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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for MXI1_MYC_MYCN
Z-value: 1.95
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Transcription factors associated with MXI1_MYC_MYCN
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000119950.16 | MAX interactor 1, dimerization protein | |
| ENSG00000136997.10 | MYC proto-oncogene, bHLH transcription factor | |
| ENSG00000134323.10 | MYCN proto-oncogene, bHLH transcription factor |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYC | hg19_v2_chr8_+_128747661_128747703 | 0.99 | 1.4e-02 | Click! |
| MXI1 | hg19_v2_chr10_+_111985837_111985844 | -0.95 | 5.4e-02 | Click! |
| MYCN | hg19_v2_chr2_+_16080659_16080686 | 0.08 | 9.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MXI1_MYC_MYCN
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.2 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.3 | 2.8 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 0.4 | 2.5 | GO:0006438 | valyl-tRNA aminoacylation(GO:0006438) |
| 0.3 | 2.4 | GO:0019262 | N-acetylneuraminate catabolic process(GO:0019262) |
| 0.5 | 2.2 | GO:0002949 | tRNA threonylcarbamoyladenosine modification(GO:0002949) |
| 0.1 | 2.1 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.0 | 2.0 | GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process(GO:0050650) |
| 0.0 | 1.7 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.4 | 1.6 | GO:0022007 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
| 0.3 | 1.6 | GO:0071051 | polyadenylation-dependent snoRNA 3'-end processing(GO:0071051) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.5 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 4.7 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 3.5 | GO:0031228 | intrinsic component of Golgi membrane(GO:0031228) |
| 0.3 | 2.7 | GO:0000408 | EKC/KEOPS complex(GO:0000408) |
| 0.2 | 1.8 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 1.7 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.3 | 1.4 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.1 | 1.4 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.1 | 1.4 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.0 | 1.4 | GO:0031526 | brush border membrane(GO:0031526) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.1 | GO:0050309 | glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309) |
| 0.3 | 2.8 | GO:0004793 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.0 | 2.8 | GO:0051213 | dioxygenase activity(GO:0051213) |
| 0.4 | 2.5 | GO:0004832 | valine-tRNA ligase activity(GO:0004832) |
| 0.0 | 2.3 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.7 | 2.1 | GO:0061711 | N(6)-L-threonylcarbamoyladenine synthase(GO:0061711) |
| 0.1 | 2.1 | GO:0016799 | hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799) |
| 0.1 | 2.0 | GO:0015929 | hexosaminidase activity(GO:0015929) |
| 0.2 | 1.9 | GO:0004985 | opioid receptor activity(GO:0004985) |
| 0.1 | 1.8 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 2.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 1.4 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 1.4 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 1.3 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 1.3 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 1.3 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 1.1 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 1.0 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.9 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 2.9 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.1 | 2.6 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.0 | 2.6 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 2.5 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 2.2 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.0 | 2.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 2.0 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.1 | 1.7 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 1.7 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |