ISMARA results: KLF8

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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for KLF8

Z-value: 1.20

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Transcription factors associated with KLF8

Gene Symbol	Gene ID	Gene Info
KLF8 Ensembl NCBI GeneCards UniProt	ENSG00000102349.10	Kruppel like factor 8

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
KLF8	hg19_v2_chrX_+_56258844_56258882	0.45	5.5e-01	Click!

Activity profile of KLF8 motif

Sorted Z-values of KLF8 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr20_+_57466629 Show fit	0.54	ENST00000371081.1 ENST00000338783.6	GNAS Ensembl NCBI GeneCards UniProt Show fit	GNAS complex locus
chr19_-_39735646 Show fit	0.53	ENST00000413851.2	IFNL3 Ensembl NCBI GeneCards UniProt Show fit	interferon, lambda 3
chr9_-_117160738 Show fit	0.51	ENST00000448674.1	RP11-9M16.2 Ensembl NCBI GeneCards UniProt Show fit	RP11-9M16.2
chr19_+_55795493 Show fit	0.41	ENST00000309383.1	BRSK1 Ensembl NCBI GeneCards UniProt Show fit	BR serine/threonine kinase 1
chr5_+_140566 Show fit	0.37	ENST00000502646.1	PLEKHG4B Ensembl NCBI GeneCards UniProt Show fit	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
chr19_-_54726850 Show fit	0.35	ENST00000245620.9 ENST00000346401.6 ENST00000424807.1 ENST00000445347.1	LILRB3 Ensembl NCBI GeneCards UniProt Show fit	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
chr1_+_6845578 Show fit	0.34	ENST00000467404.2 ENST00000439411.2	CAMTA1 Ensembl NCBI GeneCards UniProt Show fit	calmodulin binding transcription activator 1
chr6_-_10694766 Show fit	0.33	ENST00000460742.2 ENST00000259983.3 ENST00000379586.1	C6orf52 Ensembl NCBI GeneCards UniProt Show fit	chromosome 6 open reading frame 52
chr6_-_110500905 Show fit	0.33	ENST00000392587.2	WASF1 Ensembl NCBI GeneCards UniProt Show fit	WAS protein family, member 1
chr19_-_44172467 Show fit	0.32	ENST00000599892.1	PLAUR Ensembl NCBI GeneCards UniProt Show fit	plasminogen activator, urokinase receptor

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF8

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.1	GO:0040032	post-embryonic body morphogenesis(GO:0040032)
0.0	0.6	GO:1990416	cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0	0.6	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.0	0.6	GO:0002209	behavioral fear response(GO:0001662) behavioral defense response(GO:0002209)
0.0	0.5	GO:0015824	proline transport(GO:0015824)
0.0	0.5	GO:0018146	keratan sulfate biosynthetic process(GO:0018146)
0.1	0.4	GO:0007387	anterior compartment pattern formation(GO:0007387) posterior compartment specification(GO:0007388)
0.1	0.4	GO:0015910	peroxisomal long-chain fatty acid import(GO:0015910)
0.1	0.4	GO:0061626	pharyngeal arch artery morphogenesis(GO:0061626)
0.1	0.4	GO:0038195	urokinase plasminogen activator signaling pathway(GO:0038195)

Showing 1 to 10 of 535 entries

Gene overrepresentation in cellular_component category:

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Total log-likelihood	Term	Description
1.2	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
1.1	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.7	GO:0034707	chloride channel complex(GO:0034707)
0.6	GO:1902711	GABA-A receptor complex(GO:1902711)
0.5	GO:0071438	invadopodium membrane(GO:0071438)
0.5	GO:0045179	apical cortex(GO:0045179)
0.5	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.4	GO:0034688	integrin alphaM-beta2 complex(GO:0034688)
0.4	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.4	GO:0070652	HAUS complex(GO:0070652)

Showing 1 to 10 of 165 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	GO:0051430	corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0	0.9	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.8	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0	0.7	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	0.7	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	0.6	GO:0004890	GABA-A receptor activity(GO:0004890)
0.0	0.6	GO:0000146	microfilament motor activity(GO:0000146)
0.0	0.6	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.5	GO:0001851	complement component C3b binding(GO:0001851)
0.0	0.5	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)

Showing 1 to 10 of 284 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
1.8	SIG CHEMOTAXIS	Genes related to chemotaxis
1.2	PID RAS PATHWAY	Regulation of Ras family activation
1.0	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
1.0	PID BMP PATHWAY	BMP receptor signaling
0.8	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.7	PID S1P S1P1 PATHWAY	S1P1 pathway
0.7	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.6	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.6	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.5	PID GLYPICAN 1PATHWAY	Glypican 1 network

Showing 1 to 10 of 27 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
1.3	REACTOME L1CAM INTERACTIONS	Genes involved in L1CAM interactions
1.1	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
1.0	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.9	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.8	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.7	REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.6	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.6	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.6	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.6	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins

Showing 1 to 10 of 71 entries

Results for KLF8

Z-value: 1.20

Motif logo

Transcription factors associated with KLF8

Activity-expression correlation:

Activity profile of KLF8 motif

Sorted Z-values of KLF8 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF8

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: