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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for NKX2-2
Z-value: 0.91
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Transcription factors associated with NKX2-2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX2-2 | hg19_v2_chr20_-_21494654_21494678 | 0.92 | 7.6e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_+_79165222 Show fit | 0.42 |
ENST00000559930.1
|
mortality factor 4 like 1 |
|
| chr8_+_22414182 Show fit | 0.37 |
ENST00000524057.1
|
sorbin and SH3 domain containing 3 |
|
| chr10_-_112678692 Show fit | 0.34 |
ENST00000605742.1
|
BBSome interacting protein 1 |
|
| chr10_+_32735030 Show fit | 0.32 |
ENST00000277657.6
ENST00000362006.5 |
coiled-coil domain containing 7 |
|
| chr17_+_42015654 Show fit | 0.31 |
ENST00000565120.1
|
Uncharacterized protein |
|
| chr8_+_97597148 Show fit | 0.31 |
ENST00000521590.1
|
syndecan 2 |
|
| chr17_+_15604513 Show fit | 0.28 |
ENST00000481540.1
|
Homo sapiens zinc finger protein 286A (ZNF286A), transcript variant 6, mRNA. |
|
| chr7_-_120497178 Show fit | 0.27 |
ENST00000441017.1
ENST00000424710.1 ENST00000433758.1 |
tetraspanin 12 |
|
| chr3_-_121379739 Show fit | 0.27 |
ENST00000428394.2
ENST00000314583.3 |
hematopoietic cell-specific Lyn substrate 1 |
|
| chr15_+_79165296 Show fit | 0.27 |
ENST00000558746.1
ENST00000558830.1 ENST00000559345.1 |
mortality factor 4 like 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX2-2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.1 | 0.3 | GO:0098884 | postsynaptic neurotransmitter receptor internalization(GO:0098884) |
| 0.0 | 0.3 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 0.0 | 0.3 | GO:0008218 | bioluminescence(GO:0008218) |
| 0.0 | 0.3 | GO:0097500 | receptor localization to nonmotile primary cilium(GO:0097500) |
| 0.0 | 0.3 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.0 | 0.3 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.0 | 0.3 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.0 | 0.3 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.1 | 0.2 | GO:1904404 | cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.1 | 0.3 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) postsynaptic endocytic zone membrane(GO:0098844) |
| 0.0 | 0.3 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.0 | 0.3 | GO:0034464 | BBSome(GO:0034464) |
| 0.0 | 0.3 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 0.2 | GO:0071020 | post-spliceosomal complex(GO:0071020) |
| 0.0 | 0.2 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
| 0.0 | 0.2 | GO:0071008 | U2-type post-mRNA release spliceosomal complex(GO:0071008) |
| 0.0 | 0.2 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.0 | 0.2 | GO:0072487 | MSL complex(GO:0072487) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.0 | 0.4 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 0.3 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) |
| 0.0 | 0.3 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.0 | 0.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 0.2 | GO:0030626 | U12 snRNA binding(GO:0030626) |
| 0.1 | 0.2 | GO:0061663 | NEDD8 ligase activity(GO:0061663) |
| 0.1 | 0.2 | GO:0050146 | nucleoside phosphotransferase activity(GO:0050146) |
| 0.1 | 0.2 | GO:0004556 | alpha-amylase activity(GO:0004556) |
| 0.1 | 0.2 | GO:0004597 | peptide-aspartate beta-dioxygenase activity(GO:0004597) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.3 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 0.2 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 0.2 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 0.2 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 0.2 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |