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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for NR3C1
Z-value: 2.37
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Transcription factors associated with NR3C1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR3C1 | hg19_v2_chr5_-_142783365_142783447 | -0.85 | 1.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_-_47352477 Show fit | 2.20 |
ENST00000593412.1
|
Uncharacterized protein |
|
| chr15_+_31658349 Show fit | 1.50 |
ENST00000558844.1
|
Kruppel-like factor 13 |
|
| chr19_-_10445399 Show fit | 1.15 |
ENST00000592945.1
|
intercellular adhesion molecule 3 |
|
| chr17_-_15496722 Show fit | 1.08 |
ENST00000472534.1
|
CMT1A duplicated region transcript 1 |
|
| chr18_-_56985873 Show fit | 1.00 |
ENST00000299721.3
|
complexin 4 |
|
| chr15_+_33010175 Show fit | 0.89 |
ENST00000300177.4
ENST00000560677.1 ENST00000560830.1 |
gremlin 1, DAN family BMP antagonist |
|
| chr20_+_52824367 Show fit | 0.89 |
ENST00000371419.2
|
prefoldin subunit 4 |
|
| chr11_+_71544246 Show fit | 0.81 |
ENST00000328698.1
|
defensin, beta 108B |
|
| chr11_+_114271314 Show fit | 0.79 |
ENST00000541475.1
|
RNA binding motif protein 7 |
|
| chr8_+_71485681 Show fit | 0.76 |
ENST00000391684.1
|
AC120194.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR3C1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | GO:0002223 | stimulatory C-type lectin receptor signaling pathway(GO:0002223) |
| 0.0 | 1.8 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.1 | 1.5 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) |
| 0.0 | 1.4 | GO:0071044 | histone mRNA catabolic process(GO:0071044) |
| 0.0 | 1.2 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.1 | 1.0 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.0 | 1.0 | GO:0071801 | regulation of podosome assembly(GO:0071801) |
| 0.2 | 0.9 | GO:1900155 | regulation of bone trabecula formation(GO:1900154) negative regulation of bone trabecula formation(GO:1900155) |
| 0.1 | 0.9 | GO:1901906 | diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911) |
| 0.1 | 0.9 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.2 | 1.1 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) |
| 0.0 | 1.1 | GO:0008287 | protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293) |
| 0.1 | 1.0 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.0 | 1.0 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 1.0 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 1.0 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 0.9 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 0.1 | 0.9 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.0 | 0.9 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 2.2 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.0 | 2.0 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 1.1 | GO:0016015 | morphogen activity(GO:0016015) |
| 0.0 | 1.0 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.0 | 1.0 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.1 | 0.9 | GO:0008486 | endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848) |
| 0.0 | 0.8 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.0 | 0.8 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.2 | 0.7 | GO:0004817 | cysteine-tRNA ligase activity(GO:0004817) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.2 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.0 | 1.1 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 1.0 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 1.0 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 0.9 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 0.8 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 0.8 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.0 | 0.8 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 0.6 | PID IL5 PATHWAY | IL5-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.0 | 1.8 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 1.7 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 1.1 | REACTOME INTEGRATION OF PROVIRUS | Genes involved in Integration of provirus |
| 0.0 | 1.1 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 1.1 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 1.0 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.1 | 1.0 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 1.0 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS | Genes involved in Synthesis of bile acids and bile salts |
| 0.0 | 0.9 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |