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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for NKX1-1

Z-value: 0.43

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Transcription factors associated with NKX1-1

Gene Symbol Gene ID Gene Info
NKX1-1
ENSG00000235608.1 NK1 homeobox 1

Activity profile of NKX1-1 motif

Sorted Z-values of NKX1-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_8822113 0.31 ENST00000396290.1
ENST00000331129.3
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr12_+_16500599 0.26 ENST00000535309.1
ENST00000540056.1
ENST00000396209.1
ENST00000540126.1
MGST1
microsomal glutathione S-transferase 1
chr12_+_16500037 0.20 ENST00000536371.1
ENST00000010404.2
MGST1
microsomal glutathione S-transferase 1
chr14_-_88200641 0.19 ENST00000556168.1
RP11-1152H15.1
RP11-1152H15.1
chr12_+_16500571 0.18 ENST00000543076.1
ENST00000396210.3
MGST1
microsomal glutathione S-transferase 1
chr17_-_57232525 0.17 ENST00000583380.1
ENST00000580541.1
ENST00000578105.1
ENST00000437036.2
SKA2
spindle and kinetochore associated complex subunit 2
chr5_+_66300464 0.16 ENST00000436277.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr8_-_94928861 0.15 ENST00000607097.1
MIR378D2
microRNA 378d-2
chr17_-_45266542 0.14 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
CDC27
cell division cycle 27
chr1_+_100818156 0.14 ENST00000336454.3
CDC14A
cell division cycle 14A
chr5_-_159546396 0.13 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP2A
PWWP domain containing 2A
chr7_-_27239703 0.12 ENST00000222753.4
HOXA13
homeobox A13
chr17_-_57232596 0.12 ENST00000581068.1
ENST00000330137.7
SKA2
spindle and kinetochore associated complex subunit 2
chr18_-_33709268 0.11 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr1_+_100818009 0.11 ENST00000370125.2
ENST00000361544.6
ENST00000370124.3
CDC14A
cell division cycle 14A
chr15_-_78526942 0.11 ENST00000258873.4
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr3_-_105588231 0.11 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr12_+_64798826 0.11 ENST00000540203.1
XPOT
exportin, tRNA
chr20_-_17662705 0.11 ENST00000455029.2
RRBP1
ribosome binding protein 1
chr8_+_94929273 0.11 ENST00000518573.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr6_-_80247105 0.11 ENST00000369846.4
LCA5
Leber congenital amaurosis 5
chrX_-_153363125 0.11 ENST00000407218.1
ENST00000453960.2
MECP2
methyl CpG binding protein 2 (Rett syndrome)
chr11_-_4629367 0.11 ENST00000533021.1
TRIM68
tripartite motif containing 68
chr7_-_6048702 0.10 ENST00000265849.7
PMS2
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
chr19_+_32896697 0.10 ENST00000586987.1
DPY19L3
dpy-19-like 3 (C. elegans)
chr1_-_151762943 0.10 ENST00000368825.3
ENST00000368823.1
ENST00000458431.2
ENST00000368827.6
ENST00000368824.3
TDRKH
tudor and KH domain containing
chr1_-_159915386 0.10 ENST00000361509.3
ENST00000368094.1
IGSF9
immunoglobulin superfamily, member 9
chr6_-_82957433 0.09 ENST00000306270.7
IBTK
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr10_-_1095050 0.09 ENST00000381344.3
IDI1
isopentenyl-diphosphate delta isomerase 1
chr3_+_186288454 0.09 ENST00000265028.3
DNAJB11
DnaJ (Hsp40) homolog, subfamily B, member 11
chr10_+_120789223 0.09 ENST00000425699.1
NANOS1
nanos homolog 1 (Drosophila)
chr7_-_33102399 0.09 ENST00000242210.7
NT5C3A
5'-nucleotidase, cytosolic IIIA
chr7_-_33102338 0.08 ENST00000610140.1
NT5C3A
5'-nucleotidase, cytosolic IIIA
chr7_+_99647389 0.08 ENST00000543588.1
ENST00000292450.4
ENST00000456748.2
ZSCAN21
zinc finger and SCAN domain containing 21
chr3_-_105587879 0.08 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr17_+_57233087 0.08 ENST00000578777.1
ENST00000577457.1
ENST00000582995.1
PRR11
proline rich 11
chr4_+_87515454 0.07 ENST00000427191.2
ENST00000436978.1
ENST00000502971.1
PTPN13
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
chr8_+_98656693 0.07 ENST00000519934.1
MTDH
metadherin
chr16_-_66864806 0.07 ENST00000566336.1
ENST00000394074.2
ENST00000563185.2
ENST00000359087.4
ENST00000379463.2
ENST00000565535.1
ENST00000290810.3
NAE1
NEDD8 activating enzyme E1 subunit 1
chr8_+_26371763 0.07 ENST00000521913.1
DPYSL2
dihydropyrimidinase-like 2
chr8_+_94929077 0.07 ENST00000297598.4
ENST00000520614.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr10_-_1094819 0.07 ENST00000429642.1
IDI1
isopentenyl-diphosphate delta isomerase 1
chr1_+_174843548 0.07 ENST00000478442.1
ENST00000465412.1
RABGAP1L
RAB GTPase activating protein 1-like
chrX_+_19362011 0.07 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr7_+_70597109 0.06 ENST00000333538.5
WBSCR17
Williams-Beuren syndrome chromosome region 17
chr19_-_8070474 0.06 ENST00000407627.2
ENST00000593807.1
ELAVL1
ELAV like RNA binding protein 1
chr13_+_78315348 0.06 ENST00000441784.1
SLAIN1
SLAIN motif family, member 1
chr7_-_6048650 0.06 ENST00000382321.4
ENST00000406569.3
PMS2
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
chr17_-_44439084 0.06 ENST00000575960.1
ENST00000575698.1
ENST00000571246.1
ENST00000434041.2
ENST00000570618.1
ENST00000450673.3
ARL17B
ADP-ribosylation factor-like 17B
chr12_+_28410128 0.06 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr1_+_155278625 0.06 ENST00000368356.4
ENST00000356657.6
FDPS
farnesyl diphosphate synthase
chr3_+_57261743 0.06 ENST00000288266.3
APPL1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr7_-_143892748 0.06 ENST00000378115.2
ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chr19_+_32897009 0.05 ENST00000342179.5
ENST00000586427.1
DPY19L3
dpy-19-like 3 (C. elegans)
chr1_+_155278539 0.05 ENST00000447866.1
FDPS
farnesyl diphosphate synthase
chr2_-_47142884 0.05 ENST00000409105.1
ENST00000409973.1
ENST00000409913.1
ENST00000319466.4
MCFD2
multiple coagulation factor deficiency 2
chr19_-_14228541 0.05 ENST00000590853.1
ENST00000308677.4
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr8_+_94929168 0.05 ENST00000518107.1
ENST00000396200.3
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr17_+_59489112 0.05 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chr1_-_151762900 0.04 ENST00000440583.2
TDRKH
tudor and KH domain containing
chr16_-_2318111 0.04 ENST00000301730.8
ENST00000564822.1
RNPS1
RNA binding protein S1, serine-rich domain
chr1_-_197115818 0.04 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr1_+_62439037 0.04 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr3_+_186560476 0.04 ENST00000320741.2
ENST00000444204.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr1_-_159832438 0.04 ENST00000368100.1
VSIG8
V-set and immunoglobulin domain containing 8
chr3_+_23851928 0.04 ENST00000467766.1
ENST00000424381.1
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr4_-_54232144 0.04 ENST00000388940.4
ENST00000503450.1
ENST00000401642.3
SCFD2
sec1 family domain containing 2
chr21_-_37914898 0.04 ENST00000399136.1
CLDN14
claudin 14
chr11_-_105892937 0.04 ENST00000301919.4
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
MSANTD4
Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
chr3_-_59035673 0.04 ENST00000491845.1
ENST00000472469.1
ENST00000471288.1
ENST00000295966.7
C3orf67
chromosome 3 open reading frame 67
chr12_-_102513843 0.04 ENST00000551744.2
ENST00000552283.1
NUP37
nucleoporin 37kDa
chr17_+_57232690 0.04 ENST00000262293.4
PRR11
proline rich 11
chr3_+_186560462 0.04 ENST00000412955.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr17_-_44657017 0.04 ENST00000573185.1
ENST00000570550.1
ENST00000445552.2
ENST00000336125.5
ENST00000329240.4
ENST00000337845.7
ARL17A
ADP-ribosylation factor-like 17A
chr12_+_102513950 0.03 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARPBP
PARP1 binding protein
chr19_-_6424783 0.03 ENST00000398148.3
KHSRP
KH-type splicing regulatory protein
chr19_+_54641444 0.03 ENST00000221232.5
ENST00000358389.3
CNOT3
CCR4-NOT transcription complex, subunit 3
chr7_+_144052381 0.03 ENST00000498580.1
ENST00000056217.5
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr1_-_28969517 0.03 ENST00000263974.4
ENST00000373824.4
TAF12
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
chr7_+_26331541 0.03 ENST00000416246.1
ENST00000338523.4
ENST00000412416.1
SNX10
sorting nexin 10
chr11_-_71823715 0.03 ENST00000545944.1
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr6_-_167040731 0.03 ENST00000265678.4
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr15_+_64386261 0.02 ENST00000560829.1
SNX1
sorting nexin 1
chr19_+_36249057 0.02 ENST00000301165.5
ENST00000536950.1
ENST00000537459.1
ENST00000421853.2
C19orf55
chromosome 19 open reading frame 55
chr6_-_167040693 0.02 ENST00000366863.2
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr11_-_71823796 0.02 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
ANAPC15
anaphase promoting complex subunit 15
chr8_+_22132810 0.02 ENST00000356766.6
PIWIL2
piwi-like RNA-mediated gene silencing 2
chr2_-_239197238 0.02 ENST00000254657.3
PER2
period circadian clock 2
chr11_-_59383617 0.02 ENST00000263847.1
OSBP
oxysterol binding protein
chrX_+_72783026 0.02 ENST00000373504.6
ENST00000373502.5
CHIC1
cysteine-rich hydrophobic domain 1
chr18_+_55888767 0.02 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr7_+_12727250 0.02 ENST00000404894.1
ARL4A
ADP-ribosylation factor-like 4A
chr12_+_7013897 0.02 ENST00000007969.8
ENST00000323702.5
LRRC23
leucine rich repeat containing 23
chr8_+_98656336 0.02 ENST00000336273.3
MTDH
metadherin
chr2_-_167232484 0.02 ENST00000375387.4
ENST00000303354.6
ENST00000409672.1
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr7_+_6048856 0.02 ENST00000223029.3
ENST00000400479.2
ENST00000395236.2
AIMP2
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
chr8_+_22132847 0.02 ENST00000521356.1
PIWIL2
piwi-like RNA-mediated gene silencing 2
chr4_-_66536196 0.01 ENST00000511294.1
EPHA5
EPH receptor A5
chr16_-_2318055 0.01 ENST00000561518.1
ENST00000561718.1
ENST00000567147.1
ENST00000562690.1
ENST00000569598.2
RNPS1
RNA binding protein S1, serine-rich domain
chr2_-_47143160 0.01 ENST00000409800.1
ENST00000409218.1
MCFD2
multiple coagulation factor deficiency 2
chr10_+_1095416 0.01 ENST00000358220.1
WDR37
WD repeat domain 37
chr2_+_187371440 0.01 ENST00000445547.1
ZC3H15
zinc finger CCCH-type containing 15
chr4_+_128554081 0.01 ENST00000335251.6
ENST00000296461.5
INTU
inturned planar cell polarity protein
chr12_+_102514019 0.01 ENST00000537257.1
ENST00000358383.5
ENST00000392911.2
PARPBP
PARP1 binding protein
chr6_+_26501449 0.01 ENST00000244513.6
BTN1A1
butyrophilin, subfamily 1, member A1
chr1_-_108507631 0.01 ENST00000527011.1
ENST00000370056.4
VAV3
vav 3 guanine nucleotide exchange factor
chr2_-_239197201 0.01 ENST00000254658.3
PER2
period circadian clock 2
chr4_+_66536248 0.01 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
RP11-807H7.1
chr9_+_124329336 0.01 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2IP
DAB2 interacting protein
chr18_-_44181442 0.01 ENST00000398722.4
LOXHD1
lipoxygenase homology domains 1
chr8_+_94929110 0.01 ENST00000520728.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr4_-_66536057 0.00 ENST00000273854.3
EPHA5
EPH receptor A5
chr15_-_64386120 0.00 ENST00000300030.3
FAM96A
family with sequence similarity 96, member A
chr10_-_99205607 0.00 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
EXOSC1
exosome component 1
chr22_+_17956618 0.00 ENST00000262608.8
CECR2
cat eye syndrome chromosome region, candidate 2
chr4_-_103682145 0.00 ENST00000226578.4
MANBA
mannosidase, beta A, lysosomal
chr12_+_7014064 0.00 ENST00000443597.2
LRRC23
leucine rich repeat containing 23
chr11_-_4629388 0.00 ENST00000526337.1
ENST00000300747.5
TRIM68
tripartite motif containing 68
chr7_+_26331678 0.00 ENST00000446848.2
SNX10
sorting nexin 10
chr11_-_47198380 0.00 ENST00000419701.2
ENST00000526342.1
ENST00000528444.1
ENST00000530596.1
ENST00000525398.1
ENST00000319543.6
ENST00000426335.2
ENST00000527927.1
ENST00000525314.1
ARFGAP2
ADP-ribosylation factor GTPase activating protein 2
chr1_-_231004220 0.00 ENST00000366663.5
C1orf198
chromosome 1 open reading frame 198

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.1 0.3 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.2 GO:0050993 dimethylallyl diphosphate biosynthetic process(GO:0050992) dimethylallyl diphosphate metabolic process(GO:0050993)
0.0 0.1 GO:2000532 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.0 0.1 GO:0033383 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
0.0 0.1 GO:0009405 pathogenesis(GO:0009405)
0.0 0.3 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 0.0 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.0 0.2 GO:0018211 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.0 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.0 0.2 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.2 GO:0046085 adenosine metabolic process(GO:0046085)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0071547 piP-body(GO:0071547)
0.0 0.2 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.3 GO:0060091 kinocilium(GO:0060091)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0004452 isopentenyl-diphosphate delta-isomerase activity(GO:0004452)
0.0 0.2 GO:0008665 2'-phosphotransferase activity(GO:0008665)
0.0 0.2 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0 0.6 GO:0043295 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 0.1 GO:0019781 NEDD8 activating enzyme activity(GO:0019781)
0.0 0.1 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.1 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.2 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.4 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase