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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for NFIX_NFIB
Z-value: 2.62
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Transcription factors associated with NFIX_NFIB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFIX | hg19_v2_chr19_+_13135386_13135435 | 1.00 | 4.0e-03 | Click! |
| NFIB | hg19_v2_chr9_-_14180778_14180808 | -0.99 | 1.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFIX_NFIB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.2 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
| 0.0 | 3.4 | GO:0006687 | glycosphingolipid metabolic process(GO:0006687) |
| 0.2 | 3.3 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.0 | 2.6 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.1 | 2.5 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.2 | 2.2 | GO:0071394 | cellular response to testosterone stimulus(GO:0071394) |
| 0.7 | 2.1 | GO:1990575 | mitochondrial L-ornithine transmembrane transport(GO:1990575) |
| 0.4 | 2.1 | GO:0097403 | cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545) |
| 0.1 | 1.7 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
| 0.0 | 1.7 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.1 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 4.8 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 3.7 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 3.5 | GO:0031228 | intrinsic component of Golgi membrane(GO:0031228) |
| 0.0 | 1.6 | GO:0000786 | nucleosome(GO:0000786) |
| 0.2 | 1.5 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
| 0.1 | 1.5 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.1 | 1.3 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 1.3 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 1.3 | GO:0030119 | AP-type membrane coat adaptor complex(GO:0030119) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.4 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.1 | 3.9 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.2 | 3.3 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.8 | 2.5 | GO:0003941 | L-serine ammonia-lyase activity(GO:0003941) |
| 0.5 | 2.2 | GO:0015227 | acyl carnitine transmembrane transporter activity(GO:0015227) |
| 0.1 | 2.1 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.1 | 2.0 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 1.8 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.0 | 1.8 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.2 | 1.6 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.2 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 2.1 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 1.7 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 1.6 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 1.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 1.4 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 1.4 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.0 | 1.3 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 1.3 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.7 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 2.8 | REACTOME DESTABILIZATION OF MRNA BY BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.0 | 2.8 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.1 | 2.6 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 2.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 2.1 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 2.1 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 2.0 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.0 | 2.0 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 2.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |