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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for HOXB5

Z-value: 0.61

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Transcription factors associated with HOXB5

Gene Symbol Gene ID Gene Info
HOXB5
ENSG00000120075.5 homeobox B5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB5hg19_v2_chr17_-_46671323_466713230.326.8e-01Click!

Activity profile of HOXB5 motif

Sorted Z-values of HOXB5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_5322561 0.55 ENST00000396872.3
ENST00000444741.1
ENST00000297195.4
ENST00000406453.3
SLC29A4
solute carrier family 29 (equilibrative nucleoside transporter), member 4
chr16_-_1821496 0.32 ENST00000564628.1
ENST00000563498.1
NME3
NME/NM23 nucleoside diphosphate kinase 3
chr12_-_52715179 0.30 ENST00000293670.3
KRT83
keratin 83
chr9_-_130700080 0.24 ENST00000373110.4
DPM2
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
chr10_-_103603568 0.22 ENST00000356640.2
KCNIP2
Kv channel interacting protein 2
chr10_-_103603523 0.21 ENST00000370046.1
KCNIP2
Kv channel interacting protein 2
chr6_+_30749649 0.20 ENST00000422944.1
HCG20
HLA complex group 20 (non-protein coding)
chr1_+_146373546 0.16 ENST00000446760.2
NBPF12
neuroblastoma breakpoint family, member 12
chr16_-_1821721 0.15 ENST00000219302.3
NME3
NME/NM23 nucleoside diphosphate kinase 3
chr16_-_9770700 0.15 ENST00000561538.1
RP11-297M9.1
Uncharacterized protein
chrX_+_47077680 0.15 ENST00000522883.1
CDK16
cyclin-dependent kinase 16
chr17_+_46970178 0.14 ENST00000393366.2
ENST00000506855.1
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chrX_+_48380205 0.13 ENST00000446158.1
ENST00000414061.1
EBP
emopamil binding protein (sterol isomerase)
chr19_+_7571968 0.11 ENST00000599312.1
CTD-2207O23.12
Uncharacterized protein
chr2_-_70409953 0.10 ENST00000419381.1
C2orf42
chromosome 2 open reading frame 42
chr1_+_155579979 0.09 ENST00000452804.2
ENST00000538143.1
ENST00000245564.2
ENST00000368341.4
MSTO1
misato 1, mitochondrial distribution and morphology regulator
chr5_-_141061759 0.09 ENST00000508305.1
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr19_-_12267524 0.09 ENST00000455799.1
ENST00000355738.1
ENST00000439556.2
ENST00000542938.1
ZNF625
zinc finger protein 625
chr12_+_53693466 0.08 ENST00000267103.5
ENST00000548632.1
C12orf10
chromosome 12 open reading frame 10
chr1_+_154229547 0.08 ENST00000428595.1
UBAP2L
ubiquitin associated protein 2-like
chr18_+_32558380 0.08 ENST00000588349.2
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr15_+_74218787 0.08 ENST00000261921.7
LOXL1
lysyl oxidase-like 1
chr1_-_155658085 0.08 ENST00000311573.5
ENST00000438245.2
YY1AP1
YY1 associated protein 1
chr11_-_57089774 0.08 ENST00000527207.1
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr19_-_42724261 0.08 ENST00000595337.1
DEDD2
death effector domain containing 2
chr14_+_38660185 0.07 ENST00000555655.1
CTD-2142D14.1
CTD-2142D14.1
chr16_-_28936007 0.07 ENST00000568703.1
ENST00000567483.1
RABEP2
rabaptin, RAB GTPase binding effector protein 2
chr7_+_125557914 0.07 ENST00000411856.1
AC005276.1
AC005276.1
chr1_-_155658260 0.07 ENST00000368339.5
ENST00000405763.3
ENST00000368340.5
ENST00000454523.1
ENST00000443231.1
ENST00000347088.5
ENST00000361831.5
ENST00000355499.4
YY1AP1
YY1 associated protein 1
chr7_+_120969045 0.07 ENST00000222462.2
WNT16
wingless-type MMTV integration site family, member 16
chr2_-_74726710 0.07 ENST00000377566.4
LBX2
ladybird homeobox 2
chr16_-_30381580 0.07 ENST00000409939.3
TBC1D10B
TBC1 domain family, member 10B
chr6_-_133119668 0.07 ENST00000275227.4
ENST00000538764.1
SLC18B1
solute carrier family 18, subfamily B, member 1
chr12_-_6798523 0.07 ENST00000319770.3
ZNF384
zinc finger protein 384
chr19_-_16045220 0.06 ENST00000326742.8
CYP4F11
cytochrome P450, family 4, subfamily F, polypeptide 11
chr18_-_33077556 0.06 ENST00000589273.1
ENST00000586489.1
INO80C
INO80 complex subunit C
chr4_+_159122728 0.06 ENST00000505049.1
ENST00000505189.1
ENST00000511038.1
TMEM144
transmembrane protein 144
chr6_-_31509714 0.06 ENST00000456662.1
ENST00000431908.1
ENST00000456976.1
ENST00000428450.1
ENST00000453105.2
ENST00000418897.1
ENST00000415382.2
ENST00000449074.2
ENST00000419020.1
ENST00000428098.1
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr1_+_145576007 0.06 ENST00000369298.1
PIAS3
protein inhibitor of activated STAT, 3
chr6_+_167525277 0.05 ENST00000400926.2
CCR6
chemokine (C-C motif) receptor 6
chr6_-_31510181 0.05 ENST00000458640.1
ENST00000396172.1
ENST00000417556.2
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chrX_+_47077632 0.05 ENST00000457458.2
CDK16
cyclin-dependent kinase 16
chr12_+_66217911 0.05 ENST00000403681.2
HMGA2
high mobility group AT-hook 2
chr5_-_141061777 0.05 ENST00000239440.4
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr1_+_41157671 0.05 ENST00000534399.1
ENST00000372653.1
NFYC
nuclear transcription factor Y, gamma
chr1_+_155658849 0.05 ENST00000368336.5
ENST00000343043.3
ENST00000421487.2
ENST00000535183.1
ENST00000465375.1
ENST00000470830.1
DAP3
death associated protein 3
chr16_-_84651647 0.05 ENST00000564057.1
COTL1
coactosin-like 1 (Dictyostelium)
chrX_+_135230712 0.05 ENST00000535737.1
FHL1
four and a half LIM domains 1
chr1_+_145575980 0.04 ENST00000393045.2
PIAS3
protein inhibitor of activated STAT, 3
chr1_-_155658518 0.04 ENST00000404643.1
ENST00000359205.5
ENST00000407221.1
YY1AP1
YY1 associated protein 1
chr6_-_32820529 0.04 ENST00000425148.2
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr11_-_57089671 0.04 ENST00000532437.1
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr12_-_6798616 0.04 ENST00000355772.4
ENST00000417772.3
ENST00000396801.3
ENST00000396799.2
ZNF384
zinc finger protein 384
chr4_-_114900831 0.04 ENST00000315366.7
ARSJ
arylsulfatase family, member J
chr1_-_155658766 0.03 ENST00000295566.4
ENST00000368330.2
YY1AP1
YY1 associated protein 1
chr12_+_57984943 0.03 ENST00000422156.3
PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr1_+_41157421 0.03 ENST00000372654.1
NFYC
nuclear transcription factor Y, gamma
chr5_+_175298573 0.03 ENST00000512824.1
CPLX2
complexin 2
chr3_-_195538728 0.03 ENST00000349607.4
ENST00000346145.4
MUC4
mucin 4, cell surface associated
chr6_-_29395509 0.02 ENST00000377147.2
OR11A1
olfactory receptor, family 11, subfamily A, member 1
chr20_-_49308048 0.02 ENST00000327979.2
FAM65C
family with sequence similarity 65, member C
chr6_+_121756809 0.02 ENST00000282561.3
GJA1
gap junction protein, alpha 1, 43kDa
chr17_+_2496971 0.02 ENST00000397195.5
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr17_-_29233769 0.02 ENST00000581216.1
TEFM
transcription elongation factor, mitochondrial
chr12_-_6798410 0.02 ENST00000361959.3
ENST00000436774.2
ENST00000544482.1
ZNF384
zinc finger protein 384
chr12_-_56101647 0.02 ENST00000347027.6
ENST00000257879.6
ENST00000257880.7
ENST00000394230.2
ENST00000394229.2
ITGA7
integrin, alpha 7
chr2_+_219283815 0.02 ENST00000248444.5
ENST00000454069.1
ENST00000392114.2
VIL1
villin 1
chr3_-_164914640 0.02 ENST00000241274.3
SLITRK3
SLIT and NTRK-like family, member 3
chr12_-_53614155 0.02 ENST00000543726.1
RARG
retinoic acid receptor, gamma
chr1_+_116915855 0.02 ENST00000295598.5
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr1_+_41157361 0.02 ENST00000427410.2
ENST00000447388.3
ENST00000425457.2
ENST00000453631.1
ENST00000456393.2
NFYC
nuclear transcription factor Y, gamma
chr17_-_17140436 0.01 ENST00000285071.4
ENST00000389169.5
ENST00000417064.1
FLCN
folliculin
chr14_-_24020858 0.01 ENST00000419474.3
ZFHX2
zinc finger homeobox 2
chr1_-_248802559 0.01 ENST00000317450.3
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr6_-_31509506 0.01 ENST00000449757.1
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr12_-_53614043 0.01 ENST00000338561.5
RARG
retinoic acid receptor, gamma
chr1_+_248616077 0.01 ENST00000342927.3
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chr17_-_42143963 0.01 ENST00000585388.1
ENST00000293406.3
LSM12
LSM12 homolog (S. cerevisiae)
chr14_-_102704783 0.01 ENST00000522534.1
MOK
MOK protein kinase
chr1_-_119530428 0.01 ENST00000369429.3
TBX15
T-box 15
chr5_+_133842243 0.01 ENST00000515627.2
AC005355.2
AC005355.2
chr2_+_17721920 0.01 ENST00000295156.4
VSNL1
visinin-like 1
chr1_+_162351503 0.01 ENST00000458626.2
C1orf226
chromosome 1 open reading frame 226
chr17_+_46970134 0.00 ENST00000503641.1
ENST00000514808.1
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr6_-_29396243 0.00 ENST00000377148.1
OR11A1
olfactory receptor, family 11, subfamily A, member 1
chr3_-_195538760 0.00 ENST00000475231.1
MUC4
mucin 4, cell surface associated
chr18_+_32558208 0.00 ENST00000436190.2
MAPRE2
microtubule-associated protein, RP/EB family, member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.2 GO:0019348 dolichol metabolic process(GO:0019348)
0.0 0.5 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.6 GO:1901642 nucleoside transmembrane transport(GO:1901642)
0.0 0.1 GO:0033490 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.0 0.1 GO:0018277 protein deamination(GO:0018277)
0.0 0.1 GO:0042361 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.0 0.1 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.1 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.0 0.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.0 GO:2000506 negative regulation of energy homeostasis(GO:2000506)
0.0 0.1 GO:0035978 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.0 0.1 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 0.1 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.0 GO:0046967 cytosol to ER transport(GO:0046967)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.1 0.4 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.2 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 0.1 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 0.5 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.1 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.1 GO:0035501 MH1 domain binding(GO:0035501)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis