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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for NR4A3
Z-value: 0.99
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Transcription factors associated with NR4A3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR4A3 | hg19_v2_chr9_+_102584128_102584144 | -0.64 | 3.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_145752390 Show fit | 0.92 |
ENST00000529415.2
ENST00000533758.1 |
leucine rich repeat containing 24 |
|
| chr14_-_23791484 Show fit | 0.87 |
ENST00000594872.1
|
Uncharacterized protein |
|
| chr16_+_691792 Show fit | 0.81 |
ENST00000307650.4
|
family with sequence similarity 195, member A |
|
| chr19_+_6372444 Show fit | 0.60 |
ENST00000245812.3
|
alkB, alkylation repair homolog 7 (E. coli) |
|
| chr6_-_43197189 Show fit | 0.52 |
ENST00000509253.1
ENST00000393987.2 ENST00000230431.6 |
2'-deoxynucleoside 5'-phosphate N-hydrolase 1 |
|
| chr11_+_66624527 Show fit | 0.52 |
ENST00000393952.3
|
leucine rich repeat and fibronectin type III domain containing 4 |
|
| chr8_-_131028782 Show fit | 0.51 |
ENST00000519020.1
|
family with sequence similarity 49, member B |
|
| chr11_-_45939565 Show fit | 0.51 |
ENST00000525192.1
ENST00000378750.5 |
peroxisomal biogenesis factor 16 |
|
| chr15_-_75199213 Show fit | 0.51 |
ENST00000562698.1
|
family with sequence similarity 219, member B |
|
| chr11_-_45939374 Show fit | 0.50 |
ENST00000533151.1
ENST00000241041.3 |
peroxisomal biogenesis factor 16 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR4A3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.3 | 1.0 | GO:0032581 | ER-dependent peroxisome organization(GO:0032581) |
| 0.0 | 0.9 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 0.1 | 0.8 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.0 | 0.7 | GO:0030262 | apoptotic nuclear changes(GO:0030262) |
| 0.2 | 0.6 | GO:0015729 | thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356) |
| 0.0 | 0.6 | GO:0009125 | nucleoside monophosphate catabolic process(GO:0009125) |
| 0.1 | 0.5 | GO:1902445 | regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445) |
| 0.0 | 0.4 | GO:0002084 | protein depalmitoylation(GO:0002084) |
| 0.0 | 0.4 | GO:0036155 | acylglycerol acyl-chain remodeling(GO:0036155) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 0.6 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 0.5 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 0.3 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
| 0.0 | 0.3 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.0 | 0.3 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.1 | 0.2 | GO:0035525 | NF-kappaB p50/p65 complex(GO:0035525) |
| 0.0 | 0.2 | GO:0002133 | polycystin complex(GO:0002133) |
| 0.0 | 0.2 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.0 | 0.2 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | GO:0031005 | filamin binding(GO:0031005) |
| 0.3 | 0.8 | GO:0033867 | Fas-activated serine/threonine kinase activity(GO:0033867) |
| 0.0 | 0.7 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.2 | 0.6 | GO:0015117 | thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) |
| 0.1 | 0.4 | GO:0047280 | nicotinamide phosphoribosyltransferase activity(GO:0047280) |
| 0.1 | 0.4 | GO:0050252 | retinol O-fatty-acyltransferase activity(GO:0050252) |
| 0.1 | 0.4 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 0.1 | 0.4 | GO:0047045 | testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045) |
| 0.0 | 0.4 | GO:0098599 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.0 | 0.4 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.0 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.8 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.6 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.0 | 0.4 | REACTOME PEPTIDE HORMONE BIOSYNTHESIS | Genes involved in Peptide hormone biosynthesis |
| 0.0 | 0.3 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.0 | 0.3 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 0.2 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.0 | 0.2 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 0.1 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.0 | 0.1 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |