ISMARA results: OTP_PHOX2B_LHX1_LMX1A_LHX5

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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 1.64

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Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Gene Symbol	Gene ID	Gene Info
OTP Ensembl NCBI GeneCards UniProt	ENSG00000171540.6	orthopedia homeobox
PHOX2B Ensembl NCBI GeneCards UniProt	ENSG00000109132.5	paired like homeobox 2B
LHX1 Ensembl NCBI GeneCards UniProt	ENSG00000132130.7	LIM homeobox 1
LMX1A Ensembl NCBI GeneCards UniProt	ENSG00000162761.10	LIM homeobox transcription factor 1 alpha
LHX5 Ensembl NCBI GeneCards UniProt	ENSG00000089116.3	LIM homeobox 5
HOXC4 Ensembl NCBI GeneCards UniProt	ENSG00000198353.6	homeobox C4
HOXC4 Ensembl NCBI GeneCards UniProt	ENSG00000273266.1	homeobox C4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXC4	hg19_v2_chr12_+_54410664_54410715	0.85	1.5e-01	Click!
LHX1	hg19_v2_chr17_+_35294075_35294102	-0.72	2.8e-01	Click!
OTP	hg19_v2_chr5_-_76935513_76935513	0.33	6.7e-01	Click!

Activity profile of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Sorted Z-values of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr15_+_101417919 Show fit	2.11	ENST00000561338.1	ALDH1A3 Ensembl NCBI GeneCards UniProt Show fit	aldehyde dehydrogenase 1 family, member A3
chr5_-_126409159 Show fit	1.86	ENST00000607731.1 ENST00000535381.1 ENST00000296662.5 ENST00000509733.3	C5orf63 Ensembl NCBI GeneCards UniProt Show fit	chromosome 5 open reading frame 63
chr14_+_20187174 Show fit	1.82	ENST00000557414.1	OR4N2 Ensembl NCBI GeneCards UniProt Show fit	olfactory receptor, family 4, subfamily N, member 2
chr11_+_71934962 Show fit	1.68	ENST00000543234.1	INPPL1 Ensembl NCBI GeneCards UniProt Show fit	inositol polyphosphate phosphatase-like 1
chr7_+_5465382 Show fit	1.24	ENST00000609130.1	RP11-1275H24.2 Ensembl NCBI GeneCards UniProt Show fit	RP11-1275H24.2
chr11_+_327171 Show fit	0.79	ENST00000534483.1 ENST00000524824.1 ENST00000531076.1	RP11-326C3.12 Ensembl NCBI GeneCards UniProt Show fit	RP11-326C3.12
chr1_+_225600404 Show fit	0.78	ENST00000366845.2	AC092811.1 Ensembl NCBI GeneCards UniProt Show fit	AC092811.1
chr14_+_31046959 Show fit	0.77	ENST00000547532.1 ENST00000555429.1	G2E3 Ensembl NCBI GeneCards UniProt Show fit	G2/M-phase specific E3 ubiquitin protein ligase
chr12_-_64062583 Show fit	0.74	ENST00000542209.1	DPY19L2 Ensembl NCBI GeneCards UniProt Show fit	dpy-19-like 2 (C. elegans)
chr4_+_183370146 Show fit	0.65	ENST00000510504.1	TENM3 Ensembl NCBI GeneCards UniProt Show fit	teneurin transmembrane protein 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	2.1	GO:0060166	olfactory pit development(GO:0060166)
0.0	1.8	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0	1.7	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.2	1.2	GO:0046092	deoxycytidine metabolic process(GO:0046092)
0.1	0.7	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.1	0.7	GO:0018406	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1	0.7	GO:0045040	protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.7	GO:0097264	self proteolysis(GO:0097264)
0.0	0.7	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.2	0.6	GO:0002416	IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)

Showing 1 to 10 of 45 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.1	0.7	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.5	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.4	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.4	GO:0034451	centriolar satellite(GO:0034451)
0.1	0.3	GO:0042585	germinal vesicle(GO:0042585)
0.0	0.3	GO:0071004	U2-type prespliceosome(GO:0071004)
0.0	0.2	GO:1990357	terminal web(GO:1990357)
0.0	0.2	GO:0090661	box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.0	0.2	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)

Showing 1 to 10 of 16 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.1	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	1.8	GO:0004984	olfactory receptor activity(GO:0004984)
0.1	1.7	GO:0034485	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.2	1.2	GO:0004797	thymidine kinase activity(GO:0004797)
0.0	1.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.7	GO:0015266	protein channel activity(GO:0015266)
0.0	0.7	GO:0000030	mannosyltransferase activity(GO:0000030)
0.1	0.6	GO:0019770	IgG receptor activity(GO:0019770)
0.0	0.5	GO:0033038	bitter taste receptor activity(GO:0033038)
0.0	0.5	GO:0008417	fucosyltransferase activity(GO:0008417)

Showing 1 to 10 of 33 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.7	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	0.8	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling

Showing 1 to 2 of 2 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
1.8	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
1.7	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
1.2	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.7	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.5	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.4	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.3	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.3	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle

Showing 1 to 9 of 9 entries

Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 1.64

Motif logo

Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Activity-expression correlation:

Activity profile of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Sorted Z-values of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: