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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for IRF6_IRF4_IRF5

Z-value: 0.91

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Transcription factors associated with IRF6_IRF4_IRF5

Gene Symbol Gene ID Gene Info
IRF6
ENSG00000117595.6 interferon regulatory factor 6
IRF4
ENSG00000137265.10 interferon regulatory factor 4
IRF5
ENSG00000128604.14 interferon regulatory factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF5hg19_v2_chr7_+_128577972_128578047-0.356.5e-01Click!
IRF6hg19_v2_chr1_-_209979375_209979389-0.277.3e-01Click!
IRF4hg19_v2_chr6_+_391739_391759-0.059.5e-01Click!

Activity profile of IRF6_IRF4_IRF5 motif

Sorted Z-values of IRF6_IRF4_IRF5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_16254488 0.53 ENST00000588246.1
ENST00000593031.1
HSH2D
hematopoietic SH2 domain containing
chr17_+_6659153 0.37 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr9_+_111696664 0.35 ENST00000374624.3
ENST00000445175.1
FAM206A
family with sequence similarity 206, member A
chr17_+_25958174 0.33 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
LGALS9
lectin, galactoside-binding, soluble, 9
chr16_+_53412368 0.29 ENST00000565189.1
RP11-44F14.2
RP11-44F14.2
chr20_+_20033158 0.28 ENST00000340348.6
ENST00000377309.2
ENST00000389656.3
ENST00000377306.1
ENST00000245957.5
ENST00000377303.2
ENST00000475466.1
C20orf26
chromosome 20 open reading frame 26
chr15_+_23810903 0.28 ENST00000564592.1
MKRN3
makorin ring finger protein 3
chr3_-_146262352 0.26 ENST00000462666.1
PLSCR1
phospholipid scramblase 1
chr17_+_46908350 0.25 ENST00000258947.3
ENST00000509507.1
ENST00000448105.2
ENST00000570513.1
ENST00000509415.1
ENST00000513119.1
ENST00000416445.2
ENST00000508679.1
ENST00000505071.1
CALCOCO2
calcium binding and coiled-coil domain 2
chr9_-_32526184 0.25 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr12_+_113344755 0.25 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr15_-_45670717 0.25 ENST00000558163.1
ENST00000558336.1
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr3_-_146262365 0.24 ENST00000448787.2
PLSCR1
phospholipid scramblase 1
chr1_-_168464875 0.21 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr2_-_7005785 0.20 ENST00000256722.5
ENST00000404168.1
ENST00000458098.1
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr16_+_3062457 0.20 ENST00000445369.2
CLDN9
claudin 9
chr12_+_46123682 0.19 ENST00000422737.1
ARID2
AT rich interactive domain 2 (ARID, RFX-like)
chrM_+_9207 0.19 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr12_+_46123448 0.18 ENST00000334344.6
ARID2
AT rich interactive domain 2 (ARID, RFX-like)
chr15_-_30114231 0.18 ENST00000356107.6
ENST00000545208.2
TJP1
tight junction protein 1
chr2_-_37384175 0.18 ENST00000411537.2
ENST00000233057.4
ENST00000395127.2
ENST00000390013.3
EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2
chr16_-_74734672 0.17 ENST00000306247.7
ENST00000575686.1
MLKL
mixed lineage kinase domain-like
chr9_-_32526299 0.17 ENST00000379882.1
ENST00000379883.2
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr14_-_102552659 0.17 ENST00000441629.2
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr17_+_18380051 0.17 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
LGALS9C
lectin, galactoside-binding, soluble, 9C
chr1_+_179263308 0.17 ENST00000426956.1
SOAT1
sterol O-acyltransferase 1
chr20_-_20033052 0.17 ENST00000536226.1
CRNKL1
crooked neck pre-mRNA splicing factor 1
chr7_-_130597935 0.16 ENST00000447307.1
ENST00000418546.1
MIR29B1
microRNA 29a
chr7_+_12250833 0.16 ENST00000396668.3
TMEM106B
transmembrane protein 106B
chr1_+_59486129 0.15 ENST00000438195.1
ENST00000424308.1
RP4-794H19.4
RP4-794H19.4
chr2_-_152118276 0.15 ENST00000409092.1
RBM43
RNA binding motif protein 43
chr14_+_31046959 0.15 ENST00000547532.1
ENST00000555429.1
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr2_-_163175133 0.14 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr15_+_23810853 0.14 ENST00000568252.1
MKRN3
makorin ring finger protein 3
chr9_+_95820966 0.14 ENST00000375472.3
ENST00000465709.1
SUSD3
sushi domain containing 3
chr11_-_321340 0.14 ENST00000526811.1
IFITM3
interferon induced transmembrane protein 3
chr12_-_51663682 0.14 ENST00000603838.1
SMAGP
small cell adhesion glycoprotein
chrX_-_45710920 0.14 ENST00000456532.1
RP5-1158E12.3
RP5-1158E12.3
chr7_+_12250886 0.13 ENST00000444443.1
ENST00000396667.3
TMEM106B
transmembrane protein 106B
chr12_+_113344582 0.13 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr4_+_57371509 0.13 ENST00000360096.2
ARL9
ADP-ribosylation factor-like 9
chr15_+_90895471 0.13 ENST00000354377.3
ENST00000379090.5
ZNF774
zinc finger protein 774
chr6_-_86353510 0.13 ENST00000444272.1
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr7_+_151038850 0.13 ENST00000355851.4
ENST00000566856.1
ENST00000470229.1
NUB1
negative regulator of ubiquitin-like proteins 1
chr4_-_18023350 0.13 ENST00000539056.1
ENST00000382226.5
ENST00000326877.4
LCORL
ligand dependent nuclear receptor corepressor-like
chr14_+_94577074 0.12 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
IFI27
interferon, alpha-inducible protein 27
chr11_+_695787 0.12 ENST00000526170.1
ENST00000488769.1
TMEM80
transmembrane protein 80
chr3_-_179169181 0.11 ENST00000497513.1
GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr15_-_30113676 0.11 ENST00000400011.2
TJP1
tight junction protein 1
chr4_-_164534657 0.11 ENST00000339875.5
MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr1_+_210111534 0.11 ENST00000422431.1
ENST00000534859.1
ENST00000399639.2
ENST00000537238.1
SYT14
synaptotagmin XIV
chr15_-_52263937 0.11 ENST00000315141.5
ENST00000299601.5
LEO1
Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr3_+_154797781 0.11 ENST00000382989.3
MME
membrane metallo-endopeptidase
chr12_+_69004619 0.10 ENST00000250559.9
ENST00000393436.5
ENST00000425247.2
ENST00000489473.2
ENST00000422358.2
ENST00000541167.1
ENST00000538283.1
ENST00000341355.5
ENST00000537460.1
ENST00000450214.2
ENST00000545270.1
ENST00000538980.1
ENST00000542018.1
ENST00000543393.1
RAP1B
RAP1B, member of RAS oncogene family
chr3_-_182880541 0.10 ENST00000470251.1
ENST00000265598.3
LAMP3
lysosomal-associated membrane protein 3
chr4_-_77134742 0.10 ENST00000452464.2
SCARB2
scavenger receptor class B, member 2
chr2_-_32390801 0.10 ENST00000608489.1
RP11-563N4.1
RP11-563N4.1
chr4_-_104119488 0.10 ENST00000514974.1
CENPE
centromere protein E, 312kDa
chr4_+_144258021 0.10 ENST00000262994.4
GAB1
GRB2-associated binding protein 1
chr10_+_91061712 0.10 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr6_+_32937083 0.10 ENST00000456339.1
BRD2
bromodomain containing 2
chr17_+_41363854 0.09 ENST00000588693.1
ENST00000588659.1
ENST00000541594.1
ENST00000536052.1
ENST00000331615.3
TMEM106A
transmembrane protein 106A
chr1_-_238108575 0.09 ENST00000604646.1
MTRNR2L11
MT-RNR2-like 11 (pseudogene)
chr17_-_7164410 0.09 ENST00000574070.1
CLDN7
claudin 7
chr3_+_45430105 0.09 ENST00000430399.1
LARS2
leucyl-tRNA synthetase 2, mitochondrial
chr1_-_78225374 0.09 ENST00000524536.1
USP33
ubiquitin specific peptidase 33
chr15_-_75748115 0.09 ENST00000360439.4
SIN3A
SIN3 transcription regulator family member A
chr1_-_54411255 0.09 ENST00000371377.3
HSPB11
heat shock protein family B (small), member 11
chr21_+_42792442 0.09 ENST00000398600.2
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr11_-_57335280 0.09 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr3_+_159706537 0.09 ENST00000305579.2
ENST00000480787.1
ENST00000466512.1
IL12A
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
chr6_+_53794780 0.08 ENST00000505762.1
ENST00000511369.1
ENST00000431554.2
MLIP
RP11-411K7.1
muscular LMNA-interacting protein
RP11-411K7.1
chr2_-_99797473 0.08 ENST00000409107.1
ENST00000289359.2
MITD1
MIT, microtubule interacting and transport, domain containing 1
chr4_+_69917078 0.08 ENST00000502942.1
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr3_-_122283424 0.08 ENST00000477522.2
ENST00000360356.2
PARP9
poly (ADP-ribose) polymerase family, member 9
chr3_+_118892411 0.08 ENST00000479520.1
ENST00000494855.1
UPK1B
uroplakin 1B
chr12_+_69004805 0.08 ENST00000541216.1
RAP1B
RAP1B, member of RAS oncogene family
chr13_-_100624012 0.08 ENST00000267294.4
ZIC5
Zic family member 5
chr8_+_22601 0.08 ENST00000522481.3
ENST00000518652.1
AC144568.2
Uncharacterized protein
chr2_-_55920952 0.08 ENST00000447944.2
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr15_-_89764929 0.08 ENST00000268125.5
RLBP1
retinaldehyde binding protein 1
chr4_-_104119528 0.08 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chr7_-_138794081 0.08 ENST00000464606.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr3_-_122283079 0.08 ENST00000471785.1
ENST00000466126.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr5_-_159846066 0.07 ENST00000519349.1
ENST00000520664.1
SLU7
SLU7 splicing factor homolog (S. cerevisiae)
chr1_-_53018654 0.07 ENST00000257177.4
ENST00000355809.4
ENST00000528642.1
ENST00000470626.1
ENST00000371544.3
ZCCHC11
zinc finger, CCHC domain containing 11
chr5_+_68788594 0.07 ENST00000396442.2
ENST00000380766.2
OCLN
occludin
chr12_-_10978957 0.07 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr4_-_75719896 0.07 ENST00000395743.3
BTC
betacellulin
chr2_-_111435610 0.07 ENST00000447014.1
ENST00000420328.1
ENST00000535254.1
ENST00000409311.1
ENST00000302759.6
BUB1
BUB1 mitotic checkpoint serine/threonine kinase
chr5_+_56205878 0.07 ENST00000423328.1
SETD9
SET domain containing 9
chr19_-_50528392 0.07 ENST00000600137.1
ENST00000597215.1
VRK3
vaccinia related kinase 3
chr5_+_118407053 0.07 ENST00000311085.8
ENST00000539542.1
DMXL1
Dmx-like 1
chr18_+_22006646 0.07 ENST00000585067.1
ENST00000578221.1
IMPACT
impact RWD domain protein
chr1_-_154167124 0.07 ENST00000515609.1
TPM3
tropomyosin 3
chr8_-_101962777 0.07 ENST00000395951.3
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr4_+_144257915 0.07 ENST00000262995.4
GAB1
GRB2-associated binding protein 1
chr10_+_91174314 0.07 ENST00000371795.4
IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chrX_+_23801280 0.07 ENST00000379251.3
ENST00000379253.3
ENST00000379254.1
ENST00000379270.4
SAT1
spermidine/spermine N1-acetyltransferase 1
chr9_+_33264861 0.07 ENST00000223500.8
CHMP5
charged multivesicular body protein 5
chr14_-_45603657 0.07 ENST00000396062.3
FKBP3
FK506 binding protein 3, 25kDa
chr9_+_33265011 0.06 ENST00000419016.2
CHMP5
charged multivesicular body protein 5
chr3_-_108308241 0.06 ENST00000295746.8
KIAA1524
KIAA1524
chr19_-_3029011 0.06 ENST00000590536.1
ENST00000587137.1
ENST00000455444.2
ENST00000262953.6
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr1_-_25558984 0.06 ENST00000236273.4
SYF2
SYF2 pre-mRNA-splicing factor
chr2_-_99797390 0.06 ENST00000422537.2
MITD1
MIT, microtubule interacting and transport, domain containing 1
chr5_-_79946820 0.06 ENST00000604882.1
MTRNR2L2
MT-RNR2-like 2
chr1_-_25558963 0.06 ENST00000354361.3
SYF2
SYF2 pre-mRNA-splicing factor
chr17_+_6659354 0.06 ENST00000574907.1
XAF1
XIAP associated factor 1
chr21_+_42798094 0.06 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr1_+_78354330 0.06 ENST00000440324.1
NEXN
nexilin (F actin binding protein)
chr8_+_62737875 0.06 ENST00000523042.1
ENST00000518593.1
ENST00000519452.1
ENST00000519967.1
RP11-705O24.1
RP11-705O24.1
chr4_+_89378261 0.06 ENST00000264350.3
HERC5
HECT and RLD domain containing E3 ubiquitin protein ligase 5
chrX_+_154610428 0.06 ENST00000354514.4
H2AFB2
H2A histone family, member B2
chr10_+_114710516 0.06 ENST00000542695.1
ENST00000346198.4
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr6_+_139349817 0.06 ENST00000367660.3
ABRACL
ABRA C-terminal like
chr4_-_83295296 0.06 ENST00000507010.1
ENST00000503822.1
HNRNPD
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
chr7_-_138794394 0.06 ENST00000242351.5
ENST00000471652.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chrX_+_19373700 0.06 ENST00000379804.1
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr11_-_321050 0.06 ENST00000399808.4
IFITM3
interferon induced transmembrane protein 3
chr21_-_34914394 0.06 ENST00000361093.5
ENST00000381815.4
GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
chrX_-_85302531 0.06 ENST00000537751.1
ENST00000358786.4
ENST00000357749.2
CHM
choroideremia (Rab escort protein 1)
chr2_-_197664366 0.06 ENST00000409364.3
ENST00000263956.3
GTF3C3
general transcription factor IIIC, polypeptide 3, 102kDa
chr3_-_146262428 0.06 ENST00000486631.1
PLSCR1
phospholipid scramblase 1
chr19_-_17516449 0.06 ENST00000252593.6
BST2
bone marrow stromal cell antigen 2
chr3_-_96337000 0.06 ENST00000600213.2
MTRNR2L12
MT-RNR2-like 12 (pseudogene)
chr14_-_61190754 0.06 ENST00000216513.4
SIX4
SIX homeobox 4
chr3_-_146262637 0.05 ENST00000472349.1
ENST00000342435.4
PLSCR1
phospholipid scramblase 1
chr1_-_89357179 0.05 ENST00000448623.1
ENST00000418217.1
ENST00000370500.5
GTF2B
general transcription factor IIB
chr19_+_52264449 0.05 ENST00000599326.1
ENST00000598953.1
FPR2
formyl peptide receptor 2
chr3_-_113464906 0.05 ENST00000477813.1
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr2_-_198299726 0.05 ENST00000409915.4
ENST00000487698.1
ENST00000414963.2
ENST00000335508.6
SF3B1
splicing factor 3b, subunit 1, 155kDa
chr8_+_72755367 0.05 ENST00000537896.1
RP11-383H13.1
Protein LOC100132891; cDNA FLJ53548
chr8_+_22102626 0.05 ENST00000519237.1
ENST00000397802.4
POLR3D
polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
chr11_+_130184888 0.05 ENST00000602376.1
ENST00000532116.3
ENST00000602310.1
RP11-121M22.1
RP11-121M22.1
chr7_-_33080506 0.05 ENST00000381626.2
ENST00000409467.1
ENST00000449201.1
NT5C3A
5'-nucleotidase, cytosolic IIIA
chr10_+_91174486 0.05 ENST00000416601.1
IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chr14_-_103989033 0.05 ENST00000553878.1
ENST00000557530.1
CKB
creatine kinase, brain
chr9_+_112542572 0.05 ENST00000374530.3
PALM2-AKAP2
PALM2-AKAP2 readthrough
chr12_-_51664058 0.05 ENST00000605627.1
SMAGP
small cell adhesion glycoprotein
chr10_+_121410882 0.05 ENST00000369085.3
BAG3
BCL2-associated athanogene 3
chr6_-_100016678 0.05 ENST00000523799.1
ENST00000520429.1
CCNC
cyclin C
chr18_-_812231 0.05 ENST00000314574.4
YES1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr5_+_138678131 0.05 ENST00000394795.2
ENST00000510080.1
PAIP2
poly(A) binding protein interacting protein 2
chr1_-_52344416 0.05 ENST00000544028.1
NRD1
nardilysin (N-arginine dibasic convertase)
chr21_+_42797958 0.05 ENST00000419044.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr11_+_65554493 0.05 ENST00000335987.3
OVOL1
ovo-like zinc finger 1
chr6_+_32936942 0.05 ENST00000496118.2
BRD2
bromodomain containing 2
chr4_-_88141755 0.05 ENST00000273963.5
KLHL8
kelch-like family member 8
chr15_+_41136586 0.05 ENST00000431806.1
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr19_+_36705504 0.05 ENST00000456324.1
ZNF146
zinc finger protein 146
chrX_-_48858667 0.05 ENST00000376423.4
ENST00000376441.1
GRIPAP1
GRIP1 associated protein 1
chr11_-_615570 0.05 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr21_+_42798124 0.05 ENST00000417963.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chrX_-_77041685 0.05 ENST00000373344.5
ENST00000395603.3
ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr14_+_89029336 0.05 ENST00000556945.1
ENST00000556158.1
ENST00000557607.1
ZC3H14
zinc finger CCCH-type containing 14
chr12_+_75874984 0.05 ENST00000550491.1
GLIPR1
GLI pathogenesis-related 1
chr1_+_179262905 0.05 ENST00000539888.1
ENST00000540564.1
ENST00000535686.1
ENST00000367619.3
SOAT1
sterol O-acyltransferase 1
chrX_-_48858630 0.04 ENST00000376425.3
ENST00000376444.3
GRIPAP1
GRIP1 associated protein 1
chr20_+_48789087 0.04 ENST00000427333.1
RP11-112L6.4
RP11-112L6.4
chr12_-_122712038 0.04 ENST00000413918.1
ENST00000443649.3
DIABLO
diablo, IAP-binding mitochondrial protein
chr9_-_100881466 0.04 ENST00000341469.2
ENST00000342043.3
ENST00000375098.3
TRIM14
tripartite motif containing 14
chr4_-_39529180 0.04 ENST00000515021.1
ENST00000510490.1
ENST00000316423.6
UGDH
UDP-glucose 6-dehydrogenase
chr18_-_812517 0.04 ENST00000584307.1
YES1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr13_+_51483814 0.04 ENST00000336617.3
ENST00000422660.1
RNASEH2B
ribonuclease H2, subunit B
chr2_-_191878681 0.04 ENST00000409465.1
STAT1
signal transducer and activator of transcription 1, 91kDa
chr12_+_79258444 0.04 ENST00000261205.4
SYT1
synaptotagmin I
chr14_+_89029253 0.04 ENST00000251038.5
ENST00000359301.3
ENST00000302216.8
ZC3H14
zinc finger CCCH-type containing 14
chr11_-_6008215 0.04 ENST00000332249.4
OR52L1
olfactory receptor, family 52, subfamily L, member 1
chr3_+_172468505 0.04 ENST00000427830.1
ENST00000417960.1
ENST00000428567.1
ENST00000366090.2
ENST00000426894.1
ECT2
epithelial cell transforming sequence 2 oncogene
chr6_+_89855765 0.04 ENST00000275072.4
PM20D2
peptidase M20 domain containing 2
chr19_-_50528584 0.04 ENST00000594092.1
ENST00000443401.2
ENST00000594948.1
ENST00000377011.2
ENST00000593919.1
ENST00000601324.1
ENST00000316763.3
ENST00000601341.1
ENST00000600259.1
VRK3
vaccinia related kinase 3
chr12_+_62654119 0.04 ENST00000353364.3
ENST00000549523.1
ENST00000280377.5
USP15
ubiquitin specific peptidase 15
chr17_-_40264692 0.04 ENST00000591220.1
ENST00000251642.3
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr1_-_224033596 0.04 ENST00000391878.2
ENST00000343537.7
TP53BP2
tumor protein p53 binding protein, 2
chr12_+_113344811 0.04 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr17_-_49198216 0.04 ENST00000262013.7
ENST00000357122.4
SPAG9
sperm associated antigen 9
chr19_-_9546177 0.04 ENST00000592292.1
ENST00000588221.1
ZNF266
zinc finger protein 266
chr2_+_201242941 0.04 ENST00000449647.1
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr3_-_28390581 0.04 ENST00000479665.1
AZI2
5-azacytidine induced 2
chr5_+_118668846 0.04 ENST00000513374.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr4_+_190992387 0.04 ENST00000554906.2
ENST00000553820.2
DUX4L7
double homeobox 4 like 7
chr2_-_191878874 0.04 ENST00000392322.3
ENST00000392323.2
ENST00000424722.1
ENST00000361099.3
STAT1
signal transducer and activator of transcription 1, 91kDa
chr15_-_85259294 0.04 ENST00000558217.1
ENST00000558196.1
ENST00000558134.1
SEC11A
SEC11 homolog A (S. cerevisiae)
chr6_-_128222103 0.04 ENST00000434358.1
ENST00000543064.1
ENST00000368248.2
THEMIS
thymocyte selection associated
chr19_-_9546227 0.04 ENST00000361451.2
ENST00000361151.1
ZNF266
zinc finger protein 266
chr3_+_156544057 0.04 ENST00000498839.1
ENST00000470811.1
ENST00000356539.4
ENST00000483177.1
ENST00000477399.1
ENST00000491763.1
LEKR1
leucine, glutamate and lysine rich 1
chr5_-_76788024 0.04 ENST00000515253.1
ENST00000414719.2
ENST00000507654.1
ENST00000514559.1
ENST00000511791.1
WDR41
WD repeat domain 41
chr2_-_75938115 0.04 ENST00000321027.3
GCFC2
GC-rich sequence DNA-binding factor 2
chr1_-_26231589 0.04 ENST00000374291.1
STMN1
stathmin 1
chr17_-_10633535 0.04 ENST00000341871.3
TMEM220
transmembrane protein 220
chr4_-_83295103 0.04 ENST00000313899.7
ENST00000352301.4
ENST00000509107.1
ENST00000353341.4
ENST00000541060.1
HNRNPD
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
chr2_-_75937994 0.04 ENST00000409857.3
ENST00000470503.1
ENST00000541687.1
ENST00000442309.1
GCFC2
GC-rich sequence DNA-binding factor 2
chr4_+_95373037 0.04 ENST00000359265.4
ENST00000437932.1
ENST00000380180.3
ENST00000318007.5
ENST00000450793.1
ENST00000538141.1
ENST00000317968.4
ENST00000512274.1
ENST00000503974.1
ENST00000504489.1
ENST00000542407.1
PDLIM5
PDZ and LIM domain 5
chr11_-_57334732 0.04 ENST00000526659.1
ENST00000527022.1
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr13_-_76056250 0.04 ENST00000377636.3
ENST00000431480.2
ENST00000377625.2
ENST00000425511.1
TBC1D4
TBC1 domain family, member 4
chr12_+_70133152 0.04 ENST00000550536.1
ENST00000362025.5
RAB3IP
RAB3A interacting protein
chr5_+_156569944 0.04 ENST00000521769.1
ITK
IL2-inducible T-cell kinase
chr3_+_88199099 0.04 ENST00000486971.1
C3orf38
chromosome 3 open reading frame 38
chr2_+_120770645 0.04 ENST00000443902.2
EPB41L5
erythrocyte membrane protein band 4.1 like 5

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF6_IRF4_IRF5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.1 0.3 GO:0002519 natural killer cell tolerance induction(GO:0002519)
0.1 0.3 GO:1901350 cell-cell signaling involved in cell-cell junction organization(GO:1901350)
0.1 0.2 GO:0006601 creatine biosynthetic process(GO:0006601)
0.1 0.5 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.0 0.2 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0 0.5 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.0 0.2 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.0 0.2 GO:0043335 protein unfolding(GO:0043335)
0.0 0.0 GO:0060948 cardiac vascular smooth muscle cell development(GO:0060948)
0.0 0.1 GO:1904585 response to putrescine(GO:1904585) cellular response to putrescine(GO:1904586) hepatocyte dedifferentiation(GO:1990828)
0.0 0.1 GO:1905123 regulation of endosome organization(GO:1904978) regulation of glucosylceramidase activity(GO:1905123)
0.0 0.1 GO:0006429 leucyl-tRNA aminoacylation(GO:0006429)
0.0 0.1 GO:2000625 rRNA import into mitochondrion(GO:0035928) regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627)
0.0 0.3 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.2 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.0 0.1 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.0 0.2 GO:0052572 response to immune response of other organism involved in symbiotic interaction(GO:0052564) response to host immune response(GO:0052572)
0.0 0.2 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.0 0.1 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.0 0.1 GO:0071492 cellular response to UV-A(GO:0071492)
0.0 0.3 GO:0060982 coronary artery morphogenesis(GO:0060982)
0.0 0.8 GO:0035456 response to interferon-beta(GO:0035456)
0.0 0.1 GO:0071262 regulation of eIF2 alpha phosphorylation by amino acid starvation(GO:0060733) regulation of translational initiation in response to starvation(GO:0071262) positive regulation of translational initiation in response to starvation(GO:0071264)
0.0 0.1 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.0 0.0 GO:0044771 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0 0.0 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 0.1 GO:0010909 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.1 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) negative regulation of macrophage apoptotic process(GO:2000110)
0.0 0.2 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.0 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.0 0.0 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.0 0.0 GO:0033320 UDP-D-xylose metabolic process(GO:0033319) UDP-D-xylose biosynthetic process(GO:0033320)
0.0 0.1 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.0 0.1 GO:0044565 dendritic cell proliferation(GO:0044565)
0.0 0.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.1 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.0 0.1 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.0 0.1 GO:2000510 positive regulation of dendritic cell chemotaxis(GO:2000510)
0.0 0.1 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.0 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.0 0.0 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.0 0.3 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.0 0.0 GO:0030451 regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957) positive regulation of serine-type endopeptidase activity(GO:1900005) positive regulation of serine-type peptidase activity(GO:1902573)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.1 GO:0097232 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.0 0.1 GO:0031906 late endosome lumen(GO:0031906)
0.0 0.1 GO:0043291 RAVE complex(GO:0043291)
0.0 0.1 GO:0097452 GAIT complex(GO:0097452)
0.0 0.1 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.0 0.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.0 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.1 GO:0030891 VCB complex(GO:0030891)
0.0 0.0 GO:0005584 collagen type I trimer(GO:0005584)
0.0 0.2 GO:0045277 respiratory chain complex IV(GO:0045277)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0015068 amidinotransferase activity(GO:0015067) glycine amidinotransferase activity(GO:0015068)
0.1 0.2 GO:0004772 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.0 0.2 GO:0009041 uridylate kinase activity(GO:0009041)
0.0 0.3 GO:0005534 galactose binding(GO:0005534)
0.0 0.2 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.1 GO:0004823 leucine-tRNA ligase activity(GO:0004823)
0.0 0.5 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0004145 diamine N-acetyltransferase activity(GO:0004145) polyamine binding(GO:0019808)
0.0 0.1 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.1 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.2 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.2 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0004641 phosphoribosylamine-glycine ligase activity(GO:0004637) phosphoribosylformylglycinamidine cyclo-ligase activity(GO:0004641) phosphoribosylglycinamide formyltransferase activity(GO:0004644)
0.0 0.1 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.1 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.2 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.0 GO:0048040 UDP-glucuronate decarboxylase activity(GO:0048040)
0.0 0.1 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.0 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.1 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.3 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.1 GO:0008665 2'-phosphotransferase activity(GO:0008665)
0.0 0.0 GO:0046573 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0 0.0 GO:0001861 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.1 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling