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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for NKX3-1

Z-value: 0.99

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Transcription factors associated with NKX3-1

Gene Symbol Gene ID Gene Info
NKX3-1
ENSG00000167034.9 NK3 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX3-1hg19_v2_chr8_-_23540402_235404660.991.1e-02Click!

Activity profile of NKX3-1 motif

Sorted Z-values of NKX3-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_149785236 2.47 ENST00000331491.1
HIST2H3D
histone cluster 2, H3d
chr11_-_9482010 0.97 ENST00000596206.1
AC132192.1
LOC644656 protein; Uncharacterized protein
chr16_+_3068393 0.86 ENST00000573001.1
TNFRSF12A
tumor necrosis factor receptor superfamily, member 12A
chr5_+_176873446 0.71 ENST00000507881.1
PRR7
proline rich 7 (synaptic)
chr19_-_45457264 0.70 ENST00000591646.1
CTB-129P6.11
Uncharacterized protein
chr6_-_154751629 0.49 ENST00000424998.1
CNKSR3
CNKSR family member 3
chr19_+_50433476 0.49 ENST00000596658.1
ATF5
activating transcription factor 5
chr11_-_64684672 0.48 ENST00000377264.3
ENST00000421419.2
ATG2A
autophagy related 2A
chr11_-_62323702 0.44 ENST00000530285.1
AHNAK
AHNAK nucleoprotein
chr16_+_1832902 0.43 ENST00000262302.9
ENST00000563136.1
ENST00000565987.1
ENST00000543305.1
ENST00000568287.1
ENST00000565134.1
NUBP2
nucleotide binding protein 2
chr11_+_114168085 0.37 ENST00000541754.1
NNMT
nicotinamide N-methyltransferase
chr6_-_26216872 0.36 ENST00000244601.3
HIST1H2BG
histone cluster 1, H2bg
chr11_+_65266507 0.36 ENST00000544868.1
MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr12_+_110011571 0.36 ENST00000539696.1
ENST00000228510.3
ENST00000392727.3
MVK
mevalonate kinase
chr16_-_31076332 0.32 ENST00000539836.3
ENST00000535577.1
ENST00000442862.2
ZNF668
zinc finger protein 668
chr21_-_46964306 0.32 ENST00000443742.1
ENST00000528477.1
ENST00000567670.1
SLC19A1
solute carrier family 19 (folate transporter), member 1
chr17_+_42422629 0.32 ENST00000589536.1
ENST00000587109.1
ENST00000587518.1
GRN
granulin
chr16_-_31076273 0.30 ENST00000426488.2
ZNF668
zinc finger protein 668
chr6_+_26020672 0.30 ENST00000357647.3
HIST1H3A
histone cluster 1, H3a
chr19_+_56111680 0.29 ENST00000301073.3
ZNF524
zinc finger protein 524
chr19_-_55791431 0.29 ENST00000593263.1
ENST00000376343.3
HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr10_-_103347883 0.29 ENST00000339310.3
ENST00000370158.3
ENST00000299206.4
ENST00000456836.2
ENST00000413344.1
ENST00000429502.1
ENST00000430045.1
ENST00000370172.1
ENST00000436284.2
ENST00000370162.3
POLL
polymerase (DNA directed), lambda
chr12_+_70219052 0.28 ENST00000552032.2
ENST00000547771.2
MYRFL
myelin regulatory factor-like
chr15_-_93353028 0.28 ENST00000557398.2
FAM174B
family with sequence similarity 174, member B
chr17_+_67498396 0.28 ENST00000588110.1
MAP2K6
mitogen-activated protein kinase kinase 6
chr15_-_74726283 0.27 ENST00000543145.2
SEMA7A
semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
chrX_+_153237740 0.27 ENST00000369982.4
TMEM187
transmembrane protein 187
chr1_-_156399184 0.27 ENST00000368243.1
ENST00000357975.4
ENST00000310027.5
ENST00000400991.2
C1orf61
chromosome 1 open reading frame 61
chr11_+_67798090 0.27 ENST00000313468.5
NDUFS8
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr19_+_17830051 0.27 ENST00000594625.1
ENST00000324096.4
ENST00000600186.1
ENST00000597735.1
MAP1S
microtubule-associated protein 1S
chr14_-_65409502 0.26 ENST00000389614.5
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr20_-_2821271 0.26 ENST00000448755.1
ENST00000360652.2
PCED1A
PC-esterase domain containing 1A
chr16_+_28985542 0.26 ENST00000567771.1
ENST00000568388.1
SPNS1
spinster homolog 1 (Drosophila)
chr17_+_42422662 0.26 ENST00000593167.1
ENST00000585512.1
ENST00000591740.1
ENST00000592783.1
ENST00000587387.1
ENST00000588237.1
ENST00000589265.1
GRN
granulin
chr19_-_55791540 0.25 ENST00000433386.2
HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr3_-_49726104 0.25 ENST00000383728.3
ENST00000545762.1
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr16_+_32264040 0.25 ENST00000398664.3
TP53TG3D
TP53 target 3D
chr7_+_141463897 0.25 ENST00000247879.2
TAS2R3
taste receptor, type 2, member 3
chr1_+_218683438 0.24 ENST00000443836.1
C1orf143
chromosome 1 open reading frame 143
chr11_+_67798114 0.24 ENST00000453471.2
ENST00000528492.1
ENST00000526339.1
ENST00000525419.1
NDUFS8
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr4_-_90756769 0.24 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr16_+_73420942 0.24 ENST00000554640.1
ENST00000562661.1
ENST00000561875.1
RP11-140I24.1
RP11-140I24.1
chr5_+_150404904 0.24 ENST00000521632.1
GPX3
glutathione peroxidase 3 (plasma)
chr4_-_1685718 0.23 ENST00000472884.2
ENST00000489363.1
ENST00000308132.6
ENST00000463238.1
FAM53A
family with sequence similarity 53, member A
chr14_+_97925151 0.23 ENST00000554862.1
ENST00000554260.1
ENST00000499910.2
CTD-2506J14.1
CTD-2506J14.1
chr8_+_27169138 0.23 ENST00000522338.1
PTK2B
protein tyrosine kinase 2 beta
chr19_-_56110859 0.23 ENST00000221665.3
ENST00000592585.1
FIZ1
FLT3-interacting zinc finger 1
chr15_-_31521567 0.23 ENST00000560812.1
ENST00000559853.1
ENST00000558109.1
RP11-16E12.2
RP11-16E12.2
chr11_-_118901559 0.22 ENST00000330775.7
ENST00000545985.1
ENST00000357590.5
ENST00000538950.1
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr17_-_39661849 0.22 ENST00000246635.3
ENST00000336861.3
ENST00000587544.1
ENST00000587435.1
KRT13
keratin 13
chr20_-_2821756 0.22 ENST00000356872.3
ENST00000439542.1
PCED1A
PC-esterase domain containing 1A
chr16_-_3074231 0.21 ENST00000572355.1
ENST00000248089.3
ENST00000574980.1
ENST00000354679.3
ENST00000396916.1
ENST00000573842.1
HCFC1R1
host cell factor C1 regulator 1 (XPO1 dependent)
chr3_-_10334617 0.21 ENST00000429122.1
ENST00000425479.1
ENST00000335542.8
GHRL
ghrelin/obestatin prepropeptide
chr16_-_69373396 0.21 ENST00000562595.1
ENST00000562081.1
ENST00000306875.4
COG8
component of oligomeric golgi complex 8
chr10_+_46994087 0.21 ENST00000374317.1
GPRIN2
G protein regulated inducer of neurite outgrowth 2
chr11_+_64073022 0.21 ENST00000406310.1
ENST00000000442.6
ENST00000539594.1
ESRRA
estrogen-related receptor alpha
chr9_+_134065506 0.21 ENST00000483497.2
NUP214
nucleoporin 214kDa
chr6_-_26124138 0.21 ENST00000314332.5
ENST00000396984.1
HIST1H2BC
histone cluster 1, H2bc
chr19_-_2944907 0.21 ENST00000314531.4
ZNF77
zinc finger protein 77
chr19_-_1592652 0.21 ENST00000156825.1
ENST00000434436.3
MBD3
methyl-CpG binding domain protein 3
chr3_+_98482175 0.21 ENST00000485391.1
ENST00000492254.1
ST3GAL6
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr3_-_48632593 0.20 ENST00000454817.1
ENST00000328333.8
COL7A1
collagen, type VII, alpha 1
chr11_+_94277017 0.20 ENST00000358752.2
FUT4
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr10_+_18629628 0.19 ENST00000377329.4
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr17_-_7307358 0.19 ENST00000576017.1
ENST00000302422.3
ENST00000535512.1
TMEM256
TMEM256-PLSCR3
transmembrane protein 256
TMEM256-PLSCR3 readthrough (NMD candidate)
chr2_+_173686303 0.19 ENST00000397087.3
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr11_+_67798363 0.19 ENST00000525628.1
NDUFS8
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chrX_-_153236819 0.19 ENST00000354233.3
HCFC1
host cell factor C1 (VP16-accessory protein)
chr5_-_43412418 0.19 ENST00000537013.1
ENST00000361115.4
CCL28
chemokine (C-C motif) ligand 28
chr16_+_83986827 0.18 ENST00000393306.1
ENST00000565123.1
OSGIN1
oxidative stress induced growth inhibitor 1
chr2_-_27545921 0.18 ENST00000402310.1
ENST00000405983.1
ENST00000403262.2
ENST00000428910.1
ENST00000402722.1
ENST00000399052.4
ENST00000380044.1
ENST00000405076.1
MPV17
MpV17 mitochondrial inner membrane protein
chr19_+_52704346 0.18 ENST00000462990.1
PPP2R1A
protein phosphatase 2, regulatory subunit A, alpha
chr14_-_54420133 0.18 ENST00000559501.1
ENST00000558984.1
BMP4
bone morphogenetic protein 4
chr5_-_1799965 0.18 ENST00000508987.1
MRPL36
mitochondrial ribosomal protein L36
chr14_-_74551172 0.18 ENST00000553458.1
ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr19_-_42894420 0.18 ENST00000597255.1
ENST00000222032.5
CNFN
cornifelin
chr3_-_178976996 0.18 ENST00000485523.1
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr19_+_10362882 0.18 ENST00000393733.2
ENST00000588502.1
MRPL4
mitochondrial ribosomal protein L4
chr17_+_42422637 0.17 ENST00000053867.3
ENST00000588143.1
GRN
granulin
chr4_-_105416039 0.17 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr6_-_83775489 0.17 ENST00000369747.3
UBE3D
ubiquitin protein ligase E3D
chr17_+_67498295 0.17 ENST00000589295.1
MAP2K6
mitogen-activated protein kinase kinase 6
chr10_+_135204338 0.17 ENST00000468317.2
RP11-108K14.8
Mitochondrial GTPase 1
chr3_+_113251143 0.17 ENST00000264852.4
ENST00000393830.3
SIDT1
SID1 transmembrane family, member 1
chr19_+_16308711 0.17 ENST00000429941.2
ENST00000444449.2
ENST00000589822.1
AP1M1
adaptor-related protein complex 1, mu 1 subunit
chr17_+_7358889 0.17 ENST00000575379.1
CHRNB1
cholinergic receptor, nicotinic, beta 1 (muscle)
chr11_+_65337901 0.16 ENST00000309328.3
ENST00000531405.1
ENST00000527920.1
ENST00000526877.1
ENST00000533115.1
ENST00000526433.1
SSSCA1
Sjogren syndrome/scleroderma autoantigen 1
chr11_-_117688216 0.16 ENST00000525836.1
DSCAML1
Down syndrome cell adhesion molecule like 1
chr11_+_64685026 0.16 ENST00000526559.1
PPP2R5B
protein phosphatase 2, regulatory subunit B', beta
chr10_-_28571015 0.16 ENST00000375719.3
ENST00000375732.1
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr12_-_57039739 0.16 ENST00000552959.1
ENST00000551020.1
ENST00000553007.2
ENST00000552919.1
ENST00000552104.1
ENST00000262030.3
ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr4_+_159131596 0.15 ENST00000512481.1
TMEM144
transmembrane protein 144
chr14_-_68066975 0.15 ENST00000559581.1
ENST00000560722.1
ENST00000559415.1
ENST00000216452.4
PIGH
phosphatidylinositol glycan anchor biosynthesis, class H
chr22_+_44427230 0.15 ENST00000444029.1
PARVB
parvin, beta
chr2_+_238877424 0.15 ENST00000434655.1
UBE2F
ubiquitin-conjugating enzyme E2F (putative)
chr9_+_134065519 0.15 ENST00000531600.1
NUP214
nucleoporin 214kDa
chr1_+_151372010 0.15 ENST00000290541.6
PSMB4
proteasome (prosome, macropain) subunit, beta type, 4
chr6_+_43603552 0.15 ENST00000372171.4
MAD2L1BP
MAD2L1 binding protein
chr5_-_176889381 0.15 ENST00000393563.4
ENST00000512501.1
DBN1
drebrin 1
chr7_+_142374104 0.14 ENST00000604952.1
MTRNR2L6
MT-RNR2-like 6
chr17_-_7145475 0.14 ENST00000571129.1
ENST00000571253.1
ENST00000573928.1
GABARAP
GABA(A) receptor-associated protein
chr12_-_118628315 0.14 ENST00000540561.1
TAOK3
TAO kinase 3
chr11_-_104480019 0.14 ENST00000536529.1
ENST00000545630.1
ENST00000538641.1
RP11-886D15.1
RP11-886D15.1
chr5_+_112312416 0.14 ENST00000389063.2
DCP2
decapping mRNA 2
chr14_-_65409438 0.14 ENST00000557049.1
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr6_+_37321823 0.14 ENST00000487950.1
ENST00000469731.1
RNF8
ring finger protein 8, E3 ubiquitin protein ligase
chr16_+_56969284 0.14 ENST00000568358.1
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr3_-_15106747 0.14 ENST00000449354.2
ENST00000444840.2
ENST00000253686.2
MRPS25
mitochondrial ribosomal protein S25
chrX_-_153237258 0.14 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr6_-_31648150 0.13 ENST00000375858.3
ENST00000383237.4
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr1_+_27114589 0.13 ENST00000431541.1
ENST00000449950.2
ENST00000374145.1
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr1_+_186798073 0.13 ENST00000367466.3
ENST00000442353.2
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr3_+_52489503 0.13 ENST00000345716.4
NISCH
nischarin
chr17_-_39661947 0.13 ENST00000590425.1
KRT13
keratin 13
chr8_+_30300119 0.13 ENST00000520191.1
RBPMS
RNA binding protein with multiple splicing
chr10_-_61900762 0.13 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr19_-_15544099 0.13 ENST00000599910.2
WIZ
widely interspaced zinc finger motifs
chr1_-_173793458 0.13 ENST00000356198.2
CENPL
centromere protein L
chr1_-_110155671 0.13 ENST00000351050.3
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr7_+_16700806 0.12 ENST00000446596.1
ENST00000438834.1
BZW2
basic leucine zipper and W2 domains 2
chr7_-_7680601 0.12 ENST00000396682.2
RPA3
replication protein A3, 14kDa
chr3_+_39509070 0.12 ENST00000354668.4
ENST00000428261.1
ENST00000420739.1
ENST00000415443.1
ENST00000447324.1
ENST00000383754.3
MOBP
myelin-associated oligodendrocyte basic protein
chr19_+_13080296 0.12 ENST00000317060.2
DAND5
DAN domain family member 5, BMP antagonist
chr19_+_17186577 0.12 ENST00000595618.1
ENST00000594824.1
MYO9B
myosin IXB
chr6_-_116833500 0.12 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr1_-_153931052 0.12 ENST00000368630.3
ENST00000368633.1
CRTC2
CREB regulated transcription coactivator 2
chr3_+_39509163 0.12 ENST00000436143.2
ENST00000441980.2
ENST00000311042.6
MOBP
myelin-associated oligodendrocyte basic protein
chr14_+_95078714 0.12 ENST00000393078.3
ENST00000393080.4
ENST00000467132.1
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr19_-_44174330 0.12 ENST00000340093.3
PLAUR
plasminogen activator, urokinase receptor
chr1_+_161475208 0.11 ENST00000367972.4
ENST00000271450.6
FCGR2A
Fc fragment of IgG, low affinity IIa, receptor (CD32)
chr13_+_24144509 0.11 ENST00000248484.4
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr7_-_77325545 0.11 ENST00000447009.1
ENST00000416650.1
ENST00000440088.1
ENST00000430801.1
ENST00000398043.2
RSBN1L-AS1
RSBN1L antisense RNA 1
chr6_+_108616054 0.11 ENST00000368977.4
LACE1
lactation elevated 1
chr8_+_128426535 0.11 ENST00000465342.2
POU5F1B
POU class 5 homeobox 1B
chr6_-_144385698 0.11 ENST00000444202.1
ENST00000437412.1
PLAGL1
pleiomorphic adenoma gene-like 1
chr19_+_17970677 0.11 ENST00000222247.5
RPL18A
ribosomal protein L18a
chr10_-_120938303 0.10 ENST00000356951.3
ENST00000298510.2
PRDX3
peroxiredoxin 3
chr12_-_125398602 0.10 ENST00000541272.1
ENST00000535131.1
UBC
ubiquitin C
chr12_-_49333446 0.10 ENST00000537495.1
AC073610.5
Uncharacterized protein
chr12_-_53298841 0.10 ENST00000293308.6
KRT8
keratin 8
chr19_+_17970693 0.10 ENST00000600147.1
ENST00000599898.1
RPL18A
ribosomal protein L18a
chr17_-_76870222 0.09 ENST00000585421.1
TIMP2
TIMP metallopeptidase inhibitor 2
chr19_-_11266471 0.09 ENST00000592540.1
SPC24
SPC24, NDC80 kinetochore complex component
chr9_+_116263639 0.09 ENST00000343817.5
RGS3
regulator of G-protein signaling 3
chr19_-_55791563 0.09 ENST00000588971.1
ENST00000255631.5
ENST00000587551.1
HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr20_-_36661826 0.09 ENST00000373448.2
ENST00000373447.3
TTI1
TELO2 interacting protein 1
chr16_+_89628778 0.09 ENST00000472354.1
RPL13
ribosomal protein L13
chr22_+_18632666 0.08 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chr11_+_101983176 0.08 ENST00000524575.1
YAP1
Yes-associated protein 1
chr6_-_144416737 0.08 ENST00000367569.2
SF3B5
splicing factor 3b, subunit 5, 10kDa
chr18_+_61445007 0.08 ENST00000447428.1
ENST00000546027.1
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr20_-_45318051 0.08 ENST00000372102.3
TP53RK
TP53 regulating kinase
chr11_+_57435441 0.08 ENST00000528177.1
ZDHHC5
zinc finger, DHHC-type containing 5
chr3_-_39196049 0.08 ENST00000514182.1
CSRNP1
cysteine-serine-rich nuclear protein 1
chr17_+_41150479 0.08 ENST00000589913.1
RPL27
ribosomal protein L27
chrY_+_15418467 0.08 ENST00000595988.1
AC010877.1
Uncharacterized protein
chr5_+_125758813 0.08 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr20_-_50722183 0.08 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr19_+_16308659 0.08 ENST00000590263.1
ENST00000590756.1
ENST00000541844.1
AP1M1
adaptor-related protein complex 1, mu 1 subunit
chr2_-_36779411 0.08 ENST00000406220.1
AC007401.2
Uncharacterized protein
chr7_-_112430647 0.08 ENST00000312814.6
TMEM168
transmembrane protein 168
chr14_-_47812321 0.08 ENST00000357362.3
ENST00000486952.2
ENST00000426342.1
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr1_-_39339777 0.08 ENST00000397572.2
MYCBP
MYC binding protein
chr7_-_6066183 0.08 ENST00000422786.1
EIF2AK1
eukaryotic translation initiation factor 2-alpha kinase 1
chrX_-_107681633 0.08 ENST00000394872.2
ENST00000334504.7
COL4A6
collagen, type IV, alpha 6
chr4_-_90757364 0.08 ENST00000508895.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr5_+_125758865 0.07 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr6_-_33285505 0.07 ENST00000431845.2
ZBTB22
zinc finger and BTB domain containing 22
chr12_+_96883347 0.07 ENST00000524981.4
ENST00000298953.3
C12orf55
chromosome 12 open reading frame 55
chr19_-_44174305 0.07 ENST00000601723.1
ENST00000339082.3
PLAUR
plasminogen activator, urokinase receptor
chr19_-_5719860 0.07 ENST00000590729.1
LONP1
lon peptidase 1, mitochondrial
chr12_+_6602517 0.07 ENST00000315579.5
ENST00000539714.1
NCAPD2
non-SMC condensin I complex, subunit D2
chr17_-_295730 0.07 ENST00000329099.4
FAM101B
family with sequence similarity 101, member B
chr5_+_96211643 0.07 ENST00000437043.3
ENST00000510373.1
ERAP2
endoplasmic reticulum aminopeptidase 2
chr14_+_23654525 0.07 ENST00000399910.1
ENST00000492621.1
C14orf164
chromosome 14 open reading frame 164
chr19_+_37341260 0.07 ENST00000589046.1
ZNF345
zinc finger protein 345
chr8_+_77593448 0.06 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr19_-_14889349 0.06 ENST00000315576.3
ENST00000392967.2
ENST00000346057.1
ENST00000353876.1
ENST00000353005.1
EMR2
egf-like module containing, mucin-like, hormone receptor-like 2
chr18_+_61445205 0.06 ENST00000431370.1
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr16_-_69760409 0.06 ENST00000561500.1
ENST00000439109.2
ENST00000564043.1
ENST00000379046.2
ENST00000379047.3
NQO1
NAD(P)H dehydrogenase, quinone 1
chr7_-_2883928 0.06 ENST00000275364.3
GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr9_+_74729511 0.06 ENST00000545168.1
GDA
guanine deaminase
chr3_-_156840776 0.06 ENST00000471357.1
LINC00880
long intergenic non-protein coding RNA 880
chr11_+_86106208 0.06 ENST00000528728.1
CCDC81
coiled-coil domain containing 81
chr4_+_15376165 0.05 ENST00000382383.3
ENST00000429690.1
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr1_-_32169920 0.05 ENST00000373672.3
ENST00000373668.3
COL16A1
collagen, type XVI, alpha 1
chr19_-_42931567 0.05 ENST00000244289.4
LIPE
lipase, hormone-sensitive
chr22_-_50523760 0.05 ENST00000395876.2
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr12_-_22063787 0.05 ENST00000544039.1
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr1_+_173793641 0.05 ENST00000361951.4
DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr3_-_18480260 0.05 ENST00000454909.2
SATB1
SATB homeobox 1
chrX_+_9502971 0.05 ENST00000452824.1
TBL1X
transducin (beta)-like 1X-linked
chr11_-_26588634 0.05 ENST00000436318.2
ENST00000281268.8
MUC15
mucin 15, cell surface associated
chr17_-_76870126 0.05 ENST00000586057.1
TIMP2
TIMP metallopeptidase inhibitor 2
chr7_+_100303676 0.05 ENST00000303151.4
POP7
processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
chr6_+_26124373 0.05 ENST00000377791.2
ENST00000602637.1
HIST1H2AC
histone cluster 1, H2ac
chr1_+_173793777 0.05 ENST00000239457.5
DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr5_-_139937895 0.05 ENST00000336283.6
SRA1
steroid receptor RNA activator 1
chr19_+_58144529 0.04 ENST00000347302.3
ENST00000254182.7
ENST00000391703.3
ENST00000541801.1
ENST00000299871.5
ENST00000544273.1
ZNF211
zinc finger protein 211
chr7_+_33168856 0.04 ENST00000432983.1
BBS9
Bardet-Biedl syndrome 9

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX3-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.1 0.5 GO:0072709 cellular response to sorbitol(GO:0072709)
0.1 0.9 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.1 0.3 GO:0019046 release from viral latency(GO:0019046)
0.1 0.3 GO:0098838 reduced folate transmembrane transport(GO:0098838)
0.1 0.3 GO:0051585 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.1 0.2 GO:1904995 negative regulation of leukocyte adhesion to vascular endothelial cell(GO:1904995)
0.0 0.1 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.0 0.3 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.0 0.2 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.0 0.1 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.0 0.3 GO:2000538 regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.0 0.2 GO:0019859 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.1 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.0 0.2 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.0 0.1 GO:1904344 positive regulation of growth rate(GO:0040010) regulation of gastric mucosal blood circulation(GO:1904344) positive regulation of gastric mucosal blood circulation(GO:1904346) gastric mucosal blood circulation(GO:1990768)
0.0 0.2 GO:0048392 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) mesodermal cell fate determination(GO:0007500) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.0 0.2 GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
0.0 0.1 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.0 0.1 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.0 0.3 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.2 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.0 0.1 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.0 0.5 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.0 0.2 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.1 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 0.1 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.0 0.1 GO:0070407 oxidation-dependent protein catabolic process(GO:0070407)
0.0 0.2 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.3 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.4 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.0 0.1 GO:0072660 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.2 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.1 GO:0006147 guanine catabolic process(GO:0006147)
0.0 0.1 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0 0.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.3 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.4 GO:0043587 tongue morphogenesis(GO:0043587)
0.0 0.2 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.3 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.2 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.4 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.2 GO:0071896 protein localization to adherens junction(GO:0071896)
0.0 0.5 GO:0044804 nucleophagy(GO:0044804)
0.0 0.1 GO:0006447 regulation of translational initiation by iron(GO:0006447)
0.0 0.2 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.0 0.2 GO:0042354 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.2 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.1 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.2 GO:0033227 dsRNA transport(GO:0033227)
0.0 0.2 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.0 0.2 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.0 0.2 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0005593 FACIT collagen trimer(GO:0005593)
0.0 0.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.2 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 0.1 GO:0031501 mannosyltransferase complex(GO:0031501)
0.0 0.5 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.1 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:0000799 nuclear condensin complex(GO:0000799)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.1 GO:0000408 EKC/KEOPS complex(GO:0000408)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0008112 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.1 0.3 GO:0008518 reduced folate carrier activity(GO:0008518)
0.1 0.3 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.0 0.1 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.0 0.3 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.3 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.0 0.1 GO:0070984 SET domain binding(GO:0070984)
0.0 0.2 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.0 0.1 GO:0016608 growth hormone-releasing hormone activity(GO:0016608) ghrelin receptor binding(GO:0031768)
0.0 0.2 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.2 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0 0.2 GO:0015119 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0 0.2 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.0 0.1 GO:0070362 mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364)
0.0 0.2 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.2 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.4 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 0.1 GO:0003955 NAD(P)H dehydrogenase (quinone) activity(GO:0003955)
0.0 0.6 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.3 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.2 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.1 GO:0008892 guanine deaminase activity(GO:0008892)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 1.1 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.1 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 0.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.1 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.2 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.0 0.2 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.2 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.1 GO:0016015 morphogen activity(GO:0016015)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0019864 IgG binding(GO:0019864)
0.0 0.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.5 GO:0004708 MAP kinase kinase activity(GO:0004708)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.6 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.4 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.5 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.5 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation