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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for KLF7

Z-value: 0.35

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Transcription factors associated with KLF7

Gene Symbol Gene ID Gene Info
KLF7
ENSG00000118263.10 Kruppel like factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
KLF7hg19_v2_chr2_-_208030295_208030332-0.742.6e-01Click!

Activity profile of KLF7 motif

Sorted Z-values of KLF7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_19281787 0.13 ENST00000482850.1
MAPK7
mitogen-activated protein kinase 7
chr12_-_49581152 0.12 ENST00000550811.1
TUBA1A
tubulin, alpha 1a
chr1_-_157108266 0.12 ENST00000326786.4
ETV3
ets variant 3
chr12_-_49582593 0.12 ENST00000295766.5
TUBA1A
tubulin, alpha 1a
chr17_+_38375528 0.11 ENST00000583268.1
WIPF2
WAS/WASL interacting protein family, member 2
chr19_-_39390440 0.10 ENST00000249396.7
ENST00000414941.1
ENST00000392081.2
SIRT2
sirtuin 2
chr15_+_96873921 0.09 ENST00000394166.3
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr6_+_30585486 0.09 ENST00000259873.4
ENST00000506373.2
MRPS18B
mitochondrial ribosomal protein S18B
chr19_-_39390350 0.08 ENST00000447739.1
ENST00000358931.5
ENST00000407552.1
SIRT2
sirtuin 2
chr1_-_19229218 0.08 ENST00000432718.1
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr19_-_7694417 0.08 ENST00000358368.4
ENST00000534844.1
XAB2
XPA binding protein 2
chr20_-_2821271 0.08 ENST00000448755.1
ENST00000360652.2
PCED1A
PC-esterase domain containing 1A
chr12_-_49582837 0.08 ENST00000547939.1
ENST00000546918.1
ENST00000552924.1
TUBA1A
tubulin, alpha 1a
chr17_-_18218237 0.08 ENST00000542570.1
TOP3A
topoisomerase (DNA) III alpha
chr20_-_2821756 0.07 ENST00000356872.3
ENST00000439542.1
PCED1A
PC-esterase domain containing 1A
chr16_+_81772633 0.07 ENST00000566191.1
ENST00000565272.1
ENST00000563954.1
ENST00000565054.1
RP11-960L18.1
PLCG2
RP11-960L18.1
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr6_+_43603552 0.06 ENST00000372171.4
MAD2L1BP
MAD2L1 binding protein
chr17_+_41476327 0.06 ENST00000320033.4
ARL4D
ADP-ribosylation factor-like 4D
chr17_-_18218270 0.06 ENST00000321105.5
TOP3A
topoisomerase (DNA) III alpha
chr1_-_19229014 0.05 ENST00000538839.1
ENST00000290597.5
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr19_-_40931891 0.05 ENST00000357949.4
SERTAD1
SERTA domain containing 1
chr19_+_39390320 0.05 ENST00000576510.1
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr2_-_74710078 0.05 ENST00000290418.4
CCDC142
coiled-coil domain containing 142
chr9_+_130565147 0.05 ENST00000373247.2
ENST00000373245.1
ENST00000393706.2
ENST00000373228.1
FPGS
folylpolyglutamate synthase
chr1_-_19229248 0.05 ENST00000375341.3
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr8_+_72587535 0.05 ENST00000519840.1
ENST00000521131.1
RP11-1144P22.1
RP11-1144P22.1
chr22_-_30987849 0.04 ENST00000402284.3
ENST00000354694.7
PES1
pescadillo ribosomal biogenesis factor 1
chr22_-_30987837 0.04 ENST00000335214.6
PES1
pescadillo ribosomal biogenesis factor 1
chr2_+_113479063 0.04 ENST00000327581.4
NT5DC4
5'-nucleotidase domain containing 4
chr1_-_6453399 0.04 ENST00000608083.1
ACOT7
acyl-CoA thioesterase 7
chr19_+_39390587 0.04 ENST00000572515.1
ENST00000392079.3
ENST00000575359.1
ENST00000313582.5
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr8_+_17104401 0.04 ENST00000324815.3
ENST00000518038.1
VPS37A
vacuolar protein sorting 37 homolog A (S. cerevisiae)
chr1_-_21948906 0.03 ENST00000374761.2
ENST00000599760.1
RAP1GAP
RAP1 GTPase activating protein
chr5_+_141348598 0.03 ENST00000394520.2
ENST00000347642.3
RNF14
ring finger protein 14
chr19_-_14629224 0.03 ENST00000254322.2
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr5_+_141348721 0.03 ENST00000507163.1
ENST00000394519.1
RNF14
ring finger protein 14
chr9_+_130565487 0.02 ENST00000373225.3
ENST00000431857.1
FPGS
folylpolyglutamate synthase
chr11_+_18417948 0.02 ENST00000542179.1
LDHA
lactate dehydrogenase A
chr17_-_48277552 0.02 ENST00000507689.1
COL1A1
collagen, type I, alpha 1
chr1_-_6453426 0.02 ENST00000545482.1
ACOT7
acyl-CoA thioesterase 7
chr12_+_1099675 0.02 ENST00000545318.2
ERC1
ELKS/RAB6-interacting/CAST family member 1
chr17_+_38375574 0.01 ENST00000323571.4
ENST00000585043.1
ENST00000394103.3
ENST00000536600.1
WIPF2
WAS/WASL interacting protein family, member 2
chr3_-_33138624 0.01 ENST00000445488.2
ENST00000307377.8
ENST00000440656.1
ENST00000436768.1
ENST00000307363.5
GLB1
galactosidase, beta 1
chr16_+_20499024 0.01 ENST00000593357.1
AC137056.1
Uncharacterized protein; cDNA FLJ34659 fis, clone KIDNE2018863
chr6_-_33239612 0.01 ENST00000482399.1
ENST00000445902.2
VPS52
vacuolar protein sorting 52 homolog (S. cerevisiae)
chr6_+_33239787 0.01 ENST00000439602.2
ENST00000474973.1
RPS18
ribosomal protein S18
chr6_-_30585009 0.01 ENST00000376511.2
PPP1R10
protein phosphatase 1, regulatory subunit 10
chr2_+_74710194 0.01 ENST00000410003.1
ENST00000442235.2
ENST00000233623.5
TTC31
tetratricopeptide repeat domain 31
chr20_+_2821366 0.01 ENST00000453689.1
ENST00000417508.1
VPS16
vacuolar protein sorting 16 homolog (S. cerevisiae)
chr15_+_92937058 0.01 ENST00000268164.3
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr1_-_161102421 0.00 ENST00000490843.2
ENST00000368006.3
ENST00000392188.1
ENST00000545495.1
DEDD
death effector domain containing
chrX_-_92928557 0.00 ENST00000373079.3
ENST00000475430.2
NAP1L3
nucleosome assembly protein 1-like 3
chr14_+_29234870 0.00 ENST00000382535.3
FOXG1
forkhead box G1
chr9_+_130565568 0.00 ENST00000423577.1
FPGS
folylpolyglutamate synthase

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0070446 cellular response to caloric restriction(GO:0061433) negative regulation of oligodendrocyte progenitor proliferation(GO:0070446)
0.0 0.1 GO:0070376 regulation of ERK5 cascade(GO:0070376) negative regulation of ERK5 cascade(GO:0070377)
0.0 0.2 GO:0019470 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133) 4-hydroxyproline catabolic process(GO:0019470)
0.0 0.1 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.0 0.1 GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.0 0.1 GO:0009956 radial pattern formation(GO:0009956)
0.0 0.1 GO:0002316 follicular B cell differentiation(GO:0002316)
0.0 0.1 GO:1900535 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.2 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.1 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.1 GO:0071012 catalytic step 1 spliceosome(GO:0071012)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842)
0.1 0.2 GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0 0.1 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326) dihydrofolate synthase activity(GO:0008841)
0.0 0.1 GO:0003917 DNA topoisomerase type I activity(GO:0003917)