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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for NFKB1
Z-value: 0.72
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Transcription factors associated with NFKB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFKB1 | hg19_v2_chr4_+_103422499_103422632 | 0.85 | 1.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_39735646 Show fit | 0.62 |
ENST00000413851.2
|
interferon, lambda 3 |
|
| chr19_+_39759154 Show fit | 0.53 |
ENST00000331982.5
|
interferon, lambda 2 |
|
| chr6_+_138188351 Show fit | 0.50 |
ENST00000421450.1
|
tumor necrosis factor, alpha-induced protein 3 |
|
| chr1_+_6845578 Show fit | 0.43 |
ENST00000467404.2
ENST00000439411.2 |
calmodulin binding transcription activator 1 |
|
| chr4_-_74904398 Show fit | 0.41 |
ENST00000296026.4
|
chemokine (C-X-C motif) ligand 3 |
|
| chr2_-_61108449 Show fit | 0.40 |
ENST00000439412.1
ENST00000452343.1 |
AC010733.4 |
|
| chr4_+_103422499 Show fit | 0.36 |
ENST00000511926.1
ENST00000507079.1 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
|
| chr4_+_74735102 Show fit | 0.35 |
ENST00000395761.3
|
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
|
| chr6_-_31550192 Show fit | 0.34 |
ENST00000429299.2
ENST00000446745.2 |
lymphotoxin beta (TNF superfamily, member 3) |
|
| chr12_-_49259643 Show fit | 0.30 |
ENST00000309739.5
|
Rho family GTPase 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFKB1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.3 | 0.8 | GO:0072573 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of CD40 signaling pathway(GO:2000349) |
| 0.0 | 0.5 | GO:0002385 | mucosal immune response(GO:0002385) |
| 0.1 | 0.4 | GO:0045083 | negative regulation of interleukin-12 biosynthetic process(GO:0045083) |
| 0.1 | 0.4 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 0.1 | 0.4 | GO:2001034 | positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034) |
| 0.1 | 0.3 | GO:0042222 | interleukin-1 biosynthetic process(GO:0042222) regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.1 | 0.3 | GO:1904617 | negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617) |
| 0.1 | 0.3 | GO:0036343 | psychomotor behavior(GO:0036343) |
| 0.0 | 0.3 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.0 | 0.4 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 0.2 | GO:0043196 | varicosity(GO:0043196) |
| 0.0 | 0.2 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.0 | 0.2 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.0 | 0.2 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.0 | 0.2 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.0 | 0.1 | GO:0070762 | nuclear pore transmembrane ring(GO:0070762) |
| 0.0 | 0.1 | GO:0005900 | oncostatin-M receptor complex(GO:0005900) |
| 0.0 | 0.1 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 0.9 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.0 | 0.4 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.0 | 0.4 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 0.3 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.0 | 0.3 | GO:0031005 | filamin binding(GO:0031005) |
| 0.1 | 0.2 | GO:0046970 | NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970) |
| 0.0 | 0.2 | GO:0050115 | myosin-light-chain-phosphatase activity(GO:0050115) |
| 0.0 | 0.2 | GO:0045159 | myosin II binding(GO:0045159) |
| 0.0 | 0.2 | GO:0019211 | phosphatase activator activity(GO:0019211) BMP receptor binding(GO:0070700) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.1 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 0.3 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 0.3 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.2 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.0 | 0.1 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |