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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for POU5F1_POU2F3
Z-value: 1.58
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Transcription factors associated with POU5F1_POU2F3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU2F3 | hg19_v2_chr11_+_120110863_120110908 | -0.33 | 6.7e-01 | Click! |
| POU5F1 | hg19_v2_chr6_-_31138439_31138475 | 0.11 | 8.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_26183958 Show fit | 2.70 |
ENST00000356530.3
|
histone cluster 1, H2be |
|
| chr1_+_228645796 Show fit | 2.33 |
ENST00000369160.2
|
histone cluster 3, H2bb |
|
| chr6_+_27782788 Show fit | 1.79 |
ENST00000359465.4
|
histone cluster 1, H2bm |
|
| chr1_-_149783914 Show fit | 1.42 |
ENST00000369167.1
ENST00000427880.2 ENST00000545683.1 |
histone cluster 2, H2bf |
|
| chr6_+_27114861 Show fit | 1.39 |
ENST00000377459.1
|
histone cluster 1, H2ah |
|
| chr20_+_34556488 Show fit | 1.26 |
ENST00000373973.3
ENST00000349339.1 ENST00000538900.1 |
cyclic nucleotide binding domain containing 2 |
|
| chr9_-_35658007 Show fit | 1.24 |
ENST00000602361.1
|
RNA component of mitochondrial RNA processing endoribonuclease |
|
| chr10_-_10504285 Show fit | 1.20 |
ENST00000602311.1
|
RP11-271F18.4 |
|
| chr9_-_117160738 Show fit | 1.17 |
ENST00000448674.1
|
RP11-9M16.2 |
|
| chr6_-_26033796 Show fit | 1.13 |
ENST00000259791.2
|
histone cluster 1, H2ab |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU5F1_POU2F3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.6 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.0 | 5.1 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.2 | 1.6 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.1 | 0.7 | GO:0036343 | psychomotor behavior(GO:0036343) |
| 0.0 | 0.7 | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
| 0.0 | 0.7 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.1 | 0.6 | GO:1903301 | positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301) |
| 0.1 | 0.5 | GO:0002678 | positive regulation of chronic inflammatory response(GO:0002678) |
| 0.1 | 0.5 | GO:0018364 | peptidyl-glutamine methylation(GO:0018364) |
| 0.1 | 0.5 | GO:0098532 | histone H3-K27 trimethylation(GO:0098532) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.7 | GO:0000786 | nucleosome(GO:0000786) |
| 0.1 | 0.8 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.1 | 0.5 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.1 | 0.4 | GO:0030936 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.1 | 0.4 | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) |
| 0.1 | 0.4 | GO:1990037 | Lewy body core(GO:1990037) |
| 0.0 | 0.4 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
| 0.0 | 0.4 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.0 | 0.4 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.0 | 0.4 | GO:0016461 | unconventional myosin complex(GO:0016461) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.1 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.0 | 1.5 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.0 | 0.8 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 0.6 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
| 0.0 | 0.6 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.0 | 0.6 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 0.5 | GO:0004833 | tryptophan 2,3-dioxygenase activity(GO:0004833) |
| 0.1 | 0.5 | GO:0001588 | dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588) |
| 0.0 | 0.5 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 0.5 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 0.2 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 0.2 | ST STAT3 PATHWAY | STAT3 Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 15.4 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.9 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 0.8 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.0 | 0.6 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 0.5 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.0 | 0.5 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 0.5 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.5 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 0.5 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 0.5 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |