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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for IRF2_STAT2_IRF8_IRF1
Z-value: 1.18
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Transcription factors associated with IRF2_STAT2_IRF8_IRF1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000168310.6 | interferon regulatory factor 2 | |
| ENSG00000170581.9 | signal transducer and activator of transcription 2 | |
| ENSG00000140968.6 | interferon regulatory factor 8 | |
| ENSG00000125347.9 | interferon regulatory factor 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF2 | hg19_v2_chr4_-_185395191_185395340 | 0.74 | 2.6e-01 | Click! |
| IRF8 | hg19_v2_chr16_+_85936295_85936444 | -0.58 | 4.2e-01 | Click! |
| STAT2 | hg19_v2_chr12_-_56753858_56753930 | -0.04 | 9.6e-01 | Click! |
| IRF1 | hg19_v2_chr5_-_131826457_131826514 | -0.02 | 9.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF2_STAT2_IRF8_IRF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.2 | GO:0018377 | protein myristoylation(GO:0018377) |
| 0.0 | 1.6 | GO:0046825 | regulation of protein export from nucleus(GO:0046825) |
| 0.1 | 1.0 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.0 | 1.0 | GO:0035456 | response to interferon-beta(GO:0035456) |
| 0.2 | 0.9 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.2 | 0.8 | GO:0009138 | pyrimidine nucleoside diphosphate metabolic process(GO:0009138) |
| 0.1 | 0.7 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.0 | 0.7 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.0 | 0.7 | GO:0006590 | thyroid hormone generation(GO:0006590) |
| 0.0 | 0.6 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.1 | 0.6 | GO:0097179 | protease inhibitor complex(GO:0097179) |
| 0.0 | 0.6 | GO:0005688 | U6 snRNP(GO:0005688) |
| 0.0 | 0.5 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 0.1 | 0.4 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.0 | 0.4 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 0.2 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.0 | 0.2 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.0 | 0.2 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 0.2 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.5 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 1.6 | GO:0005521 | lamin binding(GO:0005521) |
| 0.2 | 0.8 | GO:0009041 | uridylate kinase activity(GO:0009041) |
| 0.1 | 0.6 | GO:0070573 | metallodipeptidase activity(GO:0070573) |
| 0.1 | 0.4 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.0 | 0.4 | GO:0089720 | caspase binding(GO:0089720) |
| 0.0 | 0.4 | GO:0031386 | protein tag(GO:0031386) |
| 0.0 | 0.4 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.3 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.0 | 0.3 | GO:0022897 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.3 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.1 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.6 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.5 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.0 | 0.4 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.0 | 0.4 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 0.3 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 0.3 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.2 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.2 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 0.1 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |