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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for IRF7
Z-value: 0.93
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Transcription factors associated with IRF7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF7 | hg19_v2_chr11_-_615942_615999 | -0.34 | 6.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_39759154 Show fit | 0.76 |
ENST00000331982.5
|
interferon, lambda 2 |
|
| chr10_+_91061712 Show fit | 0.56 |
ENST00000371826.3
|
interferon-induced protein with tetratricopeptide repeats 2 |
|
| chr17_-_40264692 Show fit | 0.44 |
ENST00000591220.1
ENST00000251642.3 |
DEXH (Asp-Glu-X-His) box polypeptide 58 |
|
| chr19_-_39735646 Show fit | 0.44 |
ENST00000413851.2
|
interferon, lambda 3 |
|
| chr17_-_40264321 Show fit | 0.39 |
ENST00000430773.1
ENST00000413196.2 |
DEXH (Asp-Glu-X-His) box polypeptide 58 |
|
| chr2_-_152118276 Show fit | 0.34 |
ENST00000409092.1
|
RNA binding motif protein 43 |
|
| chr17_-_67057047 Show fit | 0.31 |
ENST00000495634.1
ENST00000453985.2 ENST00000585714.1 |
ATP-binding cassette, sub-family A (ABC1), member 9 |
|
| chr19_+_39786962 Show fit | 0.31 |
ENST00000333625.2
|
interferon, lambda 1 |
|
| chr10_+_91152303 Show fit | 0.31 |
ENST00000371804.3
|
interferon-induced protein with tetratricopeptide repeats 1 |
|
| chr2_-_231084617 Show fit | 0.30 |
ENST00000409815.2
|
SP110 nuclear body protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF7
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.2 | 0.8 | GO:0039534 | negative regulation of MDA-5 signaling pathway(GO:0039534) |
| 0.0 | 0.6 | GO:0002385 | mucosal immune response(GO:0002385) |
| 0.1 | 0.5 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
| 0.0 | 0.5 | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) |
| 0.1 | 0.4 | GO:0060629 | meiotic DNA double-strand break formation(GO:0042138) regulation of homologous chromosome segregation(GO:0060629) |
| 0.1 | 0.4 | GO:0034344 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.0 | 0.4 | GO:1904896 | ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903) |
| 0.1 | 0.3 | GO:0032714 | negative regulation of interleukin-5 production(GO:0032714) |
| 0.1 | 0.3 | GO:0006147 | guanine catabolic process(GO:0006147) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.1 | 0.3 | GO:0032002 | interleukin-28 receptor complex(GO:0032002) |
| 0.1 | 0.3 | GO:0031906 | late endosome lumen(GO:0031906) |
| 0.0 | 0.3 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 0.2 | GO:1902737 | dendritic filopodium(GO:1902737) |
| 0.1 | 0.2 | GO:0031213 | RSF complex(GO:0031213) |
| 0.1 | 0.2 | GO:0018444 | translation release factor complex(GO:0018444) |
| 0.0 | 0.2 | GO:0097179 | protease inhibitor complex(GO:0097179) |
| 0.0 | 0.2 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) |
| 0.0 | 0.2 | GO:0008537 | proteasome activator complex(GO:0008537) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.1 | 0.3 | GO:0008892 | guanine deaminase activity(GO:0008892) |
| 0.0 | 0.3 | GO:0005143 | interleukin-12 receptor binding(GO:0005143) |
| 0.0 | 0.3 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.0 | 0.2 | GO:0047757 | chondroitin-glucuronate 5-epimerase activity(GO:0047757) |
| 0.0 | 0.2 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.0 | 0.2 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.0 | 0.2 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.0 | 0.2 | GO:0008079 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.0 | 0.2 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 0.2 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 0.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.7 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 0.5 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 0.3 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.1 | 0.2 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.0 | 0.2 | REACTOME ACTIVATED POINT MUTANTS OF FGFR2 | Genes involved in Activated point mutants of FGFR2 |
| 0.0 | 0.1 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |