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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for REST

Z-value: 0.76

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Transcription factors associated with REST

Gene Symbol Gene ID Gene Info
REST
ENSG00000084093.11 RE1 silencing transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RESThg19_v2_chr4_+_57774042_57774114-0.178.3e-01Click!

Activity profile of REST motif

Sorted Z-values of REST motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_+_31199037 0.61 ENST00000424224.1
OSBP2
oxysterol binding protein 2
chr10_+_99609996 0.44 ENST00000370602.1
GOLGA7B
golgin A7 family, member B
chr14_+_96039882 0.43 ENST00000556346.1
ENST00000553785.1
RP11-1070N10.4
RP11-1070N10.4
chr12_+_52695617 0.40 ENST00000293525.5
KRT86
keratin 86
chr19_+_39759154 0.38 ENST00000331982.5
IFNL2
interferon, lambda 2
chr19_-_40724246 0.36 ENST00000311308.6
TTC9B
tetratricopeptide repeat domain 9B
chr12_-_12837423 0.36 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chr20_+_62327996 0.33 ENST00000369996.1
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr2_-_27531313 0.27 ENST00000296099.2
UCN
urocortin
chrX_-_153141434 0.27 ENST00000407935.2
ENST00000439496.1
L1CAM
L1 cell adhesion molecule
chr19_-_55691614 0.24 ENST00000592470.1
ENST00000354308.3
SYT5
synaptotagmin V
chr17_+_30813576 0.23 ENST00000313401.3
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr14_-_94759595 0.21 ENST00000261994.4
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr3_+_193853927 0.20 ENST00000232424.3
HES1
hes family bHLH transcription factor 1
chr14_-_94759361 0.20 ENST00000393096.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr14_-_94759408 0.19 ENST00000554723.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr1_+_33352036 0.19 ENST00000373467.3
HPCA
hippocalcin
chr19_-_55691472 0.19 ENST00000537500.1
SYT5
synaptotagmin V
chr1_+_154540246 0.18 ENST00000368476.3
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr19_-_55691377 0.18 ENST00000589172.1
SYT5
synaptotagmin V
chr15_+_75287861 0.17 ENST00000425597.3
ENST00000562327.1
ENST00000568018.1
ENST00000562212.1
ENST00000567920.1
ENST00000566872.1
ENST00000361900.6
ENST00000545456.1
SCAMP5
secretory carrier membrane protein 5
chr2_-_51259641 0.17 ENST00000406316.2
ENST00000405581.1
NRXN1
neurexin 1
chr2_+_226265364 0.16 ENST00000272907.6
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr11_-_75141206 0.16 ENST00000376292.4
KLHL35
kelch-like family member 35
chrX_+_153237740 0.15 ENST00000369982.4
TMEM187
transmembrane protein 187
chrX_-_47479246 0.14 ENST00000295987.7
ENST00000340666.4
SYN1
synapsin I
chr11_+_64808675 0.14 ENST00000529996.1
SAC3D1
SAC3 domain containing 1
chr10_-_102790852 0.13 ENST00000470414.1
ENST00000370215.3
PDZD7
PDZ domain containing 7
chr12_+_119419294 0.12 ENST00000267260.4
SRRM4
serine/arginine repetitive matrix 4
chr12_-_99288536 0.12 ENST00000549797.1
ENST00000333732.7
ENST00000341752.7
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr3_+_9745510 0.12 ENST00000383831.3
CPNE9
copine family member IX
chr6_+_43603552 0.12 ENST00000372171.4
MAD2L1BP
MAD2L1 binding protein
chr1_+_212606219 0.11 ENST00000366988.3
NENF
neudesin neurotrophic factor
chr19_-_11639910 0.11 ENST00000588998.1
ENST00000586149.1
ECSIT
ECSIT signalling integrator
chr11_-_66115032 0.11 ENST00000311181.4
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chrX_+_153238220 0.10 ENST00000425274.1
TMEM187
transmembrane protein 187
chr12_+_71833550 0.10 ENST00000266674.5
LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr3_+_9745487 0.10 ENST00000383832.3
CPNE9
copine family member IX
chr19_-_45927097 0.10 ENST00000340192.7
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr3_+_62304712 0.09 ENST00000494481.1
C3orf14
chromosome 3 open reading frame 14
chr19_-_45927622 0.09 ENST00000300853.3
ENST00000589165.1
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr12_+_113796347 0.09 ENST00000545182.2
ENST00000280800.3
PLBD2
phospholipase B domain containing 2
chr15_-_72612470 0.08 ENST00000287202.5
CELF6
CUGBP, Elav-like family member 6
chr8_-_145752390 0.08 ENST00000529415.2
ENST00000533758.1
LRRC24
leucine rich repeat containing 24
chr6_+_154360616 0.08 ENST00000229768.5
ENST00000419506.2
ENST00000524163.1
ENST00000414028.2
ENST00000435918.2
ENST00000337049.4
OPRM1
opioid receptor, mu 1
chr9_-_139096955 0.08 ENST00000371748.5
LHX3
LIM homeobox 3
chr19_-_11639931 0.08 ENST00000592312.1
ENST00000590480.1
ENST00000585318.1
ENST00000252440.7
ENST00000417981.2
ENST00000270517.7
ECSIT
ECSIT signalling integrator
chr13_-_111214015 0.07 ENST00000267328.3
RAB20
RAB20, member RAS oncogene family
chr5_-_176037105 0.07 ENST00000303991.4
GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr16_+_3019246 0.07 ENST00000318782.8
ENST00000293978.8
PAQR4
progestin and adipoQ receptor family member IV
chr18_+_57567180 0.06 ENST00000316660.6
ENST00000269518.9
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr10_+_102790980 0.06 ENST00000393459.1
ENST00000224807.5
SFXN3
sideroflexin 3
chrX_-_153141302 0.06 ENST00000361699.4
ENST00000543994.1
ENST00000370057.3
ENST00000538883.1
ENST00000361981.3
L1CAM
L1 cell adhesion molecule
chr19_-_51845378 0.06 ENST00000335624.4
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr19_-_45926739 0.06 ENST00000589381.1
ENST00000591636.1
ENST00000013807.5
ENST00000592023.1
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr16_+_5008290 0.05 ENST00000251170.7
SEC14L5
SEC14-like 5 (S. cerevisiae)
chr20_+_30555805 0.05 ENST00000562532.2
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr2_-_47798044 0.05 ENST00000327876.4
KCNK12
potassium channel, subfamily K, member 12
chr1_-_40105617 0.04 ENST00000372852.3
HEYL
hes-related family bHLH transcription factor with YRPW motif-like
chr20_-_62284766 0.04 ENST00000370053.1
STMN3
stathmin-like 3
chr1_+_171750776 0.03 ENST00000458517.1
ENST00000362019.3
ENST00000367737.5
ENST00000361735.3
METTL13
methyltransferase like 13
chrX_-_153237258 0.03 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr10_+_89419370 0.03 ENST00000361175.4
ENST00000456849.1
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr17_-_27332931 0.03 ENST00000442608.3
ENST00000335960.6
SEZ6
seizure related 6 homolog (mouse)
chr7_-_65113280 0.03 ENST00000593865.1
AC104057.1
Protein LOC100996407
chr6_+_158957431 0.03 ENST00000367090.3
TMEM181
transmembrane protein 181
chr11_+_45907177 0.03 ENST00000241014.2
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr10_-_50970382 0.03 ENST00000419399.1
ENST00000432695.1
OGDHL
oxoglutarate dehydrogenase-like
chr10_-_50970322 0.02 ENST00000374103.4
OGDHL
oxoglutarate dehydrogenase-like
chr2_+_46524537 0.02 ENST00000263734.3
EPAS1
endothelial PAS domain protein 1
chr17_-_27333163 0.02 ENST00000360295.9
SEZ6
seizure related 6 homolog (mouse)
chr17_-_27333311 0.02 ENST00000317338.12
ENST00000585644.1
SEZ6
seizure related 6 homolog (mouse)
chr2_+_115199876 0.02 ENST00000436732.1
ENST00000410059.1
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr15_+_68117872 0.02 ENST00000380035.2
ENST00000389002.1
SKOR1
SKI family transcriptional corepressor 1
chr20_+_44657845 0.02 ENST00000243964.3
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr19_-_3971050 0.01 ENST00000545797.2
ENST00000596311.1
DAPK3
death-associated protein kinase 3
chr14_-_51561784 0.01 ENST00000360392.4
TRIM9
tripartite motif containing 9
chr3_+_62304648 0.01 ENST00000462069.1
ENST00000232519.5
ENST00000465142.1
C3orf14
chromosome 3 open reading frame 14
chr2_-_51259528 0.01 ENST00000404971.1
NRXN1
neurexin 1
chr11_-_92931098 0.01 ENST00000326402.4
SLC36A4
solute carrier family 36 (proton/amino acid symporter), member 4
chr12_-_99288986 0.01 ENST00000552407.1
ENST00000551613.1
ENST00000548447.1
ENST00000546364.3
ENST00000552748.1
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr10_+_60936921 0.01 ENST00000373878.3
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr12_-_57443886 0.01 ENST00000300119.3
MYO1A
myosin IA
chr8_-_91095099 0.01 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr6_+_25652432 0.00 ENST00000377961.2
SCGN
secretagogin, EF-hand calcium binding protein
chr15_+_68117844 0.00 ENST00000554054.1
SKOR1
SKI family transcriptional corepressor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.1 0.6 GO:0008218 bioluminescence(GO:0008218)
0.1 0.2 GO:0021722 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.1 0.2 GO:0060164 negative regulation of auditory receptor cell differentiation(GO:0045608) negative regulation of mechanoreceptor differentiation(GO:0045632) regulation of timing of neuron differentiation(GO:0060164) negative regulation of inner ear receptor cell differentiation(GO:2000981)
0.0 0.2 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.0 0.2 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0 0.4 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.2 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 0.2 GO:1902075 cellular response to salt(GO:1902075)
0.0 0.1 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.1 GO:0032097 positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.0 0.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.4 GO:0002385 mucosal immune response(GO:0002385)
0.0 0.0 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
0.0 0.1 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.0 0.1 GO:0032099 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:1990769 proximal neuron projection(GO:1990769)
0.1 0.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.3 GO:0043196 varicosity(GO:0043196)
0.0 0.1 GO:0002139 stereocilia coupling link(GO:0002139)
0.0 0.2 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.4 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.7 GO:0097440 apical dendrite(GO:0097440)
0.0 0.2 GO:0044327 dendritic spine head(GO:0044327)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0035033 histone deacetylase regulator activity(GO:0035033) corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.1 0.2 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.0 0.2 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.0 0.1 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.4 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.0 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.0 GO:0004781 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.0 0.2 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors