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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for NFATC1
Z-value: 1.67
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Transcription factors associated with NFATC1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFATC1 | hg19_v2_chr18_+_77160282_77160392 | -0.97 | 3.2e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_94590910 Show fit | 0.83 |
ENST00000371547.4
|
exocyst complex component 6 |
|
| chr13_+_37581115 Show fit | 0.78 |
ENST00000481013.1
|
exosome component 8 |
|
| chr3_+_69134124 Show fit | 0.75 |
ENST00000478935.1
|
ADP-ribosylation-like factor 6 interacting protein 5 |
|
| chr17_+_27573875 Show fit | 0.75 |
ENST00000225387.3
|
crystallin, beta A1 |
|
| chr3_-_71632894 Show fit | 0.74 |
ENST00000493089.1
|
forkhead box P1 |
|
| chr16_+_53412368 Show fit | 0.74 |
ENST00000565189.1
|
RP11-44F14.2 |
|
| chr5_-_78808617 Show fit | 0.67 |
ENST00000282260.6
ENST00000508576.1 ENST00000535690.1 |
homer homolog 1 (Drosophila) |
|
| chr17_+_32582293 Show fit | 0.65 |
ENST00000580907.1
ENST00000225831.4 |
chemokine (C-C motif) ligand 2 |
|
| chr1_-_43638168 Show fit | 0.59 |
ENST00000431635.2
|
EBNA1 binding protein 2 |
|
| chr12_-_13529594 Show fit | 0.58 |
ENST00000539026.1
|
chromosome 12 open reading frame 36 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFATC1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | GO:0002036 | regulation of L-glutamate transport(GO:0002036) |
| 0.2 | 1.0 | GO:1902904 | negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764) |
| 0.1 | 1.0 | GO:0007379 | segment specification(GO:0007379) |
| 0.0 | 1.0 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.2 | 0.9 | GO:0072619 | interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619) |
| 0.0 | 0.9 | GO:0033173 | calcineurin-NFAT signaling cascade(GO:0033173) |
| 0.3 | 0.8 | GO:0033386 | geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386) |
| 0.2 | 0.8 | GO:0034473 | U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) |
| 0.1 | 0.8 | GO:0045629 | negative regulation of T-helper 2 cell differentiation(GO:0045629) |
| 0.0 | 0.8 | GO:0035855 | megakaryocyte development(GO:0035855) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 1.0 | GO:0098575 | lumenal side of lysosomal membrane(GO:0098575) |
| 0.0 | 1.0 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 0.8 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.0 | 0.8 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.0 | 0.8 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 0.7 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.1 | 0.6 | GO:0051286 | cell tip(GO:0051286) |
| 0.0 | 0.6 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 0.6 | GO:0035102 | PRC1 complex(GO:0035102) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.0 | 1.0 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 1.0 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.0 | 1.0 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 1.0 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.2 | 0.8 | GO:0004337 | dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337) |
| 0.0 | 0.8 | GO:0004532 | exoribonuclease activity(GO:0004532) |
| 0.1 | 0.7 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.0 | 0.7 | GO:0003964 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
| 0.0 | 0.7 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 0.0 | 1.4 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 1.3 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 1.1 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 1.0 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.8 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 0.7 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 0.7 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.0 | 0.3 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.3 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 1.0 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 0.8 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.0 | 0.8 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 0.7 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.0 | 0.6 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 0.6 | REACTOME DOUBLE STRAND BREAK REPAIR | Genes involved in Double-Strand Break Repair |
| 0.0 | 0.6 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.6 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 0.5 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |