ISMARA results: HSF4

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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for HSF4

Z-value: 2.22

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Transcription factors associated with HSF4

Gene Symbol	Gene ID	Gene Info
HSF4 Ensembl NCBI GeneCards UniProt	ENSG00000102878.11	heat shock transcription factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HSF4	hg19_v2_chr16_+_67198683_67198715	-0.76	2.4e-01	Click!

Activity profile of HSF4 motif

Sorted Z-values of HSF4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_161494036 Show fit	2.72	ENST00000309758.4	HSPA6 Ensembl NCBI GeneCards UniProt Show fit	heat shock 70kDa protein 6 (HSP70B')
chrX_+_150866779 Show fit	1.47	ENST00000370353.3	PRRG3 Ensembl NCBI GeneCards UniProt Show fit	proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
chr13_-_31736132 Show fit	1.46	ENST00000429785.2	HSPH1 Ensembl NCBI GeneCards UniProt Show fit	heat shock 105kDa/110kDa protein 1
chr13_-_31736478 Show fit	1.26	ENST00000445273.2	HSPH1 Ensembl NCBI GeneCards UniProt Show fit	heat shock 105kDa/110kDa protein 1
chrX_+_108780062 Show fit	1.07	ENST00000372106.1	NXT2 Ensembl NCBI GeneCards UniProt Show fit	nuclear transport factor 2-like export factor 2
chr7_+_157129738 Show fit	1.02	ENST00000437030.1	DNAJB6 Ensembl NCBI GeneCards UniProt Show fit	DnaJ (Hsp40) homolog, subfamily B, member 6
chr13_-_31736027 Show fit	1.01	ENST00000380406.5 ENST00000320027.5 ENST00000380405.4	HSPH1 Ensembl NCBI GeneCards UniProt Show fit	heat shock 105kDa/110kDa protein 1
chr7_-_1199781 Show fit	1.00	ENST00000397083.1 ENST00000401903.1 ENST00000316495.3	ZFAND2A Ensembl NCBI GeneCards UniProt Show fit	zinc finger, AN1-type domain 2A
chr14_-_52535712 Show fit	0.91	ENST00000216286.5 ENST00000541773.1	NID2 Ensembl NCBI GeneCards UniProt Show fit	nidogen 2 (osteonidogen)
chr11_+_63953587 Show fit	0.86	ENST00000305218.4 ENST00000538945.1	STIP1 Ensembl NCBI GeneCards UniProt Show fit	stress-induced-phosphoprotein 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	3.7	GO:1903751	regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.4	2.7	GO:0010286	heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.2	2.5	GO:1904871	regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.3	1.5	GO:1904764	negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
0.0	1.5	GO:0043968	histone H2A acetylation(GO:0043968)
0.1	1.4	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.1	1.3	GO:0060715	syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.3	0.9	GO:0006147	guanine catabolic process(GO:0006147)
0.3	0.9	GO:0008052	sensory organ boundary specification(GO:0008052) formation of organ boundary(GO:0010160) taste bud development(GO:0061193)
0.1	0.9	GO:0032468	Golgi calcium ion homeostasis(GO:0032468)

Showing 1 to 10 of 78 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.7	GO:0071682	endocytic vesicle lumen(GO:0071682)
0.0	2.7	GO:0008180	COP9 signalosome(GO:0008180)
0.1	2.5	GO:0005832	chaperonin-containing T-complex(GO:0005832)
0.2	1.5	GO:0098575	lumenal side of lysosomal membrane(GO:0098575)
0.0	1.5	GO:0043189	NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0	1.5	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.1	0.9	GO:0097512	cardiac myofibril(GO:0097512)
0.0	0.8	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.2	0.7	GO:1990622	CHOP-ATF3 complex(GO:1990622)
0.1	0.7	GO:0030906	retromer, cargo-selective complex(GO:0030906)

Showing 1 to 10 of 28 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.8	GO:0031072	heat shock protein binding(GO:0031072)
0.3	3.7	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
0.2	1.9	GO:0055131	C3HC4-type RING finger domain binding(GO:0055131)
0.2	1.5	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.3	0.9	GO:0008892	guanine deaminase activity(GO:0008892)
0.1	0.9	GO:0005166	neurotrophin p75 receptor binding(GO:0005166)
0.0	0.9	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	0.9	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.8	GO:0031683	G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0	0.8	GO:0044183	protein binding involved in protein folding(GO:0044183)

Showing 1 to 10 of 48 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
1.7	PID CMYB PATHWAY	C-MYB transcription factor network
1.5	PID FOXM1 PATHWAY	FOXM1 transcription factor network
1.2	PID AP1 PATHWAY	AP-1 transcription factor network
1.0	PID PLK1 PATHWAY	PLK1 signaling events
0.9	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.9	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.5	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.3	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.2	PID IL27 PATHWAY	IL27-mediated signaling events

Showing 1 to 9 of 9 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.5	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0	1.5	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	1.5	REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0	1.0	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.9	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.9	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	0.8	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	0.7	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.7	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.0	0.7	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway

Showing 1 to 10 of 19 entries

Results for HSF4

Z-value: 2.22

Motif logo

Transcription factors associated with HSF4

Activity-expression correlation:

Activity profile of HSF4 motif

Sorted Z-values of HSF4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: