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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 1.64

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Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Gene Symbol Gene ID Gene Info
OTP
ENSG00000171540.6 orthopedia homeobox
PHOX2B
ENSG00000109132.5 paired like homeobox 2B
LHX1
ENSG00000132130.7 LIM homeobox 1
LMX1A
ENSG00000162761.10 LIM homeobox transcription factor 1 alpha
LHX5
ENSG00000089116.3 LIM homeobox 5
HOXC4
ENSG00000198353.6 homeobox C4
HOXC4
ENSG00000273266.1 homeobox C4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXC4hg19_v2_chr12_+_54410664_544107150.851.5e-01Click!
LHX1hg19_v2_chr17_+_35294075_35294102-0.722.8e-01Click!
OTPhg19_v2_chr5_-_76935513_769355130.336.7e-01Click!

Activity profile of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Sorted Z-values of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_101417919 2.11 ENST00000561338.1
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr5_-_126409159 1.86 ENST00000607731.1
ENST00000535381.1
ENST00000296662.5
ENST00000509733.3
C5orf63
chromosome 5 open reading frame 63
chr14_+_20187174 1.82 ENST00000557414.1
OR4N2
olfactory receptor, family 4, subfamily N, member 2
chr11_+_71934962 1.68 ENST00000543234.1
INPPL1
inositol polyphosphate phosphatase-like 1
chr7_+_5465382 1.24 ENST00000609130.1
RP11-1275H24.2
RP11-1275H24.2
chr11_+_327171 0.79 ENST00000534483.1
ENST00000524824.1
ENST00000531076.1
RP11-326C3.12
RP11-326C3.12
chr1_+_225600404 0.78 ENST00000366845.2
AC092811.1
AC092811.1
chr14_+_31046959 0.77 ENST00000547532.1
ENST00000555429.1
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr12_-_64062583 0.74 ENST00000542209.1
DPY19L2
dpy-19-like 2 (C. elegans)
chr4_+_183370146 0.65 ENST00000510504.1
TENM3
teneurin transmembrane protein 3
chr11_-_327537 0.64 ENST00000602735.1
IFITM3
interferon induced transmembrane protein 3
chr11_+_5710919 0.62 ENST00000379965.3
ENST00000425490.1
TRIM22
tripartite motif containing 22
chr3_-_141747950 0.57 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr6_+_26402517 0.57 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chr16_-_66583994 0.53 ENST00000564917.1
TK2
thymidine kinase 2, mitochondrial
chr7_-_22862406 0.52 ENST00000372879.4
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr19_+_49199209 0.52 ENST00000522966.1
ENST00000425340.2
ENST00000391876.4
FUT2
fucosyltransferase 2 (secretor status included)
chr6_-_47445214 0.50 ENST00000604014.1
RP11-385F7.1
RP11-385F7.1
chr12_-_10978957 0.49 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr14_-_51027838 0.48 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr5_+_66300464 0.47 ENST00000436277.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr6_+_3259148 0.47 ENST00000419065.2
ENST00000473000.2
ENST00000451246.2
ENST00000454610.2
PSMG4
proteasome (prosome, macropain) assembly chaperone 4
chr16_-_28937027 0.46 ENST00000358201.4
RABEP2
rabaptin, RAB GTPase binding effector protein 2
chr4_+_119810134 0.45 ENST00000434046.2
SYNPO2
synaptopodin 2
chr4_+_155484103 0.44 ENST00000302068.4
FGB
fibrinogen beta chain
chr17_-_6524159 0.43 ENST00000589033.1
KIAA0753
KIAA0753
chr1_+_117544366 0.42 ENST00000256652.4
ENST00000369470.1
CD101
CD101 molecule
chr8_-_124741451 0.41 ENST00000520519.1
ANXA13
annexin A13
chr12_-_54653313 0.40 ENST00000550411.1
ENST00000439541.2
CBX5
chromobox homolog 5
chr4_+_119809984 0.39 ENST00000307142.4
ENST00000448416.2
ENST00000429713.2
SYNPO2
synaptopodin 2
chr4_+_26324474 0.38 ENST00000514675.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr16_-_66584059 0.37 ENST00000417693.3
ENST00000544898.1
ENST00000569718.1
ENST00000527284.1
ENST00000299697.7
ENST00000451102.2
TK2
thymidine kinase 2, mitochondrial
chr17_+_4692230 0.37 ENST00000331264.7
GLTPD2
glycolipid transfer protein domain containing 2
chr1_-_168464875 0.35 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr19_-_3557570 0.35 ENST00000355415.2
MFSD12
major facilitator superfamily domain containing 12
chr19_+_50016411 0.35 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chrX_+_10126488 0.34 ENST00000380829.1
ENST00000421085.2
ENST00000454850.1
CLCN4
chloride channel, voltage-sensitive 4
chr2_-_37068530 0.34 ENST00000593798.1
AC007382.1
Uncharacterized protein
chr16_+_12059091 0.33 ENST00000562385.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr3_+_138340049 0.33 ENST00000464668.1
FAIM
Fas apoptotic inhibitory molecule
chr12_+_38710555 0.32 ENST00000551464.1
ALG10B
ALG10B, alpha-1,2-glucosyltransferase
chr16_-_66583701 0.32 ENST00000527800.1
ENST00000525974.1
ENST00000563369.2
TK2
thymidine kinase 2, mitochondrial
chr12_-_46121554 0.31 ENST00000609803.1
LINC00938
long intergenic non-protein coding RNA 938
chr17_+_74463650 0.31 ENST00000392492.3
AANAT
aralkylamine N-acetyltransferase
chr4_+_155484155 0.30 ENST00000509493.1
FGB
fibrinogen beta chain
chr7_+_138915102 0.30 ENST00000486663.1
UBN2
ubinuclein 2
chr17_+_57233087 0.30 ENST00000578777.1
ENST00000577457.1
ENST00000582995.1
PRR11
proline rich 11
chr4_+_113568207 0.30 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr6_+_114178512 0.29 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr10_+_24755416 0.28 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
KIAA1217
chr5_+_40841410 0.28 ENST00000381677.3
CARD6
caspase recruitment domain family, member 6
chr14_-_75530693 0.28 ENST00000555135.1
ENST00000357971.3
ENST00000553302.1
ENST00000555694.1
ENST00000238618.3
ACYP1
acylphosphatase 1, erythrocyte (common) type
chr1_+_151253991 0.27 ENST00000443959.1
ZNF687
zinc finger protein 687
chr19_+_50016610 0.26 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr20_-_50418947 0.26 ENST00000371539.3
SALL4
spalt-like transcription factor 4
chr15_+_75303993 0.25 ENST00000564779.1
SCAMP5
secretory carrier membrane protein 5
chr6_-_32157947 0.24 ENST00000375050.4
PBX2
pre-B-cell leukemia homeobox 2
chr19_-_36304201 0.22 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr5_+_60933634 0.21 ENST00000505642.1
C5orf64
chromosome 5 open reading frame 64
chr13_-_81801115 0.21 ENST00000567258.1
LINC00564
long intergenic non-protein coding RNA 564
chr5_+_175288631 0.21 ENST00000509837.1
CPLX2
complexin 2
chr3_+_186692745 0.21 ENST00000438590.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr14_+_102276192 0.21 ENST00000557714.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr3_-_150421752 0.20 ENST00000498386.1
FAM194A
family with sequence similarity 194, member A
chrX_+_43515467 0.19 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr4_-_177116772 0.19 ENST00000280191.2
SPATA4
spermatogenesis associated 4
chr10_+_6779326 0.19 ENST00000417112.1
RP11-554I8.2
RP11-554I8.2
chr4_+_169418255 0.19 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr12_-_10022735 0.19 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr12_-_112614506 0.18 ENST00000548588.2
HECTD4
HECT domain containing E3 ubiquitin protein ligase 4
chr12_-_118796971 0.18 ENST00000542902.1
TAOK3
TAO kinase 3
chr7_-_144435985 0.17 ENST00000549981.1
TPK1
thiamin pyrophosphokinase 1
chr5_+_179135246 0.17 ENST00000508787.1
CANX
calnexin
chr17_-_38821373 0.17 ENST00000394052.3
KRT222
keratin 222
chr4_-_74486109 0.17 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr16_-_71842706 0.17 ENST00000563104.1
ENST00000569975.1
ENST00000565412.1
ENST00000567583.1
AP1G1
adaptor-related protein complex 1, gamma 1 subunit
chrX_+_47696337 0.17 ENST00000334937.4
ENST00000376950.4
ZNF81
zinc finger protein 81
chr17_+_68164752 0.16 ENST00000535240.1
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr2_+_152214098 0.16 ENST00000243347.3
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr7_-_22862448 0.16 ENST00000358435.4
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr15_+_58702742 0.16 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr7_+_30589829 0.16 ENST00000579437.1
RP4-777O23.1
RP4-777O23.1
chr15_-_34635314 0.15 ENST00000557912.1
ENST00000328848.4
NOP10
NOP10 ribonucleoprotein
chr17_+_48823975 0.15 ENST00000513969.1
ENST00000503728.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr20_-_50418972 0.15 ENST00000395997.3
SALL4
spalt-like transcription factor 4
chr12_+_26348582 0.15 ENST00000535504.1
SSPN
sarcospan
chr14_-_21994337 0.15 ENST00000537235.1
ENST00000450879.2
SALL2
spalt-like transcription factor 2
chr7_+_133812052 0.15 ENST00000285928.2
LRGUK
leucine-rich repeats and guanylate kinase domain containing
chr4_-_120243545 0.15 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr3_+_186353756 0.15 ENST00000431018.1
ENST00000450521.1
ENST00000539949.1
FETUB
fetuin B
chr6_+_26440700 0.14 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr17_+_48823896 0.14 ENST00000511974.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr9_-_77567743 0.14 ENST00000376854.5
C9orf40
chromosome 9 open reading frame 40
chr4_+_87857538 0.14 ENST00000511442.1
AFF1
AF4/FMR2 family, member 1
chr1_+_157963063 0.13 ENST00000360089.4
ENST00000368173.3
ENST00000392272.2
KIRREL
kin of IRRE like (Drosophila)
chr6_-_136788001 0.13 ENST00000544465.1
MAP7
microtubule-associated protein 7
chr1_-_211307404 0.13 ENST00000367007.4
KCNH1
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr10_-_27529486 0.13 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr3_+_139063372 0.13 ENST00000478464.1
MRPS22
mitochondrial ribosomal protein S22
chr11_-_128894053 0.13 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr3_-_9994021 0.13 ENST00000411976.2
ENST00000412055.1
PRRT3
proline-rich transmembrane protein 3
chr8_-_145754428 0.13 ENST00000527462.1
ENST00000313465.5
ENST00000524821.1
C8orf82
chromosome 8 open reading frame 82
chr18_-_51750948 0.13 ENST00000583046.1
ENST00000398398.2
MBD2
methyl-CpG binding domain protein 2
chr19_+_48112371 0.13 ENST00000594866.1
GLTSCR1
glioma tumor suppressor candidate region gene 1
chr12_-_118797475 0.13 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr14_-_80678512 0.12 ENST00000553968.1
DIO2
deiodinase, iodothyronine, type II
chr5_-_53115506 0.12 ENST00000511953.1
ENST00000504552.1
CTD-2081C10.1
CTD-2081C10.1
chr19_+_56280507 0.12 ENST00000341750.4
RFPL4AL1
ret finger protein-like 4A-like 1
chr4_+_76481258 0.12 ENST00000311623.4
ENST00000435974.2
C4orf26
chromosome 4 open reading frame 26
chr11_-_559377 0.12 ENST00000486629.1
C11orf35
chromosome 11 open reading frame 35
chr21_-_16125773 0.12 ENST00000454128.2
AF127936.3
AF127936.3
chr18_+_56806701 0.12 ENST00000587834.1
SEC11C
SEC11 homolog C (S. cerevisiae)
chr3_+_138340067 0.11 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chrX_+_55744228 0.11 ENST00000262850.7
RRAGB
Ras-related GTP binding B
chr4_+_186990298 0.10 ENST00000296795.3
ENST00000513189.1
TLR3
toll-like receptor 3
chr11_-_8857248 0.10 ENST00000534248.1
ENST00000530959.1
ENST00000531578.1
ENST00000533225.1
ST5
suppression of tumorigenicity 5
chr8_+_23145594 0.10 ENST00000519952.1
ENST00000518840.1
R3HCC1
R3H domain and coiled-coil containing 1
chr9_-_131486367 0.10 ENST00000372663.4
ENST00000406904.2
ENST00000452105.1
ENST00000372672.2
ENST00000372667.5
ZDHHC12
zinc finger, DHHC-type containing 12
chr4_+_26344754 0.10 ENST00000515573.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr5_-_20575959 0.10 ENST00000507958.1
CDH18
cadherin 18, type 2
chr6_+_26087646 0.10 ENST00000309234.6
HFE
hemochromatosis
chr17_-_72772462 0.10 ENST00000582870.1
ENST00000581136.1
ENST00000357814.3
ENST00000579218.1
ENST00000583476.1
ENST00000580301.1
ENST00000583757.1
ENST00000582524.1
NAT9
N-acetyltransferase 9 (GCN5-related, putative)
chr9_+_124329336 0.10 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2IP
DAB2 interacting protein
chr2_-_43266680 0.10 ENST00000425212.1
ENST00000422351.1
ENST00000449766.1
AC016735.2
AC016735.2
chrX_+_84258832 0.10 ENST00000373173.2
APOOL
apolipoprotein O-like
chr14_-_39639523 0.10 ENST00000330149.5
ENST00000554018.1
ENST00000347691.5
TRAPPC6B
trafficking protein particle complex 6B
chr2_+_234826016 0.10 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr1_-_233431458 0.10 ENST00000258229.9
ENST00000430153.1
PCNXL2
pecanex-like 2 (Drosophila)
chr16_-_28634874 0.10 ENST00000395609.1
ENST00000350842.4
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr19_+_56270380 0.10 ENST00000434937.2
RFPL4A
ret finger protein-like 4A
chr5_+_95066823 0.09 ENST00000506817.1
ENST00000379982.3
RHOBTB3
Rho-related BTB domain containing 3
chr18_-_47018869 0.09 ENST00000583036.1
ENST00000580261.1
RPL17
ribosomal protein L17
chr3_-_149293990 0.09 ENST00000472417.1
WWTR1
WW domain containing transcription regulator 1
chr17_+_67498538 0.09 ENST00000589647.1
MAP2K6
mitogen-activated protein kinase kinase 6
chr7_+_134528635 0.09 ENST00000445569.2
CALD1
caldesmon 1
chr1_+_66820058 0.09 ENST00000480109.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr4_+_71019903 0.09 ENST00000344526.5
C4orf40
chromosome 4 open reading frame 40
chr5_+_140762268 0.09 ENST00000518325.1
PCDHGA7
protocadherin gamma subfamily A, 7
chr17_+_66511540 0.09 ENST00000588188.2
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr6_+_26087509 0.09 ENST00000397022.3
ENST00000353147.5
ENST00000352392.4
ENST00000349999.4
ENST00000317896.7
ENST00000357618.5
ENST00000470149.1
ENST00000336625.8
ENST00000461397.1
ENST00000488199.1
HFE
hemochromatosis
chr10_+_91152303 0.09 ENST00000371804.3
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr21_+_33671160 0.09 ENST00000303645.5
MRAP
melanocortin 2 receptor accessory protein
chr6_-_138833630 0.08 ENST00000533765.1
NHSL1
NHS-like 1
chr3_-_33686925 0.08 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr2_-_74619152 0.08 ENST00000440727.1
ENST00000409240.1
DCTN1
dynactin 1
chrM_-_14670 0.08 ENST00000361681.2
MT-ND6
mitochondrially encoded NADH dehydrogenase 6
chr15_-_55489097 0.08 ENST00000260443.4
RSL24D1
ribosomal L24 domain containing 1
chr13_+_46276441 0.08 ENST00000310521.1
ENST00000533564.1
SPERT
spermatid associated
chr4_+_169418195 0.08 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chrX_-_77225135 0.08 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr13_+_24144796 0.07 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr2_+_13677795 0.07 ENST00000434509.1
AC092635.1
AC092635.1
chr1_-_153518270 0.07 ENST00000354332.4
ENST00000368716.4
S100A4
S100 calcium binding protein A4
chr1_-_39347255 0.07 ENST00000454994.2
ENST00000357771.3
GJA9
gap junction protein, alpha 9, 59kDa
chr10_-_4285923 0.07 ENST00000418372.1
ENST00000608792.1
LINC00702
long intergenic non-protein coding RNA 702
chr7_-_143599207 0.07 ENST00000355951.2
ENST00000479870.1
ENST00000478172.1
FAM115A
family with sequence similarity 115, member A
chr12_+_4130143 0.07 ENST00000543206.1
RP11-320N7.2
RP11-320N7.2
chr16_-_71842941 0.07 ENST00000423132.2
ENST00000433195.2
ENST00000569748.1
ENST00000570017.1
AP1G1
adaptor-related protein complex 1, gamma 1 subunit
chr4_+_75174180 0.07 ENST00000413830.1
EPGN
epithelial mitogen
chr15_+_93443419 0.07 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chr7_+_13141097 0.07 ENST00000411542.1
AC011288.2
AC011288.2
chr12_-_95510743 0.07 ENST00000551521.1
FGD6
FYVE, RhoGEF and PH domain containing 6
chr19_+_36139125 0.07 ENST00000246554.3
COX6B1
cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
chr6_+_26402465 0.07 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr3_-_185538849 0.06 ENST00000421047.2
IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr15_-_98417780 0.06 ENST00000503874.3
LINC00923
long intergenic non-protein coding RNA 923
chr3_-_141719195 0.06 ENST00000397991.4
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr12_+_12510352 0.06 ENST00000298571.6
LOH12CR1
loss of heterozygosity, 12, chromosomal region 1
chr2_+_102953608 0.06 ENST00000311734.2
ENST00000409584.1
IL1RL1
interleukin 1 receptor-like 1
chr1_-_190446759 0.06 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr6_-_24645956 0.06 ENST00000543707.1
KIAA0319
KIAA0319
chr9_-_215744 0.06 ENST00000382387.2
C9orf66
chromosome 9 open reading frame 66
chr2_+_102456277 0.06 ENST00000421882.1
MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr8_-_95487272 0.06 ENST00000297592.5
RAD54B
RAD54 homolog B (S. cerevisiae)
chr6_-_41039567 0.06 ENST00000468811.1
OARD1
O-acyl-ADP-ribose deacylase 1
chr3_+_39424828 0.06 ENST00000273158.4
ENST00000431510.1
SLC25A38
solute carrier family 25, member 38
chr1_+_12806141 0.06 ENST00000288048.5
C1orf158
chromosome 1 open reading frame 158
chr9_-_99540328 0.06 ENST00000223428.4
ENST00000375231.1
ENST00000374641.3
ZNF510
zinc finger protein 510
chr12_+_26348429 0.05 ENST00000242729.2
SSPN
sarcospan
chr14_+_50234309 0.05 ENST00000298307.5
KLHDC2
kelch domain containing 2
chr20_-_50419055 0.05 ENST00000217086.4
SALL4
spalt-like transcription factor 4
chr10_-_46620012 0.05 ENST00000508602.1
ENST00000374339.3
ENST00000502254.1
ENST00000437863.1
ENST00000374342.2
ENST00000395722.3
PTPN20A
protein tyrosine phosphatase, non-receptor type 20A
chr3_+_20081515 0.05 ENST00000263754.4
KAT2B
K(lysine) acetyltransferase 2B
chr5_+_40841276 0.05 ENST00000254691.5
CARD6
caspase recruitment domain family, member 6
chr12_-_11287243 0.05 ENST00000539585.1
TAS2R30
taste receptor, type 2, member 30
chr8_-_29605625 0.05 ENST00000506121.3
LINC00589
long intergenic non-protein coding RNA 589
chr20_+_15177480 0.05 ENST00000402914.1
MACROD2
MACRO domain containing 2
chr1_-_109935819 0.05 ENST00000538502.1
SORT1
sortilin 1
chr14_+_72052983 0.05 ENST00000358550.2
SIPA1L1
signal-induced proliferation-associated 1 like 1
chr19_+_54466179 0.04 ENST00000270458.2
CACNG8
calcium channel, voltage-dependent, gamma subunit 8
chr2_+_102615416 0.04 ENST00000393414.2
IL1R2
interleukin 1 receptor, type II
chr6_-_133035185 0.04 ENST00000367928.4
VNN1
vanin 1
chr14_-_104387888 0.04 ENST00000286953.3
C14orf2
chromosome 14 open reading frame 2
chr1_-_101360205 0.04 ENST00000450240.1
EXTL2
exostosin-like glycosyltransferase 2
chr9_-_26947220 0.04 ENST00000520884.1
PLAA
phospholipase A2-activating protein
chr7_+_13141010 0.04 ENST00000443947.1
AC011288.2
AC011288.2
chr16_-_71843047 0.04 ENST00000299980.4
ENST00000393512.3
AP1G1
adaptor-related protein complex 1, gamma 1 subunit
chr4_-_36245561 0.04 ENST00000506189.1
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr9_-_95640218 0.04 ENST00000395506.3
ENST00000375495.3
ENST00000332591.6
ZNF484
zinc finger protein 484
chr2_+_166095898 0.04 ENST00000424833.1
ENST00000375437.2
ENST00000357398.3
SCN2A
sodium channel, voltage-gated, type II, alpha subunit

Network of associatons between targets according to the STRING database.

First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0060166 olfactory pit development(GO:0060166)
0.2 1.2 GO:0046092 deoxycytidine metabolic process(GO:0046092)
0.2 0.6 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.1 0.3 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.1 0.7 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.7 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1 0.3 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979)
0.1 0.2 GO:0002590 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) response to iron ion starvation(GO:1990641)
0.1 0.7 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.1 0.5 GO:1905068 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.1 0.3 GO:0043321 regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323)
0.1 0.2 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.0 0.2 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.0 1.8 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 1.7 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.5 GO:0042354 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.2 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.0 0.1 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.2 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.0 0.7 GO:0097264 self proteolysis(GO:0097264)
0.0 0.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.1 GO:0072709 cellular response to sorbitol(GO:0072709)
0.0 0.5 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.1 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.1 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.0 0.4 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.6 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.1 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.2 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 0.5 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.4 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 0.1 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.0 0.1 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0050955 thermoception(GO:0050955)
0.0 0.2 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.1 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.0 0.7 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.0 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.0 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.0 0.4 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.0 GO:0032690 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.0 0.0 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.0 0.3 GO:0003334 keratinocyte development(GO:0003334)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.7 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 0.7 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.5 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.1 GO:1990032 parallel fiber(GO:1990032)
0.0 0.4 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.2 GO:1990357 terminal web(GO:1990357)
0.0 0.2 GO:0090661 box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.2 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.1 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.1 GO:0002177 manchette(GO:0002177)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)
0.0 0.2 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.3 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.4 GO:0034451 centriolar satellite(GO:0034451)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0004797 thymidine kinase activity(GO:0004797)
0.2 2.1 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 0.6 GO:0019770 IgG receptor activity(GO:0019770)
0.1 1.7 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.1 0.2 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 0.2 GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0 0.5 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.7 GO:0015266 protein channel activity(GO:0015266)
0.0 0.4 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 0.3 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 1.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 1.8 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.5 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.1 GO:0031779 melanocortin receptor binding(GO:0031779) corticotropin hormone receptor binding(GO:0031780) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782) type 5 melanocortin receptor binding(GO:0031783) type 1 melanocortin receptor binding(GO:0070996)
0.0 0.5 GO:0000150 recombinase activity(GO:0000150)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.7 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.1 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.1 GO:0002113 interleukin-33 binding(GO:0002113)
0.0 0.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.1 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.1 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.2 GO:0016778 diphosphotransferase activity(GO:0016778)
0.0 0.2 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.1 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.0 0.2 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0 0.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.0 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.8 PID EPHRINB REV PATHWAY Ephrin B reverse signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 1.8 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 1.2 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 1.7 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.5 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.2 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle