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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for MECP2
Z-value: 2.67
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Transcription factors associated with MECP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MECP2 | hg19_v2_chrX_-_153363125_153363182 | -0.50 | 5.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_149865377 Show fit | 2.74 |
ENST00000522491.1
|
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 |
|
| chr2_-_178129551 Show fit | 2.13 |
ENST00000430047.1
|
nuclear factor, erythroid 2-like 2 |
|
| chr7_+_73082152 Show fit | 1.97 |
ENST00000324941.4
ENST00000451519.1 |
vacuolar protein sorting 37 homolog D (S. cerevisiae) |
|
| chr19_+_33685490 Show fit | 1.79 |
ENST00000253193.7
|
low density lipoprotein receptor-related protein 3 |
|
| chr16_+_770975 Show fit | 1.70 |
ENST00000569529.1
ENST00000564000.1 ENST00000219535.3 |
family with sequence similarity 173, member A |
|
| chr10_+_134210672 Show fit | 1.70 |
ENST00000305233.5
ENST00000368609.4 |
PWWP domain containing 2B |
|
| chr14_+_105559784 Show fit | 1.69 |
ENST00000548104.1
|
RP11-44N21.1 |
|
| chr11_+_842928 Show fit | 1.67 |
ENST00000397408.1
|
tetraspanin 4 |
|
| chr4_-_1723040 Show fit | 1.62 |
ENST00000382936.3
ENST00000536901.1 ENST00000303277.2 |
transmembrane protein 129 |
|
| chr9_+_130922537 Show fit | 1.54 |
ENST00000372994.1
|
chromosome 9 open reading frame 16 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MECP2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.1 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.3 | 3.9 | GO:0006477 | protein sulfation(GO:0006477) |
| 0.3 | 3.6 | GO:0030259 | lipid glycosylation(GO:0030259) |
| 0.2 | 3.6 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.7 | 3.3 | GO:0009439 | cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440) |
| 0.0 | 3.1 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
| 0.1 | 2.9 | GO:0030205 | dermatan sulfate metabolic process(GO:0030205) |
| 0.3 | 2.6 | GO:0006931 | substrate-dependent cell migration, cell attachment to substrate(GO:0006931) |
| 0.1 | 2.6 | GO:0035428 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
| 0.1 | 2.6 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 102.2 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.1 | 12.7 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 6.9 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 6.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 3.2 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 3.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 3.1 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 2.7 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.2 | 2.6 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.1 | 2.6 | GO:0044295 | axonal growth cone(GO:0044295) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.9 | GO:0005178 | integrin binding(GO:0005178) |
| 0.4 | 4.2 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.5 | 3.7 | GO:0050119 | N-acetylglucosamine deacetylase activity(GO:0050119) |
| 0.6 | 3.5 | GO:0004792 | thiosulfate sulfurtransferase activity(GO:0004792) |
| 0.2 | 3.3 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
| 0.1 | 3.0 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.3 | 2.9 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.4 | 2.7 | GO:0070026 | nitric oxide binding(GO:0070026) |
| 0.2 | 2.6 | GO:0008061 | chitin binding(GO:0008061) |
| 0.1 | 2.6 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.9 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 6.1 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 4.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.2 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.1 | 3.0 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 2.7 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 2.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 2.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 2.2 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 1.8 | PID ARF 3PATHWAY | Arf1 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.7 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 5.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.2 | 4.6 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 3.8 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.1 | 3.7 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 3.6 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 3.6 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 3.5 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 3.4 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 3.4 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |