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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for NR5A2
Z-value: 1.89
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Transcription factors associated with NR5A2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR5A2 | hg19_v2_chr1_+_200011711_200011752 | -0.57 | 4.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_27782788 Show fit | 2.69 |
ENST00000359465.4
|
histone cluster 1, H2bm |
|
| chr6_-_26235206 Show fit | 2.03 |
ENST00000244534.5
|
histone cluster 1, H1d |
|
| chr6_-_27782548 Show fit | 1.90 |
ENST00000333151.3
|
histone cluster 1, H2aj |
|
| chr6_-_27860956 Show fit | 1.73 |
ENST00000359611.2
|
histone cluster 1, H2am |
|
| chrX_+_109602039 Show fit | 1.40 |
ENST00000520821.1
|
retrotransposon gag domain containing 1 |
|
| chr6_-_26250835 Show fit | 1.13 |
ENST00000446824.2
|
histone cluster 1, H3f |
|
| chr6_+_27861190 Show fit | 1.10 |
ENST00000303806.4
|
histone cluster 1, H2bo |
|
| chr11_-_790060 Show fit | 0.93 |
ENST00000330106.4
|
cell cycle exit and neuronal differentiation 1 |
|
| chr1_+_149858461 Show fit | 0.92 |
ENST00000331380.2
|
histone cluster 2, H2ac |
|
| chr11_-_63993601 Show fit | 0.89 |
ENST00000545812.1
ENST00000394547.3 ENST00000317459.6 |
tRNA phosphotransferase 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR5A2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.6 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.0 | 2.2 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.2 | 2.0 | GO:0098532 | histone H3-K27 trimethylation(GO:0098532) |
| 0.1 | 1.5 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 0.0 | 1.5 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.1 | 1.3 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 0.4 | 1.2 | GO:0071423 | thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356) |
| 0.1 | 1.1 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 0.1 | 1.0 | GO:0006032 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
| 0.0 | 1.0 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.7 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 2.0 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 1.4 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 1.0 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.0 | 1.0 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 0.8 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.0 | 0.8 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.1 | 0.7 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.1 | 0.7 | GO:0097504 | Gemini of coiled bodies(GO:0097504) |
| 0.0 | 0.7 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.7 | GO:0033867 | Fas-activated serine/threonine kinase activity(GO:0033867) |
| 0.3 | 1.6 | GO:0008665 | 2'-phosphotransferase activity(GO:0008665) |
| 0.0 | 1.5 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.0 | 1.3 | GO:0008171 | O-methyltransferase activity(GO:0008171) |
| 0.0 | 1.3 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.4 | 1.2 | GO:0015117 | thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) |
| 0.0 | 1.1 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.1 | 1.0 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.0 | 1.0 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 1.0 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 0.8 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.7 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 0.7 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 0.6 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 0.6 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.5 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.5 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 0.4 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 0.4 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.5 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 2.9 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 1.7 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 1.5 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 1.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.2 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 1.0 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 1.0 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 1.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.8 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |