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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for HSF4

Z-value: 2.22

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Transcription factors associated with HSF4

Gene Symbol Gene ID Gene Info
HSF4
ENSG00000102878.11 heat shock transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HSF4hg19_v2_chr16_+_67198683_67198715-0.762.4e-01Click!

Activity profile of HSF4 motif

Sorted Z-values of HSF4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_161494036 2.72 ENST00000309758.4
HSPA6
heat shock 70kDa protein 6 (HSP70B')
chrX_+_150866779 1.47 ENST00000370353.3
PRRG3
proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
chr13_-_31736132 1.46 ENST00000429785.2
HSPH1
heat shock 105kDa/110kDa protein 1
chr13_-_31736478 1.26 ENST00000445273.2
HSPH1
heat shock 105kDa/110kDa protein 1
chrX_+_108780062 1.07 ENST00000372106.1
NXT2
nuclear transport factor 2-like export factor 2
chr7_+_157129738 1.02 ENST00000437030.1
DNAJB6
DnaJ (Hsp40) homolog, subfamily B, member 6
chr13_-_31736027 1.01 ENST00000380406.5
ENST00000320027.5
ENST00000380405.4
HSPH1
heat shock 105kDa/110kDa protein 1
chr7_-_1199781 1.00 ENST00000397083.1
ENST00000401903.1
ENST00000316495.3
ZFAND2A
zinc finger, AN1-type domain 2A
chr14_-_52535712 0.91 ENST00000216286.5
ENST00000541773.1
NID2
nidogen 2 (osteonidogen)
chr11_+_63953587 0.86 ENST00000305218.4
ENST00000538945.1
STIP1
stress-induced-phosphoprotein 1
chr18_+_57567180 0.85 ENST00000316660.6
ENST00000269518.9
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr1_+_154947126 0.84 ENST00000368439.1
CKS1B
CDC28 protein kinase regulatory subunit 1B
chr11_-_122932730 0.80 ENST00000532182.1
ENST00000524590.1
ENST00000528292.1
ENST00000533540.1
ENST00000525463.1
HSPA8
heat shock 70kDa protein 8
chr11_+_193065 0.80 ENST00000342878.2
SCGB1C1
secretoglobin, family 1C, member 1
chr11_+_65266507 0.79 ENST00000544868.1
MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr21_+_44394742 0.79 ENST00000432907.2
PKNOX1
PBX/knotted 1 homeobox 1
chr6_-_41168920 0.75 ENST00000483722.1
TREML2
triggering receptor expressed on myeloid cells-like 2
chr6_+_44215603 0.75 ENST00000371554.1
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr7_+_56119323 0.74 ENST00000275603.4
ENST00000335503.3
ENST00000540286.1
CCT6A
chaperonin containing TCP1, subunit 6A (zeta 1)
chr20_+_55108302 0.72 ENST00000371325.1
FAM209B
family with sequence similarity 209, member B
chr11_-_122933043 0.69 ENST00000534624.1
ENST00000453788.2
ENST00000527387.1
HSPA8
heat shock 70kDa protein 8
chr2_+_228678550 0.69 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr12_-_110939870 0.68 ENST00000447578.2
ENST00000546588.1
ENST00000360579.7
ENST00000549970.1
ENST00000549578.1
VPS29
vacuolar protein sorting 29 homolog (S. cerevisiae)
chr19_-_14628645 0.67 ENST00000598235.1
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr12_-_110883346 0.67 ENST00000547365.1
ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr1_+_212782012 0.66 ENST00000341491.4
ENST00000366985.1
ATF3
activating transcription factor 3
chr8_+_62200509 0.64 ENST00000519846.1
ENST00000518592.1
ENST00000325897.4
CLVS1
clavesin 1
chr1_+_154947148 0.62 ENST00000368436.1
ENST00000308987.5
CKS1B
CDC28 protein kinase regulatory subunit 1B
chr11_+_66512303 0.61 ENST00000532565.2
C11orf80
chromosome 11 open reading frame 80
chr1_-_6453426 0.59 ENST00000545482.1
ACOT7
acyl-CoA thioesterase 7
chr12_+_104324112 0.58 ENST00000299767.5
HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chrX_-_55515635 0.56 ENST00000500968.3
USP51
ubiquitin specific peptidase 51
chr17_+_7258442 0.55 ENST00000389982.4
ENST00000576060.1
ENST00000330767.4
TMEM95
transmembrane protein 95
chr19_+_3224700 0.54 ENST00000292672.2
ENST00000541430.2
CELF5
CUGBP, Elav-like family member 5
chr14_+_63671105 0.52 ENST00000316754.3
RHOJ
ras homolog family member J
chr18_-_6929829 0.51 ENST00000583840.1
ENST00000581571.1
ENST00000578497.1
ENST00000579012.1
LINC00668
long intergenic non-protein coding RNA 668
chr19_+_45971246 0.51 ENST00000585836.1
ENST00000417353.2
ENST00000353609.3
ENST00000591858.1
ENST00000443841.2
ENST00000590335.1
FOSB
FBJ murine osteosarcoma viral oncogene homolog B
chr1_+_92683467 0.51 ENST00000370375.3
ENST00000370373.2
C1orf146
chromosome 1 open reading frame 146
chr17_+_74723031 0.51 ENST00000586200.1
METTL23
methyltransferase like 23
chr9_+_74764340 0.49 ENST00000376986.1
ENST00000358399.3
GDA
guanine deaminase
chr15_+_79165222 0.49 ENST00000559930.1
MORF4L1
mortality factor 4 like 1
chr12_-_122658746 0.49 ENST00000377035.1
IL31
interleukin 31
chr11_-_134123142 0.49 ENST00000392595.2
ENST00000341541.3
ENST00000352327.5
ENST00000392594.3
THYN1
thymocyte nuclear protein 1
chr17_-_8286484 0.48 ENST00000582556.1
ENST00000584164.1
ENST00000293842.5
ENST00000584343.1
ENST00000578812.1
ENST00000583011.1
RPL26
ribosomal protein L26
chr19_-_6720686 0.48 ENST00000245907.6
C3
complement component 3
chr3_+_101443476 0.48 ENST00000327230.4
ENST00000494050.1
CEP97
centrosomal protein 97kDa
chr11_-_89956461 0.48 ENST00000320585.6
CHORDC1
cysteine and histidine-rich domain (CHORD) containing 1
chr21_-_30445886 0.47 ENST00000431234.1
ENST00000540844.1
ENST00000286788.4
CCT8
chaperonin containing TCP1, subunit 8 (theta)
chr19_-_49567124 0.47 ENST00000301411.3
NTF4
neurotrophin 4
chr2_+_201171064 0.46 ENST00000451764.2
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr2_+_201170999 0.46 ENST00000439395.1
ENST00000444012.1
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr18_+_11751466 0.46 ENST00000535121.1
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr7_+_26240776 0.46 ENST00000337620.4
CBX3
chromobox homolog 3
chr12_+_2904102 0.46 ENST00000001008.4
FKBP4
FK506 binding protein 4, 59kDa
chrX_+_108779870 0.45 ENST00000372107.1
NXT2
nuclear transport factor 2-like export factor 2
chr2_-_69180083 0.45 ENST00000328895.4
GKN2
gastrokine 2
chrX_-_128782722 0.45 ENST00000427399.1
APLN
apelin
chr17_+_34087888 0.45 ENST00000586491.1
ENST00000588628.1
ENST00000285023.4
C17orf50
chromosome 17 open reading frame 50
chr13_+_31191920 0.45 ENST00000255304.4
USPL1
ubiquitin specific peptidase like 1
chr19_-_14628234 0.45 ENST00000595139.1
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr5_+_172571445 0.44 ENST00000231668.9
ENST00000351486.5
ENST00000352523.6
ENST00000393770.4
BNIP1
BCL2/adenovirus E1B 19kDa interacting protein 1
chr2_-_69664586 0.44 ENST00000303698.3
ENST00000394305.1
ENST00000410022.2
NFU1
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
chr6_-_106773291 0.44 ENST00000343245.3
ATG5
autophagy related 5
chr13_+_95254085 0.43 ENST00000376958.4
GPR180
G protein-coupled receptor 180
chr3_-_53080644 0.43 ENST00000497586.1
SFMBT1
Scm-like with four mbt domains 1
chr12_-_88423164 0.42 ENST00000298699.2
ENST00000550553.1
C12orf50
chromosome 12 open reading frame 50
chr5_+_10250328 0.42 ENST00000515390.1
CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chr6_+_160693591 0.42 ENST00000419196.1
RP1-276N6.2
RP1-276N6.2
chr11_+_66512089 0.42 ENST00000524551.1
ENST00000525908.1
ENST00000360962.4
ENST00000346672.4
ENST00000527634.1
ENST00000540737.1
C11orf80
chromosome 11 open reading frame 80
chr18_-_71815051 0.42 ENST00000582526.1
ENST00000419743.2
FBXO15
F-box protein 15
chr7_-_100493744 0.41 ENST00000428317.1
ENST00000441605.1
ACHE
acetylcholinesterase (Yt blood group)
chr22_-_41252962 0.41 ENST00000216218.3
ST13
suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
chr1_-_156307992 0.41 ENST00000415548.1
CCT3
chaperonin containing TCP1, subunit 3 (gamma)
chr11_-_32816156 0.41 ENST00000531481.1
ENST00000335185.5
CCDC73
coiled-coil domain containing 73
chr11_+_65769946 0.40 ENST00000533166.1
BANF1
barrier to autointegration factor 1
chr8_-_81083618 0.40 ENST00000520795.1
TPD52
tumor protein D52
chr17_+_33474826 0.40 ENST00000268876.5
ENST00000433649.1
ENST00000378449.1
UNC45B
unc-45 homolog B (C. elegans)
chr9_+_33025209 0.39 ENST00000330899.4
ENST00000544625.1
DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr3_+_186501979 0.39 ENST00000498746.1
EIF4A2
eukaryotic translation initiation factor 4A2
chr13_-_31191642 0.39 ENST00000405805.1
HMGB1
high mobility group box 1
chr19_-_49565254 0.39 ENST00000593537.1
NTF4
neurotrophin 4
chr12_+_70132632 0.38 ENST00000378815.6
ENST00000483530.2
ENST00000325555.9
RAB3IP
RAB3A interacting protein
chr7_-_56119238 0.38 ENST00000275605.3
ENST00000395471.3
PSPH
phosphoserine phosphatase
chrX_+_123095155 0.38 ENST00000371160.1
ENST00000435103.1
STAG2
stromal antigen 2
chr22_+_32871224 0.38 ENST00000452138.1
ENST00000382058.3
ENST00000397426.1
FBXO7
F-box protein 7
chr2_-_198364581 0.38 ENST00000428204.1
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr1_-_173638976 0.37 ENST00000333279.2
ANKRD45
ankyrin repeat domain 45
chr16_-_18468926 0.37 ENST00000545114.1
RP11-1212A22.4
LOC339047 protein; Nuclear pore complex-interacting protein family member A3; Nuclear pore complex-interacting protein family member A5; Protein PKD1P1
chrX_-_102942961 0.37 ENST00000434230.1
ENST00000418819.1
ENST00000360458.1
MORF4L2
mortality factor 4 like 2
chr9_+_74764278 0.37 ENST00000238018.4
ENST00000376989.3
GDA
guanine deaminase
chr14_-_102553371 0.36 ENST00000553585.1
ENST00000216281.8
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr8_+_143781883 0.36 ENST00000522591.1
LY6K
lymphocyte antigen 6 complex, locus K
chr3_+_130613001 0.36 ENST00000504948.1
ENST00000513801.1
ENST00000505072.1
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr22_+_17082732 0.36 ENST00000558085.2
ENST00000592918.1
ENST00000400593.2
ENST00000592107.1
ENST00000426585.1
ENST00000591299.1
TPTEP1
transmembrane phosphatase with tensin homology pseudogene 1
chr11_-_82997420 0.36 ENST00000455220.2
ENST00000529689.1
CCDC90B
coiled-coil domain containing 90B
chr2_+_201170770 0.36 ENST00000409988.3
ENST00000409385.1
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr8_+_37594130 0.36 ENST00000518526.1
ENST00000523887.1
ENST00000276461.5
ERLIN2
ER lipid raft associated 2
chr11_-_89956227 0.36 ENST00000457199.2
ENST00000530765.1
CHORDC1
cysteine and histidine-rich domain (CHORD) containing 1
chr2_+_198365095 0.35 ENST00000409468.1
HSPE1
heat shock 10kDa protein 1
chr8_+_140943416 0.35 ENST00000507535.3
C8orf17
chromosome 8 open reading frame 17
chr8_-_81083731 0.34 ENST00000379096.5
TPD52
tumor protein D52
chrX_-_154563889 0.34 ENST00000369449.2
ENST00000321926.4
CLIC2
chloride intracellular channel 2
chr7_-_3083573 0.34 ENST00000396946.4
CARD11
caspase recruitment domain family, member 11
chr3_+_130613226 0.34 ENST00000509662.1
ENST00000328560.8
ENST00000428331.2
ENST00000359644.3
ENST00000422190.2
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chrX_+_123094369 0.34 ENST00000455404.1
ENST00000218089.9
STAG2
stromal antigen 2
chr14_+_101293687 0.33 ENST00000455286.1
MEG3
maternally expressed 3 (non-protein coding)
chr21_+_35445811 0.33 ENST00000399312.2
MRPS6
mitochondrial ribosomal protein S6
chr7_+_157129660 0.33 ENST00000429029.2
ENST00000262177.4
ENST00000417758.1
ENST00000452797.2
ENST00000443280.1
DNAJB6
DnaJ (Hsp40) homolog, subfamily B, member 6
chrX_-_102943022 0.33 ENST00000433176.2
MORF4L2
mortality factor 4 like 2
chr9_-_88714421 0.32 ENST00000388712.3
GOLM1
golgi membrane protein 1
chr20_-_43589109 0.32 ENST00000372813.3
TOMM34
translocase of outer mitochondrial membrane 34
chr17_+_33474860 0.32 ENST00000394570.2
UNC45B
unc-45 homolog B (C. elegans)
chr1_-_27709793 0.32 ENST00000374027.3
ENST00000374025.3
CD164L2
CD164 sialomucin-like 2
chr6_-_138833630 0.31 ENST00000533765.1
NHSL1
NHS-like 1
chr5_+_133706865 0.31 ENST00000265339.2
UBE2B
ubiquitin-conjugating enzyme E2B
chr22_+_31460091 0.31 ENST00000432777.1
ENST00000422839.1
SMTN
smoothelin
chr1_-_26232522 0.31 ENST00000399728.1
STMN1
stathmin 1
chr2_-_62115659 0.31 ENST00000544185.1
CCT4
chaperonin containing TCP1, subunit 4 (delta)
chr2_+_201171242 0.31 ENST00000360760.5
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr11_-_111781554 0.30 ENST00000526167.1
ENST00000528961.1
CRYAB
crystallin, alpha B
chr4_-_17513604 0.30 ENST00000505710.1
QDPR
quinoid dihydropteridine reductase
chr16_-_68034470 0.29 ENST00000412757.2
DPEP2
dipeptidase 2
chr5_+_118690466 0.29 ENST00000503646.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr6_+_36165133 0.29 ENST00000446974.1
ENST00000454960.1
BRPF3
bromodomain and PHD finger containing, 3
chr1_-_149459549 0.29 ENST00000369175.3
FAM72C
family with sequence similarity 72, member C
chr17_-_74722536 0.29 ENST00000585429.1
JMJD6
jumonji domain containing 6
chr3_+_136676851 0.28 ENST00000309741.5
IL20RB
interleukin 20 receptor beta
chr21_+_35445827 0.27 ENST00000608209.1
ENST00000381151.3
SLC5A3
SLC5A3
sodium/myo-inositol cotransporter
solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
chr17_-_62308087 0.26 ENST00000583097.1
TEX2
testis expressed 2
chr1_+_156308403 0.25 ENST00000481479.1
ENST00000368252.1
ENST00000466306.1
ENST00000368251.1
TSACC
TSSK6 activating co-chaperone
chr9_-_88715044 0.25 ENST00000388711.3
ENST00000466178.1
GOLM1
golgi membrane protein 1
chr11_-_14913765 0.25 ENST00000334636.5
CYP2R1
cytochrome P450, family 2, subfamily R, polypeptide 1
chr22_+_41253080 0.25 ENST00000541156.1
ENST00000414396.1
ENST00000357137.4
XPNPEP3
X-prolyl aminopeptidase (aminopeptidase P) 3, putative
chr5_+_159895275 0.25 ENST00000517927.1
MIR146A
microRNA 146a
chr11_+_112046190 0.25 ENST00000357685.5
ENST00000393032.2
ENST00000361053.4
BCO2
beta-carotene oxygenase 2
chr8_+_37594185 0.24 ENST00000518586.1
ENST00000335171.6
ENST00000521644.1
ERLIN2
ER lipid raft associated 2
chr2_+_201171268 0.24 ENST00000423749.1
ENST00000428692.1
ENST00000457757.1
ENST00000453663.1
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr17_-_46716647 0.24 ENST00000608940.1
RP11-357H14.17
RP11-357H14.17
chr1_+_67773044 0.24 ENST00000262345.1
ENST00000371000.1
IL12RB2
interleukin 12 receptor, beta 2
chr15_+_79165112 0.24 ENST00000426013.2
MORF4L1
mortality factor 4 like 1
chr11_-_47870019 0.23 ENST00000378460.2
NUP160
nucleoporin 160kDa
chr11_-_62457371 0.23 ENST00000317449.4
LRRN4CL
LRRN4 C-terminal like
chr3_-_183735731 0.23 ENST00000334444.6
ABCC5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chrX_+_123094672 0.23 ENST00000354548.5
ENST00000458700.1
STAG2
stromal antigen 2
chr22_+_50986462 0.22 ENST00000395676.2
KLHDC7B
kelch domain containing 7B
chr3_-_53080672 0.22 ENST00000483069.1
SFMBT1
Scm-like with four mbt domains 1
chrX_-_152939252 0.21 ENST00000340888.3
PNCK
pregnancy up-regulated nonubiquitous CaM kinase
chr3_+_130612803 0.21 ENST00000510168.1
ENST00000508532.1
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr2_+_203130439 0.21 ENST00000264279.5
NOP58
NOP58 ribonucleoprotein
chr15_+_79165151 0.21 ENST00000331268.5
MORF4L1
mortality factor 4 like 1
chrX_-_39923656 0.21 ENST00000413905.1
BCOR
BCL6 corepressor
chr18_-_19284724 0.21 ENST00000580981.1
ENST00000289119.2
ABHD3
abhydrolase domain containing 3
chr19_+_1354930 0.21 ENST00000591337.1
MUM1
melanoma associated antigen (mutated) 1
chr21_-_40720974 0.21 ENST00000380748.1
HMGN1
high mobility group nucleosome binding domain 1
chr21_-_40720995 0.20 ENST00000380749.5
HMGN1
high mobility group nucleosome binding domain 1
chrX_-_152939133 0.20 ENST00000370150.1
PNCK
pregnancy up-regulated nonubiquitous CaM kinase
chr8_-_37594944 0.20 ENST00000330539.1
RP11-863K10.7
Uncharacterized protein
chr3_-_185655795 0.20 ENST00000342294.4
ENST00000382191.4
ENST00000453386.2
TRA2B
transformer 2 beta homolog (Drosophila)
chr17_-_61850894 0.20 ENST00000403162.3
ENST00000582252.1
ENST00000225726.5
CCDC47
coiled-coil domain containing 47
chr11_+_107799118 0.19 ENST00000320578.2
RAB39A
RAB39A, member RAS oncogene family
chr11_-_111781454 0.19 ENST00000533280.1
CRYAB
crystallin, alpha B
chr1_+_109265033 0.19 ENST00000445274.1
FNDC7
fibronectin type III domain containing 7
chr12_-_48500085 0.19 ENST00000549518.1
SENP1
SUMO1/sentrin specific peptidase 1
chr3_+_136676707 0.19 ENST00000329582.4
IL20RB
interleukin 20 receptor beta
chr1_-_248005254 0.19 ENST00000355784.2
OR11L1
olfactory receptor, family 11, subfamily L, member 1
chr17_-_74722672 0.19 ENST00000397625.4
ENST00000445478.2
JMJD6
jumonji domain containing 6
chrX_-_106243451 0.18 ENST00000355610.4
ENST00000535534.1
MORC4
MORC family CW-type zinc finger 4
chr10_-_74856608 0.18 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
P4HA1
prolyl 4-hydroxylase, alpha polypeptide I
chr19_+_2269485 0.18 ENST00000582888.4
ENST00000602676.2
ENST00000322297.4
ENST00000583542.4
OAZ1
ornithine decarboxylase antizyme 1
chr19_+_41509851 0.18 ENST00000593831.1
ENST00000330446.5
CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr5_+_133707252 0.18 ENST00000506787.1
ENST00000507277.1
UBE2B
ubiquitin-conjugating enzyme E2B
chr2_+_201170703 0.17 ENST00000358677.5
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr5_+_56469843 0.17 ENST00000514387.2
GPBP1
GC-rich promoter binding protein 1
chr18_+_11751493 0.17 ENST00000269162.5
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr2_+_201171577 0.17 ENST00000409397.2
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr11_-_111782696 0.17 ENST00000227251.3
ENST00000526180.1
CRYAB
crystallin, alpha B
chr5_+_56469939 0.17 ENST00000506184.2
GPBP1
GC-rich promoter binding protein 1
chr16_+_14844670 0.16 ENST00000553201.1
NPIPA2
nuclear pore complex interacting protein family, member A2
chr12_+_70132458 0.16 ENST00000247833.7
RAB3IP
RAB3A interacting protein
chr4_-_22517620 0.16 ENST00000502482.1
ENST00000334304.5
GPR125
G protein-coupled receptor 125
chr4_-_6383594 0.16 ENST00000335585.5
PPP2R2C
protein phosphatase 2, regulatory subunit B, gamma
chr4_-_159644507 0.16 ENST00000307720.3
PPID
peptidylprolyl isomerase D
chr19_-_4717835 0.16 ENST00000599248.1
DPP9
dipeptidyl-peptidase 9
chr2_-_68479614 0.16 ENST00000234310.3
PPP3R1
protein phosphatase 3, regulatory subunit B, alpha
chrX_-_106243294 0.16 ENST00000255495.7
MORC4
MORC family CW-type zinc finger 4
chr19_+_11650709 0.16 ENST00000586059.1
CNN1
calponin 1, basic, smooth muscle
chr12_-_123011536 0.16 ENST00000331738.7
ENST00000354654.2
RSRC2
arginine/serine-rich coiled-coil 2
chr19_+_6135646 0.16 ENST00000588304.1
ENST00000588485.1
ENST00000588722.1
ENST00000591403.1
ENST00000586696.1
ENST00000589401.1
ENST00000252669.5
ACSBG2
acyl-CoA synthetase bubblegum family member 2
chrX_-_73072534 0.16 ENST00000429829.1
XIST
X inactive specific transcript (non-protein coding)
chr15_+_45028753 0.15 ENST00000338264.4
TRIM69
tripartite motif containing 69
chrX_-_152989798 0.15 ENST00000441714.1
ENST00000442093.1
ENST00000429550.1
ENST00000345046.6
BCAP31
B-cell receptor-associated protein 31
chr20_+_4666882 0.15 ENST00000379440.4
ENST00000430350.2
PRNP
prion protein
chr20_-_23731569 0.15 ENST00000304749.2
CST1
cystatin SN
chr14_-_68141535 0.15 ENST00000554659.1
VTI1B
vesicle transport through interaction with t-SNAREs 1B
chr12_-_123011476 0.15 ENST00000528279.1
ENST00000344591.4
ENST00000526560.2
RSRC2
arginine/serine-rich coiled-coil 2
chr11_+_63953691 0.14 ENST00000543847.1
STIP1
stress-induced-phosphoprotein 1
chr11_-_82997371 0.14 ENST00000525503.1
CCDC90B
coiled-coil domain containing 90B
chr1_-_45987526 0.13 ENST00000372079.1
ENST00000262746.1
ENST00000447184.1
ENST00000319248.8
PRDX1
peroxiredoxin 1
chr1_-_245026388 0.13 ENST00000440865.1
HNRNPU
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
chr9_-_86323118 0.13 ENST00000376395.4
UBQLN1
ubiquilin 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.7 GO:1903751 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.4 2.7 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.3 1.5 GO:1904764 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
0.3 0.9 GO:0006147 guanine catabolic process(GO:0006147)
0.3 0.9 GO:0008052 sensory organ boundary specification(GO:0008052) formation of organ boundary(GO:0010160) taste bud development(GO:0061193)
0.2 0.7 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.2 0.7 GO:0045362 interleukin-1 biosynthetic process(GO:0042222) regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.2 0.7 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.2 0.8 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.2 0.6 GO:0031247 actin rod assembly(GO:0031247)
0.2 0.4 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.2 0.7 GO:0036114 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.2 0.5 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.2 0.5 GO:0002894 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
0.2 2.5 GO:1904871 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.1 0.4 GO:0051466 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) positive regulation of corticotropin-releasing hormone secretion(GO:0051466)
0.1 1.3 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.1 0.4 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.1 0.9 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.1 0.5 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.1 0.4 GO:0051066 dihydrobiopterin metabolic process(GO:0051066)
0.1 0.4 GO:0002270 plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072) T-helper 1 cell activation(GO:0035711) negative regulation of apoptotic cell clearance(GO:2000426)
0.1 0.4 GO:0019236 response to pheromone(GO:0019236)
0.1 1.4 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 0.6 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.1 0.4 GO:0043335 protein unfolding(GO:0043335)
0.1 0.4 GO:0039689 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.1 0.5 GO:1902231 regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164) positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.1 0.5 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.1 0.9 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 0.4 GO:1903748 negative regulation of establishment of protein localization to mitochondrion(GO:1903748)
0.1 0.2 GO:1901340 negative regulation of store-operated calcium channel activity(GO:1901340)
0.1 0.8 GO:0010917 negative regulation of mitochondrial membrane potential(GO:0010917)
0.1 0.2 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.2 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378)
0.0 0.9 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.3 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.0 1.5 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.5 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.6 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.3 GO:0015798 myo-inositol transport(GO:0015798)
0.0 0.2 GO:1990535 neuron projection maintenance(GO:1990535)
0.0 0.2 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 0.2 GO:0071492 cellular response to UV-A(GO:0071492)
0.0 0.8 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.3 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.1 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386) immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.0 0.3 GO:0045086 positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0 0.4 GO:1903599 positive regulation of mitophagy(GO:1903599)
0.0 0.3 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.0 0.2 GO:0048254 snoRNA localization(GO:0048254)
0.0 0.4 GO:0015074 DNA integration(GO:0015074)
0.0 0.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.5 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.0 0.2 GO:0035799 ureter maturation(GO:0035799)
0.0 0.7 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.5 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.2 GO:0008300 isoprenoid catabolic process(GO:0008300)
0.0 0.9 GO:0071711 basement membrane organization(GO:0071711)
0.0 0.5 GO:0051412 response to corticosterone(GO:0051412)
0.0 0.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.2 GO:0042738 exogenous drug catabolic process(GO:0042738)
0.0 0.6 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.4 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.2 GO:0006983 ER overload response(GO:0006983)
0.0 0.5 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.4 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 0.1 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.0 0.2 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.0 0.1 GO:0044800 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.0 0.1 GO:0009956 radial pattern formation(GO:0009956)
0.0 0.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.1 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.0 0.4 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.0 0.1 GO:0035494 SNARE complex disassembly(GO:0035494)
0.0 0.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.7 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.1 GO:0090204 protein localization to nuclear pore(GO:0090204)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.2 1.5 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.2 4.7 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.1 0.7 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 2.5 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.7 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 0.9 GO:0097512 cardiac myofibril(GO:0097512)
0.1 0.4 GO:1990037 Lewy body core(GO:1990037)
0.1 0.4 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 0.5 GO:0033503 HULC complex(GO:0033503)
0.0 2.7 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.4 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 1.5 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.4 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.3 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 1.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0043196 varicosity(GO:0043196)
0.0 0.3 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.5 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0008892 guanine deaminase activity(GO:0008892)
0.3 3.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 0.7 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.2 1.5 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2 0.7 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.2 1.9 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.1 0.9 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.1 0.4 GO:0004155 6,7-dihydropteridine reductase activity(GO:0004155)
0.1 0.5 GO:0032767 copper-dependent protein binding(GO:0032767)
0.1 0.4 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.1 0.4 GO:0032558 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.1 0.3 GO:0005365 myo-inositol transmembrane transporter activity(GO:0005365)
0.1 0.5 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.5 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.1 0.6 GO:0046790 virion binding(GO:0046790)
0.1 0.4 GO:0019776 Atg8 ligase activity(GO:0019776)
0.1 0.7 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 0.2 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.1 0.4 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.1 0.2 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 0.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.4 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.6 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 7.8 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.2 GO:1903135 cupric ion binding(GO:1903135)
0.0 0.2 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.7 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.1 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.3 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.8 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.2 GO:0005549 odorant binding(GO:0005549)
0.0 0.8 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.3 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.2 GO:0004028 retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.2 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.0 0.2 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.4 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.5 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.1 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.2 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.5 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.7 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.9 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.9 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.2 PID IL27 PATHWAY IL27-mediated signaling events
0.0 1.2 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.0 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.9 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.6 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 1.5 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.7 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.4 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 1.0 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.4 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.7 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.4 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.7 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.5 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0 0.2 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.4 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.3 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 0.2 REACTOME XENOBIOTICS Genes involved in Xenobiotics