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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for MEIS2
Z-value: 1.80
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Transcription factors associated with MEIS2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MEIS2 | hg19_v2_chr15_-_37392703_37392717 | -0.57 | 4.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_39759154 Show fit | 1.48 |
ENST00000331982.5
|
interferon, lambda 2 |
|
| chr19_-_39735646 Show fit | 1.26 |
ENST00000413851.2
|
interferon, lambda 3 |
|
| chr8_-_124286735 Show fit | 0.99 |
ENST00000395571.3
|
zinc fingers and homeoboxes 1 |
|
| chr4_-_175443943 Show fit | 0.79 |
ENST00000296522.6
|
hydroxyprostaglandin dehydrogenase 15-(NAD) |
|
| chr2_-_170681324 Show fit | 0.79 |
ENST00000409340.1
|
methyltransferase like 5 |
|
| chrX_+_150866779 Show fit | 0.74 |
ENST00000370353.3
|
proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) |
|
| chr2_+_90458201 Show fit | 0.71 |
ENST00000603238.1
|
Uncharacterized protein |
|
| chr16_+_56782118 Show fit | 0.67 |
ENST00000566678.1
|
nucleoporin 93kDa |
|
| chr1_-_247171347 Show fit | 0.62 |
ENST00000339986.7
ENST00000487338.2 |
zinc finger protein 695 |
|
| chr6_-_52109335 Show fit | 0.62 |
ENST00000336123.4
|
interleukin 17F |
Network of associatons between targets according to the STRING database.
First level regulatory network of MEIS2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0006359 | regulation of transcription from RNA polymerase III promoter(GO:0006359) |
| 0.1 | 1.6 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 0.0 | 1.6 | GO:0000717 | nucleotide-excision repair, DNA duplex unwinding(GO:0000717) |
| 0.0 | 1.6 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
| 0.0 | 1.6 | GO:0072599 | establishment of protein localization to endoplasmic reticulum(GO:0072599) |
| 0.0 | 1.5 | GO:0010389 | regulation of G2/M transition of mitotic cell cycle(GO:0010389) |
| 0.0 | 1.3 | GO:0060396 | growth hormone receptor signaling pathway(GO:0060396) |
| 0.0 | 1.2 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.2 | 1.1 | GO:1902963 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
| 0.1 | 1.1 | GO:0016081 | synaptic vesicle docking(GO:0016081) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 1.6 | GO:0000776 | kinetochore(GO:0000776) |
| 0.0 | 1.4 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 1.4 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 1.2 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
| 0.0 | 1.2 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 1.2 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.1 | 1.1 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.2 | 1.0 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.1 | 1.0 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 1.8 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 1.4 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.0 | 1.3 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 1.3 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 1.2 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.0 | 1.2 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 1.2 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.3 | 1.1 | GO:0016404 | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404) |
| 0.1 | 1.1 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 2.5 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 1.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.7 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 1.5 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.4 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 1.4 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.0 | 1.4 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 1.1 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 1.1 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 1.9 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 1.8 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 1.8 | REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX | Genes involved in CDT1 association with the CDC6:ORC:origin complex |
| 0.0 | 1.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 1.5 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.0 | 1.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 1.4 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 1.3 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 1.3 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |