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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for PROX1
Z-value: 0.91
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Transcription factors associated with PROX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PROX1 | hg19_v2_chr1_+_214161272_214161322 | -0.50 | 5.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_142264664 Show fit | 0.84 |
ENST00000518520.1
|
Uncharacterized protein |
|
| chr6_-_8102279 Show fit | 0.71 |
ENST00000488226.2
|
eukaryotic translation elongation factor 1 epsilon 1 |
|
| chr21_-_34863693 Show fit | 0.57 |
ENST00000314399.3
|
DnaJ (Hsp40) homolog, subfamily C, member 28 |
|
| chr10_+_32735030 Show fit | 0.52 |
ENST00000277657.6
ENST00000362006.5 |
coiled-coil domain containing 7 |
|
| chr6_-_107235331 Show fit | 0.46 |
ENST00000433965.1
ENST00000430094.1 |
RP1-60O19.1 |
|
| chr1_+_95975672 Show fit | 0.46 |
ENST00000440116.2
ENST00000456933.1 |
RP11-286B14.1 |
|
| chr12_+_42624050 Show fit | 0.39 |
ENST00000601185.1
|
Uncharacterized protein |
|
| chr10_-_43633747 Show fit | 0.36 |
ENST00000609407.1
|
RP11-351D16.3 |
|
| chr21_-_26979786 Show fit | 0.34 |
ENST00000419219.1
ENST00000352957.4 ENST00000307301.7 |
mitochondrial ribosomal protein L39 |
|
| chr13_-_36788718 Show fit | 0.34 |
ENST00000317764.6
ENST00000379881.3 |
spermatogenesis and oogenesis specific basic helix-loop-helix 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PROX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 0.2 | 0.6 | GO:0048213 | Golgi vesicle prefusion complex stabilization(GO:0048213) |
| 0.0 | 0.4 | GO:1903764 | regulation of potassium ion export across plasma membrane(GO:1903764) |
| 0.1 | 0.3 | GO:0034476 | U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) |
| 0.1 | 0.3 | GO:1901143 | insulin catabolic process(GO:1901143) |
| 0.1 | 0.3 | GO:0018352 | protein-pyridoxal-5-phosphate linkage(GO:0018352) |
| 0.0 | 0.3 | GO:0034427 | nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427) |
| 0.0 | 0.3 | GO:0006526 | arginine biosynthetic process(GO:0006526) |
| 0.0 | 0.3 | GO:0044598 | polyketide metabolic process(GO:0030638) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598) |
| 0.0 | 0.3 | GO:0030043 | actin filament fragmentation(GO:0030043) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.0 | 0.6 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.0 | 0.4 | GO:0097025 | lateral loop(GO:0043219) MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.0 | 0.4 | GO:0070938 | contractile ring(GO:0070938) |
| 0.0 | 0.3 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.0 | 0.3 | GO:0000178 | exosome (RNase complex)(GO:0000178) |
| 0.0 | 0.3 | GO:0031597 | cytosolic proteasome complex(GO:0031597) |
| 0.0 | 0.3 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 0.2 | GO:0034991 | nuclear meiotic cohesin complex(GO:0034991) |
| 0.0 | 0.2 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 0.6 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 0.5 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.4 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.1 | 0.3 | GO:0003955 | NAD(P)H dehydrogenase (quinone) activity(GO:0003955) 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025) |
| 0.1 | 0.3 | GO:0031626 | beta-endorphin binding(GO:0031626) |
| 0.1 | 0.3 | GO:0016774 | phosphotransferase activity, carboxyl group as acceptor(GO:0016774) |
| 0.0 | 0.3 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.0 | 0.3 | GO:0043047 | single-stranded telomeric DNA binding(GO:0043047) |
| 0.1 | 0.2 | GO:0030626 | U12 snRNA binding(GO:0030626) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 0.5 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.2 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.0 | 0.2 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.0 | 0.1 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 0.6 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 0.4 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.3 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.0 | 0.2 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 0.2 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |