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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for HOXA2_HOXB1

Z-value: 0.30

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Transcription factors associated with HOXA2_HOXB1

Gene Symbol Gene ID Gene Info
HOXA2
ENSG00000105996.5 homeobox A2
HOXB1
ENSG00000120094.6 homeobox B1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA2hg19_v2_chr7_-_27142290_271424300.936.5e-02Click!

Activity profile of HOXA2_HOXB1 motif

Sorted Z-values of HOXA2_HOXB1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_67390474 0.10 ENST00000371023.3
ENST00000371022.3
ENST00000371026.3
ENST00000431318.1
WDR78
WD repeat domain 78
chr9_+_132099158 0.09 ENST00000444125.1
RP11-65J3.1
RP11-65J3.1
chr17_-_57229155 0.08 ENST00000584089.1
SKA2
spindle and kinetochore associated complex subunit 2
chr6_+_151561506 0.07 ENST00000253332.1
AKAP12
A kinase (PRKA) anchor protein 12
chr8_-_67874805 0.07 ENST00000563496.1
TCF24
transcription factor 24
chr16_+_85936295 0.06 ENST00000563180.1
ENST00000564617.1
ENST00000564803.1
IRF8
interferon regulatory factor 8
chr6_+_151561085 0.06 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr4_-_90756769 0.06 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr16_-_67427389 0.06 ENST00000562206.1
ENST00000290942.5
ENST00000393957.2
TPPP3
tubulin polymerization-promoting protein family member 3
chr19_+_13051206 0.06 ENST00000586760.1
CALR
calreticulin
chr7_-_27135591 0.06 ENST00000343060.4
ENST00000355633.5
HOXA1
homeobox A1
chr5_-_125930929 0.05 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr7_-_27142290 0.05 ENST00000222718.5
HOXA2
homeobox A2
chr19_-_45735138 0.05 ENST00000252482.3
EXOC3L2
exocyst complex component 3-like 2
chr16_-_49890016 0.05 ENST00000563137.2
ZNF423
zinc finger protein 423
chr6_-_159065741 0.05 ENST00000367085.3
ENST00000367089.3
DYNLT1
dynein, light chain, Tctex-type 1
chr3_-_156877997 0.04 ENST00000295926.3
CCNL1
cyclin L1
chr2_+_12857043 0.04 ENST00000381465.2
TRIB2
tribbles pseudokinase 2
chr11_-_122929699 0.04 ENST00000526686.1
HSPA8
heat shock 70kDa protein 8
chr11_-_122930121 0.04 ENST00000524552.1
HSPA8
heat shock 70kDa protein 8
chr12_-_49393092 0.04 ENST00000421952.2
DDN
dendrin
chr14_-_81893734 0.04 ENST00000555447.1
STON2
stonin 2
chr11_-_93583697 0.04 ENST00000409977.1
VSTM5
V-set and transmembrane domain containing 5
chr19_-_49944806 0.03 ENST00000221485.3
SLC17A7
solute carrier family 17 (vesicular glutamate transporter), member 7
chr2_-_44588694 0.03 ENST00000409957.1
PREPL
prolyl endopeptidase-like
chr16_+_30080857 0.03 ENST00000565355.1
ALDOA
aldolase A, fructose-bisphosphate
chr9_+_40028620 0.03 ENST00000426179.1
AL353791.1
AL353791.1
chrX_+_95939638 0.03 ENST00000373061.3
ENST00000373054.4
ENST00000355827.4
DIAPH2
diaphanous-related formin 2
chr7_+_86273218 0.03 ENST00000361669.2
GRM3
glutamate receptor, metabotropic 3
chr7_+_39017504 0.03 ENST00000403058.1
POU6F2
POU class 6 homeobox 2
chr20_+_34802295 0.03 ENST00000432603.1
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr1_+_67390578 0.03 ENST00000371018.3
ENST00000355977.6
ENST00000357692.2
ENST00000401041.1
ENST00000371016.1
ENST00000371014.1
ENST00000371012.2
MIER1
mesoderm induction early response 1, transcriptional regulator
chr5_+_145826867 0.03 ENST00000296702.5
ENST00000394421.2
TCERG1
transcription elongation regulator 1
chr16_+_15596123 0.03 ENST00000452191.2
C16orf45
chromosome 16 open reading frame 45
chr8_-_38008783 0.03 ENST00000276449.4
STAR
steroidogenic acute regulatory protein
chr2_+_26624775 0.03 ENST00000288710.2
DRC1
dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chr6_+_32006042 0.03 ENST00000418967.2
CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr12_+_56414851 0.03 ENST00000547167.1
IKZF4
IKAROS family zinc finger 4 (Eos)
chr4_-_113437328 0.03 ENST00000313341.3
NEUROG2
neurogenin 2
chr2_-_44588679 0.03 ENST00000409411.1
PREPL
prolyl endopeptidase-like
chr3_+_150264458 0.03 ENST00000487799.1
ENST00000460851.1
EIF2A
eukaryotic translation initiation factor 2A, 65kDa
chr8_-_79717750 0.03 ENST00000263851.4
ENST00000379113.2
IL7
interleukin 7
chrX_+_41583408 0.03 ENST00000302548.4
GPR82
G protein-coupled receptor 82
chr16_-_11617444 0.03 ENST00000598234.1
CTD-3088G3.8
Protein LOC388210
chr5_-_10761206 0.03 ENST00000432074.2
ENST00000230895.6
DAP
death-associated protein
chr12_+_10658489 0.02 ENST00000538173.1
EIF2S3L
Putative eukaryotic translation initiation factor 2 subunit 3-like protein
chr21_-_43430440 0.02 ENST00000398505.3
ENST00000310826.5
ENST00000449949.1
ENST00000398499.1
ENST00000398497.2
ENST00000398511.3
ZBTB21
zinc finger and BTB domain containing 21
chr14_-_21516590 0.02 ENST00000555026.1
NDRG2
NDRG family member 2
chr7_+_79765071 0.02 ENST00000457358.2
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr1_-_109584608 0.02 ENST00000400794.3
ENST00000528747.1
ENST00000369962.3
ENST00000361054.3
WDR47
WD repeat domain 47
chr17_+_7758374 0.02 ENST00000301599.6
ENST00000574668.1
TMEM88
transmembrane protein 88
chr8_-_143961236 0.02 ENST00000377675.3
ENST00000517471.1
ENST00000292427.4
CYP11B1
cytochrome P450, family 11, subfamily B, polypeptide 1
chr11_+_133902547 0.02 ENST00000529070.1
RP11-713P17.3
RP11-713P17.3
chr4_-_123542224 0.02 ENST00000264497.3
IL21
interleukin 21
chr1_+_52082751 0.02 ENST00000447887.1
ENST00000435686.2
ENST00000428468.1
ENST00000453295.1
OSBPL9
oxysterol binding protein-like 9
chr11_-_111782696 0.02 ENST00000227251.3
ENST00000526180.1
CRYAB
crystallin, alpha B
chr4_-_90757364 0.02 ENST00000508895.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chrX_+_95939711 0.02 ENST00000373049.4
ENST00000324765.8
DIAPH2
diaphanous-related formin 2
chr1_+_36621174 0.02 ENST00000429533.2
MAP7D1
MAP7 domain containing 1
chr11_+_68228186 0.02 ENST00000393799.2
ENST00000393800.2
ENST00000528635.1
ENST00000533127.1
ENST00000529907.1
ENST00000529344.1
ENST00000534534.1
ENST00000524845.1
ENST00000265637.4
ENST00000524904.1
ENST00000393801.3
ENST00000265636.5
ENST00000529710.1
PPP6R3
protein phosphatase 6, regulatory subunit 3
chr1_-_92351769 0.02 ENST00000212355.4
TGFBR3
transforming growth factor, beta receptor III
chr3_+_239652 0.02 ENST00000435603.1
CHL1
cell adhesion molecule L1-like
chr8_-_101730061 0.02 ENST00000519100.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr18_+_18943554 0.02 ENST00000580732.2
GREB1L
growth regulation by estrogen in breast cancer-like
chr12_-_88423164 0.02 ENST00000298699.2
ENST00000550553.1
C12orf50
chromosome 12 open reading frame 50
chr12_+_56414795 0.02 ENST00000431367.2
IKZF4
IKAROS family zinc finger 4 (Eos)
chr1_-_109584768 0.02 ENST00000357672.3
WDR47
WD repeat domain 47
chr20_+_21283941 0.01 ENST00000377191.3
ENST00000430571.2
XRN2
5'-3' exoribonuclease 2
chr5_+_167181917 0.01 ENST00000519204.1
TENM2
teneurin transmembrane protein 2
chr10_-_98945264 0.01 ENST00000314867.5
SLIT1
slit homolog 1 (Drosophila)
chr7_-_78400598 0.01 ENST00000536571.1
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr2_-_197226875 0.01 ENST00000409111.1
HECW2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr11_+_57365150 0.01 ENST00000457869.1
ENST00000340687.6
ENST00000378323.4
ENST00000378324.2
ENST00000403558.1
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr3_+_150264555 0.01 ENST00000406576.3
ENST00000482093.1
ENST00000273435.5
EIF2A
eukaryotic translation initiation factor 2A, 65kDa
chr20_+_21284416 0.01 ENST00000539513.1
XRN2
5'-3' exoribonuclease 2
chr6_+_32006159 0.01 ENST00000478281.1
ENST00000471671.1
ENST00000435122.2
CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr17_-_1588101 0.01 ENST00000577001.1
ENST00000572621.1
ENST00000304992.6
PRPF8
pre-mRNA processing factor 8
chr2_+_135011731 0.01 ENST00000281923.2
MGAT5
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr9_-_26947453 0.01 ENST00000397292.3
PLAA
phospholipase A2-activating protein
chr2_-_145278475 0.01 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr9_-_36276966 0.01 ENST00000543356.2
ENST00000396594.3
GNE
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
chrX_-_110655306 0.01 ENST00000371993.2
DCX
doublecortin
chr19_-_12997995 0.01 ENST00000264834.4
KLF1
Kruppel-like factor 1 (erythroid)
chr10_-_65028817 0.01 ENST00000542921.1
JMJD1C
jumonji domain containing 1C
chr1_+_68150744 0.01 ENST00000370986.4
ENST00000370985.3
GADD45A
growth arrest and DNA-damage-inducible, alpha
chr17_-_42276574 0.01 ENST00000589805.1
ATXN7L3
ataxin 7-like 3
chr2_-_145277882 0.01 ENST00000465070.1
ENST00000444559.1
ZEB2
zinc finger E-box binding homeobox 2
chr1_+_243419306 0.01 ENST00000355875.4
ENST00000391846.1
ENST00000366541.3
ENST00000343783.6
SDCCAG8
serologically defined colon cancer antigen 8
chr6_+_73331520 0.01 ENST00000342056.2
ENST00000355194.4
KCNQ5
potassium voltage-gated channel, KQT-like subfamily, member 5
chr10_+_95848824 0.01 ENST00000371385.3
ENST00000371375.1
PLCE1
phospholipase C, epsilon 1
chr4_+_77356248 0.01 ENST00000296043.6
SHROOM3
shroom family member 3
chr2_-_45236540 0.01 ENST00000303077.6
SIX2
SIX homeobox 2
chr2_+_12857015 0.01 ENST00000155926.4
TRIB2
tribbles pseudokinase 2
chr7_-_78400364 0.01 ENST00000535697.1
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr15_+_48009541 0.01 ENST00000536845.2
ENST00000558816.1
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr2_+_54684327 0.01 ENST00000389980.3
SPTBN1
spectrin, beta, non-erythrocytic 1
chr1_-_43833628 0.01 ENST00000413844.2
ENST00000372458.3
ELOVL1
ELOVL fatty acid elongase 1
chr10_+_18689637 0.01 ENST00000377315.4
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chrX_-_10645773 0.01 ENST00000453318.2
MID1
midline 1 (Opitz/BBB syndrome)
chr10_-_65028938 0.01 ENST00000402544.1
JMJD1C
jumonji domain containing 1C
chr2_+_68961934 0.01 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr2_+_68961905 0.01 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr7_+_1272522 0.01 ENST00000316333.8
UNCX
UNC homeobox
chr3_+_189507460 0.01 ENST00000434928.1
TP63
tumor protein p63
chrX_-_13835147 0.01 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr2_-_200322723 0.01 ENST00000417098.1
SATB2
SATB homeobox 2
chr17_-_46623441 0.01 ENST00000330070.4
HOXB2
homeobox B2
chr2_+_114647504 0.01 ENST00000263238.2
ACTR3
ARP3 actin-related protein 3 homolog (yeast)
chr17_-_42277203 0.01 ENST00000587097.1
ATXN7L3
ataxin 7-like 3
chr9_-_26947220 0.01 ENST00000520884.1
PLAA
phospholipase A2-activating protein
chr10_-_46342921 0.01 ENST00000448048.2
AGAP4
ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
chr19_-_41356347 0.01 ENST00000301141.5
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr1_-_223536679 0.01 ENST00000608996.1
SUSD4
sushi domain containing 4
chr1_-_92351666 0.01 ENST00000465892.2
ENST00000417833.2
TGFBR3
transforming growth factor, beta receptor III
chr20_+_42574317 0.01 ENST00000358131.5
TOX2
TOX high mobility group box family member 2
chr1_-_109584716 0.01 ENST00000531337.1
ENST00000529074.1
ENST00000369965.4
WDR47
WD repeat domain 47
chr13_+_36050881 0.00 ENST00000537702.1
NBEA
neurobeachin
chrX_-_13835461 0.00 ENST00000316715.4
ENST00000356942.5
GPM6B
glycoprotein M6B
chrX_+_48455866 0.00 ENST00000376729.5
ENST00000218056.5
WDR13
WD repeat domain 13
chr2_-_200323414 0.00 ENST00000443023.1
SATB2
SATB homeobox 2
chr6_-_64029879 0.00 ENST00000370658.5
ENST00000485906.2
ENST00000370657.4
LGSN
lengsin, lens protein with glutamine synthetase domain
chr5_+_162864575 0.00 ENST00000512163.1
ENST00000393929.1
ENST00000340828.2
ENST00000511683.2
ENST00000510097.1
ENST00000511490.2
ENST00000510664.1
CCNG1
cyclin G1
chr3_+_191046810 0.00 ENST00000392455.3
ENST00000392456.3
CCDC50
coiled-coil domain containing 50
chr6_-_112575687 0.00 ENST00000521398.1
ENST00000424408.2
ENST00000243219.3
LAMA4
laminin, alpha 4
chr17_-_37353950 0.00 ENST00000394310.3
ENST00000394303.3
ENST00000344140.5
CACNB1
calcium channel, voltage-dependent, beta 1 subunit
chr2_+_176995011 0.00 ENST00000548663.1
ENST00000450510.2
HOXD8
homeobox D8
chr19_+_52074502 0.00 ENST00000545217.1
ENST00000262259.2
ENST00000596504.1
ZNF175
zinc finger protein 175
chr13_+_97928395 0.00 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chr10_+_124320195 0.00 ENST00000359586.6
DMBT1
deleted in malignant brain tumors 1
chr10_+_124320156 0.00 ENST00000338354.3
ENST00000344338.3
ENST00000330163.4
ENST00000368909.3
ENST00000368955.3
ENST00000368956.2
DMBT1
deleted in malignant brain tumors 1
chr2_+_68962014 0.00 ENST00000467265.1
ARHGAP25
Rho GTPase activating protein 25
chr10_-_98945515 0.00 ENST00000371070.4
SLIT1
slit homolog 1 (Drosophila)
chr12_-_57472522 0.00 ENST00000379391.3
ENST00000300128.4
TMEM194A
transmembrane protein 194A
chr7_-_14029515 0.00 ENST00000430479.1
ENST00000405218.2
ENST00000343495.5
ETV1
ets variant 1
chr6_+_33387830 0.00 ENST00000293748.5
SYNGAP1
synaptic Ras GTPase activating protein 1
chr13_+_52586517 0.00 ENST00000523764.1
ENST00000521508.1
ALG11
ALG11, alpha-1,2-mannosyltransferase
chr7_-_120497178 0.00 ENST00000441017.1
ENST00000424710.1
ENST00000433758.1
TSPAN12
tetraspanin 12
chr11_-_126870683 0.00 ENST00000525704.2
KIRREL3
kin of IRRE like 3 (Drosophila)
chr6_+_33388013 0.00 ENST00000449372.2
SYNGAP1
synaptic Ras GTPase activating protein 1
chr11_-_2162162 0.00 ENST00000381389.1
IGF2
insulin-like growth factor 2 (somatomedin A)
chr2_-_242089677 0.00 ENST00000405260.1
PASK
PAS domain containing serine/threonine kinase
chr9_-_15250114 0.00 ENST00000507993.1
TTC39B
tetratricopeptide repeat domain 39B
chr18_-_53070913 0.00 ENST00000568186.1
ENST00000564228.1
TCF4
transcription factor 4
chr6_-_112575912 0.00 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
LAMA4
laminin, alpha 4

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA2_HOXB1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0021569 rhombomere 3 development(GO:0021569)
0.0 0.0 GO:0045081 negative regulation of interleukin-10 biosynthetic process(GO:0045081)
0.0 0.1 GO:1902904 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
0.0 0.1 GO:1903284 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.0 0.1 GO:0002501 MHC protein complex assembly(GO:0002396) peptide antigen assembly with MHC protein complex(GO:0002501)
0.0 0.0 GO:0042137 sequestering of neurotransmitter(GO:0042137)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0060961 phospholipase D inhibitor activity(GO:0060961)