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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for PITX3
Z-value: 1.97
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Transcription factors associated with PITX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PITX3 | hg19_v2_chr10_-_104001231_104001274 | 0.77 | 2.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_10694766 Show fit | 1.38 |
ENST00000460742.2
ENST00000259983.3 ENST00000379586.1 |
chromosome 6 open reading frame 52 |
|
| chr19_-_3479086 Show fit | 1.26 |
ENST00000587847.1
|
chromosome 19 open reading frame 77 |
|
| chr12_+_22852791 Show fit | 1.16 |
ENST00000413794.2
|
RP11-114G22.1 |
|
| chr9_+_78505581 Show fit | 1.03 |
ENST00000376767.3
ENST00000376752.4 |
proprotein convertase subtilisin/kexin type 5 |
|
| chr12_+_6949964 Show fit | 0.97 |
ENST00000541978.1
ENST00000435982.2 |
guanine nucleotide binding protein (G protein), beta polypeptide 3 |
|
| chr18_-_56985873 Show fit | 0.85 |
ENST00000299721.3
|
complexin 4 |
|
| chr19_+_39786962 Show fit | 0.84 |
ENST00000333625.2
|
interferon, lambda 1 |
|
| chr14_+_52456327 Show fit | 0.79 |
ENST00000556760.1
|
chromosome 14 open reading frame 166 |
|
| chr8_-_101718991 Show fit | 0.75 |
ENST00000517990.1
|
poly(A) binding protein, cytoplasmic 1 |
|
| chr17_-_40264692 Show fit | 0.74 |
ENST00000591220.1
ENST00000251642.3 |
DEXH (Asp-Glu-X-His) box polypeptide 58 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PITX3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | GO:0006368 | transcription elongation from RNA polymerase II promoter(GO:0006368) |
| 0.0 | 1.7 | GO:0070911 | global genome nucleotide-excision repair(GO:0070911) |
| 0.0 | 1.7 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.1 | 1.6 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.1 | 1.5 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 0.2 | 1.3 | GO:0071163 | DNA replication preinitiation complex assembly(GO:0071163) |
| 0.4 | 1.2 | GO:0071449 | cellular response to lipid hydroperoxide(GO:0071449) |
| 0.2 | 1.2 | GO:0002001 | renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure(GO:0001999) renin secretion into blood stream(GO:0002001) |
| 0.1 | 1.2 | GO:0038007 | netrin-activated signaling pathway(GO:0038007) |
| 0.0 | 1.2 | GO:2000816 | negative regulation of mitotic sister chromatid separation(GO:2000816) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 1.7 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 1.4 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.0 | 1.4 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.0 | 1.3 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 1.2 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.1 | 1.2 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 1.2 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 1.0 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.1 | 0.9 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 1.6 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.0 | 1.6 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 1.4 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.0 | 1.4 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.1 | 1.3 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.0 | 1.2 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 0.2 | 1.1 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
| 0.1 | 1.1 | GO:1900750 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 0.0 | 1.1 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.0 | 1.4 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 1.2 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 1.2 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.1 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 0.9 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.8 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 0.7 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.6 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.5 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 2.1 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 1.4 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 0.1 | 1.4 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 1.4 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.0 | 1.4 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.0 | 1.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 1.0 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.0 | 1.0 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.0 | 1.0 | REACTOME KINESINS | Genes involved in Kinesins |