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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for RCOR1_MTA3
Z-value: 1.30
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Transcription factors associated with RCOR1_MTA3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RCOR1 | hg19_v2_chr14_+_103058948_103059005 | 0.53 | 4.7e-01 | Click! |
| MTA3 | hg19_v2_chr2_+_42795839_42795887 | 0.35 | 6.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_48673465 Show fit | 1.59 |
ENST00000598938.1
|
ligase I, DNA, ATP-dependent |
|
| chr19_+_55795493 Show fit | 1.34 |
ENST00000309383.1
|
BR serine/threonine kinase 1 |
|
| chr19_+_39759154 Show fit | 1.13 |
ENST00000331982.5
|
interferon, lambda 2 |
|
| chr20_+_57466629 Show fit | 1.11 |
ENST00000371081.1
ENST00000338783.6 |
GNAS complex locus |
|
| chr8_-_144099795 Show fit | 1.09 |
ENST00000522060.1
ENST00000517833.1 ENST00000502167.2 ENST00000518831.1 |
RP11-273G15.2 |
|
| chr19_+_7571968 Show fit | 1.04 |
ENST00000599312.1
|
Uncharacterized protein |
|
| chr10_+_15001430 Show fit | 1.02 |
ENST00000407572.1
|
meiosis/spermiogenesis associated 1 |
|
| chr10_-_46342675 Show fit | 0.92 |
ENST00000492347.1
|
ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 |
|
| chrX_-_135056106 Show fit | 0.90 |
ENST00000433339.2
|
membrane magnesium transporter 1 |
|
| chr19_-_39735646 Show fit | 0.87 |
ENST00000413851.2
|
interferon, lambda 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of RCOR1_MTA3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.2 | GO:0010389 | regulation of G2/M transition of mitotic cell cycle(GO:0010389) |
| 0.1 | 5.1 | GO:0070911 | global genome nucleotide-excision repair(GO:0070911) |
| 0.1 | 4.8 | GO:0009301 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.1 | 3.8 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.1 | 3.7 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.1 | 3.6 | GO:0010574 | vascular endothelial growth factor production(GO:0010573) regulation of vascular endothelial growth factor production(GO:0010574) |
| 0.1 | 2.9 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.1 | 2.8 | GO:0071624 | positive regulation of granulocyte chemotaxis(GO:0071624) |
| 0.1 | 2.6 | GO:0006368 | transcription elongation from RNA polymerase II promoter(GO:0006368) |
| 0.0 | 2.6 | GO:0098840 | protein transport along microtubule(GO:0098840) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.3 | GO:0000776 | kinetochore(GO:0000776) |
| 0.0 | 5.8 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 5.7 | GO:0044309 | neuron spine(GO:0044309) |
| 0.0 | 4.9 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 4.6 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.2 | 4.3 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 3.8 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 3.3 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 3.2 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 3.0 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.3 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 5.2 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 0.1 | 4.5 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 4.3 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.0 | 4.0 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 3.9 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 3.8 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.1 | 3.5 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 0.1 | 3.3 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 3.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 6.3 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 4.8 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 4.5 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 3.7 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 3.4 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 3.4 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 3.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 3.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 3.2 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.1 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.1 | 4.9 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 4.5 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 4.2 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.2 | 4.1 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 4.1 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.1 | 4.1 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 4.1 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 4.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 3.9 | REACTOME EARLY PHASE OF HIV LIFE CYCLE | Genes involved in Early Phase of HIV Life Cycle |