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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for ISL2

Z-value: 0.35

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Transcription factors associated with ISL2

Gene Symbol Gene ID Gene Info
ISL2
ENSG00000159556.5 ISL LIM homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ISL2hg19_v2_chr15_+_76629064_76629073-0.964.4e-02Click!

Activity profile of ISL2 motif

Sorted Z-values of ISL2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_87248975 0.17 ENST00000409310.2
ENST00000355705.3
PLGLB1
plasminogen-like B1
chr14_-_51027838 0.17 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr4_+_156775910 0.14 ENST00000506072.1
ENST00000507590.1
TDO2
tryptophan 2,3-dioxygenase
chr1_-_168464875 0.14 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr5_-_68339648 0.12 ENST00000479830.2
CTC-498J12.1
CTC-498J12.1
chr6_-_47445214 0.11 ENST00000604014.1
RP11-385F7.1
RP11-385F7.1
chr3_+_159943362 0.11 ENST00000326474.3
C3orf80
chromosome 3 open reading frame 80
chr10_-_115904361 0.10 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chr11_+_71544246 0.10 ENST00000328698.1
DEFB108B
defensin, beta 108B
chr4_+_128702969 0.09 ENST00000508776.1
ENST00000439123.2
HSPA4L
heat shock 70kDa protein 4-like
chr11_+_73498898 0.09 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr3_+_136649311 0.09 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chr6_-_138833630 0.09 ENST00000533765.1
NHSL1
NHS-like 1
chr17_-_4710288 0.09 ENST00000571067.1
RP11-81A22.5
RP11-81A22.5
chr11_+_327171 0.09 ENST00000534483.1
ENST00000524824.1
ENST00000531076.1
RP11-326C3.12
RP11-326C3.12
chr12_+_64798095 0.09 ENST00000332707.5
XPOT
exportin, tRNA
chr4_+_113568207 0.09 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr3_-_141747950 0.09 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chrX_-_84634708 0.08 ENST00000373145.3
POF1B
premature ovarian failure, 1B
chr12_+_64798826 0.08 ENST00000540203.1
XPOT
exportin, tRNA
chr3_-_193096600 0.08 ENST00000446087.1
ENST00000342358.4
ATP13A5
ATPase type 13A5
chr15_+_79166065 0.08 ENST00000559690.1
ENST00000559158.1
MORF4L1
mortality factor 4 like 1
chr10_+_63422695 0.08 ENST00000330194.2
ENST00000389639.3
C10orf107
chromosome 10 open reading frame 107
chr12_+_122356488 0.07 ENST00000397454.2
WDR66
WD repeat domain 66
chr1_-_223853425 0.07 ENST00000366873.2
ENST00000419193.2
CAPN8
calpain 8
chr13_+_78315348 0.07 ENST00000441784.1
SLAIN1
SLAIN motif family, member 1
chr3_+_172468472 0.07 ENST00000232458.5
ENST00000392692.3
ECT2
epithelial cell transforming sequence 2 oncogene
chr2_-_190446738 0.07 ENST00000427419.1
ENST00000455320.1
SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr1_-_238108575 0.06 ENST00000604646.1
MTRNR2L11
MT-RNR2-like 11 (pseudogene)
chrX_-_84634737 0.06 ENST00000262753.4
POF1B
premature ovarian failure, 1B
chr3_+_139063372 0.06 ENST00000478464.1
MRPS22
mitochondrial ribosomal protein S22
chr1_-_223853348 0.06 ENST00000366872.5
CAPN8
calpain 8
chr3_+_172468505 0.06 ENST00000427830.1
ENST00000417960.1
ENST00000428567.1
ENST00000366090.2
ENST00000426894.1
ECT2
epithelial cell transforming sequence 2 oncogene
chr12_+_104337515 0.06 ENST00000550595.1
HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr16_-_3350614 0.06 ENST00000268674.2
TIGD7
tigger transposable element derived 7
chr14_-_73997901 0.06 ENST00000557603.1
ENST00000556455.1
HEATR4
HEAT repeat containing 4
chr12_-_58212487 0.06 ENST00000549994.1
AVIL
advillin
chr4_+_26344754 0.06 ENST00000515573.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr7_-_151330218 0.05 ENST00000476632.1
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr17_+_1674982 0.05 ENST00000572048.1
ENST00000573763.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr15_-_98417780 0.05 ENST00000503874.3
LINC00923
long intergenic non-protein coding RNA 923
chr1_+_171227069 0.05 ENST00000354841.4
FMO1
flavin containing monooxygenase 1
chr4_+_169013666 0.05 ENST00000359299.3
ANXA10
annexin A10
chr19_+_49199209 0.05 ENST00000522966.1
ENST00000425340.2
ENST00000391876.4
FUT2
fucosyltransferase 2 (secretor status included)
chr11_-_92931098 0.05 ENST00000326402.4
SLC36A4
solute carrier family 36 (proton/amino acid symporter), member 4
chr3_+_138327542 0.05 ENST00000360570.3
ENST00000393035.2
FAIM
Fas apoptotic inhibitory molecule
chr12_-_118628350 0.05 ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr12_+_75784850 0.05 ENST00000550916.1
ENST00000435775.1
ENST00000378689.2
ENST00000378692.3
ENST00000320460.4
ENST00000547164.1
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr7_-_107883678 0.05 ENST00000417701.1
NRCAM
neuronal cell adhesion molecule
chr15_-_83378638 0.05 ENST00000261722.3
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr5_+_110427983 0.05 ENST00000513710.2
ENST00000505303.1
WDR36
WD repeat domain 36
chr10_-_128359074 0.05 ENST00000544758.1
C10orf90
chromosome 10 open reading frame 90
chr3_-_191000172 0.05 ENST00000427544.2
UTS2B
urotensin 2B
chr6_+_64345698 0.04 ENST00000506783.1
ENST00000481385.2
ENST00000515594.1
ENST00000494284.2
ENST00000262043.3
PHF3
PHD finger protein 3
chr6_-_24358264 0.04 ENST00000378454.3
DCDC2
doublecortin domain containing 2
chr21_-_30445886 0.04 ENST00000431234.1
ENST00000540844.1
ENST00000286788.4
CCT8
chaperonin containing TCP1, subunit 8 (theta)
chr10_-_27529486 0.04 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr3_+_138327417 0.04 ENST00000338446.4
FAIM
Fas apoptotic inhibitory molecule
chrX_+_108779004 0.04 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr3_-_183145873 0.04 ENST00000447025.2
ENST00000414362.2
ENST00000328913.3
MCF2L2
MCF.2 cell line derived transforming sequence-like 2
chr5_+_40841410 0.04 ENST00000381677.3
CARD6
caspase recruitment domain family, member 6
chr4_-_122085469 0.04 ENST00000057513.3
TNIP3
TNFAIP3 interacting protein 3
chr16_+_53133070 0.04 ENST00000565832.1
CHD9
chromodomain helicase DNA binding protein 9
chr11_+_86085778 0.04 ENST00000354755.1
ENST00000278487.3
ENST00000531271.1
ENST00000445632.2
CCDC81
coiled-coil domain containing 81
chr4_+_25162253 0.04 ENST00000512921.1
PI4K2B
phosphatidylinositol 4-kinase type 2 beta
chrM_+_9207 0.04 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr12_-_110937351 0.04 ENST00000552130.2
VPS29
vacuolar protein sorting 29 homolog (S. cerevisiae)
chr2_-_159237472 0.04 ENST00000409187.1
CCDC148
coiled-coil domain containing 148
chr5_-_130500922 0.04 ENST00000513012.1
ENST00000508488.1
ENST00000506908.1
ENST00000304043.5
HINT1
histidine triad nucleotide binding protein 1
chr6_+_29555683 0.03 ENST00000383640.2
OR2H2
olfactory receptor, family 2, subfamily H, member 2
chr4_+_26324474 0.03 ENST00000514675.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr8_+_38662960 0.03 ENST00000524193.1
TACC1
transforming, acidic coiled-coil containing protein 1
chr4_-_69111401 0.03 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr2_+_88047606 0.03 ENST00000359481.4
PLGLB2
plasminogen-like B2
chr4_+_95128748 0.03 ENST00000359052.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr3_-_20227619 0.03 ENST00000425061.1
ENST00000443724.1
ENST00000421451.1
ENST00000452020.1
ENST00000417364.1
ENST00000306698.2
ENST00000419233.2
ENST00000263753.4
ENST00000383774.1
ENST00000437051.1
ENST00000412868.1
ENST00000429446.3
ENST00000442720.1
SGOL1
shugoshin-like 1 (S. pombe)
chrX_+_102840408 0.03 ENST00000468024.1
ENST00000472484.1
ENST00000415568.2
ENST00000490644.1
ENST00000459722.1
ENST00000472745.1
ENST00000494801.1
ENST00000434216.2
ENST00000425011.1
TCEAL4
transcription elongation factor A (SII)-like 4
chr15_-_75748115 0.03 ENST00000360439.4
SIN3A
SIN3 transcription regulator family member A
chr12_-_95945246 0.03 ENST00000258499.3
USP44
ubiquitin specific peptidase 44
chr1_-_95391315 0.03 ENST00000545882.1
ENST00000415017.1
CNN3
calponin 3, acidic
chr1_+_66820058 0.03 ENST00000480109.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr17_-_33390667 0.03 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
RFFL
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr9_-_99540328 0.03 ENST00000223428.4
ENST00000375231.1
ENST00000374641.3
ZNF510
zinc finger protein 510
chr6_-_111804905 0.03 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr14_-_74025625 0.03 ENST00000553558.1
ENST00000563329.1
ENST00000334988.2
ENST00000560393.1
HEATR4
HEAT repeat containing 4
chr11_-_28129656 0.03 ENST00000263181.6
KIF18A
kinesin family member 18A
chr14_-_60043524 0.03 ENST00000537690.2
ENST00000281581.4
CCDC175
coiled-coil domain containing 175
chr12_-_12715266 0.03 ENST00000228862.2
DUSP16
dual specificity phosphatase 16
chr7_-_55930443 0.03 ENST00000388975.3
SEPT14
septin 14
chr2_+_86669118 0.03 ENST00000427678.1
ENST00000542128.1
KDM3A
lysine (K)-specific demethylase 3A
chr2_-_231860596 0.02 ENST00000441063.1
ENST00000434094.1
ENST00000418330.1
ENST00000457803.1
ENST00000414876.1
ENST00000446741.1
ENST00000426904.1
AC105344.2
SPATA3 antisense RNA 1 (head to head)
chr1_-_174992544 0.02 ENST00000476371.1
MRPS14
mitochondrial ribosomal protein S14
chr16_+_28565230 0.02 ENST00000317058.3
CCDC101
coiled-coil domain containing 101
chr2_+_231921574 0.02 ENST00000308696.6
ENST00000373635.4
ENST00000440838.1
ENST00000409643.1
PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr2_-_169887827 0.02 ENST00000263817.6
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr2_-_85108363 0.02 ENST00000335459.5
TRABD2A
TraB domain containing 2A
chr10_-_29923893 0.02 ENST00000355867.4
SVIL
supervillin
chr4_+_95128996 0.02 ENST00000457823.2
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr4_+_86525299 0.02 ENST00000512201.1
ARHGAP24
Rho GTPase activating protein 24
chr2_-_10587897 0.02 ENST00000405333.1
ENST00000443218.1
ODC1
ornithine decarboxylase 1
chr17_-_48785216 0.02 ENST00000285243.6
ANKRD40
ankyrin repeat domain 40
chr11_-_107729887 0.02 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr9_-_100854838 0.02 ENST00000538344.1
TRIM14
tripartite motif containing 14
chr21_+_39644395 0.02 ENST00000398934.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr15_-_75748143 0.02 ENST00000568431.1
ENST00000568309.1
ENST00000568190.1
ENST00000570115.1
ENST00000564778.1
SIN3A
SIN3 transcription regulator family member A
chr15_+_58702742 0.02 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr11_-_327537 0.02 ENST00000602735.1
IFITM3
interferon induced transmembrane protein 3
chr10_-_95242044 0.02 ENST00000371501.4
ENST00000371502.4
ENST00000371489.1
MYOF
myoferlin
chr1_+_109265033 0.02 ENST00000445274.1
FNDC7
fibronectin type III domain containing 7
chr9_-_21482312 0.02 ENST00000448696.3
IFNE
interferon, epsilon
chrX_-_119077695 0.02 ENST00000371410.3
NKAP
NFKB activating protein
chr17_-_47786375 0.02 ENST00000511657.1
SLC35B1
solute carrier family 35, member B1
chrX_-_21676442 0.01 ENST00000379499.2
KLHL34
kelch-like family member 34
chr8_+_133909919 0.01 ENST00000518505.1
TG
thyroglobulin
chr6_+_151561085 0.01 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr14_+_57671888 0.01 ENST00000391612.1
AL391152.1
AL391152.1
chrX_-_32173579 0.01 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD
dystrophin
chr1_-_93257951 0.01 ENST00000543509.1
ENST00000370331.1
ENST00000540033.1
EVI5
ecotropic viral integration site 5
chr6_+_42989344 0.01 ENST00000244496.5
RRP36
ribosomal RNA processing 36 homolog (S. cerevisiae)
chr13_+_49551020 0.01 ENST00000541916.1
FNDC3A
fibronectin type III domain containing 3A
chr7_-_16844611 0.01 ENST00000401412.1
ENST00000419304.2
AGR2
anterior gradient 2
chr15_+_48483736 0.01 ENST00000417307.2
ENST00000559641.1
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
chr11_-_62521614 0.01 ENST00000527994.1
ENST00000394807.3
ZBTB3
zinc finger and BTB domain containing 3
chr10_-_95241951 0.01 ENST00000358334.5
ENST00000359263.4
ENST00000371488.3
MYOF
myoferlin
chr12_+_14369524 0.01 ENST00000538329.1
RP11-134N1.2
RP11-134N1.2
chr7_+_123241908 0.01 ENST00000434204.1
ENST00000437535.1
ENST00000451215.1
ASB15
ankyrin repeat and SOCS box containing 15
chr18_-_3845321 0.01 ENST00000539435.1
ENST00000400147.2
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr18_-_64271316 0.01 ENST00000540086.1
ENST00000580157.1
CDH19
cadherin 19, type 2
chr2_-_145277569 0.01 ENST00000303660.4
ZEB2
zinc finger E-box binding homeobox 2
chr7_-_81635106 0.01 ENST00000443883.1
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr1_+_99127225 0.01 ENST00000370189.5
ENST00000529992.1
SNX7
sorting nexin 7
chr2_-_217560248 0.01 ENST00000233813.4
IGFBP5
insulin-like growth factor binding protein 5
chr15_-_42500351 0.01 ENST00000348544.4
ENST00000318006.5
VPS39
vacuolar protein sorting 39 homolog (S. cerevisiae)
chr11_+_28129795 0.01 ENST00000406787.3
ENST00000342303.5
ENST00000403099.1
ENST00000407364.3
METTL15
methyltransferase like 15
chr11_+_12132117 0.01 ENST00000256194.4
MICAL2
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr2_+_128177253 0.01 ENST00000427769.1
PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr5_-_54988448 0.00 ENST00000503817.1
ENST00000512595.1
SLC38A9
solute carrier family 38, member 9
chr12_+_26164645 0.00 ENST00000542004.1
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr2_-_166060382 0.00 ENST00000409101.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr21_+_39644305 0.00 ENST00000398930.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr15_+_64680003 0.00 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr14_+_45605157 0.00 ENST00000542564.2
FANCM
Fanconi anemia, complementation group M
chr2_+_234580499 0.00 ENST00000354728.4
UGT1A9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr8_-_30706608 0.00 ENST00000256246.2
TEX15
testis expressed 15
chr18_+_61575200 0.00 ENST00000238508.3
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr5_+_57787254 0.00 ENST00000502276.1
ENST00000396776.2
ENST00000511930.1
GAPT
GRB2-binding adaptor protein, transmembrane
chr1_-_232651312 0.00 ENST00000262861.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr4_+_169418195 0.00 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.0 0.1 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.0 0.1 GO:0031247 actin rod assembly(GO:0031247)
0.0 0.1 GO:0070839 regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) divalent metal ion export(GO:0070839)
0.0 0.1 GO:1901297 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.1 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0001534 radial spoke(GO:0001534)
0.0 0.1 GO:0097149 centralspindlin complex(GO:0097149)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.0 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME BETA DEFENSINS Genes involved in Beta defensins