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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for POU2F2_POU3F1
Z-value: 2.58
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Transcription factors associated with POU2F2_POU3F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU2F2 | hg19_v2_chr19_-_42636543_42636607 | -0.52 | 4.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_26183958 Show fit | 5.63 |
ENST00000356530.3
|
histone cluster 1, H2be |
|
| chr6_+_27114861 Show fit | 4.03 |
ENST00000377459.1
|
histone cluster 1, H2ah |
|
| chr6_-_26033796 Show fit | 3.77 |
ENST00000259791.2
|
histone cluster 1, H2ab |
|
| chr6_+_27782788 Show fit | 3.46 |
ENST00000359465.4
|
histone cluster 1, H2bm |
|
| chr6_-_27860956 Show fit | 3.40 |
ENST00000359611.2
|
histone cluster 1, H2am |
|
| chr6_-_26043885 Show fit | 3.40 |
ENST00000357905.2
|
histone cluster 1, H2bb |
|
| chr1_+_228645796 Show fit | 3.35 |
ENST00000369160.2
|
histone cluster 3, H2bb |
|
| chr6_-_27782548 Show fit | 2.86 |
ENST00000333151.3
|
histone cluster 1, H2aj |
|
| chr1_+_149822620 Show fit | 2.69 |
ENST00000369159.2
|
histone cluster 2, H2aa4 |
|
| chr1_-_149783914 Show fit | 2.69 |
ENST00000369167.1
ENST00000427880.2 ENST00000545683.1 |
histone cluster 2, H2bf |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU2F2_POU3F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.6 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.1 | 18.2 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.3 | 2.7 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.0 | 2.2 | GO:0006805 | xenobiotic metabolic process(GO:0006805) |
| 0.1 | 1.8 | GO:0060056 | mammary gland involution(GO:0060056) |
| 0.2 | 1.7 | GO:0010159 | specification of organ position(GO:0010159) |
| 0.1 | 1.7 | GO:0002115 | store-operated calcium entry(GO:0002115) |
| 0.3 | 1.5 | GO:0036343 | psychomotor behavior(GO:0036343) |
| 0.1 | 1.3 | GO:2000773 | negative regulation of cellular senescence(GO:2000773) |
| 0.2 | 1.1 | GO:1903644 | regulation of chaperone-mediated protein folding(GO:1903644) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 40.4 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 1.4 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 1.0 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.1 | 0.8 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.0 | 0.8 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.0 | 0.7 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.0 | 0.5 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 0.4 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.0 | 0.4 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 0.3 | GO:0032301 | MutSalpha complex(GO:0032301) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 38.3 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.3 | 2.5 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 0.1 | 2.1 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.1 | 1.7 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.1 | 1.7 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.0 | 1.3 | GO:0002039 | p53 binding(GO:0002039) |
| 0.1 | 1.2 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.2 | 1.1 | GO:0052795 | exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796) |
| 0.1 | 1.1 | GO:0042923 | neuropeptide binding(GO:0042923) |
| 0.0 | 1.1 | GO:0003785 | actin monomer binding(GO:0003785) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.9 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.8 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 0.6 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 0.5 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 0.5 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 0.5 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 0.5 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 41.3 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 2.1 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 1.7 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.0 | 1.1 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 0.8 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.0 | 0.8 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 0.7 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.0 | 0.7 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.7 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.6 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |