296045 0.11 ENST00000392865.1
RGS10
regulator of G-protein signaling 10
chr8_+_66955648 0.10 ENST00000522619.1
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr2_+_162016827 0.10 ENST00000429217.1
ENST00000406287.1
ENST00000402568.1
TANK
TRAF family member-associated NFKB activator
chr7_+_112063192 0.10 ENST00000005558.4
IFRD1
interferon-related developmental regulator 1
chr17_+_44679808 0.10 ENST00000571172.1
NSF
N-ethylmaleimide-sensitive factor
chr2_-_148778323 0.09 ENST00000440042.1
ENST00000535373.1
ENST00000540442.1
ENST00000536575.1
ORC4
origin recognition complex, subunit 4
chr19_+_38924316 0.09 ENST00000355481.4
ENST00000360985.3
ENST00000359596.3
RYR1
ryanodine receptor 1 (skeletal)
chrX_-_49089771 0.08 ENST00000376251.1
ENST00000323022.5
ENST00000376265.2
CACNA1F
calcium channel, voltage-dependent, L type, alpha 1F subunit
chr3_-_45957534 0.08 ENST00000536047.1
LZTFL1
leucine zipper transcription factor-like 1
chr1_+_236849754 0.08 ENST00000542672.1
ENST00000366578.4
ACTN2
actinin, alpha 2
chr2_+_160590469 0.08 ENST00000409591.1
MARCH7
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr22_-_32022280 0.08 ENST00000442379.1
PISD
phosphatidylserine decarboxylase
chr1_+_159796534 0.08 ENST00000289707.5
SLAMF8
SLAM family member 8
chr11_-_10822029 0.08 ENST00000528839.1
EIF4G2
eukaryotic translation initiation factor 4 gamma, 2
chr3_-_45957088 0.08 ENST00000539217.1
LZTFL1
leucine zipper transcription factor-like 1
chr1_+_26869597 0.08 ENST00000530003.1
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr8_+_124780672 0.07 ENST00000521166.1
ENST00000334705.7
FAM91A1
family with sequence similarity 91, member A1
chr1_-_145826450 0.07 ENST00000462900.2
GPR89A
G protein-coupled receptor 89A
chr16_+_16326352 0.07 ENST00000399336.4
ENST00000263012.6
ENST00000538468.1
NOMO3
NODAL modulator 3
chr2_+_162016804 0.06 ENST00000392749.2
ENST00000440506.1
TANK
TRAF family member-associated NFKB activator
chr17_-_46623441 0.05 ENST00000330070.4
HOXB2
homeobox B2
chr21_+_17553910 0.05 ENST00000428669.2
LINC00478
long intergenic non-protein coding RNA 478
chr1_-_185286461 0.05 ENST00000367498.3
IVNS1ABP
influenza virus NS1A binding protein
chr12_+_56624436 0.04 ENST00000266980.4
ENST00000437277.1
SLC39A5
solute carrier family 39 (zinc transporter), member 5
chr10_-_103578162 0.04 ENST00000361464.3
ENST00000357797.5
ENST00000370094.3
MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chr10_-_103578182 0.04 ENST00000439817.1
MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chr6_-_46922659 0.04 ENST00000265417.7
GPR116
G protein-coupled receptor 116
chr3_-_164914640 0.04 ENST00000241274.3
SLITRK3
SLIT and NTRK-like family, member 3
chr1_+_154540246 0.04 ENST00000368476.3
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr2_-_30144432 0.03 ENST00000389048.3
ALK
anaplastic lymphoma receptor tyrosine kinase
chr17_-_59940705 0.03 ENST00000577913.1
BRIP1
BRCA1 interacting protein C-terminal helicase 1
chr12_+_56623827 0.03 ENST00000424625.1
ENST00000419753.1
ENST00000454355.2
ENST00000417965.1
ENST00000436633.1
SLC39A5
solute carrier family 39 (zinc transporter), member 5
chr1_-_217311090 0.03 ENST00000493603.1
ENST00000366940.2
ESRRG
estrogen-related receptor gamma
chr1_-_62190793 0.03 ENST00000371177.2
ENST00000606498.1
TM2D1
TM2 domain containing 1
chr3_-_184095923 0.03 ENST00000445696.2
ENST00000204615.7
THPO
thrombopoietin
chr10_-_105845674 0.02 ENST00000353479.5
ENST00000369733.3
COL17A1
collagen, type XVII, alpha 1
chr4_-_1188922 0.02 ENST00000515004.1
ENST00000502483.1
SPON2
spondin 2, extracellular matrix protein
chr9_-_110251836 0.02 ENST00000374672.4
KLF4
Kruppel-like factor 4 (gut)
chr4_+_110749143 0.02 ENST00000317735.4
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr7_-_43965937 0.02 ENST00000455877.1
ENST00000223341.7
ENST00000447717.3
ENST00000426198.1
URGCP
upregulator of cell proliferation
chr2_+_148778570 0.02 ENST00000407073.1
MBD5
methyl-CpG binding domain protein 5
chr1_+_104198377 0.01 ENST00000370083.4
AMY1A
amylase, alpha 1A (salivary)
chr18_-_23671139 0.01 ENST00000579061.1
ENST00000542420.2
SS18
synovial sarcoma translocation, chromosome 18
chr12_-_39734783 0.01 ENST00000552961.1
KIF21A
kinesin family member 21A
chr1_+_159796589 0.01 ENST00000368104.4
SLAMF8
SLAM family member 8
chr3_+_45986511 0.01 ENST00000458629.1
ENST00000457814.1
CXCR6
chemokine (C-X-C motif) receptor 6
chr7_+_20686946 0.01 ENST00000443026.2
ENST00000406935.1
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr12_+_7167980 0.00 ENST00000360817.5
ENST00000402681.3
C1S
complement component 1, s subcomponent

Network of associatons between targets according to the STRING database.

First level regulatory network of RORC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.0 0.2 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.0 0.8 GO:0002385 mucosal immune response(GO:0002385)
0.0 0.1 GO:1903572 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.0 0.3 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.2 GO:0097501 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0 0.6 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.1 GO:0031860 telomeric loop formation(GO:0031627) telomeric 3' overhang formation(GO:0031860)
0.0 0.1 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 0.2 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.1 GO:0021569 rhombomere 3 development(GO:0021569)
0.0 0.8 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.1 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
0.0 0.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.0 GO:0000706 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
0.0 0.1 GO:0035494 SNARE complex disassembly(GO:0035494)
0.0 0.2 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1990425 junctional membrane complex(GO:0030314) ryanodine receptor complex(GO:1990425)
0.0 0.2 GO:0033391 chromatoid body(GO:0033391)
0.0 0.3 GO:0000812 Swr1 complex(GO:0000812)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.1 0.6 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.2 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142) phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 0.3 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.1 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.0 0.1 GO:0030375 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375) FATZ binding(GO:0051373)
0.0 0.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.2 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.1 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.6 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling