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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for MEF2D_MEF2A
Z-value: 0.85
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Transcription factors associated with MEF2D_MEF2A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MEF2D | hg19_v2_chr1_-_156470515_156470542 | -0.99 | 8.3e-03 | Click! |
| MEF2A | hg19_v2_chr15_+_100106670_100106697 | 0.98 | 2.2e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_+_68165657 Show fit | 0.49 |
ENST00000243457.3
|
potassium inwardly-rectifying channel, subfamily J, member 2 |
|
| chr21_+_35107346 Show fit | 0.37 |
ENST00000456489.1
|
intersectin 1 (SH3 domain protein) |
|
| chr15_+_100106244 Show fit | 0.34 |
ENST00000557942.1
|
myocyte enhancer factor 2A |
|
| chr14_+_56046990 Show fit | 0.34 |
ENST00000438792.2
ENST00000395314.3 ENST00000395308.1 |
kinectin 1 (kinesin receptor) |
|
| chr8_+_107282368 Show fit | 0.32 |
ENST00000521369.2
|
RP11-395G23.3 |
|
| chr12_-_49393092 Show fit | 0.31 |
ENST00000421952.2
|
dendrin |
|
| chr12_+_54384370 Show fit | 0.30 |
ENST00000504315.1
|
homeobox C6 |
|
| chr7_+_143013198 Show fit | 0.30 |
ENST00000343257.2
|
chloride channel, voltage-sensitive 1 |
|
| chr1_-_226187013 Show fit | 0.29 |
ENST00000272091.7
|
SDE2 telomere maintenance homolog (S. pombe) |
|
| chr16_+_31225337 Show fit | 0.29 |
ENST00000322122.3
|
tripartite motif containing 72 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MEF2D_MEF2A
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:0055005 | ventricular cardiac myofibril assembly(GO:0055005) |
| 0.0 | 0.6 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 0.1 | 0.5 | GO:0090076 | relaxation of skeletal muscle(GO:0090076) |
| 0.0 | 0.4 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.1 | 0.3 | GO:0044026 | DNA hypermethylation(GO:0044026) hypermethylation of CpG island(GO:0044027) |
| 0.0 | 0.3 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.0 | 0.3 | GO:0098870 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.1 | 0.2 | GO:0042138 | meiotic DNA double-strand break formation(GO:0042138) regulation of homologous chromosome segregation(GO:0060629) |
| 0.1 | 0.2 | GO:0060164 | negative regulation of auditory receptor cell differentiation(GO:0045608) negative regulation of mechanoreceptor differentiation(GO:0045632) regulation of timing of neuron differentiation(GO:0060164) negative regulation of inner ear receptor cell differentiation(GO:2000981) |
| 0.1 | 0.2 | GO:0061394 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 0.4 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 0.3 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.1 | 0.2 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 0.0 | 0.2 | GO:0030936 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.0 | 0.2 | GO:0034680 | integrin alpha10-beta1 complex(GO:0034680) |
| 0.0 | 0.2 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.0 | 0.2 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 0.2 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.0 | 0.1 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 0.5 | GO:0086008 | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008) |
| 0.0 | 0.5 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.4 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 0.4 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 0.3 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.0 | 0.3 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 0.2 | GO:0032795 | heterotrimeric G-protein binding(GO:0032795) |
| 0.0 | 0.2 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 0.0 | 0.2 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.2 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 0.6 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.4 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 0.1 | REACTOME DEFENSINS | Genes involved in Defensins |