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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for PLAGL1
Z-value: 5.49
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Transcription factors associated with PLAGL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PLAGL1 | hg19_v2_chr6_-_144329384_144329405 | 0.96 | 3.8e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_2249308 Show fit | 6.50 |
ENST00000592877.1
ENST00000221496.4 |
anti-Mullerian hormone |
|
| chr11_+_393428 Show fit | 6.34 |
ENST00000533249.1
ENST00000527442.1 |
plakophilin 3 |
|
| chr14_-_21566731 Show fit | 5.64 |
ENST00000360947.3
|
zinc finger protein 219 |
|
| chr7_-_1067968 Show fit | 5.14 |
ENST00000412051.1
|
chromosome 7 open reading frame 50 |
|
| chr19_-_56092187 Show fit | 4.18 |
ENST00000325421.4
ENST00000592239.1 |
zinc finger protein 579 |
|
| chr11_+_392587 Show fit | 4.09 |
ENST00000534401.1
|
plakophilin 3 |
|
| chr14_-_21567009 Show fit | 3.89 |
ENST00000556174.1
ENST00000554478.1 ENST00000553980.1 ENST00000421093.2 |
zinc finger protein 219 |
|
| chr19_+_1104415 Show fit | 3.68 |
ENST00000585362.2
|
glutathione peroxidase 4 |
|
| chr19_-_51014460 Show fit | 3.62 |
ENST00000595669.1
|
Josephin domain containing 2 |
|
| chr16_-_28223229 Show fit | 3.57 |
ENST00000566073.1
|
exportin 6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PLAGL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 13.5 | GO:0002159 | desmosome assembly(GO:0002159) |
| 0.1 | 12.1 | GO:0006414 | translational elongation(GO:0006414) |
| 0.2 | 8.2 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 2.4 | 7.2 | GO:0043181 | vacuolar sequestering(GO:0043181) |
| 0.2 | 7.0 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 6.8 | GO:0008033 | tRNA processing(GO:0008033) |
| 2.2 | 6.6 | GO:0007506 | gonadal mesoderm development(GO:0007506) |
| 0.4 | 6.6 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.3 | 6.3 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
| 0.2 | 6.2 | GO:0070208 | protein heterotrimerization(GO:0070208) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 235.4 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.2 | 27.8 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 22.9 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 14.1 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.3 | 10.7 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.1 | 9.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 8.8 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 8.4 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 8.0 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.8 | 6.1 | GO:0000408 | EKC/KEOPS complex(GO:0000408) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 14.8 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.0 | 11.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 1.1 | 9.5 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.1 | 8.7 | GO:0005178 | integrin binding(GO:0005178) |
| 2.4 | 7.2 | GO:0004574 | oligo-1,6-glucosidase activity(GO:0004574) |
| 0.3 | 6.6 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.2 | 6.6 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.3 | 6.2 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
| 0.7 | 6.0 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.1 | 6.0 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.9 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 10.0 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 9.9 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 9.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 9.5 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 8.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 7.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.3 | 7.1 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.2 | 6.3 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 6.0 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.6 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.2 | 12.4 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.1 | 10.6 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.3 | 10.1 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.3 | 9.5 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.2 | 9.2 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 8.2 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 6.9 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.1 | 6.9 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 6.7 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |