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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for NR1H2
Z-value: 1.66
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Transcription factors associated with NR1H2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR1H2 | hg19_v2_chr19_+_50832895_50832928 | 0.98 | 1.9e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_34679725 Show fit | 2.24 |
ENST00000432589.1
|
erythrocyte membrane protein band 4.1-like 1 |
|
| chr16_-_11723066 Show fit | 1.37 |
ENST00000576036.1
|
lipopolysaccharide-induced TNF factor |
|
| chr17_-_17726907 Show fit | 1.28 |
ENST00000423161.3
|
sterol regulatory element binding transcription factor 1 |
|
| chr19_-_17622684 Show fit | 1.06 |
ENST00000596643.1
|
CTD-3131K8.2 |
|
| chr14_-_102976135 Show fit | 1.00 |
ENST00000560748.1
|
ankyrin repeat domain 9 |
|
| chr11_+_65190245 Show fit | 0.90 |
ENST00000499732.1
ENST00000501122.2 ENST00000601801.1 |
nuclear paraspeckle assembly transcript 1 (non-protein coding) |
|
| chr16_+_577697 Show fit | 0.80 |
ENST00000562370.1
ENST00000568988.1 ENST00000219611.2 |
calpain 15 |
|
| chr11_+_119038897 Show fit | 0.79 |
ENST00000454811.1
ENST00000449394.1 |
NLR family member X1 |
|
| chr11_+_844406 Show fit | 0.76 |
ENST00000397404.1
|
tetraspanin 4 |
|
| chr19_+_34287174 Show fit | 0.74 |
ENST00000587559.1
ENST00000588637.1 |
potassium channel tetramerization domain containing 15 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR1H2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.1 | 1.8 | GO:0039536 | negative regulation of RIG-I signaling pathway(GO:0039536) |
| 0.1 | 1.6 | GO:0045542 | positive regulation of cholesterol biosynthetic process(GO:0045542) |
| 0.1 | 1.2 | GO:0002084 | protein depalmitoylation(GO:0002084) |
| 0.1 | 1.2 | GO:1900746 | regulation of vascular endothelial growth factor signaling pathway(GO:1900746) |
| 0.1 | 0.7 | GO:0070245 | positive regulation of thymocyte apoptotic process(GO:0070245) |
| 0.0 | 0.7 | GO:0040016 | embryonic cleavage(GO:0040016) |
| 0.1 | 0.6 | GO:0036100 | leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569) |
| 0.1 | 0.6 | GO:0035897 | proteolysis in other organism(GO:0035897) |
| 0.0 | 0.6 | GO:0016180 | snRNA processing(GO:0016180) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.1 | 1.4 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.0 | 0.6 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.0 | 0.6 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 0.6 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 0.5 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 0.0 | 0.4 | GO:0000243 | commitment complex(GO:0000243) |
| 0.1 | 0.3 | GO:0000333 | telomerase catalytic core complex(GO:0000333) |
| 0.0 | 0.3 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.0 | 0.3 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 1.4 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 1.3 | GO:0032810 | sterol response element binding(GO:0032810) |
| 0.1 | 1.2 | GO:0098599 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.0 | 0.8 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 0.7 | GO:0005280 | hydrogen:amino acid symporter activity(GO:0005280) |
| 0.0 | 0.7 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.1 | 0.6 | GO:0050051 | leukotriene-B4 20-monooxygenase activity(GO:0050051) |
| 0.0 | 0.6 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.0 | 0.6 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 1.3 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 1.0 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 0.5 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 0.3 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.0 | 1.7 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 1.3 | REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION | Genes involved in RORA Activates Circadian Expression |
| 0.0 | 0.6 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.0 | 0.5 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.0 | 0.4 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 0.4 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.3 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 0.1 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |