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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for HOXB2_UNCX_HOXD3
Z-value: 1.81
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Transcription factors associated with HOXB2_UNCX_HOXD3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| UNCX | hg19_v2_chr7_+_1272522_1272543 | 0.97 | 2.6e-02 | Click! |
| HOXD3 | hg19_v2_chr2_+_177025619_177025619 | 0.88 | 1.2e-01 | Click! |
| HOXB2 | hg19_v2_chr17_-_46623441_46623441 | -0.62 | 3.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_53412368 Show fit | 1.80 |
ENST00000565189.1
|
RP11-44F14.2 |
|
| chr8_-_1922789 Show fit | 1.66 |
ENST00000521498.1
|
RP11-439C15.4 |
|
| chr12_-_91546926 Show fit | 1.49 |
ENST00000550758.1
|
decorin |
|
| chr5_+_66300464 Show fit | 1.30 |
ENST00000436277.1
|
microtubule associated serine/threonine kinase family member 4 |
|
| chr9_-_5304432 Show fit | 1.20 |
ENST00000416837.1
ENST00000308420.3 |
relaxin 2 |
|
| chr7_+_77428066 Show fit | 1.12 |
ENST00000422959.2
ENST00000307305.8 ENST00000424760.1 |
putative homeodomain transcription factor 2 |
|
| chr14_-_51027838 Show fit | 1.07 |
ENST00000555216.1
|
mitogen-activated protein kinase kinase kinase kinase 5 |
|
| chr16_+_53133070 Show fit | 1.06 |
ENST00000565832.1
|
chromodomain helicase DNA binding protein 9 |
|
| chr6_-_138866823 Show fit | 1.05 |
ENST00000342260.5
|
NHS-like 1 |
|
| chr15_+_63188009 Show fit | 1.04 |
ENST00000557900.1
|
RP11-1069G10.2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB2_UNCX_HOXD3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 0.3 | 1.7 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.1 | 1.6 | GO:0097475 | motor neuron migration(GO:0097475) |
| 0.1 | 1.5 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.5 | 1.4 | GO:0071449 | cellular response to lipid hydroperoxide(GO:0071449) |
| 0.1 | 1.3 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.1 | 1.3 | GO:0021516 | dorsal spinal cord development(GO:0021516) |
| 0.0 | 1.3 | GO:0030819 | positive regulation of cAMP biosynthetic process(GO:0030819) |
| 0.1 | 1.2 | GO:1903551 | regulation of extracellular exosome assembly(GO:1903551) |
| 0.0 | 1.2 | GO:0035666 | TRIF-dependent toll-like receptor signaling pathway(GO:0035666) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.2 | 1.6 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 1.2 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.1 | 1.0 | GO:0033565 | ESCRT-0 complex(GO:0033565) |
| 0.0 | 1.0 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 1.0 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 0.9 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 0.9 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.1 | 0.8 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.1 | 0.8 | GO:0030870 | Mre11 complex(GO:0030870) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.0 | 1.7 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.3 | 1.5 | GO:0008665 | 2'-phosphotransferase activity(GO:0008665) |
| 0.1 | 1.4 | GO:0043295 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 0.0 | 1.4 | GO:0005179 | hormone activity(GO:0005179) |
| 0.1 | 1.3 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.0 | 1.3 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 1.3 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.4 | 1.2 | GO:0019781 | NEDD8 activating enzyme activity(GO:0019781) |
| 0.1 | 1.2 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 1.3 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.3 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.0 | 1.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.2 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.0 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 1.0 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.9 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.8 | PID IL2 1PATHWAY | IL2-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 1.8 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 1.6 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 1.6 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 1.3 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 1.3 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 1.1 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 1.1 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 1.0 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 0.9 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |