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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for HOXA4

Z-value: 0.84

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Transcription factors associated with HOXA4

Gene Symbol Gene ID Gene Info
HOXA4
ENSG00000197576.9 homeobox A4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA4hg19_v2_chr7_-_27169801_27169844-0.643.6e-01Click!

Activity profile of HOXA4 motif

Sorted Z-values of HOXA4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_66918558 0.71 ENST00000435389.1
ENST00000428590.1
ENST00000412944.1
AC007392.3
AC007392.3
chr5_-_56778635 0.67 ENST00000423391.1
ACTBL2
actin, beta-like 2
chr9_-_3469181 0.55 ENST00000366116.2
AL365202.1
Uncharacterized protein
chr6_-_26235206 0.46 ENST00000244534.5
HIST1H1D
histone cluster 1, H1d
chr10_-_92681033 0.40 ENST00000371697.3
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr3_-_64253655 0.35 ENST00000498162.1
PRICKLE2
prickle homolog 2 (Drosophila)
chr11_+_128563652 0.34 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr19_+_45409011 0.28 ENST00000252486.4
ENST00000446996.1
ENST00000434152.1
APOE
apolipoprotein E
chr18_-_56985873 0.25 ENST00000299721.3
CPLX4
complexin 4
chr12_+_72058130 0.24 ENST00000547843.1
THAP2
THAP domain containing, apoptosis associated protein 2
chr20_+_57464200 0.21 ENST00000604005.1
GNAS
GNAS complex locus
chr14_-_36988882 0.21 ENST00000498187.2
NKX2-1
NK2 homeobox 1
chr2_-_190927447 0.21 ENST00000260950.4
MSTN
myostatin
chr11_+_112046190 0.20 ENST00000357685.5
ENST00000393032.2
ENST00000361053.4
BCO2
beta-carotene oxygenase 2
chr6_-_31514333 0.20 ENST00000376151.4
ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr19_+_12949251 0.19 ENST00000251472.4
MAST1
microtubule associated serine/threonine kinase 1
chr6_+_63921351 0.18 ENST00000370659.1
FKBP1C
FK506 binding protein 1C
chr18_-_56985776 0.18 ENST00000587244.1
CPLX4
complexin 4
chr14_-_36989336 0.18 ENST00000522719.2
NKX2-1
NK2 homeobox 1
chr17_-_67138015 0.17 ENST00000284425.2
ENST00000590645.1
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr21_+_17909594 0.17 ENST00000441820.1
ENST00000602280.1
LINC00478
long intergenic non-protein coding RNA 478
chr17_-_2117600 0.17 ENST00000572369.1
SMG6
SMG6 nonsense mediated mRNA decay factor
chr7_-_130598059 0.16 ENST00000432045.2
MIR29B1
microRNA 29a
chr3_+_159557637 0.16 ENST00000445224.2
SCHIP1
schwannomin interacting protein 1
chr14_-_54423529 0.15 ENST00000245451.4
ENST00000559087.1
BMP4
bone morphogenetic protein 4
chr1_+_155658849 0.14 ENST00000368336.5
ENST00000343043.3
ENST00000421487.2
ENST00000535183.1
ENST00000465375.1
ENST00000470830.1
DAP3
death associated protein 3
chr18_+_3247779 0.14 ENST00000578611.1
ENST00000583449.1
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr11_-_104480019 0.14 ENST00000536529.1
ENST00000545630.1
ENST00000538641.1
RP11-886D15.1
RP11-886D15.1
chr10_-_75415825 0.14 ENST00000394810.2
SYNPO2L
synaptopodin 2-like
chr5_+_133562095 0.14 ENST00000602919.1
CTD-2410N18.3
CTD-2410N18.3
chr17_-_48785216 0.13 ENST00000285243.6
ANKRD40
ankyrin repeat domain 40
chr6_-_116833500 0.13 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr14_+_101359265 0.13 ENST00000599197.1
AL117190.3
Esophagus cancer-related gene-2 interaction susceptibility protein; Uncharacterized protein
chr1_+_28586006 0.13 ENST00000253063.3
SESN2
sestrin 2
chr3_-_178984759 0.12 ENST00000349697.2
ENST00000497599.1
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr3_+_69134124 0.12 ENST00000478935.1
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr7_-_14026123 0.12 ENST00000420159.2
ENST00000399357.3
ENST00000403527.1
ETV1
ets variant 1
chr3_+_88188254 0.11 ENST00000309495.5
ZNF654
zinc finger protein 654
chrX_-_55024967 0.11 ENST00000545676.1
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr7_-_29235063 0.10 ENST00000437527.1
ENST00000455544.1
CPVL
carboxypeptidase, vitellogenic-like
chr7_-_14026063 0.10 ENST00000443608.1
ENST00000438956.1
ETV1
ets variant 1
chr12_+_56521840 0.10 ENST00000394048.5
ESYT1
extended synaptotagmin-like protein 1
chr1_-_12677714 0.10 ENST00000376223.2
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr2_+_39117010 0.10 ENST00000409978.1
ARHGEF33
Rho guanine nucleotide exchange factor (GEF) 33
chr21_+_17442799 0.09 ENST00000602580.1
ENST00000458468.1
ENST00000602935.1
LINC00478
long intergenic non-protein coding RNA 478
chr1_+_214161272 0.09 ENST00000498508.2
ENST00000366958.4
PROX1
prospero homeobox 1
chr15_+_75080883 0.08 ENST00000567571.1
CSK
c-src tyrosine kinase
chr7_+_95115210 0.08 ENST00000428113.1
ENST00000325885.5
ASB4
ankyrin repeat and SOCS box containing 4
chr14_+_45605127 0.08 ENST00000556036.1
ENST00000267430.5
FANCM
Fanconi anemia, complementation group M
chr11_+_22688150 0.08 ENST00000454584.2
GAS2
growth arrest-specific 2
chr12_+_54447637 0.08 ENST00000609810.1
ENST00000430889.2
HOXC4
HOXC4
homeobox C4
Homeobox protein Hox-C4
chr19_-_42806919 0.08 ENST00000595530.1
ENST00000538771.1
ENST00000601865.1
PAFAH1B3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chrX_-_19689106 0.07 ENST00000379716.1
SH3KBP1
SH3-domain kinase binding protein 1
chr6_+_31514622 0.07 ENST00000376146.4
NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr15_+_90744533 0.07 ENST00000411539.2
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr12_+_56522001 0.07 ENST00000267113.4
ENST00000541590.1
ESYT1
extended synaptotagmin-like protein 1
chr21_+_17443434 0.07 ENST00000400178.2
LINC00478
long intergenic non-protein coding RNA 478
chr12_+_50144381 0.07 ENST00000552370.1
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr18_-_53019208 0.07 ENST00000562607.1
TCF4
transcription factor 4
chr7_-_14028488 0.07 ENST00000405358.4
ETV1
ets variant 1
chr18_-_21017817 0.06 ENST00000542162.1
ENST00000383233.3
ENST00000582336.1
ENST00000450466.2
ENST00000578520.1
ENST00000399707.1
TMEM241
transmembrane protein 241
chr2_+_101437487 0.06 ENST00000427413.1
ENST00000542504.1
NPAS2
neuronal PAS domain protein 2
chr17_-_39538550 0.06 ENST00000394001.1
KRT34
keratin 34
chr1_-_42384343 0.06 ENST00000372584.1
HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr5_-_88179302 0.06 ENST00000504921.2
MEF2C
myocyte enhancer factor 2C
chr3_+_122103014 0.06 ENST00000232125.5
ENST00000477892.1
ENST00000469967.1
FAM162A
family with sequence similarity 162, member A
chr1_+_151739131 0.06 ENST00000400999.1
OAZ3
ornithine decarboxylase antizyme 3
chr17_+_37894570 0.05 ENST00000394211.3
GRB7
growth factor receptor-bound protein 7
chr14_+_38065052 0.05 ENST00000556845.1
TTC6
tetratricopeptide repeat domain 6
chr22_+_26138108 0.05 ENST00000536101.1
ENST00000335473.7
ENST00000407587.2
MYO18B
myosin XVIIIB
chr7_-_29234802 0.05 ENST00000449801.1
ENST00000409850.1
CPVL
carboxypeptidase, vitellogenic-like
chr5_+_49962772 0.05 ENST00000281631.5
ENST00000513738.1
ENST00000503665.1
ENST00000514067.2
ENST00000503046.1
PARP8
poly (ADP-ribose) polymerase family, member 8
chr5_+_66300446 0.05 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr14_+_45605157 0.05 ENST00000542564.2
FANCM
Fanconi anemia, complementation group M
chr7_-_75241096 0.05 ENST00000420909.1
HIP1
huntingtin interacting protein 1
chr15_+_80351977 0.05 ENST00000559157.1
ENST00000561012.1
ENST00000564367.1
ENST00000558494.1
ZFAND6
zinc finger, AN1-type domain 6
chr8_-_99954788 0.04 ENST00000523601.1
STK3
serine/threonine kinase 3
chr6_+_100054606 0.04 ENST00000369215.4
PRDM13
PR domain containing 13
chr2_-_145278475 0.04 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr8_-_141774467 0.04 ENST00000520151.1
ENST00000519024.1
ENST00000519465.1
PTK2
protein tyrosine kinase 2
chr3_+_52448539 0.04 ENST00000461861.1
PHF7
PHD finger protein 7
chr1_-_100643765 0.04 ENST00000370137.1
ENST00000370138.1
ENST00000342895.3
LRRC39
leucine rich repeat containing 39
chr7_+_100273736 0.04 ENST00000412215.1
ENST00000393924.1
GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chrX_-_119445306 0.04 ENST00000371369.4
ENST00000440464.1
ENST00000519908.1
TMEM255A
transmembrane protein 255A
chr21_+_17443521 0.04 ENST00000456342.1
LINC00478
long intergenic non-protein coding RNA 478
chr16_+_57728701 0.04 ENST00000569375.1
ENST00000360716.3
ENST00000569167.1
ENST00000394337.4
ENST00000563126.1
ENST00000336825.8
CCDC135
coiled-coil domain containing 135
chr14_+_37131058 0.03 ENST00000361487.6
PAX9
paired box 9
chr3_+_69134080 0.03 ENST00000273258.3
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr20_-_45035223 0.03 ENST00000450812.1
ENST00000290246.6
ENST00000439931.2
ENST00000396391.1
ELMO2
engulfment and cell motility 2
chr4_-_66536057 0.03 ENST00000273854.3
EPHA5
EPH receptor A5
chrX_-_119445263 0.03 ENST00000309720.5
TMEM255A
transmembrane protein 255A
chr15_+_51669444 0.03 ENST00000396399.2
GLDN
gliomedin
chr8_+_71383312 0.02 ENST00000520259.1
RP11-333A23.4
RP11-333A23.4
chrX_+_37639264 0.02 ENST00000378588.4
CYBB
cytochrome b-245, beta polypeptide
chr2_+_54683419 0.02 ENST00000356805.4
SPTBN1
spectrin, beta, non-erythrocytic 1
chr19_-_51220176 0.02 ENST00000359082.3
ENST00000293441.1
SHANK1
SH3 and multiple ankyrin repeat domains 1
chr4_-_109541539 0.02 ENST00000509984.1
ENST00000507248.1
ENST00000506795.1
RPL34-AS1
RPL34 antisense RNA 1 (head to head)
chr14_+_59100774 0.02 ENST00000556859.1
ENST00000421793.1
DACT1
dishevelled-binding antagonist of beta-catenin 1
chr12_+_12938541 0.02 ENST00000356591.4
APOLD1
apolipoprotein L domain containing 1
chr8_+_77593474 0.02 ENST00000455469.2
ENST00000050961.6
ZFHX4
zinc finger homeobox 4
chr13_-_46716969 0.02 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_+_245318279 0.02 ENST00000407071.2
KIF26B
kinesin family member 26B
chr7_+_32996997 0.02 ENST00000242209.4
ENST00000538336.1
ENST00000538443.1
FKBP9
FK506 binding protein 9, 63 kDa
chr3_-_129513259 0.01 ENST00000329333.5
TMCC1
transmembrane and coiled-coil domain family 1
chr15_+_80351910 0.01 ENST00000261749.6
ENST00000561060.1
ZFAND6
zinc finger, AN1-type domain 6
chr10_+_11047259 0.01 ENST00000379261.4
ENST00000416382.2
CELF2
CUGBP, Elav-like family member 2
chr7_+_144052381 0.01 ENST00000498580.1
ENST00000056217.5
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr12_+_53848505 0.01 ENST00000552819.1
ENST00000455667.3
PCBP2
poly(rC) binding protein 2
chr1_+_170632250 0.01 ENST00000367760.3
PRRX1
paired related homeobox 1
chr11_+_112832133 0.01 ENST00000524665.1
NCAM1
neural cell adhesion molecule 1
chr2_-_43453734 0.01 ENST00000282388.3
ZFP36L2
ZFP36 ring finger protein-like 2
chr2_-_163099885 0.01 ENST00000443424.1
FAP
fibroblast activation protein, alpha
chr15_-_33447055 0.01 ENST00000559047.1
ENST00000561249.1
FMN1
formin 1
chrX_+_37639302 0.01 ENST00000545017.1
ENST00000536160.1
CYBB
cytochrome b-245, beta polypeptide
chr4_-_152147579 0.01 ENST00000304527.4
ENST00000455740.1
ENST00000424281.1
ENST00000409598.4
SH3D19
SH3 domain containing 19
chr21_+_22370717 0.01 ENST00000284894.7
NCAM2
neural cell adhesion molecule 2
chr14_+_51026844 0.01 ENST00000554886.1
ATL1
atlastin GTPase 1
chr8_+_77593448 0.01 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr6_+_50786414 0.01 ENST00000344788.3
ENST00000393655.3
ENST00000263046.4
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr9_-_113761720 0.01 ENST00000541779.1
ENST00000374430.2
LPAR1
lysophosphatidic acid receptor 1
chr4_+_84457250 0.01 ENST00000395226.2
AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr12_-_24103954 0.01 ENST00000441133.2
ENST00000545921.1
SOX5
SRY (sex determining region Y)-box 5
chr19_-_10047219 0.00 ENST00000264833.4
OLFM2
olfactomedin 2
chr5_+_40909354 0.00 ENST00000313164.9
C7
complement component 7
chr8_-_139926236 0.00 ENST00000303045.6
ENST00000435777.1
COL22A1
collagen, type XXII, alpha 1
chr7_-_143892748 0.00 ENST00000378115.2
ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chr2_+_171571827 0.00 ENST00000375281.3
SP5
Sp5 transcription factor
chr18_-_28742813 0.00 ENST00000257197.3
ENST00000257198.5
DSC1
desmocollin 1
chr2_+_53994927 0.00 ENST00000295304.4
CHAC2
ChaC, cation transport regulator homolog 2 (E. coli)
chr14_+_39734482 0.00 ENST00000554392.1
ENST00000555716.1
ENST00000341749.3
ENST00000557038.1
CTAGE5
CTAGE family, member 5
chr2_-_163100045 0.00 ENST00000188790.4
FAP
fibroblast activation protein, alpha

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:2000646 lipid transport involved in lipid storage(GO:0010877) regulation of Cdc42 protein signal transduction(GO:0032489) positive regulation of receptor catabolic process(GO:2000646)
0.1 0.2 GO:1902725 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723) negative regulation of satellite cell differentiation(GO:1902725)
0.1 0.4 GO:0021759 globus pallidus development(GO:0021759)
0.1 0.5 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.1 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0 0.2 GO:0072099 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.0 0.1 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.0 0.2 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.1 GO:1903301 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.0 0.2 GO:0008300 isoprenoid catabolic process(GO:0008300)
0.0 0.2 GO:0002036 regulation of L-glutamate transport(GO:0002036) negative regulation of amino acid transport(GO:0051956)
0.0 0.0 GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000588)
0.0 0.4 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.1 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.3 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.2 GO:1904354 negative regulation of telomere capping(GO:1904354)
0.0 0.1 GO:0036079 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.0 0.1 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.1 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.1 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.2 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.0 0.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.3 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0 0.4 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.1 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.2 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.1 GO:0036080 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.0 0.1 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.0 0.1 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.2 GO:0070700 BMP receptor binding(GO:0070700)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport