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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for MAX_TFEB
Z-value: 0.75
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Transcription factors associated with MAX_TFEB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFEB | hg19_v2_chr6_-_41673552_41673678 | 0.90 | 9.9e-02 | Click! |
| MAX | hg19_v2_chr14_-_65569057_65569119 | -0.88 | 1.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAX_TFEB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.2 | GO:0022007 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
| 0.2 | 1.6 | GO:0019262 | N-acetylneuraminate catabolic process(GO:0019262) |
| 0.2 | 1.2 | GO:1904637 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 0.1 | 1.2 | GO:0033299 | secretion of lysosomal enzymes(GO:0033299) |
| 0.0 | 1.2 | GO:0007035 | vacuolar acidification(GO:0007035) |
| 0.3 | 1.1 | GO:0035752 | lysosomal lumen pH elevation(GO:0035752) |
| 0.2 | 0.8 | GO:0033274 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
| 0.1 | 0.8 | GO:0008626 | granzyme-mediated apoptotic signaling pathway(GO:0008626) |
| 0.1 | 0.8 | GO:0006489 | dolichyl diphosphate biosynthetic process(GO:0006489) dolichyl diphosphate metabolic process(GO:0046465) |
| 0.0 | 0.8 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 1.8 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 1.5 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 1.3 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.2 | 1.2 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.1 | 1.1 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.0 | 1.1 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 0.7 | GO:0000408 | EKC/KEOPS complex(GO:0000408) |
| 0.1 | 0.6 | GO:0044194 | cytolytic granule(GO:0044194) |
| 0.0 | 0.6 | GO:0071986 | Ragulator complex(GO:0071986) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 2.1 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 2.0 | GO:0015929 | hexosaminidase activity(GO:0015929) |
| 0.0 | 1.2 | GO:0008171 | O-methyltransferase activity(GO:0008171) |
| 0.0 | 1.2 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 1.2 | GO:0019213 | deacetylase activity(GO:0019213) |
| 0.0 | 1.0 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.1 | 0.9 | GO:0004793 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.2 | 0.8 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 0.1 | 0.8 | GO:0046624 | sphingolipid transporter activity(GO:0046624) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.1 | 1.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.4 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.3 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 1.4 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 1.0 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 1.0 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.9 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 0.8 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 0.6 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 0.6 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 0.6 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 0.6 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |