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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for NKX2-1
Z-value: 0.90
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Transcription factors associated with NKX2-1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX2-1 | hg19_v2_chr14_-_36989427_36989442 | 0.36 | 6.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_50148087 Show fit | 0.79 |
ENST00000601038.1
ENST00000595242.1 |
SR-related CTD-associated factor 1 |
|
| chr15_+_76030311 Show fit | 0.65 |
ENST00000543887.1
|
AC019294.1 |
|
| chr1_+_180165672 Show fit | 0.63 |
ENST00000443059.1
|
quiescin Q6 sulfhydryl oxidase 1 |
|
| chr11_-_62313090 Show fit | 0.56 |
ENST00000528508.1
ENST00000533365.1 |
AHNAK nucleoprotein |
|
| chr16_+_640055 Show fit | 0.53 |
ENST00000568586.1
ENST00000538492.1 ENST00000248139.3 |
RAB40C, member RAS oncogene family |
|
| chr16_-_67190152 Show fit | 0.48 |
ENST00000486556.1
|
TNFRSF1A-associated via death domain |
|
| chr17_+_38375528 Show fit | 0.42 |
ENST00000583268.1
|
WAS/WASL interacting protein family, member 2 |
|
| chr19_-_36231437 Show fit | 0.42 |
ENST00000591748.1
|
IGF-like family receptor 1 |
|
| chr6_-_27841289 Show fit | 0.41 |
ENST00000355981.2
|
histone cluster 1, H4l |
|
| chr5_-_172662303 Show fit | 0.40 |
ENST00000517440.1
ENST00000329198.4 |
NK2 homeobox 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX2-1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.8 | GO:0060927 | Purkinje myocyte differentiation(GO:0003168) cardiac pacemaker cell fate commitment(GO:0060927) atrioventricular node cell fate commitment(GO:0060929) |
| 0.2 | 0.7 | GO:0019046 | release from viral latency(GO:0019046) |
| 0.0 | 0.6 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
| 0.0 | 0.6 | GO:0016242 | negative regulation of macroautophagy(GO:0016242) |
| 0.0 | 0.5 | GO:0019375 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.0 | 0.5 | GO:0071550 | death-inducing signaling complex assembly(GO:0071550) |
| 0.0 | 0.4 | GO:0071569 | protein ufmylation(GO:0071569) |
| 0.0 | 0.4 | GO:0007220 | Notch receptor processing(GO:0007220) |
| 0.0 | 0.3 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 0.0 | 0.3 | GO:0098734 | macromolecule depalmitoylation(GO:0098734) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.0 | 0.5 | GO:0031264 | death-inducing signaling complex(GO:0031264) |
| 0.0 | 0.4 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.0 | 0.4 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.0 | 0.2 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.0 | 0.2 | GO:0031166 | integral component of vacuolar membrane(GO:0031166) |
| 0.0 | 0.2 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 0.0 | 0.2 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.0 | 0.2 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.0 | 0.1 | GO:0072687 | meiotic spindle(GO:0072687) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.8 | GO:0010736 | serum response element binding(GO:0010736) |
| 0.0 | 0.7 | GO:0043995 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
| 0.1 | 0.6 | GO:0016971 | flavin-linked sulfhydryl oxidase activity(GO:0016971) |
| 0.0 | 0.6 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.1 | 0.5 | GO:0050694 | galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694) |
| 0.0 | 0.5 | GO:0070513 | death domain binding(GO:0070513) |
| 0.0 | 0.4 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
| 0.0 | 0.4 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.3 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.0 | 0.3 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 0.4 | REACTOME REGULATED PROTEOLYSIS OF P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 0.0 | 0.2 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |