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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for MLX_USF2_USF1_PAX2
Z-value: 2.04
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Transcription factors associated with MLX_USF2_USF1_PAX2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000108788.7 | MAX dimerization protein MLX | |
| ENSG00000105698.11 | upstream transcription factor 2, c-fos interacting | |
| ENSG00000158773.10 | upstream transcription factor 1 | |
| ENSG00000075891.17 | paired box 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MLX | hg19_v2_chr17_+_40719073_40719092 | -0.95 | 5.1e-02 | Click! |
| USF1 | hg19_v2_chr1_-_161014731_161014788 | -0.93 | 6.9e-02 | Click! |
| PAX2 | hg19_v2_chr10_+_102505954_102505985 | 0.93 | 7.4e-02 | Click! |
| USF2 | hg19_v2_chr19_+_35759824_35759891 | 0.87 | 1.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MLX_USF2_USF1_PAX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 5.6 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 0.6 | 4.0 | GO:1902963 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
| 0.1 | 3.8 | GO:0070911 | global genome nucleotide-excision repair(GO:0070911) |
| 0.1 | 3.4 | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain(GO:0070816) |
| 0.1 | 3.1 | GO:0008333 | endosome to lysosome transport(GO:0008333) |
| 0.0 | 2.9 | GO:0006368 | transcription elongation from RNA polymerase II promoter(GO:0006368) |
| 0.9 | 2.8 | GO:0072573 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of CD40 signaling pathway(GO:2000349) |
| 0.2 | 2.8 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.4 | 2.7 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.1 | 2.6 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.4 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.0 | 4.7 | GO:0005938 | cell cortex(GO:0005938) |
| 0.1 | 4.1 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.7 | 4.0 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.3 | 3.3 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.0 | 3.3 | GO:0000776 | kinetochore(GO:0000776) |
| 0.1 | 2.8 | GO:0030897 | HOPS complex(GO:0030897) |
| 0.0 | 2.7 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 2.4 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 2.2 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 5.0 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.2 | 4.5 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.3 | 4.0 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.2 | 3.9 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.1 | 3.5 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.2 | 2.8 | GO:0031386 | protein tag(GO:0031386) |
| 0.1 | 2.8 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 2.8 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.1 | 2.7 | GO:0051059 | NF-kappaB binding(GO:0051059) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.0 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 3.4 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 3.3 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.1 | 3.2 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 2.7 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 2.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 2.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 2.0 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 1.8 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.1 | 1.5 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.7 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 5.7 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 3.7 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.1 | 3.6 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.1 | 3.4 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 2.6 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 2.5 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.0 | 2.4 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 2.4 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 2.3 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |