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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for NKX1-2_RAX

Z-value: 0.41

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Transcription factors associated with NKX1-2_RAX

Gene Symbol Gene ID Gene Info
NKX1-2
ENSG00000229544.6 NK1 homeobox 2
RAX
ENSG00000134438.9 retina and anterior neural fold homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RAXhg19_v2_chr18_-_56940611_569406600.307.0e-01Click!

Activity profile of NKX1-2_RAX motif

Sorted Z-values of NKX1-2_RAX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_159915386 0.17 ENST00000361509.3
ENST00000368094.1
IGSF9
immunoglobulin superfamily, member 9
chr9_-_3469181 0.17 ENST00000366116.2
AL365202.1
Uncharacterized protein
chr17_-_57232525 0.12 ENST00000583380.1
ENST00000580541.1
ENST00000578105.1
ENST00000437036.2
SKA2
spindle and kinetochore associated complex subunit 2
chr5_+_66300464 0.11 ENST00000436277.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr14_-_88200641 0.11 ENST00000556168.1
RP11-1152H15.1
RP11-1152H15.1
chr17_-_45266542 0.11 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
CDC27
cell division cycle 27
chr12_-_12837423 0.10 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chr2_-_74618907 0.10 ENST00000421392.1
ENST00000437375.1
DCTN1
dynactin 1
chr19_+_36239576 0.10 ENST00000587751.1
LIN37
lin-37 homolog (C. elegans)
chr14_+_32798547 0.09 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr6_-_33663474 0.09 ENST00000594414.1
SBP1
SBP1; Uncharacterized protein
chr7_-_99716914 0.08 ENST00000431404.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr5_+_53686658 0.08 ENST00000512618.1
LINC01033
long intergenic non-protein coding RNA 1033
chr3_-_105588231 0.08 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr7_+_70597109 0.08 ENST00000333538.5
WBSCR17
Williams-Beuren syndrome chromosome region 17
chr11_-_13011081 0.07 ENST00000532541.1
ENST00000526388.1
ENST00000534477.1
ENST00000531402.1
ENST00000527945.1
ENST00000504230.2
LINC00958
long intergenic non-protein coding RNA 958
chr11_-_111741994 0.07 ENST00000398006.2
ALG9
ALG9, alpha-1,2-mannosyltransferase
chr1_+_186265399 0.07 ENST00000367486.3
ENST00000367484.3
ENST00000533951.1
ENST00000367482.4
ENST00000367483.4
ENST00000367485.4
ENST00000445192.2
PRG4
proteoglycan 4
chr8_-_101571933 0.07 ENST00000520311.1
ANKRD46
ankyrin repeat domain 46
chrX_+_114827818 0.07 ENST00000420625.2
PLS3
plastin 3
chr13_+_78315295 0.06 ENST00000351546.3
SLAIN1
SLAIN motif family, member 1
chr17_-_57232596 0.06 ENST00000581068.1
ENST00000330137.7
SKA2
spindle and kinetochore associated complex subunit 2
chr4_-_74486109 0.06 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr9_+_135937365 0.06 ENST00000372080.4
ENST00000351304.7
CEL
carboxyl ester lipase
chr3_+_23851928 0.06 ENST00000467766.1
ENST00000424381.1
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr6_+_130339710 0.05 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr1_+_100818156 0.05 ENST00000336454.3
CDC14A
cell division cycle 14A
chr3_-_151034734 0.05 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chr4_+_80584903 0.05 ENST00000506460.1
RP11-452C8.1
RP11-452C8.1
chr3_+_129247479 0.05 ENST00000296271.3
RHO
rhodopsin
chr10_-_92681033 0.05 ENST00000371697.3
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr4_-_141348789 0.05 ENST00000414773.1
CLGN
calmegin
chr19_+_48949087 0.05 ENST00000598711.1
GRWD1
glutamate-rich WD repeat containing 1
chrX_+_43515467 0.05 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr11_+_29181503 0.05 ENST00000530960.1
RP11-466I1.1
RP11-466I1.1
chr3_-_105587879 0.05 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr18_+_63273310 0.05 ENST00000579862.1
RP11-775G23.1
RP11-775G23.1
chr14_+_67831576 0.05 ENST00000555876.1
EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr12_-_74686314 0.05 ENST00000551210.1
ENST00000515416.2
ENST00000549905.1
RP11-81H3.2
RP11-81H3.2
chr12_+_90674665 0.04 ENST00000549313.1
RP11-753N8.1
RP11-753N8.1
chr2_+_112939365 0.04 ENST00000272559.4
FBLN7
fibulin 7
chr12_-_112279694 0.04 ENST00000443596.1
ENST00000442119.1
MAPKAPK5-AS1
MAPKAPK5 antisense RNA 1
chr3_-_180397256 0.04 ENST00000442201.2
CCDC39
coiled-coil domain containing 39
chr9_-_5339873 0.04 ENST00000223862.1
ENST00000223858.4
RLN1
relaxin 1
chrX_+_77166172 0.04 ENST00000343533.5
ENST00000350425.4
ENST00000341514.6
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr2_-_169887827 0.04 ENST00000263817.6
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chrX_-_21676442 0.04 ENST00000379499.2
KLHL34
kelch-like family member 34
chr13_+_78315348 0.04 ENST00000441784.1
SLAIN1
SLAIN motif family, member 1
chr12_+_16500599 0.04 ENST00000535309.1
ENST00000540056.1
ENST00000396209.1
ENST00000540126.1
MGST1
microsomal glutathione S-transferase 1
chr5_-_159546396 0.04 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP2A
PWWP domain containing 2A
chr19_+_37808831 0.04 ENST00000589801.1
HKR1
HKR1, GLI-Kruppel zinc finger family member
chr17_+_57233087 0.04 ENST00000578777.1
ENST00000577457.1
ENST00000582995.1
PRR11
proline rich 11
chr7_+_138145076 0.04 ENST00000343526.4
TRIM24
tripartite motif containing 24
chr1_+_155278625 0.03 ENST00000368356.4
ENST00000356657.6
FDPS
farnesyl diphosphate synthase
chr8_-_30670384 0.03 ENST00000221138.4
ENST00000518243.1
PPP2CB
protein phosphatase 2, catalytic subunit, beta isozyme
chr2_-_198540719 0.03 ENST00000295049.4
RFTN2
raftlin family member 2
chr19_-_36822551 0.03 ENST00000591372.1
LINC00665
long intergenic non-protein coding RNA 665
chr1_+_155278539 0.03 ENST00000447866.1
FDPS
farnesyl diphosphate synthase
chr15_+_64680003 0.03 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr12_+_32832203 0.03 ENST00000553257.1
ENST00000549701.1
ENST00000358214.5
ENST00000266481.6
ENST00000551476.1
ENST00000550154.1
ENST00000547312.1
ENST00000414834.2
ENST00000381000.4
ENST00000548750.1
DNM1L
dynamin 1-like
chr2_+_24714729 0.03 ENST00000406961.1
ENST00000405141.1
NCOA1
nuclear receptor coactivator 1
chr1_+_162336686 0.03 ENST00000420220.1
C1orf226
chromosome 1 open reading frame 226
chr16_-_28608424 0.03 ENST00000335715.4
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr1_+_153747746 0.03 ENST00000368661.3
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chr8_-_102803163 0.03 ENST00000523645.1
ENST00000520346.1
ENST00000220931.6
ENST00000522448.1
ENST00000522951.1
ENST00000522252.1
ENST00000519098.1
NCALD
neurocalcin delta
chr11_+_73498898 0.03 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr1_-_159832438 0.03 ENST00000368100.1
VSIG8
V-set and immunoglobulin domain containing 8
chr11_+_112047087 0.03 ENST00000526088.1
ENST00000532593.1
ENST00000531169.1
BCO2
beta-carotene oxygenase 2
chr1_+_160370344 0.03 ENST00000368061.2
VANGL2
VANGL planar cell polarity protein 2
chr6_-_82957433 0.03 ENST00000306270.7
IBTK
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr8_-_112248400 0.03 ENST00000519506.1
ENST00000522778.1
RP11-946L20.4
RP11-946L20.4
chr1_+_100818009 0.03 ENST00000370125.2
ENST00000361544.6
ENST00000370124.3
CDC14A
cell division cycle 14A
chr1_+_43148059 0.03 ENST00000321358.7
ENST00000332220.6
YBX1
Y box binding protein 1
chr17_+_59489112 0.03 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chr14_+_103851712 0.03 ENST00000440884.3
ENST00000416682.2
ENST00000429436.2
ENST00000303622.9
MARK3
MAP/microtubule affinity-regulating kinase 3
chr3_+_183853052 0.03 ENST00000273783.3
ENST00000432569.1
ENST00000444495.1
EIF2B5
eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
chr4_+_66536248 0.02 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
RP11-807H7.1
chr4_-_103748880 0.02 ENST00000453744.2
ENST00000349311.8
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr6_+_26501449 0.02 ENST00000244513.6
BTN1A1
butyrophilin, subfamily 1, member A1
chr7_-_37488547 0.02 ENST00000453399.1
ELMO1
engulfment and cell motility 1
chr3_+_158519654 0.02 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
MFSD1
major facilitator superfamily domain containing 1
chr8_+_107738343 0.02 ENST00000521592.1
OXR1
oxidation resistance 1
chrX_+_77154935 0.02 ENST00000481445.1
COX7B
cytochrome c oxidase subunit VIIb
chr5_-_102898465 0.02 ENST00000507423.1
ENST00000230792.2
NUDT12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr8_+_29605825 0.02 ENST00000522158.1
AC145110.1
AC145110.1
chrX_+_114827851 0.02 ENST00000539310.1
PLS3
plastin 3
chrM_+_9207 0.02 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr17_-_71258491 0.02 ENST00000397671.1
CPSF4L
cleavage and polyadenylation specific factor 4-like
chr21_-_37914898 0.02 ENST00000399136.1
CLDN14
claudin 14
chr9_+_125133315 0.02 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr13_+_36050881 0.02 ENST00000537702.1
NBEA
neurobeachin
chr5_-_94890648 0.02 ENST00000513823.1
ENST00000514952.1
ENST00000358746.2
TTC37
tetratricopeptide repeat domain 37
chr4_-_74486217 0.02 ENST00000335049.5
ENST00000307439.5
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr10_-_105845674 0.02 ENST00000353479.5
ENST00000369733.3
COL17A1
collagen, type XVII, alpha 1
chr8_+_107738240 0.02 ENST00000449762.2
ENST00000297447.6
OXR1
oxidation resistance 1
chr2_-_86422095 0.02 ENST00000254636.5
IMMT
inner membrane protein, mitochondrial
chr1_-_190446759 0.02 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr2_+_187371440 0.02 ENST00000445547.1
ZC3H15
zinc finger CCCH-type containing 15
chr4_-_66536057 0.02 ENST00000273854.3
EPHA5
EPH receptor A5
chr20_-_1447547 0.02 ENST00000476071.1
NSFL1C
NSFL1 (p97) cofactor (p47)
chr1_+_153746683 0.02 ENST00000271857.2
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chr19_+_54641444 0.02 ENST00000221232.5
ENST00000358389.3
CNOT3
CCR4-NOT transcription complex, subunit 3
chr10_-_114206649 0.02 ENST00000369404.3
ENST00000369405.3
ZDHHC6
zinc finger, DHHC-type containing 6
chr16_+_82068585 0.02 ENST00000563491.1
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr1_-_224624730 0.01 ENST00000445239.1
WDR26
WD repeat domain 26
chr11_+_22689648 0.01 ENST00000278187.3
GAS2
growth arrest-specific 2
chr7_+_21582638 0.01 ENST00000409508.3
ENST00000328843.6
DNAH11
dynein, axonemal, heavy chain 11
chr20_-_1447467 0.01 ENST00000353088.2
ENST00000350991.4
NSFL1C
NSFL1 (p97) cofactor (p47)
chr19_+_49990811 0.01 ENST00000391857.4
ENST00000467825.2
RPL13A
ribosomal protein L13a
chr14_+_55494323 0.01 ENST00000339298.2
SOCS4
suppressor of cytokine signaling 4
chr8_+_92261516 0.01 ENST00000276609.3
ENST00000309536.2
SLC26A7
solute carrier family 26 (anion exchanger), member 7
chr10_+_124913930 0.01 ENST00000368858.5
BUB3
BUB3 mitotic checkpoint protein
chr12_+_16500571 0.01 ENST00000543076.1
ENST00000396210.3
MGST1
microsomal glutathione S-transferase 1
chr18_+_22040593 0.01 ENST00000256906.4
HRH4
histamine receptor H4
chr2_+_210518057 0.01 ENST00000452717.1
MAP2
microtubule-associated protein 2
chr1_+_62439037 0.01 ENST00000545929.1
INADL
InaD-like (Drosophila)
chrX_+_19362011 0.01 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr17_+_57232690 0.01 ENST00000262293.4
PRR11
proline rich 11
chr3_-_191000172 0.01 ENST00000427544.2
UTS2B
urotensin 2B
chr17_+_39346139 0.01 ENST00000398470.1
ENST00000318329.5
KRTAP9-1
keratin associated protein 9-1
chr3_+_45986511 0.01 ENST00000458629.1
ENST00000457814.1
CXCR6
chemokine (C-X-C motif) receptor 6
chr6_-_167040731 0.01 ENST00000265678.4
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr7_-_87342564 0.01 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr14_+_55493920 0.01 ENST00000395472.2
ENST00000555846.1
SOCS4
suppressor of cytokine signaling 4
chr11_-_124981475 0.01 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
TMEM218
transmembrane protein 218
chr4_-_66536196 0.01 ENST00000511294.1
EPHA5
EPH receptor A5
chr10_+_124913793 0.01 ENST00000368865.4
ENST00000538238.1
ENST00000368859.2
BUB3
BUB3 mitotic checkpoint protein
chr3_+_186560476 0.01 ENST00000320741.2
ENST00000444204.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr3_+_186560462 0.01 ENST00000412955.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr18_-_44181442 0.01 ENST00000398722.4
LOXHD1
lipoxygenase homology domains 1
chr12_+_64798826 0.01 ENST00000540203.1
XPOT
exportin, tRNA
chr17_-_4938712 0.01 ENST00000254853.5
ENST00000424747.1
SLC52A1
solute carrier family 52 (riboflavin transporter), member 1
chr7_-_7575477 0.01 ENST00000399429.3
COL28A1
collagen, type XXVIII, alpha 1
chr10_-_99205607 0.01 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
EXOSC1
exosome component 1
chr2_+_191221240 0.01 ENST00000409027.1
ENST00000458193.1
INPP1
inositol polyphosphate-1-phosphatase
chrX_-_13835147 0.01 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr11_+_118398178 0.01 ENST00000302783.4
ENST00000539546.1
TTC36
tetratricopeptide repeat domain 36
chr5_+_150226085 0.01 ENST00000522154.1
IRGM
immunity-related GTPase family, M
chr15_+_94899183 0.01 ENST00000557742.1
MCTP2
multiple C2 domains, transmembrane 2
chr4_-_103749105 0.00 ENST00000394801.4
ENST00000394804.2
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr6_+_52442083 0.00 ENST00000606714.1
TRAM2-AS1
TRAM2 antisense RNA 1 (head to head)
chr15_+_93443419 0.00 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chr4_-_74486347 0.00 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr1_+_28261492 0.00 ENST00000373894.3
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chrX_+_135730373 0.00 ENST00000370628.2
CD40LG
CD40 ligand
chr6_-_167040693 0.00 ENST00000366863.2
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr19_-_46285736 0.00 ENST00000291270.4
ENST00000447742.2
ENST00000354227.5
DMPK
dystrophia myotonica-protein kinase
chr10_-_105845536 0.00 ENST00000393211.3
COL17A1
collagen, type XVII, alpha 1
chr4_-_103749313 0.00 ENST00000394803.5
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr11_-_65625678 0.00 ENST00000308162.5
CFL1
cofilin 1 (non-muscle)
chr2_-_239197238 0.00 ENST00000254657.3
PER2
period circadian clock 2
chr10_+_18549645 0.00 ENST00000396576.2
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr15_+_93447675 0.00 ENST00000536619.1
CHD2
chromodomain helicase DNA binding protein 2
chr2_-_239197201 0.00 ENST00000254658.3
PER2
period circadian clock 2

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-2_RAX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.0 0.1 GO:0045337 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
0.0 0.0 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.0 0.0 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466) positive regulation of synaptic vesicle endocytosis(GO:1900244) positive regulation of synaptic vesicle recycling(GO:1903423) positive regulation of synaptic vesicle exocytosis(GO:2000302)
0.0 0.0 GO:0071284 cellular response to lead ion(GO:0071284)
0.0 0.0 GO:0015722 canalicular bile acid transport(GO:0015722)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 GO:0043614 multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993)
0.0 0.2 GO:0060077 inhibitory synapse(GO:0060077)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.1 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.0 GO:0015432 bile acid-exporting ATPase activity(GO:0015432)
0.0 0.1 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.0 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532) copper-dependent protein binding(GO:0032767)