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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for IKZF1
Z-value: 4.09
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Transcription factors associated with IKZF1
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_51152702 Show fit | 5.77 |
ENST00000425202.1
|
chromosome 19 open reading frame 81 |
|
| chr19_+_48673949 Show fit | 3.68 |
ENST00000328759.7
|
chromosome 19 open reading frame 68 |
|
| chr11_-_9482010 Show fit | 2.72 |
ENST00000596206.1
|
LOC644656 protein; Uncharacterized protein |
|
| chr11_+_393428 Show fit | 2.57 |
ENST00000533249.1
ENST00000527442.1 |
plakophilin 3 |
|
| chr22_+_43547937 Show fit | 2.54 |
ENST00000329563.4
|
translocator protein (18kDa) |
|
| chr4_-_1723040 Show fit | 2.52 |
ENST00000382936.3
ENST00000536901.1 ENST00000303277.2 |
transmembrane protein 129 |
|
| chr12_-_25150373 Show fit | 2.44 |
ENST00000549828.1
|
chromosome 12 open reading frame 77 |
|
| chr22_-_50970506 Show fit | 2.35 |
ENST00000428989.2
ENST00000403326.1 |
outer dense fiber of sperm tails 3B |
|
| chr8_-_21966893 Show fit | 2.22 |
ENST00000522405.1
ENST00000522379.1 ENST00000309188.6 ENST00000521807.2 |
nudix (nucleoside diphosphate linked moiety X)-type motif 18 |
|
| chr19_+_56652643 Show fit | 2.20 |
ENST00000586123.1
|
zinc finger protein 444 |
Network of associatons between targets according to the STRING database.
First level regulatory network of IKZF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.1 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.4 | 7.1 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 1.0 | 6.1 | GO:0010940 | positive regulation of necrotic cell death(GO:0010940) |
| 0.6 | 5.6 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
| 0.1 | 5.6 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
| 0.6 | 5.5 | GO:0002159 | desmosome assembly(GO:0002159) |
| 0.2 | 5.0 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
| 0.4 | 4.3 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.0 | 4.3 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.1 | 4.1 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 167.7 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.0 | 21.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 12.2 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 6.5 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 6.4 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 4.6 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.3 | 4.2 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
| 0.2 | 4.2 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.0 | 4.1 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 4.0 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.2 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 7.3 | GO:0003954 | NADH dehydrogenase activity(GO:0003954) |
| 0.5 | 6.9 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.9 | 6.1 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
| 0.2 | 5.7 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.6 | 5.6 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.1 | 5.2 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.6 | 4.5 | GO:0015186 | L-glutamine transmembrane transporter activity(GO:0015186) |
| 0.4 | 4.2 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.2 | 4.2 | GO:0017049 | GTP-Rho binding(GO:0017049) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 7.3 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 6.4 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 6.1 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 6.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 5.6 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 5.0 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 4.2 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 4.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 3.9 | NABA COLLAGENS | Genes encoding collagen proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.6 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 7.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.1 | 7.2 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 7.1 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.1 | 6.7 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 6.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.2 | 6.0 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 5.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 5.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 5.1 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |