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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for IRF2_STAT2_IRF8_IRF1

Z-value: 1.18

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Transcription factors associated with IRF2_STAT2_IRF8_IRF1

Gene Symbol Gene ID Gene Info
IRF2
ENSG00000168310.6 interferon regulatory factor 2
STAT2
ENSG00000170581.9 signal transducer and activator of transcription 2
IRF8
ENSG00000140968.6 interferon regulatory factor 8
IRF1
ENSG00000125347.9 interferon regulatory factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF2hg19_v2_chr4_-_185395191_1853953400.742.6e-01Click!
IRF8hg19_v2_chr16_+_85936295_85936444-0.584.2e-01Click!
STAT2hg19_v2_chr12_-_56753858_56753930-0.049.6e-01Click!
IRF1hg19_v2_chr5_-_131826457_131826514-0.029.8e-01Click!

Activity profile of IRF2_STAT2_IRF8_IRF1 motif

Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_94577074 1.52 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
IFI27
interferon, alpha-inducible protein 27
chr12_+_113416265 0.86 ENST00000449768.2
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr2_-_7005785 0.76 ENST00000256722.5
ENST00000404168.1
ENST00000458098.1
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr12_+_113416191 0.70 ENST00000342315.4
ENST00000392583.2
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr12_+_113416340 0.67 ENST00000552756.1
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr8_+_97657531 0.57 ENST00000519900.1
ENST00000517742.1
CPQ
carboxypeptidase Q
chr4_+_147096837 0.56 ENST00000296581.5
ENST00000502781.1
LSM6
LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr17_+_6659153 0.55 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr10_+_91152303 0.54 ENST00000371804.3
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr19_-_17516449 0.51 ENST00000252593.6
BST2
bone marrow stromal cell antigen 2
chr10_+_91087651 0.50 ENST00000371818.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr2_-_163175133 0.49 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr10_+_91092241 0.47 ENST00000371811.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr1_+_59486129 0.44 ENST00000438195.1
ENST00000424308.1
RP4-794H19.4
RP4-794H19.4
chr4_+_186990298 0.43 ENST00000296795.3
ENST00000513189.1
TLR3
toll-like receptor 3
chr3_-_172241250 0.42 ENST00000420541.2
ENST00000241261.2
TNFSF10
tumor necrosis factor (ligand) superfamily, member 10
chr19_-_49371711 0.39 ENST00000355496.5
ENST00000263265.6
PLEKHA4
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
chr1_+_948803 0.38 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr9_-_14322319 0.37 ENST00000606230.1
NFIB
nuclear factor I/B
chr11_-_104916034 0.37 ENST00000528513.1
ENST00000375706.2
ENST00000375704.3
CARD16
caspase recruitment domain family, member 16
chr7_-_92777606 0.33 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr14_-_80678512 0.32 ENST00000553968.1
DIO2
deiodinase, iodothyronine, type II
chr10_-_18948208 0.31 ENST00000607346.1
ARL5B-AS1
ARL5B antisense RNA 1
chr1_-_151319654 0.29 ENST00000430227.1
ENST00000412774.1
RFX5
regulatory factor X, 5 (influences HLA class II expression)
chr4_-_169239921 0.29 ENST00000514995.1
ENST00000393743.3
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr1_+_79115503 0.28 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr4_+_187112674 0.27 ENST00000378802.4
CYP4V2
cytochrome P450, family 4, subfamily V, polypeptide 2
chr11_-_615942 0.26 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr11_-_63330842 0.25 ENST00000255695.1
HRASLS2
HRAS-like suppressor 2
chr4_-_100140331 0.25 ENST00000407820.2
ENST00000394897.1
ENST00000508558.1
ENST00000394899.2
ADH6
alcohol dehydrogenase 6 (class V)
chr7_-_105332084 0.25 ENST00000472195.1
ATXN7L1
ataxin 7-like 1
chr19_-_1168936 0.25 ENST00000587655.1
SBNO2
strawberry notch homolog 2 (Drosophila)
chr14_-_69263043 0.25 ENST00000408913.2
ZFP36L1
ZFP36 ring finger protein-like 1
chr13_+_110958124 0.24 ENST00000400163.2
COL4A2
collagen, type IV, alpha 2
chr16_+_12059091 0.24 ENST00000562385.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr2_+_231191875 0.24 ENST00000444636.1
ENST00000415673.2
ENST00000243810.6
ENST00000396563.4
SP140L
SP140 nuclear body protein-like
chr11_-_57334732 0.24 ENST00000526659.1
ENST00000527022.1
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr4_-_169401628 0.23 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr21_+_42792442 0.22 ENST00000398600.2
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr17_-_74489215 0.21 ENST00000585701.1
ENST00000591192.1
ENST00000589526.1
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr11_+_5710919 0.21 ENST00000379965.3
ENST00000425490.1
TRIM22
tripartite motif containing 22
chr12_+_97300995 0.21 ENST00000266742.4
ENST00000429527.2
ENST00000554226.1
ENST00000557478.1
ENST00000557092.1
ENST00000411739.2
ENST00000553609.1
NEDD1
neural precursor cell expressed, developmentally down-regulated 1
chr2_-_231084820 0.20 ENST00000258382.5
ENST00000338556.3
SP110
SP110 nuclear body protein
chr4_-_156875003 0.20 ENST00000433477.3
CTSO
cathepsin O
chr11_-_615570 0.20 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr17_+_25958174 0.20 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
LGALS9
lectin, galactoside-binding, soluble, 9
chr1_-_146644036 0.20 ENST00000425272.2
PRKAB2
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr22_-_36635225 0.19 ENST00000529194.1
APOL2
apolipoprotein L, 2
chr4_+_142557717 0.19 ENST00000320650.4
ENST00000296545.7
IL15
interleukin 15
chr5_+_131746575 0.19 ENST00000337752.2
ENST00000378947.3
ENST00000407797.1
C5orf56
chromosome 5 open reading frame 56
chr4_+_26165074 0.19 ENST00000512351.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr6_+_26402517 0.19 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chr17_+_79369249 0.19 ENST00000574717.2
RP11-1055B8.6
Uncharacterized protein
chr11_-_14358620 0.18 ENST00000531421.1
RRAS2
related RAS viral (r-ras) oncogene homolog 2
chr3_+_159706537 0.18 ENST00000305579.2
ENST00000480787.1
ENST00000466512.1
IL12A
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
chr11_-_321050 0.18 ENST00000399808.4
IFITM3
interferon induced transmembrane protein 3
chr3_+_63898275 0.18 ENST00000538065.1
ATXN7
ataxin 7
chr17_+_76311791 0.18 ENST00000586321.1
AC061992.2
AC061992.2
chr12_-_121477039 0.18 ENST00000257570.5
OASL
2'-5'-oligoadenylate synthetase-like
chr1_+_110453109 0.17 ENST00000525659.1
CSF1
colony stimulating factor 1 (macrophage)
chr2_-_231084659 0.17 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110
SP110 nuclear body protein
chr9_+_74764278 0.17 ENST00000238018.4
ENST00000376989.3
GDA
guanine deaminase
chr10_+_91174486 0.17 ENST00000416601.1
IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chr11_-_4629367 0.17 ENST00000533021.1
TRIM68
tripartite motif containing 68
chr11_-_8795787 0.16 ENST00000528196.1
ENST00000533681.1
ST5
suppression of tumorigenicity 5
chr2_-_152118276 0.16 ENST00000409092.1
RBM43
RNA binding motif protein 43
chr11_-_104905840 0.16 ENST00000526568.1
ENST00000393136.4
ENST00000531166.1
ENST00000534497.1
ENST00000527979.1
ENST00000446369.1
ENST00000353247.5
ENST00000528974.1
ENST00000533400.1
ENST00000525825.1
ENST00000436863.3
CASP1
caspase 1, apoptosis-related cysteine peptidase
chr12_-_121476959 0.16 ENST00000339275.5
OASL
2'-5'-oligoadenylate synthetase-like
chr3_+_164924716 0.16 ENST00000470138.1
ENST00000498616.1
RP11-85M11.2
RP11-85M11.2
chr2_+_210288760 0.16 ENST00000199940.6
MAP2
microtubule-associated protein 2
chr3_-_28389922 0.15 ENST00000415852.1
AZI2
5-azacytidine induced 2
chr11_-_60719213 0.15 ENST00000227880.3
SLC15A3
solute carrier family 15 (oligopeptide transporter), member 3
chr16_-_67970990 0.15 ENST00000358514.4
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chrX_-_154689596 0.15 ENST00000369444.2
H2AFB3
H2A histone family, member B3
chr1_-_89531041 0.15 ENST00000370473.4
GBP1
guanylate binding protein 1, interferon-inducible
chr22_+_39417118 0.15 ENST00000216099.8
APOBEC3D
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
chr9_+_21409146 0.15 ENST00000380205.1
IFNA8
interferon, alpha 8
chr1_-_52520828 0.14 ENST00000610127.1
TXNDC12
thioredoxin domain containing 12 (endoplasmic reticulum)
chr15_+_89182156 0.14 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr15_+_89182178 0.14 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr21_+_42733870 0.14 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr12_-_51663682 0.14 ENST00000603838.1
SMAGP
small cell adhesion glycoprotein
chr17_+_46908350 0.14 ENST00000258947.3
ENST00000509507.1
ENST00000448105.2
ENST00000570513.1
ENST00000509415.1
ENST00000513119.1
ENST00000416445.2
ENST00000508679.1
ENST00000505071.1
CALCOCO2
calcium binding and coiled-coil domain 2
chrX_+_154113317 0.14 ENST00000354461.2
H2AFB1
H2A histone family, member B1
chr9_-_80437915 0.13 ENST00000397476.3
GNAQ
guanine nucleotide binding protein (G protein), q polypeptide
chr19_+_16254488 0.13 ENST00000588246.1
ENST00000593031.1
HSH2D
hematopoietic SH2 domain containing
chr17_+_41994576 0.13 ENST00000588043.2
FAM215A
family with sequence similarity 215, member A (non-protein coding)
chr11_-_60720002 0.13 ENST00000538739.1
SLC15A3
solute carrier family 15 (oligopeptide transporter), member 3
chr3_-_141747439 0.13 ENST00000467667.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr4_-_187112626 0.13 ENST00000596414.1
AC110771.1
Uncharacterized protein
chr8_-_145060593 0.13 ENST00000313059.5
ENST00000524918.1
ENST00000313028.7
ENST00000525773.1
PARP10
poly (ADP-ribose) polymerase family, member 10
chr7_+_42971799 0.13 ENST00000223324.2
MRPL32
mitochondrial ribosomal protein L32
chr3_-_121467983 0.13 ENST00000472475.1
GOLGB1
golgin B1
chr3_-_61237050 0.12 ENST00000476844.1
ENST00000488467.1
ENST00000492590.1
ENST00000468189.1
FHIT
fragile histidine triad
chr12_+_113344755 0.12 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr1_+_27668505 0.12 ENST00000318074.5
SYTL1
synaptotagmin-like 1
chr19_+_10196981 0.12 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr1_-_27998689 0.12 ENST00000339145.4
ENST00000362020.4
ENST00000361157.6
IFI6
interferon, alpha-inducible protein 6
chr1_+_174843548 0.12 ENST00000478442.1
ENST00000465412.1
RABGAP1L
RAB GTPase activating protein 1-like
chr3_-_28390581 0.12 ENST00000479665.1
AZI2
5-azacytidine induced 2
chr7_-_102985288 0.12 ENST00000379263.3
DNAJC2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr16_+_53412368 0.12 ENST00000565189.1
RP11-44F14.2
RP11-44F14.2
chr14_+_35452169 0.12 ENST00000555557.1
SRP54
signal recognition particle 54kDa
chr4_-_147442817 0.12 ENST00000507030.1
SLC10A7
solute carrier family 10, member 7
chr21_+_42797958 0.12 ENST00000419044.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr2_-_191399073 0.12 ENST00000421038.1
TMEM194B
transmembrane protein 194B
chr12_+_94542459 0.12 ENST00000258526.4
PLXNC1
plexin C1
chr17_+_4643337 0.12 ENST00000592813.1
ZMYND15
zinc finger, MYND-type containing 15
chr7_-_130597935 0.11 ENST00000447307.1
ENST00000418546.1
MIR29B1
microRNA 29a
chr1_+_210502238 0.11 ENST00000545154.1
ENST00000537898.1
ENST00000391905.3
ENST00000545781.1
ENST00000261458.3
ENST00000308852.6
HHAT
hedgehog acyltransferase
chr14_+_32798547 0.11 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr3_-_28390415 0.11 ENST00000414162.1
ENST00000420543.2
AZI2
5-azacytidine induced 2
chr19_-_57656570 0.11 ENST00000269834.1
ZIM3
zinc finger, imprinted 3
chr11_+_74811578 0.11 ENST00000531713.1
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr12_+_14369524 0.11 ENST00000538329.1
RP11-134N1.2
RP11-134N1.2
chr1_+_113217309 0.11 ENST00000544796.1
ENST00000369644.1
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr5_-_39203093 0.11 ENST00000515010.1
FYB
FYN binding protein
chr21_+_42798094 0.11 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr4_-_14889791 0.11 ENST00000509654.1
ENST00000515031.1
ENST00000505089.2
LINC00504
long intergenic non-protein coding RNA 504
chr12_+_43086018 0.11 ENST00000550177.1
RP11-25I15.3
RP11-25I15.3
chr6_-_8102714 0.11 ENST00000502429.1
ENST00000429723.2
ENST00000507463.1
ENST00000379715.5
EEF1E1
eukaryotic translation elongation factor 1 epsilon 1
chr12_-_10022735 0.11 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr17_-_43339453 0.11 ENST00000543122.1
SPATA32
spermatogenesis associated 32
chr4_-_120222076 0.11 ENST00000504110.1
C4orf3
chromosome 4 open reading frame 3
chr7_-_112635675 0.11 ENST00000447785.1
ENST00000451962.1
AC018464.3
AC018464.3
chr5_-_74807418 0.10 ENST00000405807.4
ENST00000261415.7
COL4A3BP
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
chr17_+_41363854 0.10 ENST00000588693.1
ENST00000588659.1
ENST00000541594.1
ENST00000536052.1
ENST00000331615.3
TMEM106A
transmembrane protein 106A
chr2_+_201981527 0.10 ENST00000441224.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr17_+_36858694 0.10 ENST00000563897.1
CTB-58E17.1
CTB-58E17.1
chr12_-_11002063 0.10 ENST00000544994.1
ENST00000228811.4
ENST00000540107.1
PRR4
proline rich 4 (lacrimal)
chr22_+_36649056 0.10 ENST00000397278.3
ENST00000422706.1
ENST00000426053.1
ENST00000319136.4
APOL1
apolipoprotein L, 1
chr3_+_122399444 0.10 ENST00000474629.2
PARP14
poly (ADP-ribose) polymerase family, member 14
chr16_-_11350036 0.10 ENST00000332029.2
SOCS1
suppressor of cytokine signaling 1
chrX_+_102841064 0.10 ENST00000469586.1
TCEAL4
transcription elongation factor A (SII)-like 4
chr9_+_100174232 0.10 ENST00000355295.4
TDRD7
tudor domain containing 7
chrX_+_154610428 0.09 ENST00000354514.4
H2AFB2
H2A histone family, member B2
chr11_-_57335280 0.09 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr6_-_121655593 0.09 ENST00000398212.2
TBC1D32
TBC1 domain family, member 32
chr1_+_79086088 0.09 ENST00000370751.5
ENST00000342282.3
IFI44L
interferon-induced protein 44-like
chr10_-_46640660 0.09 ENST00000395727.2
ENST00000509900.1
ENST00000503851.1
ENST00000506080.1
ENST00000513266.1
ENST00000502705.1
ENST00000505814.1
ENST00000509774.1
ENST00000511769.1
ENST00000509599.1
ENST00000513156.1
PTPN20A
protein tyrosine phosphatase, non-receptor type 20A
chr12_-_54653313 0.09 ENST00000550411.1
ENST00000439541.2
CBX5
chromobox homolog 5
chr17_+_4643300 0.09 ENST00000433935.1
ZMYND15
zinc finger, MYND-type containing 15
chr17_+_9745786 0.09 ENST00000304773.5
GLP2R
glucagon-like peptide 2 receptor
chr11_+_34663913 0.09 ENST00000532302.1
EHF
ets homologous factor
chr9_-_117568365 0.09 ENST00000374045.4
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr10_+_91174314 0.09 ENST00000371795.4
IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chr12_-_10978957 0.09 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr18_-_2982869 0.09 ENST00000584915.1
LPIN2
lipin 2
chr17_-_57232596 0.09 ENST00000581068.1
ENST00000330137.7
SKA2
spindle and kinetochore associated complex subunit 2
chr1_-_198906528 0.09 ENST00000432296.1
MIR181A1HG
MIR181A1 host gene (non-protein coding)
chr2_-_37384175 0.09 ENST00000411537.2
ENST00000233057.4
ENST00000395127.2
ENST00000390013.3
EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2
chr20_-_47894936 0.09 ENST00000371754.4
ZNFX1
zinc finger, NFX1-type containing 1
chr9_+_33265011 0.09 ENST00000419016.2
CHMP5
charged multivesicular body protein 5
chr3_+_119316721 0.09 ENST00000488919.1
ENST00000495992.1
PLA1A
phospholipase A1 member A
chr1_+_61542922 0.09 ENST00000407417.3
NFIA
nuclear factor I/A
chr10_+_23384435 0.09 ENST00000376510.3
MSRB2
methionine sulfoxide reductase B2
chr2_+_102686820 0.09 ENST00000409929.1
ENST00000424272.1
IL1R1
interleukin 1 receptor, type I
chr11_+_5711010 0.09 ENST00000454828.1
TRIM22
tripartite motif containing 22
chr6_+_29691056 0.09 ENST00000414333.1
ENST00000334668.4
ENST00000259951.7
HLA-F
major histocompatibility complex, class I, F
chr16_-_74734672 0.09 ENST00000306247.7
ENST00000575686.1
MLKL
mixed lineage kinase domain-like
chr3_-_146262352 0.09 ENST00000462666.1
PLSCR1
phospholipid scramblase 1
chr17_+_6659354 0.09 ENST00000574907.1
XAF1
XIAP associated factor 1
chr17_+_47296865 0.09 ENST00000573347.1
ABI3
ABI family, member 3
chr11_-_104972158 0.09 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
CASP1
CARD16
CARD17
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr6_-_133119649 0.08 ENST00000367918.1
SLC18B1
solute carrier family 18, subfamily B, member 1
chr15_+_89181974 0.08 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr1_+_150229554 0.08 ENST00000369111.4
CA14
carbonic anhydrase XIV
chr17_-_57232525 0.08 ENST00000583380.1
ENST00000580541.1
ENST00000578105.1
ENST00000437036.2
SKA2
spindle and kinetochore associated complex subunit 2
chr2_+_239756671 0.08 ENST00000448943.2
TWIST2
twist family bHLH transcription factor 2
chr4_-_130014729 0.08 ENST00000281142.5
ENST00000434680.1
SCLT1
sodium channel and clathrin linker 1
chr14_-_100841794 0.08 ENST00000556295.1
ENST00000554820.1
WARS
tryptophanyl-tRNA synthetase
chr1_+_901847 0.08 ENST00000379410.3
ENST00000379409.2
ENST00000379407.3
PLEKHN1
pleckstrin homology domain containing, family N member 1
chr11_-_321340 0.08 ENST00000526811.1
IFITM3
interferon induced transmembrane protein 3
chr5_-_133702761 0.08 ENST00000521118.1
ENST00000265334.4
ENST00000435211.1
CDKL3
cyclin-dependent kinase-like 3
chr10_+_111985837 0.08 ENST00000393134.1
MXI1
MAX interactor 1, dimerization protein
chr10_-_90751038 0.08 ENST00000458159.1
ENST00000415557.1
ENST00000458208.1
ACTA2
actin, alpha 2, smooth muscle, aorta
chr4_-_76944621 0.08 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr6_+_3259148 0.08 ENST00000419065.2
ENST00000473000.2
ENST00000451246.2
ENST00000454610.2
PSMG4
proteasome (prosome, macropain) assembly chaperone 4
chr11_+_46402482 0.08 ENST00000441869.1
MDK
midkine (neurite growth-promoting factor 2)
chr11_+_313503 0.08 ENST00000528780.1
ENST00000328221.5
IFITM1
interferon induced transmembrane protein 1
chr4_-_147442982 0.08 ENST00000511374.1
ENST00000264986.3
SLC10A7
solute carrier family 10, member 7
chr17_+_18380051 0.08 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
LGALS9C
lectin, galactoside-binding, soluble, 9C
chr4_-_122148620 0.08 ENST00000509841.1
TNIP3
TNFAIP3 interacting protein 3
chr5_+_140734570 0.08 ENST00000571252.1
PCDHGA4
protocadherin gamma subfamily A, 4
chr16_-_28223229 0.08 ENST00000566073.1
XPO6
exportin 6
chr7_-_92146729 0.08 ENST00000541751.1
PEX1
peroxisomal biogenesis factor 1
chr11_-_96076334 0.08 ENST00000524717.1
MAML2
mastermind-like 2 (Drosophila)
chr17_+_15604513 0.08 ENST00000481540.1
ZNF286A
Homo sapiens zinc finger protein 286A (ZNF286A), transcript variant 6, mRNA.
chr14_-_92414294 0.08 ENST00000554468.1
FBLN5
fibulin 5
chr12_+_27677085 0.08 ENST00000545334.1
ENST00000540114.1
ENST00000537927.1
ENST00000318304.8
ENST00000535047.1
ENST00000542629.1
ENST00000228425.6
PPFIBP1
PTPRF interacting protein, binding protein 1 (liprin beta 1)
chr19_+_41509851 0.08 ENST00000593831.1
ENST00000330446.5
CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr14_+_35452104 0.08 ENST00000216774.6
ENST00000546080.1
SRP54
signal recognition particle 54kDa
chr7_-_102985035 0.08 ENST00000426036.2
ENST00000249270.7
ENST00000454277.1
ENST00000412522.1
DNAJC2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr11_+_63304273 0.07 ENST00000439013.2
ENST00000255688.3
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr3_+_187957646 0.07 ENST00000457242.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr1_+_39670360 0.07 ENST00000494012.1
MACF1
microtubule-actin crosslinking factor 1
chr1_+_221051699 0.07 ENST00000366903.6
HLX
H2.0-like homeobox
chr3_+_63897605 0.07 ENST00000487717.1
ATXN7
ataxin 7
chr11_+_940729 0.07 ENST00000527024.1
AP2A2
adaptor-related protein complex 2, alpha 2 subunit
chr17_-_67057047 0.07 ENST00000495634.1
ENST00000453985.2
ENST00000585714.1
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF2_STAT2_IRF8_IRF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.2 2.2 GO:0018377 protein myristoylation(GO:0018377)
0.2 0.8 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.2 0.5 GO:0002731 negative regulation of dendritic cell cytokine production(GO:0002731)
0.1 0.5 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.1 0.4 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
0.1 0.2 GO:0045062 extrathymic T cell selection(GO:0045062)
0.1 0.4 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 1.0 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.1 0.4 GO:1904141 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) positive regulation of microglial cell migration(GO:1904141)
0.1 0.2 GO:0006147 guanine catabolic process(GO:0006147)
0.1 0.2 GO:2001190 natural killer cell tolerance induction(GO:0002519) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.1 0.3 GO:0071348 cellular response to interleukin-11(GO:0071348)
0.1 0.7 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 0.1 GO:0002859 negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) negative regulation of natural killer cell mediated immune response to tumor cell(GO:0002856) negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002859)
0.0 0.4 GO:0071494 cellular response to UV-C(GO:0071494)
0.0 0.4 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.1 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.0 0.2 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.0 0.2 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.0 0.3 GO:0044565 dendritic cell proliferation(GO:0044565)
0.0 0.2 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.0 0.1 GO:0035621 ER to Golgi ceramide transport(GO:0035621)
0.0 0.7 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.0 0.0 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.0 1.6 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.0 0.0 GO:0044029 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.1 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.0 0.1 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827) negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.0 0.7 GO:0006590 thyroid hormone generation(GO:0006590)
0.0 0.0 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
0.0 0.2 GO:0070383 DNA cytosine deamination(GO:0070383)
0.0 0.1 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
0.0 0.1 GO:0097403 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.0 1.0 GO:0035456 response to interferon-beta(GO:0035456)
0.0 0.2 GO:1901297 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.3 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.0 0.1 GO:0034761 positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440)
0.0 0.1 GO:0060151 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.0 0.0 GO:0006349 regulation of gene expression by genetic imprinting(GO:0006349)
0.0 0.3 GO:0006069 ethanol oxidation(GO:0006069)
0.0 0.2 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.2 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.1 GO:0019085 early viral transcription(GO:0019085)
0.0 0.1 GO:2000508 regulation of dendritic cell chemotaxis(GO:2000508)
0.0 0.1 GO:1990535 neuron projection maintenance(GO:1990535)
0.0 0.1 GO:1902990 leading strand elongation(GO:0006272) mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.0 0.1 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.0 0.0 GO:1901147 pronephric field specification(GO:0039003) pattern specification involved in pronephros development(GO:0039017) kidney field specification(GO:0072004) regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis(GO:0072304) negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis(GO:0072305) mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis(GO:0072309) apoptotic process involved in metanephric collecting duct development(GO:1900204) apoptotic process involved in metanephric nephron tubule development(GO:1900205) regulation of apoptotic process involved in metanephric collecting duct development(GO:1900214) negative regulation of apoptotic process involved in metanephric collecting duct development(GO:1900215) regulation of apoptotic process involved in metanephric nephron tubule development(GO:1900217) negative regulation of apoptotic process involved in metanephric nephron tubule development(GO:1900218) mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis(GO:1901147) regulation of metanephric DCT cell differentiation(GO:2000592) positive regulation of metanephric DCT cell differentiation(GO:2000594)
0.0 0.1 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.0 0.1 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
0.0 0.2 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.1 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.0 0.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.1 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.0 GO:0097198 histone H3-K36 trimethylation(GO:0097198)
0.0 0.1 GO:1902724 mineralocorticoid receptor signaling pathway(GO:0031959) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.0 0.1 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.0 GO:0060139 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139)
0.0 0.1 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.1 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.0 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.0 0.0 GO:1904253 lipid transport involved in lipid storage(GO:0010877) positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.0 0.2 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.0 GO:0030225 macrophage differentiation(GO:0030225)
0.0 0.1 GO:0052564 response to immune response of other organism involved in symbiotic interaction(GO:0052564) response to host immune response(GO:0052572)
0.0 0.1 GO:0035634 response to stilbenoid(GO:0035634)
0.0 0.1 GO:0010819 regulation of T cell chemotaxis(GO:0010819)
0.0 0.2 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.1 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:1901315 negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.6 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.1 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.0 0.0 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.0 0.1 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.0 0.0 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.0 0.0 GO:0052026 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.0 0.3 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0097179 protease inhibitor complex(GO:0097179)
0.1 0.4 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.6 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.1 GO:0031213 RSF complex(GO:0031213)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.1 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 0.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.5 GO:0036020 endolysosome membrane(GO:0036020)
0.0 0.1 GO:0001534 radial spoke(GO:0001534)
0.0 0.0 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 1.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.1 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.0 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)
0.0 0.0 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.2 0.8 GO:0009041 uridylate kinase activity(GO:0009041)
0.1 0.4 GO:0008859 exoribonuclease II activity(GO:0008859)
0.1 0.2 GO:0008892 guanine deaminase activity(GO:0008892)
0.1 0.2 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1 0.6 GO:0070573 metallodipeptidase activity(GO:0070573)
0.0 0.3 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0 0.3 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 1.6 GO:0005521 lamin binding(GO:0005521)
0.0 0.2 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.4 GO:0089720 caspase binding(GO:0089720)
0.0 0.3 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.4 GO:0031386 protein tag(GO:0031386)
0.0 0.2 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.2 GO:0005534 galactose binding(GO:0005534)
0.0 0.1 GO:0004967 glucagon receptor activity(GO:0004967)
0.0 0.1 GO:0042007 interleukin-18 binding(GO:0042007)
0.0 0.0 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.0 0.1 GO:0097001 ceramide binding(GO:0097001)
0.0 0.1 GO:0052739 phosphatidylserine 1-acylhydrolase activity(GO:0052739)
0.0 0.2 GO:0061513 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0 0.1 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.2 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.1 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.0 0.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.1 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.0 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.0 GO:0015633 zinc transporting ATPase activity(GO:0015633)
0.0 0.2 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.1 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.1 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.0 0.1 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.1 GO:0004977 melanocortin receptor activity(GO:0004977)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.8 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.5 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.6 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.3 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.2 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.4 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.1 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide