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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for NKX2-3
Z-value: 1.13
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Transcription factors associated with NKX2-3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX2-3 | hg19_v2_chr10_+_101292684_101292706 | -0.98 | 2.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_26027480 Show fit | 0.98 |
ENST00000377364.3
|
histone cluster 1, H4b |
|
| chr6_+_42123141 Show fit | 0.70 |
ENST00000418175.1
ENST00000541991.1 ENST00000053469.4 ENST00000394237.1 ENST00000372963.1 |
guanylate cyclase activator 1A (retina) RP1-139D8.6 |
|
| chr11_+_65266507 Show fit | 0.62 |
ENST00000544868.1
|
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) |
|
| chr17_-_15469590 Show fit | 0.58 |
ENST00000312127.2
|
CMT duplicated region transcript 1; Uncharacterized protein |
|
| chr4_-_111536534 Show fit | 0.58 |
ENST00000503456.1
ENST00000513690.1 |
RP11-380D23.2 |
|
| chr4_-_90758227 Show fit | 0.55 |
ENST00000506691.1
ENST00000394986.1 ENST00000506244.1 ENST00000394989.2 ENST00000394991.3 |
synuclein, alpha (non A4 component of amyloid precursor) |
|
| chrX_+_109602039 Show fit | 0.54 |
ENST00000520821.1
|
retrotransposon gag domain containing 1 |
|
| chr19_-_44174330 Show fit | 0.49 |
ENST00000340093.3
|
plasminogen activator, urokinase receptor |
|
| chr6_-_26216872 Show fit | 0.46 |
ENST00000244601.3
|
histone cluster 1, H2bg |
|
| chr3_-_167191814 Show fit | 0.45 |
ENST00000466903.1
ENST00000264677.4 |
serpin peptidase inhibitor, clade I (pancpin), member 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX2-3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:0051621 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
| 0.0 | 0.7 | GO:0031284 | positive regulation of guanylate cyclase activity(GO:0031284) |
| 0.0 | 0.6 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.1 | 0.5 | GO:0038195 | urokinase plasminogen activator signaling pathway(GO:0038195) |
| 0.1 | 0.4 | GO:2000646 | regulation of Cdc42 protein signal transduction(GO:0032489) positive regulation of receptor catabolic process(GO:2000646) |
| 0.1 | 0.4 | GO:0021523 | somatic motor neuron differentiation(GO:0021523) |
| 0.1 | 0.4 | GO:0002501 | MHC protein complex assembly(GO:0002396) peptide antigen assembly with MHC protein complex(GO:0002501) |
| 0.0 | 0.4 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.0 | 0.4 | GO:1903071 | positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071) |
| 0.1 | 0.3 | GO:0045337 | geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 0.7 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.0 | 0.7 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 0.5 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.1 | 0.4 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.0 | 0.4 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) |
| 0.0 | 0.4 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.0 | 0.4 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.0 | 0.4 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 0.3 | GO:1990037 | Lewy body core(GO:1990037) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.1 | 0.7 | GO:0008048 | calcium sensitive guanylate cyclase activator activity(GO:0008048) |
| 0.1 | 0.5 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
| 0.1 | 0.4 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 0.0 | 0.4 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.0 | 0.4 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.0 | 0.4 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 0.4 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 0.3 | GO:0031752 | D5 dopamine receptor binding(GO:0031752) |
| 0.1 | 0.3 | GO:0004161 | dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.7 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 0.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.4 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 0.3 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.2 | PID IL2 1PATHWAY | IL2-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 0.7 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.6 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.0 | 0.5 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.0 | 0.4 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.4 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.4 | REACTOME PERK REGULATED GENE EXPRESSION | Genes involved in PERK regulated gene expression |
| 0.0 | 0.3 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.0 | 0.3 | REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
| 0.0 | 0.3 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |