ISMARA results: HOXB6

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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for HOXB6_PRRX2

Z-value: 1.81

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Transcription factors associated with HOXB6_PRRX2

Gene Symbol	Gene ID	Gene Info
HOXB6 Ensembl NCBI GeneCards UniProt	ENSG00000108511.8	homeobox B6
PRRX2 Ensembl NCBI GeneCards UniProt	ENSG00000167157.9	paired related homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXB6	hg19_v2_chr17_-_46682321_46682362	-0.76	2.4e-01	Click!
PRRX2	hg19_v2_chr9_+_132427883_132427951	-0.72	2.8e-01	Click!

Activity profile of HOXB6_PRRX2 motif

Sorted Z-values of HOXB6_PRRX2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_57233966 Show fit	2.11	ENST00000473921.1 ENST00000295934.3	HESX1 Ensembl NCBI GeneCards UniProt Show fit	HESX homeobox 1
chr8_+_142264664 Show fit	1.86	ENST00000518520.1	RP11-10J21.3 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein
chr7_-_27205136 Show fit	1.80	ENST00000396345.1 ENST00000343483.6	HOXA9 Ensembl NCBI GeneCards UniProt Show fit	homeobox A9
chr9_+_2159850 Show fit	1.42	ENST00000416751.1	SMARCA2 Ensembl NCBI GeneCards UniProt Show fit	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr5_+_66300464 Show fit	1.34	ENST00000436277.1	MAST4 Ensembl NCBI GeneCards UniProt Show fit	microtubule associated serine/threonine kinase family member 4
chr16_-_51185172 Show fit	1.28	ENST00000251020.4	SALL1 Ensembl NCBI GeneCards UniProt Show fit	spalt-like transcription factor 1
chr4_+_108815402 Show fit	1.27	ENST00000503385.1	SGMS2 Ensembl NCBI GeneCards UniProt Show fit	sphingomyelin synthase 2
chr17_-_38956205 Show fit	1.16	ENST00000306658.7	KRT28 Ensembl NCBI GeneCards UniProt Show fit	keratin 28
chr9_-_16705069 Show fit	1.14	ENST00000471301.2	BNC2 Ensembl NCBI GeneCards UniProt Show fit	basonuclin 2
chr6_-_10115007 Show fit	1.09	ENST00000485268.1	OFCC1 Ensembl NCBI GeneCards UniProt Show fit	orofacial cleft 1 candidate 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB6_PRRX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.1	GO:0030916	otic vesicle formation(GO:0030916)
0.1	1.8	GO:0042118	endothelial cell activation(GO:0042118)
0.3	1.5	GO:0072619	interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0	1.5	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.0	1.5	GO:0070268	cornification(GO:0070268)
0.2	1.4	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.0	1.4	GO:0006625	protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.3	1.3	GO:0061034	olfactory bulb mitral cell layer development(GO:0061034)
0.1	1.3	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.3	1.2	GO:0060437	lung growth(GO:0060437)

Showing 1 to 10 of 238 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.4	GO:0010369	chromocenter(GO:0010369)
0.0	1.4	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	1.2	GO:0071564	npBAF complex(GO:0071564)
0.1	1.1	GO:0097025	lateral loop(GO:0043219) MPP7-DLG1-LIN7 complex(GO:0097025)
0.1	1.1	GO:0045277	respiratory chain complex IV(GO:0045277)
0.1	0.9	GO:0060201	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0	0.9	GO:0043198	dendritic shaft(GO:0043198)
0.1	0.8	GO:1990578	perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1	0.8	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.7	GO:0044300	cerebellar mossy fiber(GO:0044300)

Showing 1 to 10 of 87 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.9	GO:0047485	protein N-terminus binding(GO:0047485)
0.0	1.8	GO:0004407	histone deacetylase activity(GO:0004407)
0.0	1.7	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	1.6	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	1.5	GO:0043621	protein self-association(GO:0043621)
0.2	1.3	GO:0047493	sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1	1.3	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.1	1.1	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
0.1	1.1	GO:0097016	L27 domain binding(GO:0097016)
0.1	1.1	GO:0005168	neurotrophin TRK receptor binding(GO:0005167) neurotrophin TRKA receptor binding(GO:0005168)

Showing 1 to 10 of 139 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
1.8	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
1.6	PID E2F PATHWAY	E2F transcription factor network
1.4	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
1.2	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
1.1	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
1.0	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.8	PID IL5 PATHWAY	IL5-mediated signaling events
0.8	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.8	PID AP1 PATHWAY	AP-1 transcription factor network
0.7	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling

Showing 1 to 10 of 20 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.3	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.1	1.2	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.0	1.2	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	1.1	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.1	1.0	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0	1.0	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	1.0	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	1.0	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.8	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.7	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination

Showing 1 to 10 of 31 entries

Results for HOXB6_PRRX2

Z-value: 1.81

Motif logo

Transcription factors associated with HOXB6_PRRX2

Activity-expression correlation:

Activity profile of HOXB6_PRRX2 motif

Sorted Z-values of HOXB6_PRRX2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB6_PRRX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: