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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for RFX7_RFX4_RFX1
Z-value: 2.40
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Transcription factors associated with RFX7_RFX4_RFX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX4 | hg19_v2_chr12_+_107078474_107078533 | 0.85 | 1.5e-01 | Click! |
| RFX7 | hg19_v2_chr15_-_56535464_56535521 | -0.19 | 8.1e-01 | Click! |
| RFX1 | hg19_v2_chr19_-_14117074_14117141 | 0.06 | 9.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_51014345 Show fit | 5.62 |
ENST00000391815.3
ENST00000594350.1 ENST00000601423.1 |
Josephin domain containing 2 |
|
| chr19_+_55888186 Show fit | 2.18 |
ENST00000291934.3
|
transmembrane protein 190 |
|
| chr19_-_50316517 Show fit | 1.90 |
ENST00000313777.4
ENST00000445575.2 |
fuzzy planar cell polarity protein |
|
| chr9_-_138391692 Show fit | 1.75 |
ENST00000429260.2
|
chromosome 9 open reading frame 116 |
|
| chr19_-_51014460 Show fit | 1.75 |
ENST00000595669.1
|
Josephin domain containing 2 |
|
| chr19_-_41220540 Show fit | 1.68 |
ENST00000594490.1
|
aarF domain containing kinase 4 |
|
| chr19_-_51014588 Show fit | 1.67 |
ENST00000598418.1
|
Josephin domain containing 2 |
|
| chr12_-_108154705 Show fit | 1.53 |
ENST00000547188.1
|
PR domain containing 4 |
|
| chr17_+_73642315 Show fit | 1.44 |
ENST00000556126.2
|
small integral membrane protein 6 |
|
| chr4_+_6784358 Show fit | 1.37 |
ENST00000508423.1
|
KIAA0232 |
Network of associatons between targets according to the STRING database.
First level regulatory network of RFX7_RFX4_RFX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.4 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.7 | 2.7 | GO:0090301 | regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314) |
| 0.4 | 2.2 | GO:0035617 | stress granule disassembly(GO:0035617) |
| 0.1 | 1.7 | GO:0043985 | histone H4-R3 methylation(GO:0043985) |
| 0.1 | 1.6 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 1.4 | GO:0007520 | myoblast fusion(GO:0007520) |
| 0.1 | 1.2 | GO:2001166 | regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168) |
| 0.1 | 1.1 | GO:0010826 | negative regulation of centrosome duplication(GO:0010826) |
| 0.0 | 0.9 | GO:0043485 | endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757) |
| 0.0 | 0.9 | GO:0071625 | vocalization behavior(GO:0071625) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.2 | GO:0002079 | inner acrosomal membrane(GO:0002079) |
| 0.0 | 2.1 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 1.4 | GO:0005818 | astral microtubule(GO:0000235) aster(GO:0005818) |
| 0.1 | 1.2 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.1 | 1.2 | GO:0033503 | HULC complex(GO:0033503) |
| 0.1 | 0.9 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.1 | 0.9 | GO:0005883 | neurofilament(GO:0005883) |
| 0.0 | 0.9 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 0.9 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.1 | 0.8 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.6 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 3.9 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.0 | 2.2 | GO:0043621 | protein self-association(GO:0043621) |
| 0.1 | 1.6 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.1 | 1.6 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.1 | 1.2 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.1 | 1.2 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 1.2 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 1.2 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 1.1 | GO:0031005 | filamin binding(GO:0031005) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 1.5 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 1.2 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.9 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.5 | PID IL3 PATHWAY | IL3-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.7 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.6 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.6 | REACTOME REGULATORY RNA PATHWAYS | Genes involved in Regulatory RNA pathways |
| 0.0 | 0.5 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 0.4 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.4 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.1 | 0.3 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 0.3 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.0 | 0.3 | REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway |